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Journal Article
Science, ISSN 0036-8075, 3/2010, Volume 327, Issue 5971, pp. 1345 - 1350
Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today,... 
Receptors | Messenger RNA | Delta cells | Ubiquitins | Substrate specificity | Teratogenicity | HeLa cells | Pectorals | Cellular immunity | Embryos | Research Article | MULTIPLE-MYELOMA | CELLS | LIMB DEFECTS | ORIGIN | ZEBRAFISH | UBIQUITIN LIGASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | OUTGROWTH | EXPRESSION | Teratogens - toxicity | Thalidomide - metabolism | Peptide Hydrolases - genetics | Forelimb - embryology | Humans | Fibroblast Growth Factors - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | Zebrafish - embryology | Embryo, Nonmammalian - drug effects | DNA-Binding Proteins - metabolism | Fibroblast Growth Factors - metabolism | Ubiquitination | Forelimb - abnormalities | Gene Expression Regulation, Developmental | Cullin Proteins - metabolism | Peptide Hydrolases - metabolism | Zebrafish Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Mutant Proteins - metabolism | Chick Embryo | Thalidomide - toxicity | Zebrafish - genetics | Animals | Carrier Proteins - metabolism | HeLa Cells | Zebrafish Proteins - genetics | Embryonic Development - drug effects | Teratogens - metabolism | Dosage and administration | Research | Teratogenic agents | Thalidomide | Protein binding | Pharmacology | Birth defects | Developmental biology | DNA damage | Binding sites | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 15, pp. 2975 - 2987
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress immune responses. MDSCs have been... 
CANCER-PATIENTS | DENDRITIC CELLS | T-REGULATORY CELLS | IMMUNOSUPPRESSION | BONE-MARROW | GROWTH | PERIPHERAL-BLOOD | DIFFERENTIATION | IDENTIFICATION | HEMATOLOGY | PROGRESSION | Cell Proliferation | Reactive Oxygen Species - metabolism | Coculture Techniques | Humans | Sialic Acid Binding Ig-like Lectin 3 - immunology | Multiple Myeloma - immunology | Thalidomide - pharmacology | Lewis X Antigen - metabolism | Lipopolysaccharides - immunology | Thalidomide - analogs & derivatives | Flow Cytometry | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Reactive Oxygen Species - immunology | Myeloid Cells - drug effects | Antineoplastic Agents - pharmacology | HLA-DR Antigens - metabolism | Sialic Acid Binding Ig-like Lectin 3 - metabolism | Cytokines - immunology | Tumor Microenvironment - drug effects | Bortezomib | CD11b Antigen - immunology | Cytokines - metabolism | Cells, Cultured | Lewis X Antigen - immunology | Multiple Myeloma - metabolism | Tumor Microenvironment - immunology | Multiple Myeloma - pathology | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Myeloid Cells - metabolism | T-Lymphocytes - immunology | HLA-DR Antigens - immunology | CD11b Antigen - metabolism | Pyrazines - pharmacology | Immunologic Factors - pharmacology | Boronic Acids - pharmacology | Tumor Burden - immunology | Lymphoid Neoplasia
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2427 - 2437
Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined. Here we demonstrate that impaired actin polymerization results... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | ACTIVATION | LYTIC FUNCTION | IMMUNOTHERAPY | ACTIN POLYMERIZATION | GENE-EXPRESSION | LENALIDOMIDE | MALIGNANCIES | CANCER | Protein-Tyrosine Kinases - metabolism | Humans | Actins - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Thalidomide - pharmacology | Lymphocyte Culture Test, Mixed | CD4-Positive T-Lymphocytes - immunology | Thalidomide - analogs & derivatives | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - blood | Antineoplastic Agents - pharmacology | Microfilament Proteins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Interleukin-2 - metabolism | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell - metabolism | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Superantigens - immunology | Antigen Presentation - immunology | Mice, Inbred Strains | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - drug effects | T-Lymphocytes - immunology | Antigen Presentation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | Immunologic Factors - pharmacology | Polymerization | Chronic lymphocytic leukemia | T cells | Muscle proteins | Tumors
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2003, Volume 305, Issue 3, pp. 1222 - 1232
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 49 - 53
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 16, pp. 6187 - 6200
Journal Article
eLife, ISSN 2050-084X, 08/2018, Volume 7
In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite... 
