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1. Full Text 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4 H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesic-anti-inflammatory and antimicrobial activities
by Salgın-Gökşen, Umut and Gökhan-Kelekçi, Nesrin and Göktaş, Özgür and Köysal, Yavuz and Kılıç, Ekrem and Işık, Şamil and Aktay, Göknur and Özalp, Meral
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 17, pp. 5738 - 5751
Thiosemicarbazide | Triazol | Hydrazone | Analgesic-anti-inflammatory and antimicrobial activities | Thiadiazole | 2-Benzoxazolinone | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | General aspects | Analgesics | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Biological and medical sciences | Medical sciences | Neuropharmacology | Antibiotics. Antiinfectious agents. Antiparasitic agents | Analgesics - pharmacology | Triazoles - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Analgesics - chemical synthesis | Thiadiazoles - chemistry | Thiadiazoles - therapeutic use | Anti-Bacterial Agents - chemistry | Hydrazones - therapeutic use | Semicarbazides - pharmacology | Semicarbazides - chemistry | Anti-Inflammatory Agents - therapeutic use | Triazoles - chemical synthesis | Molecular Structure | Thiadiazoles - pharmacology | Triazoles - therapeutic use | Microbial Viability - drug effects | Anti-Inflammatory Agents - pharmacology | Models, Molecular | Edema - drug therapy | Hydrazones - chemical synthesis | Semicarbazides - therapeutic use | Hydrazones - chemistry | Hydrazones - pharmacology | Anti-Bacterial Agents - chemical synthesis | Semicarbazides - chemical synthesis | Triazoles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzoxazoles - chemistry | Thiadiazoles - chemical synthesis | Analgesics - chemistry | Hindlimb - drug effects | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis | Mice | Methylation | Edema - pathology | Index Medicus
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2. Full Text Novel ATP‐competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells
by Yamaji, Masayuki and Ota, Akinobu and Wahiduzzaman, Md and Karnan, Sivasundaram and Hyodo, Toshinori and Konishi, Hiroyuki and Tsuzuki, Shinobu and Hosokawa, Yoshitaka and Haniuda, Masayuki
Cancer medicine (Malden, MA), ISSN 2045-7634, 11/2017, Volume 6, Issue 11, pp. 2646 - 2659
Afuresertib | cancer therapy | Mesothelioma | Akt inhibitor | Life Sciences & Biomedicine | Oncology | Science & Technology | Caspase 7 - metabolism | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Caspase 3 - metabolism | Phosphorylcholine - analogs & derivatives | Heterocyclic Compounds, 4 or More Rings - pharmacology | Pleural Neoplasms - drug therapy | Quinoxalines - pharmacology | Oxadiazoles - pharmacology | Phosphorylcholine - pharmacology | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Pyrazoles - pharmacology | Thiadiazoles - pharmacology | Forkhead Box Protein O1 - metabolism | Thiophenes - pharmacology | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Glycogen Synthase Kinase 3 beta - metabolism | Mesothelioma - drug therapy | Pyrroles - pharmacology | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Benzylamines - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Proteins | Analysis | Cell proliferation | Phosphorylation | Asbestos | Cell survival | Caspase | Cytotoxicity | Occupational diseases | AKT protein | Thorax | Myc protein | Cisplatin | Western blotting | 1-Phosphatidylinositol 3-kinase | Cyclin-dependent kinase inhibitor p21 | Cell number | Cell cycle | Forkhead protein | Apoptosis | G1 phase | Index Medicus
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3. Full Text Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions
by Xu, Xi and Meng, Ying and Li, Lei and Xu, Pengfei and Wang, Jubo and Li, Zhiyu and Bian, Jinlei
Journal of medicinal chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 3, pp. 1096 - 1115
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Humans | Thiazolidinediones - therapeutic use | Thiadiazoles - therapeutic use | Benzophenanthridines - therapeutic use | Sulfides - metabolism | Thiadiazoles - metabolism | Thiazolidinediones - pharmacology | Benzoquinones - metabolism | Sulfides - pharmacology | Thiadiazoles - pharmacology | Catalytic Domain | Enzyme Inhibitors - metabolism | Enzyme Inhibitors - pharmacology | Sulfides - therapeutic use | Glutaminase - metabolism | Drug Discovery | Enzyme Inhibitors - therapeutic use | Glutaminase - antagonists & inhibitors | Thiazolidinediones - metabolism | Benzophenanthridines - pharmacology | Glutaminase - chemistry | Benzoquinones - pharmacology | Animals | Cell Line, Tumor | Protein Binding | Mice | Molecular Docking Simulation | Benzoquinones - therapeutic use | Benzophenanthridines - metabolism | Index Medicus
