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American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 08/2016, Volume 311, Issue 2, pp. E530 - E541
To better understand the role of irisin in humans, we examined the effects of irisin in human primary adipocytes and fresh human subcutaneous white adipose... 
Irisin | Thermogenesis | Human white adipose tissue | Brown adipose tissue | Adipocytes browning | Osteogenesis | Adipogenesis | Immunohistochemistry | Thermogenesis - genetics | Up-Regulation | Phosphoproteins - drug effects | Extracellular Signal-Regulated MAP Kinases - drug effects | Adipocytes, Brown - metabolism | Adipogenesis - drug effects | Humans | Middle Aged | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Young Adult | Adipocytes, White - drug effects | Exercise | Cell Respiration - drug effects | Adult | Female | p38 Mitogen-Activated Protein Kinases - metabolism | Adipogenesis - genetics | Real-Time Polymerase Chain Reaction | Osteogenesis - genetics | STAT3 Transcription Factor - metabolism | RNA, Messenger - drug effects | Uncoupling Protein 1 - drug effects | Fibronectins - pharmacology | Signal Transduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Osteoblasts - drug effects | Osteogenesis - drug effects | Cells, Cultured | Mitochondria - metabolism | Mitochondria - drug effects | Subcutaneous Fat - cytology | Blotting, Western | Obesity - metabolism | p38 Mitogen-Activated Protein Kinases - drug effects | Cell Differentiation - drug effects | STAT3 Transcription Factor - drug effects | Adolescent | Aged | Thermogenesis - drug effects | Osteoblasts - metabolism | Adipocytes, White - metabolism | Fat cells | Growth | Physiological aspects | Bones | Physiological research | Research
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7382, pp. 463 - 468
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional... 
SKELETAL-MUSCLE | COACTIVATOR | PHOSPHORYLATION | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | DISEASE | MYOBLAST | EXPRESSION | EXERCISE | ADIPOSE-TISSUE | PROTECTS | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Adipocytes - drug effects | Obesity - blood | Adipose Tissue, White - cytology | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Models, Animal | Energy Metabolism - physiology | Intracellular Signaling Peptides and Proteins - genetics | Obesity - chemically induced | Mice, Transgenic | Trans-Activators - deficiency | Obesity - prevention & control | Plasma - chemistry | Adipose Tissue, Brown - drug effects | Exercise - physiology | Mice | Mice, Inbred BALB C | Transcription Factors | Energy Metabolism - drug effects | Thermogenesis - genetics | Adipose Tissue, White - metabolism | Adipocytes - cytology | Culture Media, Conditioned - pharmacology | Subcutaneous Fat - metabolism | Insulin Resistance - physiology | Cell Respiration - drug effects | Subcutaneous Fat - drug effects | Trans-Activators - genetics | Energy Metabolism - genetics | Gene Expression Regulation - genetics | Cells, Cultured | Hormones - secretion | Muscle Cells - metabolism | Physical Conditioning, Animal - physiology | Subcutaneous Fat - cytology | Gene Expression Regulation - drug effects | Adipose Tissue, Brown - cytology | Animals | Hormones - metabolism | Ion Channels - metabolism | Adipocytes - metabolism | Trans-Activators - secretion | Trans-Activators - metabolism | Adipose Tissue, Brown - metabolism | Thermogenesis - drug effects | Uncoupling Protein 1 | Adipose Tissue, White - drug effects
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2015, Volume 21, Issue 12, pp. 1497 - 1501
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2017, Volume 26, Issue 3, pp. 493 - 508.e4
Type 2 cytokines are important signals triggering biogenesis of thermogenic beige adipocytes in white adipose tissue (WAT) during cold acclimation. However,... 
