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1. Full Text Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose
by Obach, R. Scott and Kalgutkar, Amit S and Soglia, John R and Zhao, Sabrina X
Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
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2. Full Text Construction of Nitrogen Heterocycles Bearing an Aminomethyl Group by Copper-Catalyzed Domino Three-Component Coupling−Cyclization
by Ohta, Yusuke and Chiba, Hiroaki and Oishi, Shinya and Fujii, Nobutaka and Ohno, Hiroaki
The Journal of Organic Chemistry, ISSN 0022-3263, 09/2009, Volume 74, Issue 18, pp. 7052 - 7058
A direct approach to 2-(aminomethyl)indoles by copper-catalyzed domino three-component coupling−cyclization of 2-ethynylanilines with a secondary amine and... 
MONOTERPENOID INDOLE ALKALOIDS | CARBON BOND FORMATION | SELECTIVE PREPARATION | HIGHLY ENANTIOSELECTIVE SYNTHESIS | CASCADE REACTIONS | ONE-POT SYNTHESIS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | TANDEM CYCLIZATIONS | OXICAM ANTIINFLAMMATORY AGENTS | ALLENIC COMPOUNDS | Indenes - chemical synthesis | Models, Chemical | Sulfonamides - chemistry | Formaldehyde - chemistry | Bromides - chemistry | Indoles - chemical synthesis | Heterocyclic Compounds - chemical synthesis | Indenes - chemistry | Thiazines - chemical synthesis | Thiazines - chemistry | Copper - chemistry | Cyclization | Heterocyclic Compounds - chemistry | Nitrogen - chemistry | Acetylene - chemistry | Malonates - chemistry | Acetylene - analogs & derivatives | Polymers - chemistry | Aniline Compounds - chemistry | Catalysis | Indoles - chemistry | Methylamines - chemistry | Aldehydes - chemistry | Sulfonamides | Indole | Malonates | Copper compounds | Nitrogen compounds | Chemical properties | Aldehydes | Structure
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3. Full Text Synthesis and bioactivity of novel triazole incorporated benzothiazinone derivatives as antitubercular and antioxidant agent
by Shaikh, Mubarak H and Subhedar, Dnyaneshwar D and Arkile, Manisha and Khedkar, Vijay M and Jadhav, Nandadeep and Sarkar, Dhiman and Shingate, Bapurao B
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2016, Volume 26, Issue 2, pp. 561 - 569
In search of new active molecules against ( ) H37Ra and , a small focused library of benzothiazinone based 1,2,3-triazoles has been efficiently prepared via... 
Docking study | ADME prediction | 1,2,3-Triazole | Antioxidant | Antitubercular | 1,3-DIPOLAR CYCLOADDITIONS | MULTIDRUG-RESISTANT | CHEMISTRY, MEDICINAL | CLICK CHEMISTRY | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | MYCOBACTERIUM-BOVIS BCG | 1,2,3-TRIAZOLE DERIVATIVES | MATERIALS SCIENCE | DRUG-RESISTANT TUBERCULOSIS | IN-VITRO | BIOLOGICAL EVALUATION | Free Radical Scavengers - pharmacology | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Click Chemistry | Free Radical Scavengers - chemistry | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Antitubercular Agents - pharmacology | Bacterial Proteins - chemistry | Antineoplastic Agents - chemistry | Mycobacterium tuberculosis - drug effects | Thiazines - chemical synthesis | Thiazines - chemistry | Triazoles - pharmacology | Mycobacterium bovis - drug effects | Hydrogen Bonding | Alcohol Oxidoreductases - chemistry | Cell Line, Tumor | Free Radical Scavengers - chemical synthesis | Thiazines - pharmacology | Triazoles - chemical synthesis | Antineoplastic Agents - pharmacology | Molecular Docking Simulation | Antioxidants | Triazoles | Antitubercular agents
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4. Full Text Multi-residue method for determination of selected neonicotinoid insecticides in honey using optimized dispersive liquid–liquid microextraction combined with liquid chromatography-tandem mass spectrometry
by Jovanov, Pavle and Guzsvány, Valéria and Franko, Mladen and Lazić, Sanja and Sakač, Marijana and Šarić, Bojana and Banjac, Vojislav
Talanta, ISSN 0039-9140, 07/2013, Volume 111, pp. 125 - 133
The objective of this study was to develop analytical method based on optimized dispersive liquid–liquid microextraction (DLLME) as a pretreatment procedure... 
