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Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 11/2014, Volume 475, Issue 1-2, pp. 25 - 34
Postcataract endophthalmitis treatment through eye drops is of low corneal bioavailability and short residence time. The dominant NSAIDs therapy also suffers... 
Meloxicam | Postcataract endophthalmitis | Drug delivery | Contact lenses | Nanoaggregates | GLAUCOMA THERAPY | GELLING SYSTEM | PENETRATION | PHARMACOLOGY & PHARMACY | RELEASE | Administration, Ophthalmic | Serum Albumin, Bovine - adverse effects | Thiazines - administration & dosage | Thiazines - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Delayed-Action Preparations - chemistry | Male | Thiazoles - administration & dosage | Endophthalmitis - etiology | Polyhydroxyethyl Methacrylate - chemistry | Thiazoles - adverse effects | Thiazoles - pharmacokinetics | Delayed-Action Preparations - administration & dosage | Tissue Distribution | Cornea - drug effects | Cattle | Surface Properties | Delayed-Action Preparations - pharmacokinetics | Drug Compounding | Female | Nanostructures - adverse effects | Serum Albumin, Bovine - chemistry | Postoperative Complications - drug therapy | Endophthalmitis - drug therapy | Thiazines - pharmacokinetics | Nanostructures - ultrastructure | Rabbits | Gels | Cornea - chemistry | Solubility | Thiazines - chemistry | Contact Lenses - adverse effects | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Delayed-Action Preparations - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Cataract Extraction - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Nanostructures - chemistry | Thiazoles - chemistry | Polyhydroxyethyl Methacrylate - adverse effects | Drug Delivery Systems - adverse effects | Drugs | Drug delivery systems | Ophthalmic drugs | Pharmacy | Albumin | Drugstores | Vehicles | Index Medicus
Journal Article
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 2013, Volume 69, Issue 3, pp. 365 - 371
Journal Article
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 09/2014, Volume 40, Issue 5, pp. 538 - 547
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2008, Volume 64, Issue 4, pp. 293 - 301
Background Depression and anxiety disorders have been linked to dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis and structural changes within the... 
Psychiatry | unpredictable chronic mild stress | x-irradiation | Corticotrophin-releasing factor | fluoxetine | depression | vasopressin | ADULT HIPPOCAMPUS | PSYCHIATRY | corticotrophin-releasing factor | CHRONIC MILD STRESS | CEREBRAL METABOLITES | CELL-PROLIFERATION | MAJOR DEPRESSION | NEUROSCIENCES | PREFRONTAL CORTEX | FLUOXETINE TREATMENT | FACTOR RECEPTOR ANTAGONIST | HYDROCHLORIDE SSR125543A | DENTATE GYRUS | Depression - pathology | Motor Activity - drug effects | Male | Hemibody Irradiation - methods | Pyrrolidines - pharmacology | Depression - drug therapy | Hemibody Irradiation - adverse effects | Time Factors | Exploratory Behavior - radiation effects | Reaction Time - drug effects | Exploratory Behavior - drug effects | Thiazines - pharmacology | Behavior, Animal - drug effects | Indoles - pharmacology | Antidepressive Agents - pharmacology | Bromodeoxyuridine - metabolism | Neurons - drug effects | Hydrocarbons, Halogenated - pharmacology | Disease Models, Animal | Antidepressive Agents - classification | Hippocampus - pathology | Corticotropin-Releasing Hormone - metabolism | Antidepressive Agents - therapeutic use | Animals | Cell Count - methods | Analysis of Variance | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Biogenic Monoamines - metabolism | Neurons - radiation effects | Cell Proliferation - radiation effects | Reaction Time - radiation effects | Anxiety | Pituitary hormones | Stress (Psychology) | Fluoxetine | Analysis | Index Medicus
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 10/2006, Volume 33, Issue 10, pp. 917 - 924
SUMMARY • Non-steroidal anti-inflammatory drugs (NSAIDs) cause renal side-effects. In the present study, we tested the hypothesis that the extent of the renal... 
