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PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175153
IL-1 beta is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis.... 
VITAMIN-D | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON-GAMMA | MULTIDISCIPLINARY SCIENCES | PSORIASIN S100A7 | INFLAMMATORY CASPASES | KERATINOCYTES | 1,25-DIHYDROXYVITAMIN D-3 | MOLECULAR-CLONING | EXPRESSION | T-CELLS | Caspases - immunology | Humans | Interleukin-17 - immunology | Interleukin-17 - pharmacology | Interleukin-1beta - genetics | S100 Proteins - immunology | Psoriasis - genetics | S100 Proteins - genetics | Th17 Cells - drug effects | Transfection | Inflammasomes - drug effects | Psoriasis - pathology | Adaptor Proteins, Signal Transducing - immunology | Apoptosis Regulatory Proteins - genetics | Skin - pathology | Skin - immunology | Th17 Cells - pathology | Interleukin-1beta - secretion | Psoriasis - immunology | S100 Calcium Binding Protein A7 | Apoptosis Regulatory Proteins - immunology | DNA - immunology | Signal Transduction | Caspases - genetics | Cells, Cultured | Gene Expression Regulation | Interleukin-17 - genetics | Interleukin-1beta - immunology | Vitamin D - pharmacology | Keratinocytes - cytology | Keratinocytes - immunology | DNA - genetics | Interleukin-17 - antagonists & inhibitors | Keratinocytes - drug effects | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Interferon-gamma - pharmacology | Interleukins | Physiological aspects | Development and progression | Skin diseases | Genetic aspects | Inflammation | Research | Cell culture | Transcription | Interleukin | Helper cells | Lymphocytes T | Inflammatory diseases | Vitamin D | Lymphocytes | Interleukin 1 | Lesions | Deoxyribonucleic acid--DNA | Psoriasis | Cytokines | Dermatology | Keratinocytes | Caspase | Epidermis | Hazards | Gene expression | Caspase-5 | Hospitals | Biopsy | Interferon | Autoimmune diseases | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e24776
.... First, we determined the cytokine pattern induced by 21 Bifidobacterium strains in peripheral blood mononuclear cells (PBMCs... 
CYTOKINES | HUMAN DENDRITIC CELLS | T(H)17 CELLS | MULTIDISCIPLINARY SCIENCES | LACTIC-ACID BACTERIA | IN-VIVO | REGULATORY T-CELLS | PROINFLAMMATORY IL-17(+) | INDUCTION | SURFACE-MARKERS | INTESTINAL BACTERIA | Bifidobacterium - immunology | Tumor Necrosis Factor-alpha - metabolism | Leukocytes, Mononuclear - metabolism | T-Lymphocytes, Regulatory - metabolism | Species Specificity | Dendritic Cells - immunology | Humans | Interleukin-17 - immunology | Monocytes - metabolism | Monocytes - immunology | Th2 Cells - immunology | Interferon-gamma - metabolism | Th1 Cells - immunology | Host-Pathogen Interactions - immunology | T-Lymphocytes, Regulatory - immunology | Th2 Cells - microbiology | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | Flow Cytometry | Th17 Cells - metabolism | Leukocytes, Mononuclear - immunology | Tumor Necrosis Factor-alpha - immunology | Interleukin-10 - metabolism | Bifidobacterium - physiology | Dendritic Cells - metabolism | Leukocytes, Mononuclear - microbiology | Cytokines - immunology | Monocytes - microbiology | T-Lymphocytes, Regulatory - microbiology | CD4-Positive T-Lymphocytes - microbiology | Cytokines - metabolism | Bifidobacterium - classification | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Th2 Cells - metabolism | Interleukin-17 - metabolism | Th1 Cells - microbiology | Interferon-gamma - immunology | Dendritic Cells - microbiology | Th17 Cells - immunology | Interleukin-10 - immunology | Th17 Cells - microbiology | Bacteria | Dendritic cells | T cells | Tumor necrosis factor | Analysis | Dairy products | Genomics | Mucosa | Helper cells | Leukocytes (mononuclear) | Biochemistry | Lymphocytes T | Inductors | Cell activation | Microorganisms | Immunology | Lymphocytes | Plasticity | Peripheral blood mononuclear cells | Strains (organisms) | Immune system | Antigens | Automation | Immune response | Cytokines | Interleukin 12 | T cell receptors | Tumor necrosis factor-α | Metabolism | Immunological tolerance | Interleukin 17 | CD4 antigen | Inflammatory bowel disease | Probiotics | γ-Interferon | Interleukin 10 | Proteomics | Plastic properties | Differentiation
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2008, Volume 205, Issue 8, pp. 1903 - 1916
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2015, Volume 43, Issue 3, pp. 515 - 526
...) by tissue-resident cells early during infection, but the mechanism of cytokine production has not been precisely defined... 