Neonicotinoids | Honey | LC–MS/MS | DLLME | LC-MS/MS | ELECTROCHEMICAL DETECTOR | CHEMISTRY, ANALYTICAL | CHLORAMPHENICOL | GAS-CHROMATOGRAPHY | MULTIRESIDUE DETERMINATION | PESTICIDE-RESIDUES | SAMPLES | DRINKING-WATER | ELECTRON-CAPTURE | SOLID-PHASE EXTRACTION | ORGANOCHLORINE PESTICIDES | Insecticides - chemistry | Oxazines - analysis | Pyridines - chemistry | Anabasine - analysis | Imidazoles - chemistry | Nitro Compounds - chemistry | Honey - analysis | Guanidines - analysis | Anabasine - chemistry | Nitro Compounds - analysis | Molecular Structure | Tandem Mass Spectrometry - methods | Thiazines - analysis | Insecticides - analysis | Reproducibility of Results | Liquid Phase Microextraction - methods | Pyridines - analysis | Thiazines - chemistry | Thiazoles - analysis | Guanidines - chemistry | Imidazoles - analysis | Thiazoles - chemistry | Oxazines - chemistry | Chromatography, Liquid - methods | Analysis | Nitriles | Insecticides | Liquid chromatography | Mass spectrometry | Methods
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5. Full Text Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated h-bonding network
by Xu, Shu and Hermanson, Daniel J and Banerjee, Surajit and Ghebreselasie, Kebreab and Clayton, Gina M and Garavito, R. Michael and Marnett, Lawrence J and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of Biological Chemistry, ISSN 0021-9258, 03/2014, Volume 289, Issue 10, pp. 6799 - 6808
Background: The oxicams are anti-inflammatory drugs targeting the cyclooxygenase enzymes. Results: Crystal complexes of mCOX-2isoxicam, mCOX-2meloxicam, and... 
Enzyme Structure | SELECTIVE-INHIBITION | ANTIINFLAMMATORY ACTIVITY | COX-2 | MECHANISM | X-ray Crystallography | Protein Drug Interactions | CRYSTAL-STRUCTURE | OXYGENATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARACHIDONIC-ACID | Cyclooxygenase (COX) Pathway | NSAID BINDING | STRUCTURAL BASIS | Drug Action | INSIGHTS | Water | Thiazoles - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Thiazines - metabolism | Cyclooxygenase 2 - genetics | Arginine - genetics | Cyclooxygenase 1 - chemistry | Piroxicam - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Leucine - genetics | Tyrosine - chemistry | Leucine - metabolism | Catalytic Domain | Cyclooxygenase 1 - genetics | Cyclooxygenase Inhibitors - metabolism | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Serine - genetics | Cyclooxygenase Inhibitors - chemistry | Serine - chemistry | Serine - metabolism | Thiazines - chemistry | Arginine - chemistry | Leucine - chemistry | Piroxicam - metabolism | Tyrosine - metabolism | Animals | Piroxicam - chemistry | Hydrogen Bonding | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Mice | Cyclooxygenase 1 - metabolism | Mutation | Arginine - metabolism | Amino Acid Substitution | Tyrosine - genetics | Lipids
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6. Full Text Sensitivity of the early-life stages of freshwater mollusks to neonicotinoid and butenolide insecticides
by Prosser, R.S and de Solla, S.R and Holman, E.A.M and Osborne, R and Robinson, S.A and Bartlett, A.J and Maisonneuve, F.J and Gillis, P.L
Environmental Pollution, ISSN 0269-7491, 11/2016, Volume 218, pp. 428 - 435
Neonicotinoid insecticides can be transported from agricultural fields, where they are used as foliar sprays or seed treatments, to surface waters by surface... 
