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1. Full Text The influence of hydro-ethanolic extract of Portulaca oleracea L. on Th-1/Th-2 balance in isolated human lymphocytes
by Askari, VR and Rezaee, SA and Abnous, K and Iranshahi, M and Boskabady, MH
JOURNAL OF ETHNOPHARMACOLOGY, ISSN 0378-8741, 12/2016, Volume 194, pp. 1112 - 1121
Ethnopharmacological relevance: The anti-inflammatory and anti-oxidants activity of Portulaca oleracea L. (P. oleracea) were mentioned in traditional texts. In... 
CHEMISTRY, MEDICINAL | MECHANISM | IL-4 | ALPHA | CYTOKINE | Nitric Oxide | IL-10 | ANTIOXIDANT PROPERTIES | PLANT SCIENCES | IN-VITRO | GAMMA PRODUCTION | INHIBITION | Treg/Th2 (IL-10/IL-4) balance | IFN-gamma | INTEGRATIVE & COMPLEMENTARY MEDICINE | POLYSACCHARIDES | Portulaca oleracea L | Th1/Th2 (IFN-gamma/IL-4) balance | REGULATORY T-CELLS | PHARMACOLOGY & PHARMACY | MODULATION | Plant Extracts - chemistry | T-Lymphocytes, Regulatory - metabolism | Th1 Cells - drug effects | Anti-Inflammatory Agents - pharmacology | Plant Extracts - pharmacology | Antioxidants - metabolism | Humans | Interleukin-4 - metabolism | Male | Interferon-gamma - metabolism | Th2 Cells - drug effects | Th2 Cells - metabolism | Th1 Cells - metabolism | Young Adult | T-Lymphocytes, Regulatory - drug effects | Anti-Inflammatory Agents - chemistry | Dexamethasone - pharmacology | Ethanol - chemistry | Lymphocyte Activation - drug effects | Interleukin-10 - metabolism | Adult | Nitric Oxide - metabolism | Th1-Th2 Balance - drug effects | Portulaca - chemistry
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2. Full Text Anti IL-17A therapy inhibits bone loss in TNF-alpha-mediated murine arthritis by modulation of the T-cell balance
by Zwerina, K and Koenders, M.I and Hueber, A and Marijnissen, R.J and Baum, W and Heiland, G.R and Zaiss, M and McLnnes, I and Joosten, L.A.B and Berg, W.B. van den and Zwerina, J and Schett, G
European Journal of Immunology, ISSN 0014-2980, 2012, Volume 42, Issue 2, pp. 413 - 423
Tumour necrosis factor alpha (TNF-alpha) is a major inducer for inflammation and bone loss. Here, we investigated whether interleukin (IL)-17 plays a role in... 
Arthritis | Osteoclast | IL‐17 | T cells | Cytokine | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | CARTILAGE DESTRUCTION | IMMUNOLOGY | JOINT INFLAMMATION | TUMOR-NECROSIS-FACTOR | IN-VITRO | INTERFERON-GAMMA | INTERLEUKIN-17 | OSTEOCLAST FORMATION | IL-17 | MARROW MACROPHAGES | Interleukin-1 - genetics | T-Lymphocytes, Regulatory - metabolism | Arthritis, Experimental - genetics | Bone Resorption | Arthritis, Experimental - physiopathology | Arthritis, Experimental - therapy | Humans | Th1-Th2 Balance | Antibodies, Monoclonal - adverse effects | Cells, Cultured | Interleukin-17 - immunology | Arthritis, Experimental - immunology | Inflammation | T-Lymphocytes, Regulatory - pathology | Mice, Knockout | T-Lymphocytes, Regulatory - immunology | Animals | Interleukin-17 - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Arthritis, Experimental - chemically induced | Immunotherapy | Tumor Necrosis Factor-alpha - administration & dosage | Mice
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3. Full Text Effects of sustained sleep restriction on mitogen-stimulated cytokines, chemokines and T helper 1/T helper 2 balance in humans
by Axelsson, John and Rehman, Javaid-Ur and Akerstedt, Torbjorn and Ekman, Rolf and Miller, Gregory E and Höglund, Caroline Olgart and Lekander, Mats and Stockholms universitet and Samhällsvetenskapliga fakulteten and Stressforskningsinstitutet
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e82291
Background: Recent studies suggest that acute sleep deprivation disrupts cellular immune responses by shifting T helper (Th) cell activity towards a Th2... 