PRIMATE CALLITHRIX-JACCHUS | COMPLEX | GENE | BIOLOGY | LENALIDOMIDE | EMBRYOPATHY | OKIHIRO-SYNDROME | CEREBLON | CLINICAL PHARMACOKINETICS | PROTEINS | CRL4(CRBN) UBIQUITIN LIGASE | Abnormalities, Multiple - metabolism | Embryonic Stem Cells - metabolism | Teratogens - toxicity | Transcription Factors - chemistry | Species Specificity | Humans | Substrate Specificity | Duane Retraction Syndrome - metabolism | Thalidomide - pharmacology | Proteolysis - drug effects | Protein Binding - drug effects | HEK293 Cells | Heart Septal Defects, Atrial - metabolism | Peptide Hydrolases - metabolism | Lower Extremity Deformities, Congenital - metabolism | Amino Acid Sequence | Reproducibility of Results | CYS2-HIS2 Zinc Fingers | Thalidomide - chemistry | Ubiquitin-Protein Ligases - metabolism | Upper Extremity Deformities, Congenital - metabolism | Transcription Factors - metabolism | Phenotype | Embryonic Stem Cells - drug effects | Heart Defects, Congenital - metabolism | Care and treatment | Genetic disorders | Gastrointestinal agents | Developmental biology | Congenital heart disease | DNA binding proteins | Embryonic stem cells | Pregnant women | Genetic research | Thalidomide | Heart diseases | Cancer | Protein binding | Transcription factors | Peptides | Congenital defects | Birth defects | Birth | Phocomelia | Kinases | Cancer therapies | Coronary artery disease | Proteins | Stem cells | Teratogenicity | Proteomics | Scientific imaging | Children | Zinc finger proteins | Mass spectrometry | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 08/2015, Volume 126, Issue 6, pp. 779 - 789
Cereblon (CRBN), a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex, is the target of the immunomodulatory drugs lenalidomide and... 
B-CELL LYMPHOMA | COMPLEX | IKAROS | PROTEIN EXPRESSION | GENE-EXPRESSION | C-MYC | LENALIDOMIDE | NON-HODGKINS-LYMPHOMA | HEMATOLOGY | T-CELLS | E3 UBIQUITIN LIGASE | RNA, Small Interfering - genetics | Peptide Hydrolases - genetics | Humans | Gene Expression Regulation, Neoplastic | Interferon Regulatory Factor-7 - genetics | Lymphoma, Large B-Cell, Diffuse - metabolism | Thalidomide - pharmacology | Ikaros Transcription Factor - genetics | Lentivirus - metabolism | Proteolysis - drug effects | Thalidomide - analogs & derivatives | Molecular Mimicry | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Lentivirus - genetics | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Ikaros Transcription Factor - metabolism | Interferons - genetics | T-Lymphocytes - pathology | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Peptide Hydrolases - metabolism | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | Signal Transduction - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Piperidones - pharmacology | Interferon Regulatory Factor-7 - metabolism | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Piperidones - chemistry | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Interferons - metabolism | Mice | Quinazolinones - chemistry | Lymphoma, Large B-Cell, Diffuse - genetics | RNA, Small Interfering - metabolism | Lymphoid Neoplasia
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2016, Volume 213, Issue 8, pp. 1429 - 1440
The analysis of individuals with telomere defects may shed light on the delicate interplay of factors controlling genome stability, premature aging, and... 
ZEBRAFISH EMBRYOS | MEDICINE, RESEARCH & EXPERIMENTAL | REPLICATION RESTART | COMPONENT 1 | HUMAN-CELLS | CTC1 MUTATIONS | END-PROTECTION | HUMAN CST | DUPLEX REPLICATION | IMMUNOLOGY | BONE-MARROW FAILURE | STRAND FILL-IN | Calcinosis - genetics | Central Nervous System Cysts - metabolism | Retinal Diseases - genetics | Leukoencephalopathies - genetics | Seizures - genetics | Humans | Brain Neoplasms - pathology | Seizures - drug therapy | Male | Retinal Diseases - metabolism | Seizures - metabolism | Brain Neoplasms - metabolism | Muscle Spasticity - drug therapy | Leukoencephalopathies - drug therapy | Telomere-Binding Proteins - genetics | Seizures - pathology | Ataxia - drug therapy | Retinal Diseases - pathology | Female | Telomere - metabolism | Ataxia - genetics | Calcinosis - metabolism | Ataxia - metabolism | Ataxia - pathology | Disease Models, Animal | Telomere - genetics | Thalidomide - adverse effects | Leukoencephalopathies - pathology | Calcinosis - drug therapy | Telomere-Binding Proteins - biosynthesis | Brain Neoplasms - genetics | Zebrafish | Leukoencephalopathies - metabolism | Muscle Spasticity - metabolism | Thalidomide - administration & dosage | Brain Neoplasms - drug therapy | Muscle Spasticity - pathology | Central Nervous System Cysts - pathology | Central Nervous System Cysts - genetics | Gene Expression Regulation - drug effects | Central Nervous System Cysts - drug therapy | Telomere - pathology | Animals | Mutation | Retinal Diseases - drug therapy | Calcinosis - pathology | Muscle Spasticity - genetics
Journal Article