Neonicotinoid | Butenolide | Snail | Mollusk | Freshwater mussel | ENVIRONMENTAL SCIENCES | FEEDING SYSTEM | CHRONIC TOXICITY | AQUATIC INVERTEBRATES | LYMNAEA-STAGNALIS | PESTICIDES | 4-Butyrolactone - toxicity | Insecticides - chemistry | Pyridines - chemistry | Imidazoles - chemistry | Nitro Compounds - chemistry | Neonicotinoids | Fresh Water - chemistry | Unionidae - drug effects | Oxazines - toxicity | Thiamethoxam | 4-Butyrolactone - chemistry | Imidazoles - toxicity | Nitro Compounds - toxicity | Environmental Monitoring - methods | Water Pollutants, Chemical - chemistry | Thiazines - chemistry | Guanidines - chemistry | Thiazoles - toxicity | Unionidae - growth & development | Animals | Water Pollutants, Chemical - toxicity | Pyridines - toxicity | Guanidines - toxicity | Thiazoles - chemistry | Oxazines - chemistry | 4-Butyrolactone - analogs & derivatives | Insecticides - toxicity | Thiazines - toxicity | Insecticides | Global temperature changes | Runoff | Mortality | Insects, Aquatic | Index Medicus
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7. Full Text Scavenging of photogenerated ROS by Oxicams. Possible biological and environmental implications
by Ferrari, Gabriela V and Natera, José and Paulina Montaña, M and Muñoz, Vanesa and Gutiérrez, Eduardo L and Massad, Walter and Miskoski, Sandra and García, Norman A
Journal of Photochemistry & Photobiology, B: Biology, ISSN 1011-1344, 12/2015, Volume 153, pp. 233 - 239
The profusely employed drugs Piroxicam (Piro), Tenoxicam (Teno) and Meloxicam (Melo) belonging to the non-steroidal antiinflammatory drug (NSAID) family of the... 
Photodegradation | Photosensitization | Riboflavin | Oxicams | Photoprotection | ROS | PHOTOCHEMICAL FATE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOTOSENSITIZED OXIDATION | ASCORBIC-ACID | ELECTRON-TRANSFER | BIOPHYSICS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | AMINO-ACIDS | RATE CONSTANTS | SINGLET OXYGEN | MOLECULAR-OXYGEN | Riboflavin - chemistry | Oxidation-Reduction | Free Radical Scavengers - chemistry | Pyridines - chemistry | Superoxides - chemistry | Tryptophan - chemistry | Water Pollutants, Chemical - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Thiazines - chemistry | Photolysis - radiation effects | Piroxicam - chemistry | Reactive Oxygen Species - chemistry | Singlet Oxygen - chemistry | Light | Thiazoles - chemistry | Piroxicam - analogs & derivatives | Rhodamines - chemistry | Tyrosine - chemistry | Antioxidants | Tryptophan | Environmental aspects | Superoxide | Nonsteroidal anti-inflammatory drugs | Analysis
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8. Full Text Coordination chemistry of thiazoles, isothiazoles and thiadiazoles
by Frija, Luís M.T and Pombeiro, Armando J.L and Kopylovich, Maximilian N
Coordination Chemistry Reviews, ISSN 0010-8545, 02/2016, Volume 308, pp. 32 - 55
This review aims to systematize the existing information on the coordination chemistry of thiazole, isothiazole and thiadiazole polyfunctional ligands and to... 
Thiadiazoles | Nitrogen ligands | Isothiazoles | Sulfur ligands | Thiazoles | AMIDOPYRIDINATE LIGANDS SYNTHESIS | TRANSITION-METAL-COMPLEXES | STRUCTURAL-CHARACTERIZATION | CU(II) COMPLEXES | CHEMISTRY, INORGANIC & NUCLEAR | COPPER(II) COMPLEXES | FACILE SYNTHESIS | THIAZINE DERIVATIVE LIGANDS | RAY CRYSTAL-STRUCTURES | SPECTROSCOPIC CHARACTERIZATION | LIGHT-EMITTING DEVICES
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9. Full Text Bioactive thiazine and benzothiazine derivatives: Green synthesis methods and their medicinal importance
by Badshah, Syed Lal and Naeem, Abdul
Molecules, ISSN 1420-3049, 08/2016, Volume 21, Issue 8, p. 1054
Thiazines are a group of heterocyclic organic compounds that are still largely unexplored for their pharmacological activities. There are different available... 
