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1. Full Text MCR synthesis of a tetracyclic tetrazole scaffold
by Patil, Pravin and Khoury, Kareem and Herdtweck, Eberhardt and Dömling, Alexander
Bioorganic & medicinal chemistry, ISSN 0968-0896, 06/2015, Volume 23, Issue 11, pp. 2699 - 2715
Synthesis | Tetrazol | Parallel | Isocyanide | Ugi | Pictet–Spengler | unclassified drug | n [[(4 chlorophenyl)[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]methyl] 2 3,4 dimethoxyphenyl]ethanamine | 8 ethyl 2,3 dimethoxy 8 methyl 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | n [2 (1h indol 3 yl)ethyl] 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]propan 1 amine | tetracyclic tetrazole scaffold | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)cyclohexanamine | n [[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl](4 fluorophenyl)methyl] 2 (3,4 dimethoxy phenyl)ethanamine | 8 (4 chlorophenyl) 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 isopropyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 phenylethanamine | high throughput screening | mass spectrometry | Pictet-Spengler | multicomponent reaction chemistry | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)propan 1 amine | thin layer chromatography | 1 benzyl 4 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxy phenethyl)piperidin 4 amine | proton nuclear magnetic resonance | n [2 (1h indol 3 yl)ethyl] 1 benzyl 4 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]piperidin 4 amine | 2,3 dimethoxy 8 phenyl 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 7',12',12b',13' tetrahydro 6'h spiro[cyclohexane 1,4' tetrazolo[1'',5'' 4',5']pyrazino[1',2' 1,2]pyrido[3,4 b]indole] | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 phenylpropan 1 amine | 2,3 dimethoxy 8 phenethyl 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | chemical reaction | supercritical fluid chromatography | tetrazole derivative | n [2 (1h indol 3 yl)ethyl] 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]cyclohexanamine | article | carbon nuclear magnetic resonance | n [[1,1' biphenyl] 4 yl[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl]methyl] 2 (3,4 dimethoxyphenyl)ethanamine | controlled study | 8 (4 fluorophenyl) 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 benzyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 8 ethyl 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazoleo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl) 2 methylpropan 1 amine | 8 [[1,1' biphenyl] 4 yl] 2,3 dimethoxy 6,8,13,13a tetrahydro 5h tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline | 1 benzyl 2',3'dimethoxy 5',6',13',13a' tetrahydrospiro[piperidine 4,8' tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline] | 4 ethyl 4,6,7,12,12b,13 hexahydro tetrazolo[1'',5'' 4',5']pyrazino[1',2' 1,2]pyrido[3,4 b]indole | 2',3'dimethoxy 5',6',13',13a' tetrahydrospiro[cyclohexane 1,8' tetrazolo[1',5' 4,5]pyrazino [2,1 a]isoquinoline] | unindexed drug | pharmacophore | n [[1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl](phenyl)methyl] 2 (3,4 dimethoxy phenyl)ethanamine | 2 [1 (2,2 dimethoxyethyl) 1h tetrazole 5 yl] n (3,4 dimethoxyphenethyl)butan 2 amine | Models, Molecular | Molecular Structure | Tetrazoles - chemical synthesis | Polycyclic Compounds - chemical synthesis | Drug Discovery | Index Medicus | Pictet-spengler
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2. Full Text One-pot synthesis of 1-substituted 1 H -1,2,3,4-tetrazoles from 2aminothiazoles using tributylmethylammonium chloride as a catalyst
by Kerru Nagaraju and Gummidi Lalitha and Parvesh Singh and Chunduri Venkata Rao
Heterocyclic communications, ISSN 0793-0283, 10/2017, Volume 23, Issue 5, p. 365
Tetrazoles
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3. Full Text Tetrazoles via Multicomponent Reactions
by Neochoritis, Constantinos G and Zhao, Ting and Dömling, Alexander
Chemical reviews, ISSN 0009-2665, 02/2019, Volume 119, Issue 3, pp. 1970 - 2042
