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1. Full Text Efficient synthesis of arylaminotetrazoles in water
by Habibi, Davood and Nasrollahzadeh, Mahmoud and Faraji, Ali Reza and Bayat, Yadollah
Tetrahedron, ISSN 0040-4020, 2010, Volume 66, Issue 21, pp. 3866 - 3870
Arylaminotetrazole derivatives are synthesized efficiently by the reaction of arylcyanamides and sodium azide in the presence of ZnCl under aqueous conditions... 
1-Aryl-5-amino-1 H-tetrazole | Arylcyanamide | 5-Arylamino-1 H-tetrazole | Sodium azide | ZnCl 2 | 5-Arylamino-1H-tetrazole | 1-Aryl-5-amino-1H-tetrazole | ZnCl | 5-SUBSTITUTED 1H-TETRAZOLES | SODIUM-AZIDE | CHEMISTRY, ORGANIC | 5-ARYLTETRAZOLES | SUBSTITUTED 5-AMINOTETRAZOLES | CYCLOADDITION | ZnCl2 | NITRILES | CHEMISTRY | CHLORIDES | TETRAZOLE-DERIVATIVES | HETEROGENEOUS CATALYST
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2. Full Text Safe and Efficient Tetrazole Synthesis in a Continuous‐Flow Microreactor
by Palde, Prakash B and Jamison, Timothy F
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2011, Volume 50, Issue 15, pp. 3525 - 3528
Safer flow: The synthesis of 5‐substituted tetrazoles in flow (see scheme) is safe, efficient, scalable, requires no metal promoter, and uses a near‐equimolar... 
tetrazoles | azides | continuous‐flow synthesis | microreactors | synthetic methods | continuous-flow synthesis | 5-SUBSTITUTED 1H-TETRAZOLES | HYDRAZOIC ACID | REACTORS | CONVERSION | CATALYZED SYNTHESIS | AZIDE | CHEMISTRY, MULTIDISCIPLINARY | NITRILES | CHEMISTRY | TOOL | Microchemistry | Tetrazoles - chemical synthesis | Tetrazoles - chemistry | Bioreactors
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3. Tetrazole derivatives as promising anticancer agents
by Popova, Elena A and Protas, Aleksandra V and Trifonov, Rostislav E
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2017, Volume 17, Issue 14, pp. 1856 - 1868
Tetrazole cycle is a promising pharmacophore fragment frequently used in the development of novel drugs. This moiety is a stable, practically non-metabolized... 
Tetrazoles | Antitumor agents | Anticancer agents | Coordination compounds | Natural compounds | Cancer | natural compounds | CHEMISTRY, MEDICINAL | THYMIDYLATE SYNTHASE | 1,5-DISUBSTITUTED TETRAZOLES | VIVO ANTITUMOR-ACTIVITY | MOLECULAR DOCKING | anticancer agents | antitumor agents | MEDICINAL CHEMISTRY | COMBRETASTATIN A-4 ANALOGS | IN-VITRO | coordination compounds | ONCOLOGY | BIOLOGICAL EVALUATION | cancer | CARBOXYLIC-ACID ISOSTERES | DINUCLEAR PLATINUM(II) COMPLEXES | Neoplasms - metabolism | Tetrazoles - chemical synthesis | Tetrazoles - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Animals | Tetrazoles - chemistry | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Neoplasms - pathology
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4. Visible-light driven regioselective synthesis of 1H-tetrazoles from aldehydes through isocyanide-based [3 + 2] cycloaddition
by Fooleswar Verma and Anjumala Sahu and Puneet K Singh and Ankita Rai and Manorama Singh and Vijai K Rai
Green Chemistry, ISSN 1463-9262, 01/2018, Volume 20, Issue 16, pp. 3783 - 3789
A novel and green Co@g-C3N4 catalyzed visible light driven direct regioselective synthesis of 1H-tetrazoles directly from various aldehydes and sodium azide is... 
Purification | Regioselectivity | Recyclability | Tetrazoles | Nitrogen | Aldehydes | Carbon nitride | Cycloaddition | Sodium | Sodium azide | Morphology | Sodium azides | Catalysis | Chemical synthesis | Column chromatography
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5. Full Text H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation
by Sharma, Pankaj and Senwar, Kishna Ram and Jeengar, Manish Kumar and Reddy, T. Srinivasa and Naidu, V.G.M and Kamal, Ahmed and Shankaraiah, Nagula
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2015, Volume 104, pp. 11 - 24
A simple method for isatin -epoxide ring-opening by sodium cyanide in water to obtain a variety of isatin hydroxy nitriles has been developed. Further, these... 