HOST-DEFENSE | CONTACT HYPERSENSITIVITY | INDEPENDENT GENERATION | DELTA T-CELLS | MICE | IMMUNOLOGY | ALBICANS | CHRONIC MUCOCUTANEOUS CANDIDIASIS | SKIN INFLAMMATION | LANGERHANS CELLS | TH17 CELLS | Candidiasis - genetics | Skin - microbiology | Oligonucleotide Array Sequence Analysis | Skin - metabolism | Dendritic Cells - immunology | Sensory Receptor Cells - immunology | Interleukin-17 - immunology | Lectins, C-Type - immunology | Receptors, Antigen, T-Cell, gamma-delta - genetics | Transcriptome - immunology | Candidiasis - microbiology | Receptors, Calcitonin Gene-Related Peptide - metabolism | Host-Pathogen Interactions - immunology | Interleukin-23 - genetics | Lectins, C-Type - metabolism | Flow Cytometry | Interleukin-23 - metabolism | T-Lymphocytes - metabolism | Candida albicans - physiology | Sensory Receptor Cells - metabolism | Candidiasis - immunology | Dermis - cytology | Dendritic Cells - metabolism | Skin - immunology | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Cells, Cultured | Immunity - immunology | Interleukin-17 - genetics | Mice, Transgenic | Receptors, Antigen, T-Cell, gamma-delta - immunology | Transcriptome - genetics | Candida albicans - immunology | Mice, Inbred Strains | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-23 - immunology | Mice, Knockout | Interleukin-17 - metabolism | Animals | Receptors, Calcitonin Gene-Related Peptide - immunology | Receptors, Calcitonin Gene-Related Peptide - genetics | T-Lymphocytes - immunology | Immunity - genetics | Flow cytometry | Immunology | Dendritic cells | Lymphocytes | Colleges & universities | Infections | Grants | Gene expression | Experiments
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2012, Volume 287, Issue 33, pp. 28017 - 28026
.... A reduction of IFN-gamma-producing CD4(+) T cells is observed in DMF-treated patients and may contribute to its clinical efficacy... 
TRANSCRIPTIONAL ACTIVATION | MULTIPLE-SCLEROSIS | PHOSPHORYLATION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTHELIAL-CELLS | GENE-EXPRESSION | INDUCTION | T-BET | P65 | INNATE IMMUNITY | Dendritic Cells - immunology | Th1 Cells - immunology | MAP Kinase Signaling System - immunology | Th1 Cells - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Th17 Cells - metabolism | Transcription Factor RelA - immunology | Th17 Cells - cytology | Phosphorylation - immunology | B7-1 Antigen - biosynthesis | Phosphorylation - drug effects | B7-2 Antigen - immunology | Dimethyl Fumarate | Immunosuppressive Agents - pharmacology | Interleukin-6 - metabolism | Dendritic Cells - metabolism | Mitogen-Activated Protein Kinase 3 - immunology | B7-1 Antigen - immunology | Cells, Cultured | Histocompatibility Antigens Class II - biosynthesis | Interleukin-12 - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - immunology | Cell Differentiation - immunology | Animals | B7-2 Antigen - biosynthesis | Histocompatibility Antigens Class II - immunology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Transcription Factor RelA - metabolism | Cell Differentiation - drug effects | Fumarates - pharmacology | Interleukin-12 - immunology | Interleukin-6 - immunology | Th17 Cells - immunology | Dendritic Cells - cytology | Mice | Th1 Cells - cytology | Multiple Sclerosis | MAP Kinases (MAPKs) | Immunology | Dendritic Cells | Antigen Presentation | NF-Kappa B (NF-KB) | Cytokine
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2015, Volume 194, Issue 8, pp. 3829 - 3839
...) on human T cell responses. Human PBMCs or isolated monocytes were stimulated in vitro with CT, mmCT, or dmLT plus a polyclonal stimulus... 
