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1. Full Text Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose
by Obach, R. Scott and Kalgutkar, Amit S and Soglia, John R and Zhao, Sabrina X
Chemical research in toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
Physical Sciences | Toxicology | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
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2. Full Text Construction of Nitrogen Heterocycles Bearing an Aminomethyl Group by Copper-Catalyzed Domino Three-Component Coupling−Cyclization
by Ohta, Yusuke and Chiba, Hiroaki and Oishi, Shinya and Fujii, Nobutaka and Ohno, Hiroaki
Journal of organic chemistry, ISSN 0022-3263, 09/2009, Volume 74, Issue 18, pp. 7052 - 7058
Organic chemistry | Chemistry | Heterocyclic compounds | Heterocyclic compounds with only one n hetero atom and condensed derivatives | Exact sciences and technology | Alicyclic compounds, terpenoids, prostaglandins, steroids | Alicyclic compounds | Preparations and properties | Aliphatic compounds | Noncondensed benzenic compounds | Indenes - chemical synthesis | Models, Chemical | Sulfonamides - chemistry | Formaldehyde - chemistry | Bromides - chemistry | Indoles - chemical synthesis | Heterocyclic Compounds - chemical synthesis | Indenes - chemistry | Thiazines - chemical synthesis | Thiazines - chemistry | Copper - chemistry | Cyclization | Heterocyclic Compounds - chemistry | Nitrogen - chemistry | Acetylene - chemistry | Malonates - chemistry | Acetylene - analogs & derivatives | Polymers - chemistry | Aniline Compounds - chemistry | Catalysis | Indoles - chemistry | Methylamines - chemistry | Aldehydes - chemistry | Sulfonamides | Indole | Malonates | Copper compounds | Nitrogen compounds | Chemical properties | Aldehydes | Structure | Index Medicus
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3. Full Text Multi-residue method for determination of selected neonicotinoid insecticides in honey using optimized dispersive liquid–liquid microextraction combined with liquid chromatography-tandem mass spectrometry
by Jovanov, Pavle and Guzsvány, Valéria and Franko, Mladen and Lazić, Sanja and Sakač, Marijana and Šarić, Bojana and Banjac, Vojislav
Talanta (Oxford), ISSN 0039-9140, 07/2013, Volume 111, pp. 125 - 133
Neonicotinoids | Honey | LC–MS/MS | DLLME | LC-MS/MS | Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Insecticides - chemistry | Oxazines - analysis | Pyridines - chemistry | Anabasine - analysis | Imidazoles - chemistry | Nitro Compounds - chemistry | Honey - analysis | Guanidines - analysis | Anabasine - chemistry | Nitro Compounds - analysis | Molecular Structure | Tandem Mass Spectrometry - methods | Thiazines - analysis | Insecticides - analysis | Reproducibility of Results | Liquid Phase Microextraction - methods | Pyridines - analysis | Thiazines - chemistry | Thiazoles - analysis | Guanidines - chemistry | Imidazoles - analysis | Thiazoles - chemistry | Oxazines - chemistry | Chromatography, Liquid - methods | Analysis | Nitriles | Insecticides | Liquid chromatography | Mass spectrometry | Methods | Index Medicus
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4. Full Text Brinzolamide loaded chitosan-pectin mucoadhesive nanocapsules for management of glaucoma: Formulation, characterization and pharmacodynamic study
by Dubey, Vibhuti and Mohan, Parasuraman and Dangi, Jawahar Singh and Kesavan, Karthikeyan
International journal of biological macromolecules, ISSN 0141-8130, 06/2020, Volume 152, pp. 1224 - 1232
Glaucoma | Polyelectrolyte complex coacervation | Chitosan-pectin nanocapsules | Brinzolamide | Intraocular pressure | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Applied | Polymer Science | Science & Technology | Ophthalmic Solutions - pharmacology | Rabbits | Polyelectrolytes - chemistry | Intraocular Pressure - drug effects | Nanoparticles - chemistry | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Ophthalmic Solutions - chemistry | Biological Availability | Glaucoma - drug therapy | Carbonic Anhydrase Inhibitors - pharmacology | Sulfonamides - pharmacology | Nanocapsules - chemistry | Thiazines - chemistry | Drug Carriers - chemistry | Pectins - chemistry | Polyelectrolytes - pharmacology | Particle Size | Animals | Chitosan - chemistry | Cornea - drug effects | Thiazines - pharmacology | Drug Delivery Systems - methods | Index Medicus
