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Cancer Cell, ISSN 1535-6108, 09/2012, Volume 22, Issue 3, pp. 345 - 358
Bortezomib therapy has proven successful for the treatment of relapsed/refractory, relapsed, and newly diagnosed multiple myeloma (MM); however, dose-limiting... 
DEUBIQUITINATING ENZYME | INACTIVATION | PROTEIN | THERAPY | ONCOLOGY | MDM2 | DEGRADATION | MECHANISMS | HAUSP | CANCER | P53 REGULATION | CELL BIOLOGY | Thiophenes - therapeutic use | Apoptosis - drug effects | Humans | Molecular Sequence Data | Antineoplastic Agents - therapeutic use | Pyrazines - therapeutic use | Thalidomide - pharmacology | Boronic Acids - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Protease Inhibitors - pharmacology | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Dexamethasone - pharmacology | Antineoplastic Agents - pharmacology | Drug Therapy, Combination | Multiple Myeloma - enzymology | Protease Inhibitors - therapeutic use | Proto-Oncogene Proteins c-mdm2 - metabolism | Ubiquitin Thiolesterase - antagonists & inhibitors | Bortezomib | Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors | Thiophenes - pharmacology | Random Allocation | Mice, SCID | Ubiquitin Thiolesterase - genetics | Xenograft Model Antitumor Assays | Dexamethasone - therapeutic use | Multiple Myeloma - pathology | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Mice | Thalidomide - therapeutic use | Pyrazines - pharmacology | Ubiquitin-Specific Peptidase 7 | Boronic Acids - pharmacology | Drug Resistance, Neoplasm - drug effects | Medical colleges | Dexamethasone | Proteases | Analysis | Multiple myeloma | Lymphomas | Apoptosis | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2002, Volume 277, Issue 19, pp. 16639 - 16647
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2010, Volume 285, Issue 43, pp. 33520 - 33528
Although gamma-tocotrienol (T3), a vitamin E isolated primarily from palm and rice bran oil, has been linked with anticancer activities, the mechanism of this... 
MULTIPLE-MYELOMA | ACTIVATION | INHIBITION | CANCER CELLS | INDUCED APOPTOSIS | SRC | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-PRODUCTS | TRANSCRIPTION | FACTOR-KAPPA-B | NATURAL VITAMIN-E | Neoplasms - metabolism | Inhibitor of Apoptosis Proteins - genetics | Humans | Vitamin E - analogs & derivatives | G1 Phase - drug effects | Thalidomide - pharmacology | Neoplasm Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - biosynthesis | Janus Kinase 1 - metabolism | Chromans - pharmacology | Neoplasms - genetics | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | gamma-Tocopherol - pharmacology | src-Family Kinases - metabolism | Enzyme Induction - drug effects | Antineoplastic Agents - pharmacology | G1 Phase - genetics | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Inhibitor of Apoptosis Proteins - biosynthesis | Bortezomib | Gene Silencing | Janus Kinase 2 - genetics | Angiogenesis Inhibitors - pharmacology | Antioxidants - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Neoplasms - drug therapy | Animals | Mice | RNA, Small Interfering | Pyrazines - pharmacology | src-Family Kinases - genetics | Apoptosis | Boronic Acids - pharmacology | Vitamin E - pharmacology | Index Medicus | Molecular Bases of Disease | STAT Transcription Factor | Signal Transduction | Tocotrienol | Src | Jak Kinase | Tyrosine-protein Phosphatase (Tyrosine Phosphatase)
Journal Article
Blood, ISSN 0006-4971, 11/2011, Volume 118, Issue 18, pp. 4771 - 4779
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2011, Volume 17, Issue 16, pp. 5311 - 5321
Purpose: The success of bortezomib therapy for treatment of multiple myeloma (MM) led to the development of structurally and pharmacologically distinct novel... 