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4. Full Text Novel N -Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential
by De La Fuente Revenga, Mario and Fernández-Sáez, Nerea and Herrera-Arozamena, Clara and Morales-García, José A and Alonso-Gil, Sandra and Pérez-Castillo, Ana and Caignard, Daniel-Henri and Rivara, Silvia and Rodríguez-Franco, María Isabel
Journal of medicinal chemistry, ISSN 0022-2623, 06/2015, Volume 58, Issue 12, pp. 4998 - 5014
Cricetulus | Rats, Wistar | Humans | Cells, Cultured | Neural Stem Cells - drug effects | Models, Molecular | Rats | Male | Neural Stem Cells - cytology | Receptors, Melatonin - metabolism | Melatonin - analogs & derivatives | Animals | Oxadiazoles - pharmacology | Thiadiazoles - chemistry | Receptors, Melatonin - agonists | Neurogenesis - drug effects | Oxadiazoles - chemistry | Melatonin - pharmacology | Receptors, Melatonin - antagonists & inhibitors | CHO Cells | Thiadiazoles - pharmacology | Index Medicus
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5. Full Text Neuroendocrine modulation of IL-27 in macrophages
by Roewe, Julian and Higer, Maximilian and Riehl, Dennis R and Gericke, Adrian and Radsak, Markus P and Bosmann, Markus
The Journal of immunology (1950), ISSN 0022-1767, 10/2017, Volume 199, Issue 7, pp. 2503 - 2514
Life Sciences & Biomedicine | Immunology | Science & Technology | Norepinephrine - pharmacology | Albuterol - pharmacology | Sympathetic Nervous System - immunology | Zymosan - pharmacology | Interleukins - metabolism | Interleukins - genetics | Sympathetic Nervous System - physiology | Receptors, Adrenergic - drug effects | Interleukins - immunology | Macrophages - immunology | Thiadiazoles - pharmacology | Interleukins - blood | Formoterol Fumarate - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Inflammation | Sulfonamides - pharmacology | Toll-Like Receptor 3 - metabolism | Anthracenes - pharmacology | Animals | Shock, Septic | Signal Transduction - drug effects | Poly I-C - metabolism | Lipopolysaccharides - pharmacology | Interleukin-10 - biosynthesis | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Interleukin-10 - immunology | Epinephrine - pharmacology | Shock | Adrenal glands | Nervous system | Leukocytes (mononuclear) | Feedback loops | Macrophages | Neuromodulation | Interleukin 27 | Neoplasms | Neuroendocrine system | Interleukin 6 | Cell activation | Autonomic nervous system | Modulation | Formoterol | Autocrine signalling | Noradrenaline | Endotoxemia | Epinephrine | CD11b antigen | Immune response | Immunoregulation | Interleukin 12 | Catecholamines | JNK protein | Pharmacology | Sympathetic nervous system | Catecholamine | Gene silencing | Interleukin 10 | Adrenergic receptors | Receptors (physiology) | Hypothermia | Index Medicus | Abridged Index Medicus
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6. Full Text Antagonistic Interaction between Systemic Acquired Resistance and the Abscisic Acid: Mediated Abiotic Stress Response in Arabidopsis
by Michiko Yasuda and Atsushi Ishikawa and Yusuke Jikumaru and Motoaki Seki and Taishi Umezawa and Tadao Asami and Akiko Maruyama-Nakashita and Toshiaki Kudo and Kazuo Shinozaki and Shigeo Yoshida and Hideo Nakashita
The Plant cell, ISSN 1040-4651, 6/2008, Volume 20, Issue 6, pp. 1678 - 1692
Pathogens | Disease resistance | Leaves | Signal transduction | Systemic acquired resistance | Genes | Plants | Pretreatment | Plant cells | Rice | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Cell Biology | Oligonucleotide Array Sequence Analysis | Sulfhydryl Compounds - pharmacology | Salicylic Acid - metabolism | rab GTP-Binding Proteins - genetics | Ethylenes - metabolism | Salicylic Acid - pharmacology | Abscisic Acid - metabolism | Ethylenes - pharmacology | Drug Resistance | Thiadiazoles - pharmacology | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Plants, Genetically Modified - genetics | Signal Transduction | Plants, Genetically Modified - drug effects | Cyclopentanes - pharmacology | Arabidopsis - metabolism | Arabidopsis - genetics | Abscisic Acid - pharmacology | Oxylipins - metabolism | Gene Expression Regulation, Plant - drug effects | Plants, Genetically Modified - metabolism | Oxylipins - pharmacology | Cyclopentanes - metabolism | Mutation | Plant Growth Regulators - metabolism | Plant Growth Regulators - pharmacology | Arabidopsis thaliana | Abscisic acid | Analysis | Index Medicus
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7. Full Text Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives
by Shih, Mei-Hsiu and Ke, Fang-Ying
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2004, Volume 12, Issue 17, pp. 4633 - 4643