CELLS | TRANSCRIPTIONAL ACTIVITY | ACTIVATION | IMMUNOGENICITY | HEAT-LABILE ENTEROTOXIN | IMMUNE-RESPONSES | ESCHERICHIA-COLI | ETEC VACCINE | IMMUNOLOGY | NF-KAPPA-B | MUCOSAL ADJUVANT | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | Adjuvants, Immunologic - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Interleukin-1beta - immunology | Male | Caspase 1 - immunology | Enzyme Activation - drug effects | Enzyme Activation - immunology | Signal Transduction - immunology | Signal Transduction - drug effects | Calcium-Binding Proteins - immunology | Cyclic AMP-Dependent Protein Kinases - immunology | Cyclic AMP - immunology | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - immunology | Th17 Cells - immunology | Adult | Female | Th17 Cells - cytology | Cholera Toxin - pharmacology | Carrier Proteins - immunology | Calcium-Binding Proteins/immunology | Signal Transducing/immunology | Apoptosis Regulatory Proteins/immunology | Cyclic AMP/ immunology | Enzyme Activation/drug effects/immunology | Adjuvants | Immunologi inom det medicinska området | Interleukin-1beta/ immunology | Adaptor Proteins | Th17 Cells/cytology/ immunology | Signal Transduction/ drug effects/immunology | Caspase 1/immunology | Carrier Proteins/immunology | Cholera Toxin/ pharmacology | Cyclic AMP-Dependent Protein Kinases/ immunology | CARD Signaling Adaptor Proteins/immunology | Immunologic/ pharmacology | Immunology in the medical area | Inflammasomes/ immunology
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2017, Volume 46, Issue 4, pp. 660 - 674
Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue environments and against many inflammatory insults, yet the tissue-enriched factor... 
HOMEOSTASIS | TGF-BETA | AUTOIMMUNITY | INFLAMMATION | IN-VIVO | REG-CELLS | CENTRAL-NERVOUS-SYSTEM | IMMUNOLOGY | CD103 EXPRESSION | MEDIATED REGULATION | TH17 CELLS | Forkhead Transcription Factors - immunology | Antigens, CD - immunology | T-Lymphocytes, Regulatory - metabolism | Receptors, Transforming Growth Factor beta - genetics | Cell Proliferation | Receptors, Transforming Growth Factor beta - immunology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, G-Protein-Coupled - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Gastrointestinal Tract - pathology | Antigens, CD - metabolism | Organ Specificity - immunology | Receptors, G-Protein-Coupled - immunology | T-Lymphocytes, Regulatory - immunology | Gastrointestinal Tract - immunology | Signal Transduction - immunology | Flow Cytometry | Th17 Cells - metabolism | Forkhead Transcription Factors - metabolism | Integrin alpha Chains - immunology | Encephalomyelitis, Autoimmune, Experimental - genetics | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta - immunology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Homeostasis - immunology | Mice, Transgenic | Integrin alpha Chains - metabolism | Forkhead Transcription Factors - genetics | Gastrointestinal Tract - metabolism | Mice, Knockout | Animals | Receptors, Transforming Growth Factor beta - metabolism | Th17 Cells - immunology | Protein-Serine-Threonine Kinases - immunology | Transforming Growth Factor beta - metabolism | Transcription factors | Immune response | Differentiation (biology) | Homeostasis | Nervous system | Inflammation | Lymphocytes T | Gastrointestinal tract | Cell differentiation | Lymphocytes | Rodents | Regulation | Colon | Immune system
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2017, Volume 18, Issue 7, pp. 800 - 812
An imbalance in the lineages of immunosuppressive regulatory T cells (T cells) and the inflammatory T 17 subset of helper T cells leads to the development of autoimmune and/or inflammatory disease... 
Forkhead Transcription Factors - immunology | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Sjogren's Syndrome - immunology | Immunoblotting | Intracellular Signaling Peptides and Proteins - immunology | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | DNA-Binding Proteins - metabolism | Flow Cytometry | Chromatin Immunoprecipitation | Forkhead Transcription Factors - metabolism | Histone Acetyltransferases - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | HEK293 Cells | Adaptor Proteins, Signal Transducing - immunology | Acetylation | Colitis - immunology | Lysine Acetyltransferase 5 | Transcription Factors - immunology | Real-Time Polymerase Chain Reaction | STAT3 Transcription Factor - metabolism | Cytokines - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | DNA-Binding Proteins - immunology | Smad Proteins - immunology | Mice, Transgenic | Mice, Knockout | Transcription Factors - metabolism | Cell Differentiation - immunology | Microscopy, Confocal | Animals | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Trans-Activators - metabolism | Mice | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | Smad Proteins - metabolism | Microscopy, Fluorescence
Journal Article
Immunity, ISSN 1074-7613, 03/2011, Volume 34, Issue 3, pp. 422 - 434
Th17 cells and CD4+CD25+Foxp3+ regulatory T (Treg) cells are thought to promote and suppress inflammatory responses, respectively... 
ORAL CANDIDIASIS | INTERLEUKIN-2 | RESPONSES | DEFENSE |