adipose remodeling | macrophages | adipocyte precursor cells | beiging | adaptive thermogenesis | eotaxin | eosinophils | type 2 immunity | ANTIDIABETIC ACTIONS | CELLS | ENERGY-EXPENDITURE | ADIPOCYTES | ADIPONECTIN | EOSINOPHILS | ENDOCRINOLOGY & METABOLISM | INSULIN SENSITIVITY | EOTAXIN | GROWTH-FACTOR 21 | FGF21 | CELL BIOLOGY | Eosinophils - metabolism | Eosinophils - drug effects | Sympathetic Nervous System - drug effects | Adaptation, Physiological - drug effects | Glucuronidase - metabolism | Adipose Tissue, White - metabolism | Adipocytes - cytology | Male | Autocrine Communication - drug effects | Stem Cells - cytology | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Stem Cells - metabolism | Sympathetic Nervous System - metabolism | Immunity - drug effects | Fibroblast Growth Factors - metabolism | Cold Temperature | Chemokine CCL11 - metabolism | Mice, Inbred C57BL | Fibroblast Growth Factors - deficiency | Recombinant Proteins - pharmacology | Mice, Knockout | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Adipocytes - metabolism | Stem Cells - drug effects | Adipose Tissue, Beige - drug effects | Macrophages - drug effects | Cell Proliferation - drug effects | Thermogenesis - drug effects | Adipose Tissue, Beige - metabolism | Adipose Tissue, White - drug effects | Adipose tissues | Fibroblast growth factors | Immune response | Macrophages | Pharmaceutical biotechnology
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2016, Volume 24, Issue 1, pp. 118 - 129
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7656, pp. 107 - 112
Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the beta-subunit of the pituitary hormone... 
WHITE | OBESITY | ENERGY-EXPENDITURE | BROWN-FAT | OSTEOCLAST FORMATION | MULTIDISCIPLINARY SCIENCES | FOLLICLE-STIMULATING-HORMONE | RECEPTOR | BONE MASS | MENOPAUSAL TRANSITION | OVARIECTOMIZED MICE | Obesity - drug therapy | Receptors, FSH - genetics | Adipose Tissue, White - metabolism | Diet, High-Fat - adverse effects | Follicle Stimulating Hormone, beta Subunit - antagonists & inhibitors | Male | Osteoporosis - drug therapy | Adipocytes - drug effects | Uncoupling Protein 1 - biosynthesis | Adipose Tissue - metabolism | Antibodies - immunology | Female | Receptors, FSH - metabolism | Adiposity - drug effects | Ovariectomy | Mitochondria - metabolism | Mitochondria - drug effects | Receptors, FSH - antagonists & inhibitors | Haploinsufficiency | Antibodies - pharmacology | Animals | Oxygen Consumption - drug effects | Adipocytes - metabolism | Obesity - prevention & control | Follicle Stimulating Hormone, beta Subunit - immunology | Adipose Tissue, Beige - drug effects | Mice | Thermogenesis - drug effects | Adipose Tissue - drug effects | Adipose Tissue, Beige - metabolism | Adipose Tissue, White - drug effects | Adipose tissues | Physiological aspects | Physiological research | Follicle-stimulating hormone | Thermogenesis | Research | Adipose tissue | Body fat | Menopause | Adipocytes | Hormones | Density | Osteoporosis | Mitochondria | Biomedical materials | Biocompatibility | Bone loss | Adipose tissue (brown) | Binding | Obesity | Immunoglobulins | Pituitary hormones | Blocking | Metabolism | Bone mass | Pituitary | Bone
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 03/2018, Volume 10, Issue 3, p. n/a
Brown adipose tissue ( BAT ) activation stimulates energy expenditure in human adults, which makes it an attractive target to combat obesity and related... 
GPR | brown adipose tissue | mitochondria | lipid metabolism | 120 | GPR120 | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ACTIVATION | PROTEIN | INSULIN-SECRETION | THERMOGENESIS | POTENT | Ca2 | GLUCOSE-METABOLISM | GENE-EXPRESSION | ACID RECEPTOR GPR40 | ADIPOSE-TISSUE | Adipocytes, White - cytology | Adipocytes, Brown - metabolism | Receptors, G-Protein-Coupled - metabolism | Adipose Tissue, White - metabolism | Body Weight - drug effects | Lipids | Male | Receptors, G-Protein-Coupled - agonists | Adipocytes, White - drug effects | Biphenyl Compounds - pharmacology | Cell Respiration - drug effects | Adiposity - drug effects | Oxidation-Reduction | Adipocytes, Brown - drug effects | Uncoupling Protein 1 - metabolism | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Gene Expression Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Receptors, G-Protein-Coupled - deficiency | Cell Differentiation - drug effects | Models, Biological | Oxygen Consumption - drug effects | Glucose - metabolism | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Adipocytes, Brown - cytology | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Physiological aspects | Obesity | G proteins | Body weight | Membrane proteins | Pharmacology & Drug Discovery | Metabolism | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cell- och molekylärbiologi
Journal Article
Diabetes, ISSN 0012-1797, 10/2014, Volume 63, Issue 10, pp. 3346 - 3358
GLP-1 receptor (GLP-1R) is widely located throughout the brain, but the precise molecular mechanisms mediating the actions of GLP-1 and its long-acting analogs... 