CELLS | GROWTH-HORMONE | DEPRIVATION | IMMUNE-RESPONSES | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DISEASE | ASTHMA | PROLACTIN | DURATION | CORTISOL | Th1 Cells - drug effects | Chemokines - biosynthesis | Sleep Deprivation - immunology | Humans | Th1-Th2 Balance | Hydrocortisone - metabolism | Male | Phytohemagglutinins - immunology | Th2 Cells - immunology | Mitogens - immunology | Th1 Cells - immunology | Th2 Cells - drug effects | Young Adult | Adult | Leukocyte Count | Chemokines - immunology | Corticosteroids | Interleukins | Analysis | Research | Stress (Psychology) | Mitogens | Sleep deprivation | Neurosciences | Disease | Laboratories | Interleukin | Alcohol | Leukocytes (mononuclear) | Lymphocytes T | Hydrocortisone | Males | Interleukin 4 | Interleukin 2 | Physiology | Chronic obstructive pulmonary disease | Sleep and wakefulness | Psychological stress | Deprivation | Immune response | Cytokines | Secretion | Inflammation | Tumor necrosis factor-α | Asthma | White blood cells | Medicine | Studies | Sleep | Monocyte chemoattractant protein | Growth hormones | Chemokines | Monocyte chemoattractant protein 1 | Integrative medicine | Long-term effects | Samhällsvetenskap | Social Sciences | Medical and Health Sciences | Medicin och hälsovetenskap | Public Health, Global Health, Social Medicine and Epidemiology | Psychology | Hälsovetenskaper | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Psykologi | Health Sciences
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4. Full Text The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma
by Pradhan, Pallab and Qin, Hong and Leleux, Jardin A and Gwak, Dongho and Sakamaki, Ippei and Kwak, Larry W and Roy, Krishnendu
Biomaterials, ISSN 0142-9612, 2014, Volume 35, Issue 21, pp. 5491 - 5504
Abstract Success of an immunotherapy for cancer often depends on the critical balance of T helper 1 (Th1) and T helper 2 (Th2) responses driven by antigen... 
Advanced Basic Science | Dentistry | Microparticle | siRNA | CpG | Lymphoma | Immunotherapy | Cancer | SiRNA | T-Lymphocytes, Cytotoxic - immunology | Biomimetics - methods | Immunotherapy - methods | Poly I-C - pharmacology | Dendritic Cells - immunology | Th1-Th2 Balance | Cells, Cultured | Oligodeoxyribonucleotides - chemistry | Toll-Like Receptor 3 - agonists | Poly I-C - chemistry | Antineoplastic Agents - chemistry | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 9 - agonists | Animals | Mesenchymal Stromal Cells | Cell-Derived Microparticles - immunology | Lymphoma, B-Cell - immunology | Antineoplastic Agents - pharmacology | Mice | Mice, Inbred BALB C | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Interleukin-10 - immunology | RNA, Small Interfering - metabolism | Biological products | Cytokines | Dendritic cells | Analysis | Lymphomas | T cells
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5. Full Text MicroRNA-138 regulates the balance of Th1/Th2 via targeting RUNX3 in psoriasis
by Fu, Dandan and Yu, Wenfa and Li, Min and Wang, Huimin and Liu, Dong and Song, Xiangfeng and Li, Zhanguo and Tian, Zhongwei
Immunology Letters, ISSN 0165-2478, 2015, Volume 166, Issue 1, pp. 55 - 62
Highlights • The expression level of RUNX3 was increased, whereas the expression of miR-138 was decreased in CD4+ T cells from psoriasis patients. • RUNX3 was... 
Allergy and Immunology | CD4+ T cells | Psoriasis | RUNX3 | microRNA-138 | CD4 + T cells | MicroRNA-138 | TRANSCRIPTION FACTORS | INTERLEUKIN-4 | IMMUNOLOGY | CANCER | PATHOGENESIS | HELPER TYPE-1 CELLS | THERAPY | VULGARIS | CD4(+) T cells | AUTOIMMUNE-DISEASE | EXPRESSION | T-CELLS | Psoriasis - genetics | MicroRNAs - antagonists & inhibitors | Humans | Th1-Th2 Balance | Core Binding Factor Alpha 3 Subunit - biosynthesis | Core Binding Factor Alpha 3 Subunit - genetics | Female | Male | MicroRNAs - biosynthesis | MicroRNAs - genetics | Th2 Cells - immunology | Th1 Cells - immunology | T cells | MicroRNA
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6. Full Text Administration of poly(I:C) improved dermatophagoides farinae -induced atopic dermatitis-like skin lesions in NC/Nga mice by the regulation of Th1/Th2 balance
by Kim, Chang-Hyun and Park, Chan Do and Lee, Ai-Young
Vaccine, ISSN 0264-410X, 2011, Volume 30, Issue 14, pp. 2405 - 2410
Highlights ► Suppression of Df-induced AD-like skin lesions in NC/Nga mice model by poly(I:C). ► Poly(I:C) regulated the balance of Th1/Th2 cytokine... 
