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1. Full Text CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity
by Kumamoto, Yosuke and Linehan, Melissa and Weinstein, Jason S and Laidlaw, Brian J and Craft, Joseph E and Iwasaki, Akiko
Immunity, ISSN 1074-7613, 10/2013, Volume 39, Issue 4, pp. 733 - 743
Unlike other types of T helper (Th) responses, whether the development of Th2 cells requires instruction from particular subset of dendritic cells (DCs)... 
HELMINTH INFECTION | TH2 CELLS | IN-VIVO | HELPER-CELLS | DISTINCT | CD4(+) T-CELLS | INDUCTION | SKIN | IMMUNOLOGY | TRANSCRIPTION FACTOR GATA-3 | LANGERHANS CELLS | Ovalbumin - immunology | Dendritic Cells - immunology | Lectins, C-Type - immunology | Dendritic Cells - pathology | Th2 Cells - immunology | Nippostrongylus - immunology | Lectins, C-Type - genetics | Th2 Cells - drug effects | Th2 Cells - parasitology | Allergens - immunology | Strongylida Infections - parasitology | Strongylida Infections - immunology | Dendritic Cells - drug effects | Cell Differentiation | Interleukin-4 - genetics | Skin - pathology | Th2 Cells - pathology | Skin - immunology | Dendritic Cells - parasitology | Signal Transduction | Gene Expression Regulation | Skin - parasitology | Mice, Transgenic | Strongylida Infections - pathology | Interleukin-4 - immunology | Animals | Ovalbumin - administration & dosage | Mice | Alum Compounds - administration & dosage | Immunity, Cellular | Skin - drug effects | Proteins | Antigens | Lymphocytes | Rheumatic diseases | Software | Metabolic disorders | Immune system | Index Medicus | dendritic cell subset | T cell priming | Th2
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2. Th1 and Th2 cells in health and disease
by Romagnani, S
1996, Chemical immunology, ISBN 3805562411, Volume 63., ix, 222
Book
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3. Full Text IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction
by Barlow, Jillian L., PhD and Peel, Samantha, PhD and Fox, Jane, PhD and Panova, Veera, MRes and Hardman, Clare S., BSc and Camelo, Ana, PhD and Bucks, Christine, PhD and Wu, Xiaoying, MD and Kane, Colleen M., PhD and Neill, Daniel R., PhD and Flynn, Robin J., PhD and Sayers, Ian, PhD and Hall, Ian P., DM and McKenzie, Andrew N.J., PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 132, Issue 4, pp. 933 - 941
Background IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse studies suggest their immunologic functions in type 2 immunity are... 
Allergy and Immunology | type 2 innate lymphoid cells | contraction | IL-25 | asthma | IL-13 | IL-33 | Nuocytes | TH2 RESPONSES | HYPERREACTIVITY | SEVERE ASTHMA | ALLERGIC LUNG INFLAMMATION | CYTOKINE | IMMUNOLOGY | ADAPTIVE IMMUNITY | ALLERGY | IN-VIVO | SMOOTH-MUSCLE-CELLS | EXPRESSION | Lymphocytes - metabolism | Asthma - physiopathology | Bronchial Hyperreactivity - immunology | Interleukin-33 | Humans | Th2 Cells - cytology | Th2 Cells - immunology | Th2 Cells - metabolism | Interleukins - metabolism | Interleukin-13 - biosynthesis | Animals | Lymphocytes - immunology | Bronchial Hyperreactivity - physiopathology | Interleukins - immunology | Asthma - immunology | Lung - metabolism | Mice | Mice, Inbred BALB C | Lung - immunology | Genomics | Asthma | Flow cytometry | Cloning | Software | Genomes | Gene expression | Allergies | Index Medicus | Abridged Index Medicus
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4. Full Text Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer
by Tosolini, Marie and Kirilovsky, Amos and Mlecnik, Bernhard and Fredriksen, Tessa and Mauger, Stéphanie and Bindea, Gabriela and Berger, Anne and Bruneval, Patrick and Fridman, Wolf-Herman and Pagès, Franck and Galon, Jérôme
Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 4, pp. 1263 - 1271
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic... 
