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Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 10/2006, Volume 33, Issue 10, pp. 917 - 924
SUMMARY • Non-steroidal anti-inflammatory drugs (NSAIDs) cause renal side-effects. In the present study, we tested the hypothesis that the extent of the renal... 
pharmacokinetics | kidney | non-steroidal anti-inflammatory drugs | cyclo-oxygenase-2 | sodium urinary excretion | cyclo‐oxygenase‐2 | non‐steroidal anti‐inflammatory drugs | Cyclo-oxygenase-2 | Pharmacokinetics | Kidney | Non-steroidal anti-inflammatory drugs | Sodium urinary excretion | GASTROINTESTINAL TOXICITY | PHYSIOLOGY | CYCLOOXYGENASE-2 | RAT | HYPERKALEMIA | PROTEIN-BINDING | MELOXICAM | INTERSPECIES DIFFERENCES | GENTAMICIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PHARMACOLOGY & PHARMACY | Thiazoles - blood | Area Under Curve | Thiazines - administration & dosage | Thiazines - adverse effects | Sulfones - adverse effects | Male | Thiazoles - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - blood | Thiazoles - adverse effects | Thiazoles - pharmacokinetics | Dose-Response Relationship, Drug | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Lactones - pharmacokinetics | Sodium - urine | Lactones - administration & dosage | Pyrazoles - blood | Pyrazoles - pharmacokinetics | Sulfones - blood | Placebos - administration & dosage | Pyrazoles - adverse effects | Thiazines - pharmacokinetics | Kidney - drug effects | Administration, Oral | Cyclooxygenase 2 Inhibitors - administration & dosage | Rats | Thiazines - blood | Celecoxib | Lactones - adverse effects | Placebos - pharmacokinetics | Sulfones - pharmacokinetics | Cyclooxygenase 2 Inhibitors - pharmacokinetics | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Pyrazoles - administration & dosage | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Potassium - urine | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Sulfonamides - adverse effects | Sulfonamides - administration & dosage | Sulfones - administration & dosage | Kidney, drug effects | Lactones, adverse effects | Sulfones, administration and dosage | Thiazoles, administration and dosage | Anti-Inflammatory Agents, Non-Steroidal, pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal, adverse effects | Sodium, urine | Thiazines, blood | Anti-Inflammatory Agents, Non-Steroidal, blood | Lactones, administration and dosage | Cyclooxygenase 2 Inhibitors, adverse effects | Pyrazoles, blood | Sulfonamides, pharmacokinetics | Thiazines, pharmacokinetics | Pyrazoles, administration and dosage | Thiazoles, blood | Sulfonamides, administration and dosage | Cyclooxygenase 2 Inhibitors, administration and dosage | Lactones, pharmacokinetics | Sulfonamides, blood | Cyclooxygenase 2 Inhibitors, pharmacokinetics | Thiazines, adverse effects | Lactones, blood | Thiazoles, adverse effects | Thiazoles, pharmacokinetics | Sulfones, blood | Sulfonamides, adverse effects | Thiazines, administration and dosage | Placebos, pharmacokinetics | Sulfones, pharmacokinetics | Pyrazoles, adverse effects | Placebos, administration and dosage | Potassium, urine | Sulfones, adverse effects | Pyrazoles, pharmacokinetics
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2007, Volume 100, Issue 3, pp. 802 - 809
Generation and deposition of the amyloid β (Aβ) peptide following proteolytic processing of the amyloid precursor protein (APP) by BACE‐1 and γ‐secretase is... 
secretase | TASTPM | glycoprotein | amyloid precursor protein | Alzheimer's disease | β‐site amyloid precursor protein cleaving enzyme 1 | β-site amyloid precursor protein cleaving enzyme 1 | p-glycoprotein | Amyloid precursor protein | Secretase | SITE | ASPARTYL PROTEASE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | NEUROSCIENCES | beta-site amyloid precursor protein cleaving enzyme 1 | SECRETASE ACTIVITY | PURIFICATION | MICE | BRAIN | STRUCTURE-BASED DESIGN | Thiazines - therapeutic use | Amyloid beta-Protein Precursor - chemistry | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Brain - metabolism | Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Thiazines - pharmacology | Disease Models, Animal | Alzheimer Disease - physiopathology | Administration, Oral | Aspartic Acid Endopeptidases - antagonists & inhibitors | Amyloid beta-Peptides - biosynthesis | Brain - physiopathology | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Mice, Transgenic | Treatment Outcome | Down-Regulation - drug effects | Enzyme Inhibitors - therapeutic use | Thiazines - chemical synthesis | Brain - drug effects | Down-Regulation - physiology | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors
Journal Article
Life Sciences, ISSN 0024-3205, 11/2013, Volume 93, Issue 21, pp. 763 - 772
The main objective of the current investigation was to develop nanostructured lipid carriers (NLC) based gel for the enhancement of transdermal absorption of... 