Allergy and Immunology | NC/Nga mice | Polyinosinic–polycytidylic acid | Vaccine | Atopic dermatitis | Polyinosinic-polycytidylic acid | MEDICINE, RESEARCH & EXPERIMENTAL | DOUBLE-STRANDED-RNA | DENDRITIC CELLS | IFN-GAMMA | HYPERPRODUCTION | IMMUNOLOGY | ADJUVANT | MURINE MODEL | INFLAMMATION | TOLL-LIKE RECEPTORS | POLARIZATION | EXPRESSION | Mast Cells - immunology | Th1 Cells - drug effects | Poly I-C - pharmacology | Poly I-C - administration & dosage | Immunologic Factors - administration & dosage | Male | Dermatitis, Atopic - pathology | Th2 Cells - immunology | Th1 Cells - immunology | Eosinophils - immunology | Th2 Cells - drug effects | Immunoglobulin E - blood | Dermatitis, Atopic - prevention & control | Animals | Immunoglobulin E - immunology | Dermatitis, Atopic - immunology | Mice | Th1-Th2 Balance - drug effects | Cytokines - biosynthesis | Dermatophagoides farinae - immunology | Immunologic Factors - pharmacology | Skin - drug effects | Skin - pathology | Analysis | Skin | Spleen | Cytokines | Immunomodulation | Hypersensitivity | Leukocytes (eosinophilic) | Helper cells | Immunoglobulin E | eotaxin | Inflammation | Lymphocytes T | gamma -Interferon | Skin diseases | Mast cells | Chemokines
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7. Full Text Hydrogen sulfide protects against bleomycin-induced pulmonary fibrosis in rats by inhibiting NF-κB expression and regulating Th1/Th2 balance
by Cao, Hua and Zhou, Xiaohong and Zhang, Jianping and Zhang, Xuejing and Huang, Xinli and Zhai, Yu and Chu, Li
Toxicology Letters, ISSN 0378-4274, 01/2014, Volume 224, Issue 3, pp. 387 - 394
Hydrogen sulfide (H S) displays vasodilative, anti-oxidative, anti-inflammatory and cytoprotective activities. The objective of this study was to evaluate the... 
Hydrogen sulfide | Bleomycin | Pulmonary fibrosis | Cytokine | Nuclear factor kappa B | CELLS | ACTIVATION | INTERLEUKIN-4 | INDUCED LUNG INJURY | SUBSETS | INTERFERON-GAMMA | MICE | TOXICOLOGY | TNF-ALPHA | STRESS | Immunohistochemistry | Antibiotics, Antineoplastic - toxicity | Bleomycin - antagonists & inhibitors | Rats, Wistar | Transcription Factor RelA - antagonists & inhibitors | Cell Count | Hydroxyproline - analysis | Male | Interleukin-4 - biosynthesis | Bronchoalveolar Lavage Fluid - cytology | Th1-Th2 Balance - drug effects | Bleomycin - toxicity | Hydrogen Sulfide - pharmacology | Lung - pathology | NF-kappa B - antagonists & inhibitors | Pulmonary Alveoli - pathology | Hydroxyproline - metabolism | Rats | Interleukin-4 - analysis | Interferon-gamma - analysis | Animals | Antibiotics, Antineoplastic - antagonists & inhibitors | Cell Differentiation - drug effects | NF-kappa B - biosynthesis | Transcription Factor RelA - biosynthesis | Pulmonary Fibrosis - prevention & control | Pulmonary Fibrosis - chemically induced | Interferon-gamma - biosynthesis | Index Medicus
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8. Full Text Involvement of the IL-23/IL-17 axis and the Th17/Treg balance in the pathogenesis and control of autoimmune arthritis
by Astry, Brian and Venkatesha, Shivaprasad H and Moudgil, Kamal D
Cytokine, ISSN 1043-4666, 07/2015, Volume 74, Issue 1, pp. 54 - 61
The T helper (Th) cell subsets are characterized by the type of cytokines produced and the master transcription factor expressed. Th1 cells participate in... 