BREAST-CANCER | SURVIVAL | LUNG-CANCER | FOXP3 EXPRESSION | RECRUITMENT | ONCOLOGY | GASTRIC-CANCER | EOSINOPHILS | MACROPHAGES | CARCINOMA | LYMPHOCYTES | Th1 Cells - pathology | Th1 Cells - physiology | Prognosis | Th2 Cells - physiology | Tissue Array Analysis | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma - mortality | Gene Expression Profiling | Th2 Cells - immunology | Th1 Cells - immunology | Colorectal Neoplasms - diagnosis | Lymphocytes, Tumor-Infiltrating - physiology | T-Lymphocytes, Cytotoxic - pathology | Th1 Cells - metabolism | Th17 Cells - metabolism | Forkhead Transcription Factors - metabolism | Microarray Analysis | T-Lymphocytes, Helper-Inducer - immunology | Lymphocytes, Tumor-Infiltrating - metabolism | T-Lymphocytes, Helper-Inducer - pathology | Interleukin-4 - genetics | Th2 Cells - pathology | Th17 Cells - pathology | Colorectal Neoplasms - mortality | T-Lymphocytes, Cytotoxic - immunology | Th17 Cells - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Carcinoma - immunology | Interleukin-4 - metabolism | Carcinoma - diagnosis | Forkhead Transcription Factors - genetics | Th2 Cells - metabolism | T-Lymphocytes, Cytotoxic - physiology | T-Lymphocytes, Helper-Inducer - physiology | Colorectal Neoplasms - immunology | Lymphocytes, Tumor-Infiltrating - pathology | T-Lymphocytes, Cytotoxic - metabolism | Survival Analysis | Th17 Cells - immunology | Carcinoma - genetics | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
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5. Full Text Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
by Zheng, Y and Chaudhry, A and Kas, A and deRoos, P and Kim, JM and Chu, TT and Corcoran, L and Treuting, P and Klein, U and Rudensky, AY
NATURE, ISSN 0028-0836, 03/2009, Volume 458, Issue 7236, pp. 351 - U116
In the course of infection or autoimmunity, particular transcription factors orchestrate the differentiation of T(H)1, T(H)2 or T(H)17 effector cells, the... 
TARGET GENES | MULTIDISCIPLINARY SCIENCES | DISEASE | ADENOSINE | ABSENCE | DIFFERENTIATION | INTERLEUKIN-10 | FOXP3 | LINEAGE | SELF-TOLERANCE | TH2 | Immunoglobulin G - blood | Lymphocyte Activation | Mice, Inbred C57BL | Interferon Regulatory Factors - metabolism | Thymus Gland - cytology | Interferon Regulatory Factors - genetics | Th2 Cells - cytology | CD4 Lymphocyte Count | Th2 Cells - immunology | Forkhead Transcription Factors - genetics | Interferon Regulatory Factors - deficiency | Th2 Cells - metabolism | Immunoglobulin E - blood | T-Lymphocytes, Regulatory - immunology | Animals | Immunoglobulin E - immunology | Forkhead Transcription Factors - metabolism | Immunoglobulin G - immunology | Cell Differentiation | Mice | Autoimmune Diseases - pathology | Forkhead Transcription Factors - deficiency | Index Medicus
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6. Full Text Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
by Bettelli, Estelle and Carrier, Yijun and Gao, Wenda and Korn, Thomas and Strom, Terry B and Oukka, Mohamed and Weiner, Howard L and Kuchroo, Vijay K
Nature, ISSN 0028-0836, 05/2006, Volume 441, Issue 7090, pp. 235 - 238
On activation, T cells undergo distinct developmental pathways, attaining specialized properties and effector functions. T-helper (T(H)) cells are... 