3-Aryl-4-formylsydnone thiosemicarbazones | Thiazolindinones | Antioxidant activity | Thiazolines | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | General and cellular metabolism. Vitamins | Pharmacology. Drug treatments | Free Radical Scavengers - pharmacology | Hydrazines - pharmacology | Thiosemicarbazones - chemical synthesis | Structure-Activity Relationship | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Animals | Thiadiazoles - chemical synthesis | Biphenyl Compounds - pharmacology | Cyclization | Picrates | Thiosemicarbazones - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Thiadiazoles - pharmacology | Vitamin E - pharmacology | Index Medicus
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8. Full Text Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition
by Jacque, Nathalie and Ronchetti, Anne Marie and Larrue, Clément and Meunier, Godelieve and Birsen, Rudy and Willems, Lise and Saland, Estelle and Decroocq, Justine and Maciel, Thiago Trovati and Lambert, Mireille and Poulain, Laury and Hospital, Marie Anne and Sujobert, Pierre and Joseph, Laure and Chapuis, Nicolas and Lacombe, Catherine and Moura, Ivan Cruz and Demo, Susan and Sarry, Jean Emmanuel and Recher, Christian and Mayeux, Patrick and Tamburini, Jérôme and Bouscary, Didier and Marie Anne Hosp
Blood, ISSN 0006-4971, 09/2015, Volume 126, Issue 11, pp. 1346 - 1356
Life Sciences & Biomedicine | Hematology | Science & Technology | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Glutamine - metabolism | Gene Knockdown Techniques | Oxidative Phosphorylation - drug effects | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Thiadiazoles - pharmacology | Citric Acid Cycle - drug effects | Enzyme Inhibitors - pharmacology | Glutaminase - metabolism | Mitochondria - metabolism | Sulfonamides - pharmacology | Glutaminase - antagonists & inhibitors | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Oxygen Consumption - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Glutaminase - genetics | Leukemia, Myeloid, Acute - genetics | Index Medicus | Abridged Index Medicus | 33 | Myeloid Neoplasia
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9. Full Text Synthesis of novel sulfonamide-1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studies
by Zoumpoulakis, P and Camoutsis, Ch and Pairas, G and Soković, M and Glamočlija, J and Potamitis, C and Pitsas, A
Bioorganic & medicinal chemistry, ISSN 0968-0896, 02/2012, Volume 20, Issue 4, pp. 1569 - 1583
Thiadiazoles | Oxadiazoles | Antifungal | Sulfonamides | Triazoles | Conformational analysis | Antibacterial | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Antibacterial agents | Pharmacology. Drug treatments | Antifungal agents | Antibiotics. Antiinfectious agents. Antiparasitic agents | Antifungal Agents - pharmacology | Oxadiazoles - chemical synthesis | Fungi - drug effects | Magnetic Resonance Spectroscopy | Triazoles - chemistry | Bacteria - drug effects | Models, Molecular | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Microbial Sensitivity Tests | Triazoles - pharmacology | Thiadiazoles - chemical synthesis | Oxadiazoles - pharmacology | Thiadiazoles - chemistry | Anti-Bacterial Agents - chemistry | Triazoles - chemical synthesis | Anti-Bacterial Agents - pharmacology | Molecular Structure | Oxadiazoles - chemistry | Thiadiazoles - pharmacology | Plant physiology | Analysis | Index Medicus | Bifonazole | Magnetic resonance spectroscopy | Antifungal activity | Molecular modelling | Streptomycin | Fungicides | Chloramphenicol | Structure-activity relationships | Nuclei
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10. Full Text A small-molecule dye for NIR-II imaging
by Antaris, Alexander L and Chen, Hao and Cheng, Kai and Sun, Yao and Hong, Guosong and Qu, Chunrong and Diao, Shuo and Deng, Zixin and Hu, Xianming and Zhang, Bo and Zhang, Xiaodong and Yaghi, Omar K and Alamparambil, Zita R and Hong, Xuechuan and Cheng, Zhen and Dai, Hongjie
Nature materials, ISSN 1476-1122, 02/2016, Volume 15, Issue 2, pp. 235 - 242
Physical Sciences | Chemistry | Materials Science | Technology | Materials Science, Multidisciplinary | Physics, Condensed Matter | Chemistry, Physical | Physics | Science & Technology | Physics, Applied | Carcinoma, Squamous Cell - pathology | Humans | Mice, Inbred C57BL | Benzopyrans - urine | Male | Benzopyrans - chemistry | Diagnostic Imaging - methods | Neoplasms, Experimental - pathology | Phenylpropionates - pharmacology | Animals | Spectroscopy, Near-Infrared | Cell Line, Tumor | Female | Fluorescent Dyes - pharmacology | Indoles - pharmacology | Mice | Mice, Inbred BALB C | Benzopyrans - pharmacology | Indoles - chemistry | Indoles - urine | Thiadiazoles - pharmacology | Fluorescence | Molecules | Medical imaging | Dyes | Index Medicus | Uptakes | Tumours | Surgery | Imaging | Translations | Chemical compounds
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