GLYCOGEN-PHOSPHORYLASE-B | ONE-POT SYNTHESIS | BAYLIS-HILLMAN REACTION | SOLUTION-PHASE PREPARATION | tetrazole derivative | article | To be checked by Faculty | AZIDO-UGI REACTION | CLICK CHEMISTRY APPROACH | HUMAN DIHYDROFOLATE-REDUCTASE | GROWTH-HORMONE SECRETAGOGUE | receptor binding | HUISGEN 1,3-DIPOLAR CYCLOADDITION | substitution reaction | MICROWAVE-ASSISTED SYNTHESIS | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Animals | Tetrazoles - pharmacology | Tetrazoles - chemistry | Humans | Models, Molecular | Drug Discovery | Chemistry, Pharmaceutical | Binding | Organic chemistry | Tetrazoles | Derivatives | Carboxylic acids | Physicochemical properties | Index Medicus | Review
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4. Full Text Asymmetric Synthesis of 5‐(1‐Hydroxyalkyl)tetrazoles by Catalytic Enantioselective Passerini‐Type Reactions
by Yue, Tao and Wang, Mei‐Xiang and Wang, De‐Xian and Zhu, Jieping
Angewandte Chemie (International ed.), ISSN 1433-7851, 11/2008, Volume 47, Issue 49, pp. 9454 - 9457
multicomponent reactions | isocyanides | asymmetric synthesis | homogeneous catalysis | nitrogen heterocycles | Multicomponent reactions | Asymmetric synthesis | Nitrogen heterocycles | Isocyanides | Homogeneous catalysis | Organometallic Compounds - chemistry | Molecular Structure | Tetrazoles - chemical synthesis | Catalysis | Tetrazoles - chemistry | Ethylenediamines - chemistry | Index Medicus | Organometallic Compounds | Life Sciences | Tetrazoles | Cellular Biology | Ethylenediamines
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5. Full Text Safe and Efficient Tetrazole Synthesis in a Continuous‐Flow Microreactor
by Palde, Prakash B and Jamison, Timothy F
Angewandte Chemie (International ed.), ISSN 1433-7851, 04/2011, Volume 50, Issue 15, pp. 3525 - 3528
tetrazoles | azides | continuous‐flow synthesis | microreactors | synthetic methods | continuous-flow synthesis | Microchemistry | Tetrazoles - chemical synthesis | Tetrazoles - chemistry | Bioreactors | Index Medicus
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6. Full Text Azole antimicrobial pharmacophore-based tetrazoles: Synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents
by Rostom, Sherif A.F and Ashour, Hayam M.A and Razik, Heba A. Abd El and Fattah, Abd El Fattah H. Abd El and El-Din, Nagwa N
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 6, pp. 2410 - 2422
1 H-Tetrazoles | 1,3,4-Oxadiazoles | Antifungal activity | Azoles | Pyrazoles | 1,3,4-Triazoles | Anticonvulsant activity | Antibacterial activity | 1H-Tetrazoles | General aspects | Pharmacology. Drug treatments | Antifungal agents | Biological and medical sciences | Anticonvulsants. Antiepileptics. Antiparkinson agents | Medical sciences | Neuropharmacology | Antibacterial agents | Antibiotics. Antiinfectious agents. Antiparasitic agents | Microbial Sensitivity Tests | Tetrazoles - chemical synthesis | Tetrazoles - pharmacology | Magnetic Resonance Spectroscopy | Tetrazoles - chemistry | Anticonvulsants - chemical synthesis | Anti-Infective Agents - chemistry | Anti-Infective Agents - pharmacology | Anticonvulsants - chemistry | Drug Evaluation, Preclinical | Anticonvulsants - pharmacology | Anti-Infective Agents - chemical synthesis | Anticonvulsants | Ampicillin | Pharmacy | Universities and colleges | Seizures (Medicine) | Public health | Index Medicus
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7. Full Text Tert‐Butyl Nitrite Mediated Expeditious Methylsulfoxidation of Tetrazole‐amines with DMSO: Metal‐free Synthesis of Antifungal Active Methylsulfinyl‐1H‐tetrazole Derivatives
by Dai, Peng and Luo, Kai and Yu, Xiang and Yang, Wen‐Chao and Wu, Lei and Zhang, Wei‐Hua
Advanced synthesis & catalysis, ISSN 1615-4150, 02/2018, Volume 360, Issue 3, pp. 468 - 473
Methylsulfinyl-1H-tetrazole | Methylsulfoxidation | Tetrazole-amines | Antifungal Activity | tert-butyl Nitrite | Amines | Antifungal agents | Tetrazoles | Derivatives | Fungicides
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8. Full Text H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation
by Sharma, Pankaj and Senwar, Kishna Ram and Jeengar, Manish Kumar and Reddy, T. Srinivasa and Naidu, V.G.M and Kamal, Ahmed and Shankaraiah, Nagula
European journal of medicinal chemistry, ISSN 0223-5234, 11/2015, Volume 104, pp. 11 - 24