Isatin epoxide | Tetrazoles | Azide-nitrile cycloaddition | 3-Hydroxy-oxindole | Anticancer | Apoptosis | 5-SUBSTITUTED 1H-TETRAZOLES | HIGHLY ENANTIOSELECTIVE SYNTHESIS | CHEMISTRY, MEDICINAL | DNA-BINDING AFFINITY | POTENTIAL ANTICANCER | UNACTIVATED KETONES | ASYMMETRIC ALDOL REACTION | BIOLOGICAL EVALUATION | DERIVATIVES | Reactive Oxygen Species - metabolism | Tetrazoles - chemical synthesis | Tetrazoles - pharmacology | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Sodium Cyanide - chemistry | Structure-Activity Relationship | Isatin - chemistry | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Tetrazoles - chemistry | Epoxy Compounds - chemistry | Water - chemistry | Cell Line, Tumor | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Indoles - chemistry | Spiro Compounds - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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6. Full Text AgNO3 catalyzed synthesis of 5-substituted-1H-tetrazole via [3+2] cycloaddition of nitriles and sodium azide
by Mani, Pavnesh and Singh, Ashawani Kumar and Awasthi, Satish Kumar
Tetrahedron Letters, ISSN 0040-4039, 03/2014, Volume 55, Issue 11, pp. 1879 - 1882
An efficient one-pot, convenient catalysis for the synthesis of 5-substituted-1 -tetrazoles is reported. The [3+2] cycloaddition involves various nitriles,... 
Nitriles | Cycloaddition | Tetrazole | AgNO3 | 1H-TETRAZOLES | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | MECHANISMS | HETEROGENEOUS CATALYST | TETRAZOLE FORMATION | ORGANIC NITRILES | Synthesis (chemistry) | Refluxing | Tetrahedrons | Formations | Sodium azides | Tetrazoles
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7. Full Text Azole antimicrobial pharmacophore-based tetrazoles: Synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents
by Rostom, Sherif A.F and Ashour, Hayam M.A and Razik, Heba A. Abd El and Fattah, Abd El Fattah H. Abd El and El-Din, Nagwa N
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 6, pp. 2410 - 2422
This study presents the synthesis and antimicrobial evaluation of a new series of substituted tetrazoles that are structurally related to the famous... 
1 H-Tetrazoles | 1,3,4-Oxadiazoles | Antifungal activity | Azoles | Pyrazoles | 1,3,4-Triazoles | Anticonvulsant activity | Antibacterial activity | 1H-Tetrazoles | DENZIMOL | CHEMISTRY, MEDICINAL | ACID HYDRAZIDE | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIBACTERIAL | CHEMISTRY, ORGANIC | THIAZOLE | RING-SYSTEMS | ANTITUMOR EVALUATION | INHIBITORS | DERIVATIVES | Microbial Sensitivity Tests | Tetrazoles - chemical synthesis | Tetrazoles - pharmacology | Magnetic Resonance Spectroscopy | Tetrazoles - chemistry | Anticonvulsants - chemical synthesis | Anti-Infective Agents - chemistry | Anti-Infective Agents - pharmacology | Anticonvulsants - chemistry | Drug Evaluation, Preclinical | Anticonvulsants - pharmacology | Anti-Infective Agents - chemical synthesis | Anticonvulsants | Ampicillin | Pharmacy | Universities and colleges | Seizures (Medicine) | Public health
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8. Full Text Synthesis, molecular docking and xanthine oxidase inhibitory activity of 5-aryl-1H-tetrazoles
by Fatima, Itrat and Zafar, Humaira and Khan, Khalid Mohammed and Saad, Syed Muhammad and Javaid, Sumaira and Perveen, Shahnaz and Choudhary, M. Iqbal
Bioorganic Chemistry, ISSN 0045-2068, 09/2018, Volume 79, pp. 201 - 211
5-Aryl-1 -tetrazoles ( – ) were synthesized and screened for their xanthine oxidase (XO) inhibitory activity using allopurinol as standard inhibitor (IC... 