Nanostructured lipid carriers | Meloxicam | Carrageenan induced paw edema model | Permeation rate | Hemocompatibility | Controlled release | MEDICINE, RESEARCH & EXPERIMENTAL | NLC | NANOPARTICLES SLN | STRATUM-CORNEUM | ELECTRON-MICROSCOPY | FORMULATION | IN-VITRO | PHASE-BEHAVIOR | PHARMACOLOGY & PHARMACY | PERCUTANEOUS-ABSORPTION | SKIN PERMEABILITY | TOPICAL DELIVERY | Thiazines - therapeutic use | Thiazines - administration & dosage | Thiazines - adverse effects | Drug Carriers - administration & dosage | Delayed-Action Preparations - chemistry | Thiazoles - administration & dosage | Administration, Cutaneous | Thiazoles - therapeutic use | Drug Carriers - chemistry | Thiazoles - adverse effects | Thiazoles - pharmacokinetics | Delayed-Action Preparations - administration & dosage | Surface Properties | Delayed-Action Preparations - pharmacokinetics | Gels - pharmacokinetics | Thiazines - pharmacokinetics | Rheology | Gels - administration & dosage | Rats | Skin Absorption | Drug Carriers - chemical synthesis | Edema - drug therapy | Particle Size | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Delayed-Action Preparations - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Nanostructures - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Nanostructures - chemistry | Drug Carriers - pharmacokinetics | Hydrogen-Ion Concentration | Drugs | Drug delivery systems | Vehicles | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Phytomedicine, ISSN 0944-7113, 07/2016, Volume 23, Issue 8, pp. 864 - 871
Glycyrrhetinic acid (GA) and paeoniflorin (PF) are the main active ingredients in Chinese peony- Liquorice Decoction, a widely used Traditional Chinese... 
Transdermal drug delivery | Paeoniflorin | Pharmacodynamics | Analgesic | Pharmacokinetics | Glycyrrhetinic acid | CHEMISTRY, MEDICINAL | MORPHINE | TOLERANCE | MECHANISMS | RELEASE | CONTRACTIONS | PLANT SCIENCES | GLYCYRRHIZIC ACID | PAIN | INTEGRATIVE & COMPLEMENTARY MEDICINE | SYNOVIOCYTES | PHARMACOLOGY & PHARMACY | SHAKUYAKUKANZOTO | Dysmenorrhea - drug therapy | Thiazines - administration & dosage | Drugs, Chinese Herbal - pharmacology | Thiazoles - administration & dosage | Glucosides - pharmacokinetics | Administration, Cutaneous | Thiazoles - pharmacokinetics | Tissue Distribution | Monoterpenes - pharmacology | Glycyrrhetinic Acid - pharmacology | Monoterpenes - pharmacokinetics | Thiazines - pharmacology | Anti-Inflammatory Agents - administration & dosage | Anti-Inflammatory Agents - pharmacokinetics | Female | Monoterpenes - administration & dosage | Drugs, Chinese Herbal - administration & dosage | Disease Models, Animal | Thiazines - pharmacokinetics | Transdermal Patch | Glucosides - pharmacology | Anti-Inflammatory Agents - pharmacology | Glycyrrhetinic Acid - pharmacokinetics | Glycyrrhetinic Acid - administration & dosage | Skin Absorption | Drug Synergism | Drugs, Chinese Herbal - pharmacokinetics | Animals | Glucosides - administration & dosage | Mice | Thiazoles - pharmacology | Care and treatment | Analysis | Peonies | Pharmacology | Health aspects | Dysmenorrhea | Materia medica, Vegetable | Plant extracts
Journal Article
Journal Article
Drug Development and Industrial Pharmacy, ISSN 0363-9045, 08/2015, Volume 41, Issue 8, pp. 1368 - 1375
Aim: Our investigation was aimed to investigate the potential suitability of meloxicam-loaded nanostructured lipid carriers (MLX-NLC) gel for topical... 
storage stability | meloxicam | skin tolerance | Analgesic | nanostructured lipid carriers | Meloxicam | Nanostructured lipid carriers | Skin tolerance | Storage stability | RHEUMATOID-ARTHRITIS | CHEMISTRY, MEDICINAL | NLC | PERMEABILITY | DRUG-DELIVERY | TRANSDERMAL DELIVERY | NANOPARTICLES SLN | FORMULATION | GEL | PHYSICOCHEMICAL PROPERTIES | PENETRATION ENHANCERS | PHARMACOLOGY & PHARMACY | Skin Absorption - physiology | Thiazoles - metabolism | Thiazines - administration & dosage | Drug Carriers - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Polyethylene Glycols - chemistry | Thiazoles - administration & dosage | Administration, Cutaneous | Drug Carriers - chemistry | Thiazines - metabolism | Lipids - chemistry | Polyethyleneimine - chemistry | Skin Absorption - drug effects | Female | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Polyethylene Glycols - metabolism | Drug Evaluation, Preclinical - methods | Rabbits | Drug Carriers - metabolism | Polyethyleneimine - metabolism | Drug Stability | Rats | Lipids - administration & dosage | Thiazines - chemistry | Polyethylene Glycols - administration & dosage | Animals | Polyethyleneimine - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Thiazoles - chemistry | Drug Delivery Systems - methods | Index Medicus
Journal Article
American Journal of Veterinary Research, ISSN 0002-9645, 03/2007, Volume 68, Issue 3, pp. 258 - 264
Objective-To evaluate adverse effects of long-term oral administration of carprofen, etodolac, flunixin meglumine, ketoprofen, and meloxicam in dogs.... 
SURGERY | ELECTIVE OVARIOHYSTERECTOMY | ANESTHESIA | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BUTORPHANOL | RENAL-FUNCTION | VETERINARY SCIENCES | OSTEOARTHRITIS | HEALTHY DOGS | GASTRODUODENAL MUCOSA | POSTOPERATIVE PAIN |