pharmacokinetics | kidney | non-steroidal anti-inflammatory drugs | cyclo-oxygenase-2 | sodium urinary excretion | cyclo‐oxygenase‐2 | non‐steroidal anti‐inflammatory drugs | Cyclo-oxygenase-2 | Pharmacokinetics | Kidney | Non-steroidal anti-inflammatory drugs | Sodium urinary excretion | GASTROINTESTINAL TOXICITY | PHYSIOLOGY | CYCLOOXYGENASE-2 | RAT | HYPERKALEMIA | PROTEIN-BINDING | MELOXICAM | INTERSPECIES DIFFERENCES | GENTAMICIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PHARMACOLOGY & PHARMACY | Thiazoles - blood | Area Under Curve | Thiazines - administration & dosage | Thiazines - adverse effects | Sulfones - adverse effects | Male | Thiazoles - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - blood | Thiazoles - adverse effects | Thiazoles - pharmacokinetics | Dose-Response Relationship, Drug | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Lactones - pharmacokinetics | Sodium - urine | Lactones - administration & dosage | Pyrazoles - blood | Pyrazoles - pharmacokinetics | Sulfones - blood | Placebos - administration & dosage | Pyrazoles - adverse effects | Thiazines - pharmacokinetics | Kidney - drug effects | Administration, Oral | Cyclooxygenase 2 Inhibitors - administration & dosage | Rats | Thiazines - blood | Celecoxib | Lactones - adverse effects | Placebos - pharmacokinetics | Sulfones - pharmacokinetics | Cyclooxygenase 2 Inhibitors - pharmacokinetics | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Pyrazoles - administration & dosage | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Potassium - urine | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Sulfonamides - adverse effects | Sulfonamides - administration & dosage | Sulfones - administration & dosage | Kidney, drug effects | Lactones, adverse effects | Sulfones, administration and dosage | Thiazoles, administration and dosage | Anti-Inflammatory Agents, Non-Steroidal, pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal, adverse effects | Sodium, urine | Thiazines, blood | Anti-Inflammatory Agents, Non-Steroidal, blood | Lactones, administration and dosage | Cyclooxygenase 2 Inhibitors, adverse effects | Pyrazoles, blood | Sulfonamides, pharmacokinetics | Thiazines, pharmacokinetics | Pyrazoles, administration and dosage | Thiazoles, blood | Sulfonamides, administration and dosage | Cyclooxygenase 2 Inhibitors, administration and dosage | Lactones, pharmacokinetics | Sulfonamides, blood | Cyclooxygenase 2 Inhibitors, pharmacokinetics | Thiazines, adverse effects | Lactones, blood | Thiazoles, adverse effects | Thiazoles, pharmacokinetics | Sulfones, blood | Sulfonamides, adverse effects | Thiazines, administration and dosage | Placebos, pharmacokinetics | Sulfones, pharmacokinetics | Pyrazoles, adverse effects | Placebos, administration and dosage | Potassium, urine | Sulfones, adverse effects | Pyrazoles, pharmacokinetics | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2016, Volume 479, Issue 4, pp. 847 - 852
It is well known that radiation exposure to the heart and the use of non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of myocardial infarction... 
COX inhibitor | ICAM-1 | COX-2 | NSAIDs | Endothelial cells | Radiation | INTERCELLULAR-ADHESION MOLECULE-1 | MYOCARDIAL-INFARCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RISK | IN-VITRO | HODGKINS-DISEASE | BIOPHYSICS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | TNF-ALPHA | NF-KAPPA-B | Diclofenac - pharmacology | Human Umbilical Vein Endothelial Cells - metabolism | Nitriles - pharmacology | Humans | Thiazines - adverse effects | Up-Regulation - radiation effects | NF-kappa B - metabolism | Sulfones - pharmacology | Thiazoles - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Contraindications | Heart - radiation effects | Myocardium - metabolism | Thiazines - pharmacology | Myocardial Infarction - etiology | Indomethacin - adverse effects | NF-kappa B - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - drug effects | Diclofenac - adverse effects | Risk Factors | E-Selectin - metabolism | Indomethacin - pharmacology | Up-Regulation - drug effects | Intercellular Adhesion Molecule-1 - metabolism | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclooxygenase 2 - metabolism | Heart - drug effects | Thiazoles - pharmacology | Human Umbilical Vein Endothelial Cells - radiation effects | Vascular Cell Adhesion Molecule-1 - metabolism | Meloxicam | Medical colleges | Ionizing radiation | Indomethacin | Fluocinolone acetonide | Endothelium | COX-2 inhibitors | Anti-inflammatory drugs | Index Medicus | HEART | INHIBITION | MYOCARDIAL INFARCTION | 60 APPLIED LIFE SCIENCES | IONIZING RADIATIONS | HAZARDS
Journal Article
Life Sciences, ISSN 0024-3205, 11/2013, Volume 93, Issue 21, pp. 763 - 772
The main objective of the current investigation was to develop nanostructured lipid carriers (NLC) based gel for the enhancement of transdermal absorption of... 
Nanostructured lipid carriers | Meloxicam | Carrageenan induced paw edema model | Permeation rate | Hemocompatibility | Controlled release | MEDICINE, RESEARCH & EXPERIMENTAL | NLC | NANOPARTICLES SLN | STRATUM-CORNEUM | ELECTRON-MICROSCOPY | FORMULATION | IN-VITRO | PHASE-BEHAVIOR | PHARMACOLOGY & PHARMACY | PERCUTANEOUS-ABSORPTION | SKIN PERMEABILITY | TOPICAL DELIVERY | Thiazines - therapeutic use | Thiazines - administration & dosage | Thiazines - adverse effects | Drug Carriers - administration & dosage | Delayed-Action Preparations - chemistry | Thiazoles - administration & dosage | Administration, Cutaneous | Thiazoles - therapeutic use | Drug Carriers - chemistry | Thiazoles - adverse effects | Thiazoles - pharmacokinetics | Delayed-Action Preparations - administration & dosage | Surface Properties | Delayed-Action Preparations - pharmacokinetics | Gels - pharmacokinetics | Thiazines - pharmacokinetics | Rheology | Gels - administration & dosage | Rats | Skin Absorption | Drug Carriers - chemical synthesis | Edema - drug therapy | Particle Size | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Delayed-Action Preparations - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Nanostructures - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Nanostructures - chemistry | Drug Carriers - pharmacokinetics | Hydrogen-Ion Concentration | Drugs | Drug delivery systems | Vehicles | Index Medicus
Journal Article