5-Aryl-1H-tetrazoles | Xanthine oxidase Inhibition | Hyperuricemia | Uric acid | Gout | Structure-activity relationship | 5-SUBSTITUTED 1H-TETRAZOLES | DESIGN | ACID | MECHANISM | CATALYZED SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXIDOREDUCTASE | CHEMISTRY, ORGANIC | 5-SUBSTITUTED-1H-TETRAZOLES | CYCLOADDITION | POTENT | NITRILES | Xanthine Oxidase - metabolism | Tetrazoles - chemical synthesis | Tetrazoles - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Dose-Response Relationship, Drug | Tetrazoles - chemistry | Enzyme Inhibitors - chemistry | Allopurinol - pharmacology | Molecular Docking Simulation | Molecular Structure | Kinetics | Xanthine Oxidase - antagonists & inhibitors | Oxidases | Iron compounds | Research institutes
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9. Full Text Asymmetric Synthesis of 5‐(1‐Hydroxyalkyl)tetrazoles by Catalytic Enantioselective Passerini‐Type Reactions
by Yue, Tao and Wang, Mei‐Xiang and Wang, De‐Xian and Zhu, Jieping
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2008, Volume 47, Issue 49, pp. 9454 - 9457
Three‐part harmony: Three‐component Passerini reactions (P‐3CR, see Scheme) of a wide range of aldehydes 2 and isocyanides 3, with hydrazoic acid 4 in toluene,... 
multicomponent reactions | isocyanides | asymmetric synthesis | homogeneous catalysis | nitrogen heterocycles | Multicomponent reactions | Asymmetric synthesis | Nitrogen heterocycles | Isocyanides | Homogeneous catalysis | ALPHA-AMINO | ALDEHYDES | TETRAZOLE ANALOGS | CHEMISTRY, MULTIDISCIPLINARY | ALUMINUM COMPLEX | KETONES | CHIRAL SALEN | AMINO-ACID-DERIVATIVES | CONJUGATE ADDITION | Organometallic Compounds - chemistry | Molecular Structure | Tetrazoles - chemical synthesis | Catalysis | Tetrazoles - chemistry | Ethylenediamines - chemistry | Organometallic Compounds | Life Sciences | Tetrazoles | Cellular Biology | Ethylenediamines
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10. Full Text Synthesis of 5‐Substituted 1H‐Tetrazoles from Nitriles and Hydrazoic Acid by Using a Safe and Scalable High‐Temperature Microreactor Approach
by Gutmann, Bernhard and Roduit, Jean‐Paul and Roberge, Dominique and Kappe, C. Oliver
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2010, Volume 49, Issue 39, pp. 7101 - 7105
Harnessing hydrazoic acid in a microreactor! Tetrazoles have been synthesized in a very efficient manner by using a high‐temperature/high‐pressure process... 
process intensification | hydrazoic acid | cycloaddition | tetrazoles | microreactors | SODIUM-AZIDE | CATALYZED SYNTHESIS | AQUEOUS-MEDIA | EFFICIENT SYNTHESIS | DIRECT CONVERSION | TRIMETHYLSILYL AZIDE | CHEMISTRY, MULTIDISCIPLINARY | ORGANIC NITRILES | POT TANDEM REACTIONS | HETEROGENEOUS CATALYST | TETRAZOLE FORMATION | Microfluidic Analytical Techniques - methods | Tetrazoles - chemical synthesis | Tetrazoles - chemistry | Microfluidic Analytical Techniques - instrumentation | Nitriles - chemistry | Hot Temperature | Miniaturization | Azides - chemistry
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11. Full Text Design, synthesis and evaluation of 5-substituted 1-H-tetrazoles as potent anticonvulsant agents
by Liao, Ai-Mei and Wang, Tiantian and Cai, Bangrong and Jin, Yi and Cheon, Seunghoon and Chun, ChangJu and Wang, Zengtao
Archives of Pharmacal Research, ISSN 0253-6269, 4/2017, Volume 40, Issue 4, pp. 435 - 443
A series of 5-substituted 1-H-tetrazoles were designed and synthesized as potent anticonvulsant agents. Their preliminary anticonvulsant activities were... 