Antibacterial activity | Green synthesis | Biologically active | Anticancer agents | Thiazine | antibacterial activity | ONE-POT SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | green synthesis | 1,3-THIAZINE DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | biologically active | anticancer agents | NEUTROPHIL RESPIRATORY BURST | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BIOLOGICAL-ACTIVITY | CANNABINOID RECEPTOR AGONISTS | IMMUNODEFICIENCY VIRUS FIV | MICROWAVE-ASSISTED SYNTHESIS | ALDOSE REDUCTASE | ANTIMICROBIAL ACTIVITY | thiazine | Analgesics - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Structure-Activity Relationship | Analgesics - chemical synthesis | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Thiazines - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Green Chemistry Technology | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Thiazines - chemical synthesis | Thiazines - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Anti-Inflammatory Agents - chemistry | Analgesics - chemistry | Antimalarials - chemistry | Antiviral Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis
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10. Full Text Anti‐Inflammatory Oxicams as Multi‐donor Ligand Systems: pH‐ and Solvent‐Dependent Coordination Modes of Meloxicam and Piroxicam to Ru and Os
by Aman, Farhana and Hanif, Muhammad and Kubanik, Mario and Ashraf, Adnan and Söhnel, Tilo and Jamieson, Stephen M. F and Siddiqui, Waseeq Ahmad and Hartinger, Christian G
Chemistry – A European Journal, ISSN 0947-6539, 04/2017, Volume 23, Issue 20, pp. 4893 - 4902
The nitrogen‐ and sulfur‐containing 1,2‐benzothiazines meloxicam and piroxicam are widely used as nonsteroidal anti‐inflammatory drugs. Intrigued by the... 
coordination modes | ruthenium | osmium | anticancer activity | oxicams | ARENE ANTICANCER COMPLEXES | CHEMISTRY, MULTIDISCIPLINARY | AGENT | COPPER(II)-ISOXICAM | DRUGS | 3-HYDROXY-2(1H)-PYRIDONES | CANCER PREVENTION | CYTOTOXICITY | COPPER(II)-PIROXICAM | Cell Survival - drug effects | Magnetic Resonance Spectroscopy | Solvents - chemistry | Antineoplastic Agents - chemical synthesis | HCT116 Cells | Humans | Molecular Conformation | Osmium - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Ruthenium - chemistry | Thiazines - chemistry | Antineoplastic Agents - toxicity | Piroxicam - chemistry | Cell Line, Tumor | Coordination Complexes - chemical synthesis | Ligands | Thiazoles - chemistry | Coordination Complexes - toxicity | Hydrogen-Ion Concentration | Meloxicam | Sulfur compounds | Piroxicam | Ruthenium | Analysis | Nuclear magnetic resonance spectroscopy | Hydrogen-ion concentration | Berries | Cancer | Solvents | Parameters | Metalorganic compounds | Derivatives | Parameter identification | Anticancer properties
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11. Full Text Synthesis of seven-membered iminosugars fused thiazolidin-4-one and benzthiazinan-4-one and their HIV-RT inhibitory activity
by Hou, Yuheng and Xing, Shunkai and Shao, Jie and Yin, Zhuqing and Hao, Le and Yang, Tianyu and Zhang, Hongzhi and Zhu, Mo and Chen, Hua and Li, Xiaoliu
Carbohydrate Research, ISSN 0008-6215, 06/2016, Volume 429, pp. 105 - 112
Novel seven-membered iminosugars fused thiazolidin-4-one and benzthiazinan-4-one were conveniently synthesized by the tandem Staudinger/aza-Wittig/cyclization... 
Thiazolidin-4-one | Benzthiazinan-4-one | Anti-HIV RT activity | Staudinger/aza-Wittig | Seven-membered iminosugar | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | C-GLYCOSIDES | INDOLIZIDINES | SUGARS | AZASUGARS | KIFUNENSINE | THIAZINAN-4-ONE | MANNOSIDASE | AGENTS | CHEMISTRY, APPLIED | DERIVATIVES | ACCESS | Glycoconjugates - chemistry | HIV-1 - drug effects | Stereoisomerism | HIV Reverse Transcriptase - antagonists & inhibitors | Enzyme Assays | Galactosides - chemistry | Structure-Activity Relationship | Mannosides - chemistry | Anti-HIV Agents - chemical synthesis | Glycoconjugates - chemical synthesis | Thiazines - chemistry | Reverse Transcriptase Inhibitors - chemistry | Reverse Transcriptase Inhibitors - chemical synthesis | Anti-HIV Agents - chemistry | Cyclization | HIV-1 - chemistry | HIV-1 - enzymology | Thiazoles - chemistry | HIV Reverse Transcriptase - chemistry | Microwaves | Imino Sugars - chemistry | HIV (Viruses) | DNA polymerases | Analysis
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12. Full Text Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions
by Borbás, Enikő and Sinkó, Bálint and Tsinman, Oksana and Tsinman, Konstantin and Kiserdei, Éva and Démuth, Balázs and Balogh, Attila and Bodák, Brigitta and Domokos, András and Dargó, Gergő and Balogh, György T and Nagy, Zsombor K
Molecular Pharmaceutics, ISSN 1543-8384, 11/2016, Volume 13, Issue 11, pp. 3816 - 3826
The aim of this study was to investigate the impact of formulation excipients and solubilizing additives on dissolution, supersaturation, and membrane... 