Isatin epoxide | Tetrazoles | Azide-nitrile cycloaddition | 3-Hydroxy-oxindole | Anticancer | Apoptosis | Reactive Oxygen Species - metabolism | Tetrazoles - chemical synthesis | Tetrazoles - pharmacology | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Sodium Cyanide - chemistry | Structure-Activity Relationship | Isatin - chemistry | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Tetrazoles - chemistry | Epoxy Compounds - chemistry | Water - chemistry | Cell Line, Tumor | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Indoles - chemistry | Spiro Compounds - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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9. Full Text A chitosan-graft-PEI-candesartan conjugate for targeted co-delivery of drug and gene in anti-angiogenesis cancer therapy
by Bao, Xiuli and Wang, Wei and Wang, Cheng and Wang, Yu and Zhou, Jianping and Ding, Yang and Wang, Xiaoyi and Jin, Yuting
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 29, pp. 8450 - 8466
Advanced Basic Science | Dentistry | Wild type p53 | Co-delivery | Candesartan | Angiotensin II type 1 receptor targeting | Multifunctional copolymer–anticancer conjugate | Tumor anti-angiogenesis therapy | Multifunctional copolymer-anticancer conjugate | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Neoplasms - metabolism | Genetic Therapy | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | DNA - therapeutic use | Male | Benzimidazoles - chemistry | Angiotensin II Type 1 Receptor Blockers - metabolism | Drug Delivery Systems | Tetrazoles - metabolism | Genes, p53 | Neoplasms - therapy | Benzimidazoles - administration & dosage | Neoplasms - genetics | Tetrazoles - chemistry | Tetrazoles - administration & dosage | Polyethyleneimine - chemistry | Chitosan - analogs & derivatives | Chitosan - metabolism | Neovascularization, Pathologic - therapy | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Benzimidazoles - therapeutic use | Gene Transfer Techniques | Polyethyleneimine - metabolism | Angiotensin II Type 1 Receptor Blockers - chemistry | DNA - administration & dosage | Neoplasms - blood supply | DNA - genetics | Polyethyleneimine - analogs & derivatives | Animals | Chitosan - chemistry | Benzimidazoles - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Tetrazoles - therapeutic use | Mice, Inbred BALB C | RNA | Political corruption | Genes | Analysis | Angiotensin | Genetic research | Genetic aspects | Pharmaceutical industry | Tumor proteins | Health aspects | Vascular endothelial growth factor | Cancer | Index Medicus | Drugs | Therapy | Cadmium | Nanostructure | Buffers | Density | Tumors
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10. Full Text Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: Insights from PARADIGM-HF
by Jhund, Pardeep S and Fu, Michael and Bayram, Edmundo and Chen, Chen-Huan and Negrusz-Kawecka, Marta and Rosenthal, Arvo and Desai, Akshay S and Lefkowitz, Martin P and Rizkala, Adel R and Rouleau, Jean L and Shi, Victor C and Solomon, Scott D and Swedberg, Karl and Zile, Michael R and McMurray, John J.V and Packer, Milton and PARADIGM-HF Investigators Comm and PARADIGM-HF Investigators and Committees and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
European heart journal, ISSN 0195-668X, 10/2015, Volume 36, Issue 38, pp. 2576 - 2584
Heart failure | Receptors | Neprilysin | Age | Angiotensin | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Age Factors | Humans | Middle Aged | Aminobutyrates - adverse effects | Treatment Outcome | Cause of Death | Heart Failure - drug therapy | Young Adult | Tetrazoles - administration & dosage | Adolescent | Aged, 80 and over | Adult | Aged | Aminobutyrates - administration & dosage | Tetrazoles - adverse effects | Angiotensin Receptor Antagonists - administration & dosage | Angiotensin Receptor Antagonists - adverse effects | Index Medicus | Clinical Research | enalapril | program | Kardiologi | Cardiac and Cardiovascular Systems | neprilysin inhibition | comorbidities | management | clinical-trials | mortality | systolic heart-failure | risk
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