Arthritis | T helper 17 | Interleukin-17 | Interleukin-23 | Regulatory T cell | RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | SYNOVIAL-FLUID | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUCOSAL HOST-DEFENSE | MONOCLONAL-ANTIBODY | INNATE LYMPHOID-CELLS | IMMUNOLOGY | ACTIVE PSORIATIC-ARTHRITIS | CELL BIOLOGY | REGULATORY T-CELLS | DOUBLE-BLIND | TH17 CELLS | Autoimmune Diseases - physiopathology | Arthritis - physiopathology | Arthritis, Experimental - physiopathology | Humans | Th1-Th2 Balance | Autoimmune Diseases - immunology | Interleukin-17 - immunology | Arthritis, Experimental - immunology | Interleukin-23 - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Arthritis, Rheumatoid - therapy | Interleukin-17 - metabolism | Animals | Interleukin-23 - metabolism | Arthritis - immunology | Autoimmune Diseases - therapy | Th17 Cells - immunology | Arthritis - therapy | Arthritis, Rheumatoid - immunology | Arthritis, Rheumatoid - physiopathology | Th17 Cells - pathology
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9. Full Text Influenza A(H1N1) vaccination during early pregnancy transiently promotes hippocampal neurogenesis and working memory. Involvement of Th1/Th2 balance
by Xia, Yucen and Qi, Fangfang and Zou, Juntao and Yao, Zhibin
Brain Research, ISSN 0006-8993, 2014, Volume 1592, pp. 34 - 43
Abstract The 2009 influenza A(H1N1) pandemic led to a particularly high risk of morbidity and mortality among pregnant women. Therefore, inactivated influenza... 
Neurology | Dentate gyrus | Vaccine | Cognitive function | Prolactin | Growth factor | IMMUNE-RESPONSE | CELLS | GLUCOCORTICOIDS | ADULT NEUROGENESIS | PROLIFERATION | NEUROSCIENCES | INFLAMMATION | ADAPTATION | STRESS | PLASTICITY | Influenza A Virus, H1N1 Subtype - immunology | Tumor Necrosis Factor-alpha - metabolism | Humans | Th1-Th2 Balance | Vaccination | Memory, Short-Term - physiology | Interferon-gamma - metabolism | Antibodies, Viral - blood | Female | Brain-Derived Neurotrophic Factor - metabolism | Interleukin-6 - metabolism | Maze Learning - physiology | Interleukin-4 - metabolism | Mice, Inbred C57BL | Random Allocation | Pregnancy | Prolactin - blood | Vaccines, Inactivated - immunology | Animals | Influenza Vaccines - immunology | Vaccines, Inactivated - administration & dosage | Neurogenesis - physiology | Hippocampus - physiology | Influenza, Human - prevention & control | Transforming Growth Factor beta - metabolism | Influenza vaccines | Pituitary hormones | Pregnant women | Influenza | Short-term memory | Neurophysiology
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10. Full Text Cytokine balance and behavioral intervention; findings from the Peer Approaches to Lupus Self-Management (PALS) project
by Williams, Edith M and Hyer, J. Madison and Viswanathan, Ramakrishnan and Faith, Trevor D and Egede, Leonard and Oates, Jim C and Marshall, Gailen D
Human Immunology, ISSN 0198-8859, 09/2017, Volume 78, Issue 9, pp. 574 - 581
The Peer Approaches to Lupus Self-Management program sought to address the disparate impact of systemic lupus erythematosus (SLE) on African American women... 
