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Journal of Heterocyclic Chemistry, ISSN 0022-152X, 11/2018, Volume 55, Issue 11, pp. 2447 - 2479
Theophylline, also known as 1,3‐dimethylxanthine, belongs to class of purine‐based drugs, which are used in the treatment of air ways disorders such as asthma... 
ACID-DERIVATIVES | DESIGN | ANTICANCER | LIGANDS | ANALOGS | AMINO-ACIDS | CAFFEINE | CHEMISTRY, ORGANIC | AGENTS | EFFICIENT | Theophylline | Chronic obstructive pulmonary disease | Derivatives | Fungicides | Asthma | Anticancer properties
Journal Article
Phytochemistry, ISSN 0031-9422, 08/2013, Volume 92, pp. 128 - 136
Journal Article
Steroids, ISSN 0039-128X, 5/2012, Volume 77, Issue 6, pp. 596 - 601
The progesterone receptor (PR) plays a key role in reproduction and is important in cancers of the reproductive tract. Current PR antagonists usually compete... 
Steroid receptor | Structure activity relationship | Progesterone receptor | Small molecule inhibitor | Theophylline analogue
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | TICLOPIDINE | PHARMACOKINETICS | HEALTHY-SUBJECTS | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | ATORVASTATIN | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6 | Index Medicus
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2008, Volume 16, Issue 17, pp. 8142 - 8150
Journal Article
Epilepsy and Behavior, ISSN 1525-5050, 2008, Volume 14, Issue 1, pp. 48 - 53
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2014, Volume 34, Issue 5, pp. 1879 - 1891
Journal Article
Journal Article
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, 2005, Volume 61, Issue 7, pp. 1453 - 1459
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2006, Volume 149, Issue 5, pp. 523 - 531
Background and purpose: Our knowledge of the effects of P2-receptor activation on renal vascular tone comes mostly from in vitro models. We aimed to... 
adenosine | renal circulation | sulphophenyl)theophylline | ibuprofen | purinoceptors | renal medulla | ATP | methylene ATP | A(2A) RECEPTORS | BLOOD-FLOW | SENSORY NEURONS | AUTOREGULATION | RENAL NERVE-STIMULATION | SMOOTH-MUSCLE | 8-(p-sulphophenyl)theophylline | P2X RECEPTORS | VASOCONSTRICTOR | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | alpha,beta-methylene ATP | beta,gamma-methylene ATP | EXPRESSION | Kidney - physiology | Kidney Cortex - drug effects | Purinergic P1 Receptor Antagonists | Theophylline - analogs & derivatives | Kidney - blood supply | Nitric Oxide Synthase - antagonists & inhibitors | Male | Kidney Medulla - blood supply | Adenosine Triphosphate - pharmacology | Regional Blood Flow - drug effects | Kidney Cortex - physiology | Laser-Doppler Flowmetry - methods | Renal Circulation - drug effects | Purinergic P1 Receptor Agonists | Rabbits | Ibuprofen - pharmacology | Kidney - drug effects | Kidney Cortex - blood supply | Kidney Medulla - drug effects | Purinergic P2 Receptor Antagonists | Receptors, Purinergic P1 - physiology | Receptors, Purinergic P2 - physiology | Purinergic P2 Receptor Agonists | Adenosine - pharmacology | Adenosine Triphosphate - analogs & derivatives | Cyclooxygenase Inhibitors - pharmacology | Nitroarginine - pharmacology | Animals | Theophylline - pharmacology | Nitric Oxide Synthase - metabolism | Kidney Medulla - physiology | Regional Blood Flow - physiology | Prostaglandins - metabolism | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2006, Volume 530, Issue 1-2, pp. 179 - 187
Acyclic nucleoside phosphonates are widely recognised antivirals. The oral prodrugs of prototype compounds, e.g., 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA;... 
Chemokine | Adenosine receptor | Acyclic nucleoside phosphonate | Cytokine | Anti-HIV Agents - pharmacology | Purinergic P1 Receptor Antagonists | 2-Aminopurine - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | RNA, Messenger - metabolism | Chemokine CCL5 - secretion | Chemokine CCL5 - antagonists & inhibitors | Macrophage Inflammatory Proteins - secretion | 2-Aminopurine - analogs & derivatives | Caffeine - pharmacology | Interleukin-10 - secretion | 2-Aminopurine - chemistry | Cell Survival - drug effects | Chemokine CCL4 | Adenine - analogs & derivatives | Chemokine CCL3 | Tumor Necrosis Factor-alpha - secretion | Receptors, Purinergic P1 - physiology | Reverse Transcriptase Polymerase Chain Reaction | Anti-HIV Agents - chemistry | Macrophages - metabolism | Interleukin-10 - antagonists & inhibitors | Interleukin-10 - genetics | Chemokine CCL5 - genetics | Lipopolysaccharides - pharmacology | Dihydropyridines - pharmacology | Theophylline - pharmacology | Mice | Quinazolines - pharmacology | Anti-HIV Agents - immunology | Theophylline - analogs & derivatives | Adjuvants, Immunologic - pharmacology | Caffeine - analogs & derivatives | Dose-Response Relationship, Drug | Female | Molecular Structure | Adenine - immunology | Flavins - pharmacology | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Adenine - pharmacology | Macrophages - cytology | 2-Aminopurine - pharmacology | Macrophage Inflammatory Proteins - genetics | Organophosphonates - immunology | Triazoles - pharmacology | Organophosphonates - pharmacology | Animals | Macrophages - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article