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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 404 - 421
Parkinson's disease (PD) is a debilitating neurodegenerative disorder associated with severe motor impairments caused by the loss of dopaminergic innervation... 
LOCALIZATION | TRANSMISSION | ACTIVATION | MEDIATED MODULATION | GLUTAMATE-RECEPTOR-4 | MGLUR4 | NEURONS | PHARMACOLOGY & PHARMACY | RAT-BRAIN | DYSFUNCTION | AGONISTS | Catalepsy - drug therapy | Receptors, G-Protein-Coupled - metabolism | Pyrimidines - blood | Humans | Male | Thallium - metabolism | Picolinic Acids - metabolism | Pyrimidines - metabolism | Brain - metabolism | Motor Neuron Disease - drug therapy | Corpus Striatum - pathology | Disease Models, Animal | Triazoles - therapeutic use | Glutamic Acid - pharmacology | Adenosine A2 Receptor Antagonists - therapeutic use | Brain - physiopathology | Rats | Psychomotor Performance - drug effects | Motor Neuron Disease - chemically induced | Rats, Sprague-Dawley | Motor Neuron Disease - pathology | Brain - drug effects | Drug Synergism | Triazoles - metabolism | Calcium Signaling - drug effects | Picolinic Acids - pharmacokinetics | Receptors, G-Protein-Coupled - antagonists & inhibitors | Brain - pathology | Corpus Striatum - drug effects | Tyrosine 3-Monooxygenase - metabolism | Triazoles - blood | Rats, Wistar | Substantia Nigra - pathology | Picolinic Acids - blood | Parkinson Disease - drug therapy | Receptors, Metabotropic Glutamate - metabolism | Receptors, G-Protein-Coupled - agonists | Substantia Nigra - metabolism | Corpus Striatum - metabolism | Dose-Response Relationship, Drug | Adenosine A2 Receptor Antagonists - metabolism | Motor Neuron Disease - metabolism | Oxidopamine - pharmacology | Transfection | Receptors, Metabotropic Glutamate - genetics | Reaction Time - drug effects | HEK293 Cells | Catalepsy - chemically induced | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Drug Therapy, Combination | Motor Neuron Disease - physiopathology | Haloperidol - pharmacology | Picolinic Acids - pharmacology | 3,4-Dihydroxyphenylacetic Acid - metabolism | Corpus Striatum - physiopathology | Levodopa - therapeutic use | Substantia Nigra - drug effects | Animals | Picolinic Acids - therapeutic use | Pyrimidines - therapeutic use | Adenosine A2 Receptor Antagonists - blood | Protein Binding | Receptors, Metabotropic Glutamate - agonists | Levodopa - metabolism | Monoamine Oxidase - metabolism
Journal Article
CIRCULATION RESEARCH, ISSN 0009-7330, 08/2012, Volume 111, Issue 4, pp. 446 - 454
Rationale: Activation of the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) has been implicated in the mechanism of cardiac ischemic... 
SENSITIVE POTASSIUM CHANNELS | CARDIAC & CARDIOVASCULAR SYSTEMS | cytoprotection | mitochondria | K-ATP CHANNELS | apoptosis | IDENTIFICATION | ATP-sensitive potassium channel | preconditioning | ischemia | INFARCT SIZE | ACTION-POTENTIAL DURATION | HIGH-AFFINITY INHIBITOR | DISEASE | renal outer medullary potassium channel | PERIPHERAL VASCULAR DISEASE | MATRIX VOLUME | CARDIOPROTECTION | HEMATOLOGY | EXPRESSION | Diazoxide - pharmacology | Mitochondria, Heart - metabolism | Cricetulus | Mitochondria, Heart - pathology | Humans | Thallium - metabolism | Mitochondria, Heart - drug effects | RNA, Messenger - metabolism | Necrosis | Mitochondrial Membranes - drug effects | Potassium Channels - metabolism | Transfection | RNA Interference | Time Factors | Cattle | Adenosine Triphosphate - metabolism | Mass Spectrometry | Proteomics - methods | Potassium Channel Blockers - pharmacology | CHO Cells | Cytoprotection | Animals, Newborn | Cricetinae | Potassium Channels, Inwardly Rectifying - drug effects | Bee Venoms - pharmacology | Gene Expression Regulation | Rats | Potassium Channels, Inwardly Rectifying - genetics | Potassium Channels - drug effects | Mitochondrial Proton-Translocating ATPases - metabolism | Mitochondrial Membranes - metabolism | Potassium Channels - genetics | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - metabolism | Potassium Channels, Inwardly Rectifying - metabolism | Apoptosis
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2009, Volume 236, Issue 1, pp. 59 - 70
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14297 - 14302
Glutamate transporters maintain low synaptic concentrations of neurotransmitter by coupling uptake to flux of other ions. Their transport cycle consists of two... 
Anions | Sodium | Amino acid transport system XAG | HeLa cells | Lithium | Acidic amino acids | Potassium | Electric current | Oocytes | Binding sites | Cation binding site | Sodium selectivity | Obligate exchange mutant | SUBSTRATE INTERACTIONS | INDIVIDUAL SUBUNITS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | obligate exchange mutant | NA+-BINDING | EXTRACELLULAR GATE | sodium selectivity | cation binding site | MEMBRANE-VESICLES | REENTRANT LOOP | RAT-BRAIN | CHLORIDE CHANNEL | AMINOBUTYRIC-ACID TRANSPORTER | Potassium - metabolism | Excitatory Amino Acid Transporter 3 - physiology | Excitatory Amino Acid Transporter 2 - physiology | Cations - metabolism | Humans | Thallium - metabolism | Sodium - metabolism | Aspartic Acid - genetics | Brain - metabolism | Lithium - metabolism | Oocytes - drug effects | Archaeal Proteins - genetics | Female | Ion Transport - drug effects | Excitatory Amino Acid Transporter 2 - genetics | Binding Sites | Archaeal Proteins - metabolism | Membrane Potentials - drug effects | Rabbits | Sodium - pharmacology | Lithium - pharmacology | Oocytes - metabolism | Xenopus laevis | Rats | Excitatory Amino Acid Transporter 3 - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Potassium - pharmacology | Animals | Excitatory Amino Acid Transporter 3 - metabolism | Oocytes - physiology | Protein Binding | Aspartic Acid - metabolism | HeLa Cells | Liposomes | Mutation | Aspartic Acid - pharmacology | Physiological aspects | Thallium | Research | Glutamate | Biological transport | Biological Sciences
Journal Article
Journal Article
Environmental Science and Pollution Research, ISSN 0944-1344, 4/2016, Volume 23, Issue 7, pp. 6524 - 6534
Journal Article
Journal Article
Journal Article