NERVOUS-SYSTEM | GLUCOSE-HOMEOSTASIS | ENERGY-EXPENDITURE | GLUCAGON-LIKE PEPTIDE-1 | FOOD-INTAKE | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | RAT-BRAIN | DIET-INDUCED OBESITY | RECEPTORS | TYPE-2 DIABETES-MELLITUS | Protein Kinases - metabolism | Metformin - therapeutic use | Obesity - drug therapy | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Eating - physiology | Young Adult | Glucagon-Like Peptide 1 - agonists | Aged, 80 and over | Adult | Female | Hypothalamus - drug effects | Drug Therapy, Combination | Energy Metabolism - physiology | Hypoglycemic Agents - therapeutic use | Glucagon-Like Peptide 1 - analogs & derivatives | Metformin - pharmacology | Glucagon-Like Peptide 1 - pharmacology | Rats | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Peptides - pharmacology | Eating - drug effects | Animals | Hypothalamus - metabolism | Venoms - therapeutic use | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Aged | Mice | Venoms - pharmacology | Thermogenesis - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Energy Metabolism - drug effects | Liraglutide | Peptides - therapeutic use | Glucagon-Like Peptide 1 - therapeutic use | Type 2 diabetes | Complications and side effects | Thermogenesis | Body weight | Brown adipose tissue | Development and progression | Research | Risk factors
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2011, Volume 589, Issue 14, pp. 3641 - 3658
Non‐technical summary  Shivering is an involuntary somatic motor response that occurs in skeletal muscles to produce heat during exposure to cold environments... 
PHYSIOLOGY | NONSHIVERING THERMOGENESIS | 5-HT1A RECEPTORS | SYMPATHETIC PREMOTOR NEURONS | SPINAL-CORD | DORSOMEDIAL HYPOTHALAMUS | BROWN ADIPOSE-TISSUE | EXPRESSING PREOPTIC NEURONS | BODY-TEMPERATURE | NEUROSCIENCES | PROSTAGLANDIN EP3 RECEPTOR | RAPHE PALLIDUS | Skin Temperature - physiology | Neural Pathways - drug effects | Efferent Pathways - physiology | Fever - metabolism | Male | Preoptic Area - metabolism | Neural Pathways - physiology | Fever - physiopathology | N-Methylaspartate - pharmacology | Neurons - metabolism | Medulla Oblongata - physiology | Preoptic Area - physiology | Dinoprostone - pharmacology | Body Temperature Regulation - physiology | Shivering - physiology | Rats | Mediodorsal Thalamic Nucleus - drug effects | Tachycardia - metabolism | Raphe Nuclei - drug effects | Raphe Nuclei - physiology | Neural Pathways - metabolism | Adipose Tissue, Brown - drug effects | Receptors, GABA-A - metabolism | Muscimol - pharmacology | Rats, Wistar | Preoptic Area - drug effects | Sympathetic Nervous System - drug effects | GABA-A Receptor Antagonists - metabolism | Sympathetic Nervous System - metabolism | Raphe Nuclei - metabolism | Thermogenesis - physiology | Heart Rate - drug effects | Mediodorsal Thalamic Nucleus - metabolism | Sympathetic Nervous System - physiology | Shivering - drug effects | Neurons - physiology | Heart Rate - physiology | Blood Pressure - drug effects | Blood Pressure - physiology | Tachycardia - pathology | Mediodorsal Thalamic Nucleus - physiology | Neurons - drug effects | Receptor, Serotonin, 5-HT1A - metabolism | Cold Temperature | Medulla Oblongata - drug effects | Medulla Oblongata - metabolism | Adipose Tissue, Brown - physiology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Efferent Pathways - metabolism | Animals | Thermogenesis - drug effects | GABA | Heart beat | Neurons | Analysis | Prostaglandins E | Heart rate | Skin | Cooling | Thermogenesis | Cold | Rodents | Integrative
Journal Article
Diabetes, ISSN 0012-1797, 07/2009, Volume 58, Issue 7, pp. 1509 - 1517
Journal Article