5-Substituted 1- H -tetrazoles | Anticonvulsant | Synthesis | Pharmacology/Toxicology | Pharmacy | 5-Substituted 1-H-tetrazoles | CHEMISTRY, MEDICINAL | REFRACTORY EPILEPSY | 1H-TETRAZOLES | GLUTAMATE | ANTIEPILEPTIC DRUG DEVELOPMENT | PHARMACOLOGY & PHARMACY | IDENTIFICATION | DISCOVERY | Tetrazoles - chemical synthesis | Anticonvulsants - chemical synthesis | Seizures - drug therapy | Anticonvulsants - therapeutic use | Male | Structure-Activity Relationship | Mice, Inbred Strains | Seizures - chemically induced | Dose-Response Relationship, Drug | Animals | Pentylenetetrazole - administration & dosage | Tetrazoles - chemistry | Anticonvulsants - chemistry | Drug Design | Tetrazoles - therapeutic use | Mice | Molecular Structure | Anticonvulsants | Analysis | Medicine, Botanic | Drugstores | Medicine, Herbal | Seizures (Medicine)
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12. Full Text Lewis Acid Mediated Tandem Reaction of Propargylic Alcohols to Tetrazoles Involving CO‐ and CC‐Bond Cleavage Reactions and a CN‐Bond Formation
by Song, Xian‐Rong and Han, Ya‐Ping and Qiu, Yi‐Feng and Qiu, Zi‐Hang and Liu, Xue‐Yuan and Xu, Peng‐Fei and Liang, Yong‐Min
Chemistry – A European Journal, ISSN 0947-6539, 09/2014, Volume 20, Issue 38, pp. 12046 - 12050
A novel and direct synthesis of 1‐aryl‐5‐arylvinyl‐tetrazoles from easily prepared propargylic alcohols and TMSN3 is developed in the presence of TMSCl under... 
Lewis acids | 1‐aryl‐5‐arylvinyl‐tetrazoles | propargylic alcohols | CN‐bond formation | CC‐bond cleavage | 1-aryl-5-arylvinyl-tetrazoles | C-N-bond formation | C-C-bond cleavage | CC-bond cleavage | CN-bond formation | MEYER-SCHUSTER REARRANGEMENT | AZIDES | SCHMIDT REACTION | ISOMERIZATION | EFFICIENT SYNTHESIS | ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS | 1,5-DISUBSTITUTED TETRAZOLES | ASYMMETRIC SYNTHESES | CHEMISTRY, MULTIDISCIPLINARY | KETONES | DERIVATIVES | Lewis Acids - chemistry | Alcohols - chemistry | Propanols - chemistry | Tetrazoles - chemistry | Stereoisomerism | Alkynes - chemistry | Molecular Structure | Catalysis | Lewis acid | Synthesis | Cleavage | Formations | Tetrazoles | Cascade chemical reactions | Sieves | Alcohols
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13. Full Text The Development of Copper‐Catalyzed Aerobic Oxidative Coupling of H‐Tetrazoles with Boronic Acids and an Insight into the Reaction Mechanism
by Liu, Chao‐You and Li, Yu and Ding, Jin‐Ying and Dong, De‐Wen and Han, Fu‐She
Chemistry – A European Journal, ISSN 0947-6539, 02/2014, Volume 20, Issue 8, pp. 2373 - 2381
The development of a highly efficient and practical protocol for the direct CN coupling of H‐tetrazole and boronic acid was presented. A careful and patient... 
copper | boronic acid | tetrazole | cross‐coupling | CN bond formation | cross-coupling | C-N bond formation | PALLADIUM | CLICK CHEMISTRY | COMPLEXES | ARYLATION | DIARYLIODONIUM SALTS | CHEMISTRY, MULTIDISCIPLINARY | PHOTOCLICK CHEMISTRY | CN bond formation | 1,3-DIPOLAR CYCLOADDITION | ARYL | 2,5-DISUBSTITUTED TETRAZOLES | C-H | Copper - chemistry | Tetrazoles - chemical synthesis | Oxidation-Reduction | Tetrazoles - chemistry | Coordination Complexes - chemical synthesis | Boronic Acids - chemistry | Molecular Structure | Anions - chemistry | Catalysis | Coordination Complexes - chemistry | Boronic Acids - chemical synthesis | Copper | Design engineering | Stirring | Chemical reactions | Joining | Tetrazoles | Optimization
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14. Full Text Iron Salts in the Catalyzed Synthesis of 5‐Substituted 1H‐Tetrazoles
by Bonnamour, Julien and Bolm, Carsten
Chemistry – A European Journal, ISSN 0947-6539, 04/2009, Volume 15, Issue 18, pp. 4543 - 4545
Clicking iron: Cheap and environmentally friendly [Fe(OAc)2] is used for the catalysis of cycloadditions between aryl nitriles and trimethylsilyl azide to... 
catalysis | iron | cycloaddition reactions | tetrazole | azides | heterocycles | Azides | Heterocycles | Cycloaddition reactions | Iron | Catalysis | Tetrazole | ORGANIC-SYNTHESIS | ACIDS | ARYLATION | TRIMETHYLSILYL AZIDE | CHEMISTRY, MULTIDISCIPLINARY | MILD | CYCLOADDITION | NITRILES | CHEMISTRY | ARYL IODIDES | TETRAZOLE FORMATION | Ferric Compounds - chemistry | Tetrazoles - chemical synthesis | Cyclization | Tetrazoles - chemistry
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