THERAPY | CANCER CELLS | ONCOLOGY | INDUCED APOPTOSIS | GROWTH | DRUG-RESISTANCE | BORTEZOMIB | COMBINATION | NF-KAPPA-B | GENETIC ABNORMALITIES | P53 | Glycine - analogs & derivatives | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Caspase 8 - metabolism | Biological Availability | NF-kappa B - metabolism | Thalidomide - pharmacology | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Dexamethasone - pharmacology | Antineoplastic Agents - pharmacology | Glycine - pharmacokinetics | Boron Compounds - pharmacology | Cell Survival - drug effects | Bortezomib | Administration, Oral | Boron Compounds - pharmacokinetics | Enzyme Activation - drug effects | Mice, SCID | Multiple Myeloma - metabolism | Blotting, Western | Drug Synergism | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Glycine - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Index Medicus | Histone deacetylase | Animal models | Dexamethasone | Multiple myeloma | proteasomes | Hydroxamic acid | proteasome inhibitors | Caspase-3 | Stress | p53 protein | Caspase-8 | Angiogenesis | E2F protein | Caspase-9 | Xenografts | Antitumor activity | Endoplasmic reticulum | Apoptosis | Cancer | Tumors | Novel therapeutics | Myeloma | Proteasome inhibitor | Proteasome
Journal Article
Journal Article
Journal Article
Journal Article
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 15, pp. 2975 - 2987
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress immune responses. MDSCs have been... 
CANCER-PATIENTS | DENDRITIC CELLS | T-REGULATORY CELLS | IMMUNOSUPPRESSION | BONE-MARROW | GROWTH | PERIPHERAL-BLOOD | DIFFERENTIATION | IDENTIFICATION | HEMATOLOGY | PROGRESSION | Cell Proliferation | Reactive Oxygen Species - metabolism | Coculture Techniques | Humans | Sialic Acid Binding Ig-like Lectin 3 - immunology | Multiple Myeloma - immunology | Thalidomide - pharmacology | Lewis X Antigen - metabolism | Lipopolysaccharides - immunology | Thalidomide - analogs & derivatives | Flow Cytometry | T-Lymphocytes - metabolism | Myeloid Cells - immunology | Reactive Oxygen Species - immunology | Myeloid Cells - drug effects | Antineoplastic Agents - pharmacology | HLA-DR Antigens - metabolism | Sialic Acid Binding Ig-like Lectin 3 - metabolism | Cytokines - immunology | Tumor Microenvironment - drug effects | Bortezomib | CD11b Antigen - immunology | Cytokines - metabolism | Cells, Cultured | Lewis X Antigen - immunology | Multiple Myeloma - metabolism | Tumor Microenvironment - immunology | Multiple Myeloma - pathology | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Myeloid Cells - metabolism | T-Lymphocytes - immunology | HLA-DR Antigens - immunology | CD11b Antigen - metabolism | Pyrazines - pharmacology | Immunologic Factors - pharmacology | Boronic Acids - pharmacology | Tumor Burden - immunology | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Journal Article
Blood, ISSN 0006-4971, 09/2007, Volume 110, Issue 5, pp. 1656 - 1663
Activation of the extracellular signal-regulated kinase1/2 (ERK1/2) signaling cascade mediates human multiple myeloma (MM) growth and survival triggered by... 
Stromal Cells - pathology | RANK Ligand | Phosphorylcholine - analogs & derivatives | Thalidomide - pharmacology | Boronic Acids - therapeutic use | Thalidomide - analogs & derivatives | Cytotoxins - pharmacology | Dexamethasone - pharmacology | Benzimidazoles - therapeutic use | Cell Survival - drug effects | MAP Kinase Kinase 1 - antagonists & inhibitors | Osteoclasts - pathology | Bortezomib | Bone Marrow Cells - pathology | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Cell Adhesion - drug effects | Dexamethasone - therapeutic use | Mitogen-Activated Protein Kinase 3 - metabolism | Benzimidazoles - pharmacology | Ligands | Mice | Thalidomide - therapeutic use | Pyrazines - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Neoplasm Transplantation | Bone Marrow Cells - enzymology | Transplantation, Heterologous | Pyrazines - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Multiple Myeloma - drug therapy | Stromal Cells - enzymology | Phosphorylcholine - pharmacology | Tumor Cells, Cultured | Multiple Myeloma - enzymology | Cytotoxins - therapeutic use | Macrophage Colony-Stimulating Factor - metabolism | Mice, SCID | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | MAP Kinase Signaling System - drug effects | Interleukin-6 - pharmacology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Differentiation - drug effects | MAP Kinase Kinase 2 - antagonists & inhibitors | Cell Proliferation - drug effects | Osteoclasts - enzymology | Boronic Acids - pharmacology | Phosphorylcholine - therapeutic use | Index Medicus | Abridged Index Medicus | Neoplasia
Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2010, Volume 127, Issue 2, pp. 282 - 292
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2002, Volume 99, Issue 16, pp. 10730 - 10735
Journal Article