Th1 Cells - drug effects | Central Nervous System - metabolism | Cytokines - metabolism | Receptors, Interleukin-2 - metabolism | Th2 Cells - cytology | Th2 Cells - immunology | Interleukin-17 - biosynthesis | Th1 Cells - immunology | Th2 Cells - drug effects | Th2 Cells - metabolism | Central Nervous System - immunology | Th1 Cells - metabolism | Interleukin-17 - metabolism | Animals | Autoimmunity - immunology | Cell Differentiation - drug effects | Forkhead Transcription Factors - metabolism | Interleukin-6 - immunology | Mice | Th1 Cells - cytology | Interleukin-6 - metabolism | Transforming Growth Factor beta - metabolism | CD4 Antigens - metabolism | Cytokines - immunology | Immunology | Cytokines | Cellular biology | Rodents | Bacteria | T cell receptors | Autoimmune diseases | Inflammatory diseases | Index Medicus
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7. Full Text A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
by Wang, YH and Voo, KS and Liu, B and Chen, CY and Uygungil, B and Spoede, W and Bernstein, JA and Huston, DP and Liu, YJ
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 10/2010, Volume 207, Issue 11, pp. 2479 - 2491
The inflammatory cytokine interleukin (IL)-17 is involved in the pathogenesis of allergic diseases. However, the identity and functions of IL-17-producing T... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR-BETA | TGF-BETA | TH2 CELLS | INTERFERON-REGULATORY FACTOR-4 | COLONY-STIMULATING FACTOR | ROR-GAMMA-T | AUTOIMMUNE INFLAMMATION | MOUSE MODEL | PROINFLAMMATORY CYTOKINES | IMMUNOLOGY | NEUTROPHIL RECRUITMENT | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Asthma - metabolism | Gene Expression Regulation - immunology | GATA3 Transcription Factor - immunology | Humans | Interleukin-17 - immunology | GATA3 Transcription Factor - biosynthesis | Th2 Cells - immunology | Interleukin-17 - biosynthesis | Th2 Cells - metabolism | Lymphocyte Subsets - immunology | Lymphocyte Subsets - metabolism | Animals | Asthma - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - biosynthesis | Immunologic Memory | Mice | Mice, Inbred BALB C | Asthma - pathology | Chronic Disease | Lymphocyte Subsets - pathology | Cytokines - biosynthesis | Th2 Cells - pathology | Cytokines - immunology | Index Medicus
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8. Full Text Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk
by Xue, Luzheng and Fergusson, Joannah and Salimi, Maryam and Panse, Isabel and Ussher, James E and Hegazy, Ahmed N and Vinall, Shân L and Jackson, David G and Hunter, Michael G and Pettipher, Roy and Ogg, Graham and Klenerman, Paul
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 05/2015, Volume 135, Issue 5, pp. 1358 - 1366.e11
Prostaglandin D (PGD ) and cysteinyl leukotrienes (cysLTs) are lipid mediators derived from mast cells, which activate T 2 cells. The combination of PGD and... 
leukotriene E4 | TH2 cells | Prostaglandin D2 | chemoattractant receptor-homologous molecule expressed on TH2 cells | neutrophils | leukotriene E | Prostaglandin D | chemoattractant receptor-homologous molecule expressed on T | 2 cells | Leukotriene E4 - metabolism | Cell Communication - immunology | Cell Adhesion Molecules - genetics | Apoptosis - drug effects | Humans | Gene Expression Profiling | Th2 Cells - immunology | Th2 Cells - drug effects | Leukotriene E4 - pharmacology | Chemotaxis, Leukocyte - genetics | Chemotaxis, Leukocyte - drug effects | Prostaglandin D2 - metabolism | Inflammation Mediators - metabolism | Neutrophils - metabolism | Gene Expression | Neutrophils - drug effects | Neutrophils - immunology | Cell Communication - genetics | Cell Adhesion Molecules - metabolism | Th2 Cells - metabolism | Drug Synergism | Apoptosis - immunology | Cell Communication - drug effects | Prostaglandin D2 - pharmacology | Chemotaxis, Leukocyte - immunology | Cluster Analysis | Index Medicus | Abridged Index Medicus | LTE4, Cysteinyl leukotriene E4 | CysLT2, Cysteinyl leukotriene receptor 2 | CRTH2, Chemoattractant receptor-homologous molecule expressed on TH2 cells | PMA, Phorbol 12-myristate 13-acetate | LTC4, Cysteinyl leukotriene C4 | PGD2, Prostaglandin D2 | CAIA, Cell activation–induced aggregation | cysLT, Cysteinyl leukotriene | qPCR, Quantitative PCR | PI3K, Phosphoinositide 3-kinase | LTD4, Cysteinyl leukotriene D4 | CysLT1, Cysteinyl leukotriene receptor 1 | ICAM, Intercellular adhesion molecule | RORγt, Retinoic acid–related orphan receptor γt | Mechanisms of Allergy and Clinical Immunology
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9. Full Text Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
by Flavell, Richard A and Wan, Yisong Y
Nature, ISSN 0028-0836, 02/2007, Volume 445, Issue 7129, pp. 766 - 770
The naturally occurring regulatory T cell (Tr) is the pivotal cell type that maintains self-tolerance and exerts active immune suppression. The development and... 
