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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 514, Issue 1, pp. 329 - 335
Endothelial dysfunction plays an important role in the pathogenesis of acute lung injury (ALI) Tetramethylpyrazine (TMP) has been reported to attenuate harmful... 
Rho/ROCK pathway | HUVEC | Tetramethylpyrazine | LPS | Inflammatory injury
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 01/2020, Volume 177, p. 112885
Tianma pills, a traditional formula made from and , are efficacious for the treatment of primary headache. Tetramethylpyrazine (TMP) and Ferulic acid (FA) are... 
Gastrodia | Gastrodigenin | Tetramethylpyrazine | Migraine | Pharmacokinetic | Ferulic acid
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2017, Volume 65, Issue 4, pp. 381 - 388
Myocardial ischemia is a primary cause of sudden death worldwide. Numerous active ingredients of traditional Chinese medicines including danshensu (DSS) and... 
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 8, pp. 1370 - 1373
Intravenous tetramethylpyrazine has been widely used in China as a complementary and/or alternative medicine to treat patients with ischemic heart disease. We... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2018, Volume 61, Issue 5, pp. 1821 - 1832
Piperlongumine 1 increases reactive oxygen species (ROS) levels and preferably induces cancer cell apoptosis by triggering different pathways. However, the... 
SYSTEM | APOPTOSIS | DESIGN | CHEMISTRY, MEDICINAL | INHIBITION | MECHANISM | PIPLARTINE | TETRAMETHYLPYRAZINE | ROS STRESS | DERIVATIVES | EXPRESSION
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 09/2018, Volume 105, pp. 1254 - 1268
Huntington’s disease (HD) is an autosomal neurodegenerative disease characterized by chorea, dystonia, motor ataxia, cognitive decline and psychiatric... 
Oxidative stress | Huntington’s disease | 3-nitropropionic acid | Histopathology | Neurochemicals | Tetramethylpyrazine
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2019, p. 172763
Journal Article
NeuroReport, ISSN 0959-4965, 06/2019, Volume 30, Issue 9, pp. 658 - 663
Neuronal death is among the deleterious pathological changes that occur after cerebral ischemia and can lead to transient or permanent neurological deficits.... 
neurogenesis | brain-derived neurotrophic factor | tetramethylpyrazine analog | ischemic stroke | CELLS | RECOVERY | NEUROREGENERATION | NITRONE | NEUROSCIENCES
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 2018, Volume 24, Issue 30, pp. 3529 - 3533
Background: Andrographolide (Andro) is a main active ingredient of the natural plant Andrographis paniculata, which has special effects on bacterial infections... 
anti-inflammatory | picolinic acid | tetramethylpyrazine | Andrographolide derivative | benzimidazole | MTT | PHARMACOLOGY & PHARMACY
Journal Article
CRYSTAL GROWTH & DESIGN, ISSN 1528-7483, 08/2019, Volume 19, Issue 8, pp. 4526 - 4537
Here we report the dynamics of organic cations as guest molecules in the novel perovskite host framework. The novel switchable crystals from the coordination... 
PHASE-TRANSITIONS | MATERIALS SCIENCE, MULTIDISCIPLINARY | SINGLE-PARTICLE DYNAMICS | TETRAMETHYLPYRAZINE | CONSTANT | CRYSTALLOGRAPHY | SPECTRA | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 9/2017, Volume 54, Issue 7, pp. 4866 - 4878
Parkinson’s disease (PD) is a slowly progressive neurodegenerative movement disorder. Apoptosis, neuroinflammation, and oxidative stress are the current... 
Neurology | Neurosciences | Biomedicine | Neurobiology | Neuroinflammation | Tetramethylpyrazine | Parkinson’s disease | Cell Biology | Rotenone | Apoptosis
Journal Article
Zhongguo Zhongyao Zazhi, ISSN 1001-5302, 06/2015, Volume 40, Issue 11, pp. 2186 - 2190
Journal Article
CRYSTENGCOMM, ISSN 1466-8033, 10/2018, Volume 20, Issue 38, pp. 5772 - 5781
Crystals of tetrafluoroboric acid with tetramethylpyrazine, TMP + HBF4 + H2O (1:1:2, A), TMP + HBF4 (1:1, B) and TMP + HBF4 (1:2, C) were synthesized and... 
HSQ | RAMAN | TETRAMETHYLPYRAZINE TMP | CRYSTALLOGRAPHY | VIBRATIONAL-SPECTRA | CHEMISTRY, MULTIDISCIPLINARY | INS
Journal Article
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 12/2018, Volume 2018, Issue 12
Background Diabetic retinopathy is one of the major causes of blindness and the number of cases has risen in recent years. Herbal medicine has been used to... 
MEDICINE, GENERAL & INTERNAL | GINKGO-BILOBA EXTRACT | VISION | INTRAVITREAL TRIAMCINOLONE ACETONIDE
Journal Article
by Dong, YX and Zhang, XH and Liu, MJ and Yang, Y and Guo, T and Mao, YH and Zhang, JQ and Fu, XZ and Zhao, YL and Chen, JL and Dong, L and Qiao, CH
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 10/2019, Volume 29, Issue 19, p. 126608
A series of hybrid molecules of scutellarein and tertramethylpyrazine's active metabolites have been synthesized. Compared to the original compound, these... 
Cereralral | CHEMISTRY, MEDICINAL | LIGANDS | Antithrombosis | AMINO-ACIDS | CHEMISTRY, ORGANIC | TETRAMETHYLPYRAZINE | Tertramethylpyrazine | Antioxidant | Scutellarein | Ischemia-reperfusion (I/R) injury
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 2013, Volume 8, Issue 4, pp. 984 - 988
Journal Article
Experimental and Molecular Pathology, ISSN 0014-4800, 12/2019, Volume 111, p. 104317
Tetramethylpyrazine (TMP) has been reported to play a significant role in the cardiovascular and neuronal diseases. But, the functions of TMP in osteoarthritis... 
Myeloid differentiation factor 88 | Lipopolysaccharide | NF-κB | Osteoarthritis | Tetramethylpyrazine | p38MAPK
Journal Article
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