cosolvent | microflux | meloxicam | DMSO | electrospinning | nanofiber | flux | Soluplus | supersaturation | in vitro dissolution-permeation test | ENABLING FORMULATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | DELIVERY SYSTEMS | ELECTROSPUN | METRIC LOG-P | IMPROVED DISSOLUTION | IMPACT | POORLY SOLUBLE DRUG | PHARMACOLOGY & PHARMACY | MEMBRANE-TRANSPORT | SOLUBILITY-PERMEABILITY INTERPLAY | AMORPHOUS SOLID DISPERSION | Models, Theoretical | Nanofibers - chemistry | Povidone - chemistry | beta-Cyclodextrins - chemistry | Dimethyl Sulfoxide - chemistry | Polyethylene Glycols - chemistry | Polymers - chemistry | Thiazoles - chemistry | Molecular Structure | Polyvinyls - chemistry | Thiazines - chemistry | Solutions - chemistry
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13. Full Text Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases
by Pinard, Melissa A and Boone, Christopher D and Rife, Brittany D and Supuran, Claudiu T and McKenna, Robert
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2013, Volume 21, Issue 22, pp. 7210 - 7215
Overlay of BRZ (magenta) and DRZ (orange) in the active site of CA II. Hydrophobic region, red; hydrophilic region, blue. Carbonic anhydrases (CAs, EC 4.2.1.1)... 
Human carbonic anhydrase | Dorzolamide | Brinzolamide | SYSTEM | CHEMISTRY, MEDICINAL | ACTIVE-SITE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | EXTRACELLULAR DOMAIN | DIFFRACTION | MODEL | Carbonic Anhydrase Inhibitors - chemistry | Humans | Carbonic Anhydrase II - metabolism | Crystallography, X-Ray | Thiophenes - metabolism | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Antigens, Neoplasm - chemistry | Carbonic Anhydrases - metabolism | Thiazines - metabolism | Thermodynamics | Antigens, Neoplasm - metabolism | Binding Sites | Carbonic Anhydrase II - genetics | Carbonic Anhydrase IX | Catalytic Domain | Mutagenesis, Site-Directed | Sulfonamides - chemistry | Thiazines - chemistry | Sulfonamides - metabolism | Protein Binding | Molecular Docking Simulation | Kinetics | Carbonic Anhydrase Inhibitors - metabolism | Thiophenes - chemistry | Carbonic Anhydrase II - chemistry | Ophthalmic drugs | Index Medicus
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14. Full Text Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: Reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds
by Okazaki, Shiho and Oishi, Shinya and Mizuhara, Tsukasa and Shimura, Kazuya and Murayama, Hiroto and Ohno, Hiroaki and Matsuoka, Masao and Fujii, Nobutaka
Organic and Biomolecular Chemistry, ISSN 1477-0520, 04/2015, Volume 13, Issue 16, pp. 4706 - 4713
3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine (PD 404182) and 3,4-dihydro-2H-benzo-[4,5]isothiazolo[2,3-a]pyrimidine are the heterocyclic... 
TARGET | HEPATITIS-C VIRUS | NUCLEOCAPSID ZINC FINGERS | CHEMISTRY, ORGANIC | IDENTIFICATION | POTENT INHIBITORS | PD 404,182 | Magnetic Resonance Spectroscopy | HIV-1 - drug effects | Humans | Prodrugs - chemistry | Structure-Activity Relationship | Thiazines - chemistry | Chemistry, Pharmaceutical | Pyrimidines - chemistry | Anti-HIV Agents - chemistry | Nitrogen - chemistry | Benzothiadiazines - chemistry | Drug Design | Imines - chemistry | HIV Infections - drug therapy | Thiazoles - chemistry | Glutathione - chemistry | Sulfur - chemistry
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