INTERLEUKIN-2 | PROTEIN | INFLAMMATION | CD25(+) | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION FACTOR FOXP3 | IMMUNOLOGICAL SELF-TOLERANCE | SCURFY MOUSE | T-Lymphocytes, Regulatory - metabolism | Down-Regulation | Autoimmune Diseases - immunology | Thymus Gland - cytology | Autoimmunity - genetics | Th2 Cells - cytology | Th2 Cells - immunology | Thymus Gland - drug effects | Forkhead Transcription Factors - genetics | Th2 Cells - drug effects | Th2 Cells - metabolism | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Transforming Growth Factor beta - pharmacology | T-Lymphocytes, Regulatory - drug effects | Animals | Autoimmunity - immunology | Forkhead Transcription Factors - metabolism | T-Lymphocytes, Regulatory - cytology | Thymus Gland - immunology | Mice | Autoimmune Diseases - pathology | Models | Immunology | Cellular biology | Gene expression | Rodents | Index Medicus
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10. Full Text IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization
by Chu, Derek K., BHSc and Llop-Guevara, Alba, BHSc and Walker, Tina D., BSc and Flader, Kristin, BSc and Goncharova, Susanna, MD, PhD and Boudreau, Jeanette E., PhD and Moore, Cheryl Lynn, BSc and In, Tracy Seunghyun, BHSc and Waserman, Susan, MD, MSc and Coyle, Anthony J., PhD and Kolbeck, Roland, PhD and Humbles, Alison A., PhD and Jordana, Manel, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 131, Issue 1, pp. 187 - 200.e8
Background Allergen exposure at lung and gut mucosae can lead to aberrant TH 2 immunity and allergic disease. The epithelium-associated cytokines thymic... 
Allergy and Immunology | thymic stromal lymphopoietin | OX40 ligand | house dust mite | allergy | asthma | peanut | IL-25 | innate lymphoid cells | IL-33 | TH2 | TH2 RESPONSES | DENDRITIC CELLS | TSLP | AIRWAY INFLAMMATION | INNATE | RECEPTOR | IMMUNOLOGY | T(H)2 | IMMUNE-RESPONSES | IN-VIVO | OX40 Ligand - metabolism | Dendritic Cells - immunology | Humans | Hypersensitivity - immunology | Th2 Cells - immunology | Gastrointestinal Tract - immunology | Allergens - immunology | Hypersensitivity - metabolism | Interleukins - immunology | Female | Lung - metabolism | Receptors, Immunologic - immunology | Dendritic Cells - metabolism | Signal Transduction | Interleukin-33 | Interleukin-4 - metabolism | Stromal Cells - metabolism | Thymus Gland - cytology | Stromal Cells - immunology | STAT6 Transcription Factor - metabolism | Th2 Cells - metabolism | Interleukin-4 - immunology | Animals | OX40 Ligand - immunology | Arachis - immunology | Thymus Gland - immunology | Mice | Lung - immunology | Receptors, Immunologic - metabolism | Pyroglyphidae - immunology | Autoimmunity | Allergy | Allergens | Allergic reaction | Studies | Food allergies | Antigens | Airway management | Disease | Rodents | Software | Allergies | Index Medicus | Abridged Index Medicus
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11. Full Text The Transcription Factors T-Bet and GATA-3 Control Alternative Pathways of T-Cell Differentiation through a Shared Set of Target Genes
by Richard G. Jenner and Michael J. Townsend and Ian Jackson and Kaiming Sun and Russell D. Bouwman and Richard A. Young and Laurie H. Glimcher and Graham M. Lord
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2009, Volume 106, Issue 42, pp. 17876 - 17881
Upon detection of antigen, CD4⁺ T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens.... 
T lymphocytes | Transcription factors | Natural killer T cells | Genes | Genomics | Antibodies | Mice | Natural killer cells | Cellular differentiation | Cells | Cytokines | Genomic map | T helper differentiation | TH2 CELLS | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | DYNAMIC CHANGES | HISTONE ACETYLATION | LINEAGE COMMITMENT | RESPONSES | HELPER TYPE-1 CELLS | ENCODING INTERFERON-GAMMA | cytokines | T(H)1 CELLS | EXPRESSION | Genes, MHC Class II | Oligonucleotide Array Sequence Analysis | GATA3 Transcription Factor - immunology | Humans | Th2 Cells - cytology | T-Box Domain Proteins - immunology | Th2 Cells - immunology | Transcriptional Activation - immunology | Th1 Cells - immunology | Th2 Cells - metabolism | T-Box Domain Proteins - metabolism | Th1 Cells - metabolism | Cell Differentiation - genetics | Cell Differentiation - immunology | Chromatin Immunoprecipitation | Th1 Cells - cytology | In Vitro Techniques | GATA3 Transcription Factor - metabolism | Chromosome mapping | Genetic aspects | DNA binding proteins | Properties | T cells | Cell differentiation |