Women | Systemic Lupus Erythematosus | Cytokines | Behavioral intervention | African American | RHEUMATOID-ARTHRITIS | GENERALIZED ANXIETY DISORDER | RANDOMIZED-TRIAL | IMMUNOLOGY | DISEASE-ACTIVITY | PATIENT ACTIVATION MEASURE | PSYCHOLOGICAL DISTRESS | QUALITY-OF-LIFE | IMMUNE FUNCTION | HEALTH-STATUS | ILLNESS PERCEPTIONS | Behavior Therapy | Humans | Middle Aged | Th1-Th2 Balance | African Americans | Male | Self-Management | Depression - rehabilitation | Stress, Psychological - psychology | Stress, Psychological - immunology | Stress, Psychological - rehabilitation | Lupus Erythematosus, Systemic - immunology | Adult | Female | Lupus Erythematosus, Systemic - rehabilitation | Lupus Erythematosus, Systemic - psychology | Cytokines - metabolism | Anxiety - psychology | Cells, Cultured | Anxiety - rehabilitation | Anxiety - immunology | Depression - psychology | Aged | Mentoring | Depression - immunology | Lupus | Anxiety | Analysis | Mentors | African American women | Medical research | Systemic lupus erythematosus | Medicine, Experimental | Medical records | Chronic diseases | Stress (Psychology)
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11. Full Text The Antidiabetic Effect of Mesenchymal Stem Cells Is Unrelated to Their Transdifferentiation Potential But to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment
by Ezquer, Fernando and Ezquer, Marcelo and Contador, David and Ricca, Micaela and Simon, Valeska and Conget, Paulette
STEM CELLS, ISSN 1066-5099, 08/2012, Volume 30, Issue 8, pp. 1664 - 1674
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease that results from cell‐mediated autoimmune destruction of insulin‐producing cells. In T1DM... 
Multipotent mesenchymal stromal cells | Pathophysiological markers | Regenerative medicine | Type 1 diabetes mellitus | Mesenchymal stem cells | DEPENDENT DIABETES-MELLITUS | IMMUNE-RESPONSE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | BONE-MARROW | BETA-CELLS | LYMPH-NODES | MULTIPOTENT STROMAL CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EPIDERMAL-GROWTH-FACTOR | REGULATORY T-CELLS | INSULIN-PRODUCING CELLS | HEMATOLOGY | T-Lymphocytes, Regulatory - metabolism | Diabetes Mellitus, Experimental - surgery | Diabetes Mellitus, Type 1 - surgery | Humans | Pancreas - cytology | Th1-Th2 Balance | Diabetes Mellitus, Type 1 - metabolism | Male | Th2 Cells - immunology | Th1 Cells - immunology | Mesenchymal Stromal Cells - immunology | T-Lymphocytes, Regulatory - immunology | Th1 Cells - metabolism | Insulin-Secreting Cells - metabolism | Cell Transdifferentiation - physiology | T-Lymphocytes, Regulatory - cytology | Insulin-Secreting Cells - cytology | Diabetes Mellitus, Type 1 - immunology | Diabetes Mellitus, Experimental - metabolism | Disease Models, Animal | Gene Expression | Mice, Inbred C57BL | Th2 Cells - cytology | Pancreas - metabolism | Pancreas - immunology | Th2 Cells - metabolism | Insulin-Secreting Cells - immunology | Diabetes Mellitus, Experimental - immunology | Animals | Mice | Th1 Cells - cytology | Mesenchymal Stem Cell Transplantation | Hyperglycemia | Epidermal growth factor | Type 1 diabetes | Analysis | Stem cells | Information management | T cells | Financial disclosure
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12. Full Text Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance are potential risk factors for diabetic retinopathy
by Kaviarasan, Kuppan and Jithu, Mohanlal and Arif Mulla, Mohammad and Sharma, Tarun and Sivasankar, Shanmuganathan and Das, Undurti Narasimha and Angayarkanni, Narayanasamy
Metabolism, ISSN 0026-0495, 2015, Volume 64, Issue 9, pp. 958 - 966
Abstract Objective The study was conducted to observe the serum and vitreous levels of LXA4 , BDNF and Th1/Th2 cytokines in type 2 diabetes mellitus (DM) and... 
Endocrinology & Metabolism | Type 2 diabetes | Diabetic retinopathy | Cytokines | LXA4 | BDNF | Cell Line | Prospective Studies | Humans | Middle Aged | Risk Factors | Th1-Th2 Balance | Vascular Endothelial Growth Factor A - blood | Male | Brain-Derived Neurotrophic Factor - blood | Lipoxins - blood | Case-Control Studies | Diabetic Retinopathy - blood | Diabetic Retinopathy - epidemiology | Retina - cytology | Lipopolysaccharides - pharmacology | Adult | Female | Aged | In Vitro Techniques | Diabetes Mellitus, Type 2 - complications | Cytokines - blood
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