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5. Full Text Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated h-bonding network
by Xu, Shu and Hermanson, Daniel J and Banerjee, Surajit and Ghebreselasie, Kebreab and Clayton, Gina M and Garavito, R. Michael and Marnett, Lawrence J and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
The Journal of biological chemistry, ISSN 0021-9258, 03/2014, Volume 289, Issue 10, pp. 6799 - 6808
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Water | Thiazoles - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Thiazines - metabolism | Cyclooxygenase 2 - genetics | Arginine - genetics | Cyclooxygenase 1 - chemistry | Piroxicam - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Leucine - genetics | Tyrosine - chemistry | Meloxicam | Leucine - metabolism | Catalytic Domain | Cyclooxygenase 1 - genetics | Cyclooxygenase Inhibitors - metabolism | Protein Structure, Secondary | Cyclooxygenase 2 - chemistry | Serine - genetics | Cyclooxygenase Inhibitors - chemistry | Serine - chemistry | Serine - metabolism | Thiazines - chemistry | Arginine - chemistry | Leucine - chemistry | Piroxicam - metabolism | Tyrosine - metabolism | Animals | Piroxicam - chemistry | Hydrogen Bonding | Cyclooxygenase 2 - metabolism | Thiazoles - chemistry | Mice | Cyclooxygenase 1 - metabolism | Mutation | Arginine - metabolism | Amino Acid Substitution | Tyrosine - genetics | Index Medicus | Enzyme Structure | Lipids | Drug Action | X-ray Crystallography | Cyclooxygenase (COX) Pathway | Protein Drug Interactions
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6. Full Text Bioactive thiazine and benzothiazine derivatives: Green synthesis methods and their medicinal importance
by Badshah, Syed Lal and Naeem, Abdul
Molecules (Basel, Switzerland), ISSN 1420-3049, 08/2016, Volume 21, Issue 8, p. 1054
Antibacterial activity | Green synthesis | Biologically active | Anticancer agents | Thiazine | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Analgesics - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Structure-Activity Relationship | Analgesics - chemical synthesis | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Thiazines - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Green Chemistry Technology | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Thiazines - chemical synthesis | Thiazines - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Anti-Inflammatory Agents - chemistry | Analgesics - chemistry | Antimalarials - chemistry | Antiviral Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis | Index Medicus | antibacterial activity | green synthesis | thiazine | biologically active | anticancer agents
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7. Full Text Sensitivity of the early-life stages of freshwater mollusks to neonicotinoid and butenolide insecticides
by Prosser, R.S and de Solla, S.R and Holman, E.A.M and Osborne, R and Robinson, S.A and Bartlett, A.J and Maisonneuve, F.J and Gillis, P.L
Environmental pollution (1987), ISSN 0269-7491, 11/2016, Volume 218, pp. 428 - 435
Neonicotinoid | Butenolide | Snail | Mollusk | Freshwater mussel | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | 4-Butyrolactone - toxicity | Insecticides - chemistry | Pyridines - chemistry | Imidazoles - chemistry | Nitro Compounds - chemistry | Neonicotinoids | Fresh Water - chemistry | Unionidae - drug effects | Oxazines - toxicity | Thiamethoxam | 4-Butyrolactone - chemistry | Imidazoles - toxicity | Nitro Compounds - toxicity | Environmental Monitoring - methods | Water Pollutants, Chemical - chemistry | Thiazines - chemistry | Guanidines - chemistry | Thiazoles - toxicity | Unionidae - growth & development | Animals | Water Pollutants, Chemical - toxicity | Pyridines - toxicity | Guanidines - toxicity | Thiazoles - chemistry | Oxazines - chemistry | 4-Butyrolactone - analogs & derivatives | Insecticides - toxicity | Thiazines - toxicity | Insecticides | Global temperature changes | Runoff | Mortality | Insects, Aquatic | Index Medicus
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8. Full Text Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases
by Pinard, Melissa A and Boone, Christopher D and Rife, Brittany D and Supuran, Claudiu T and McKenna, Robert
Bioorganic & medicinal chemistry, ISSN 0968-0896, 11/2013, Volume 21, Issue 22, pp. 7210 - 7215
Human carbonic anhydrase | Dorzolamide | Brinzolamide | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Carbonic Anhydrase Inhibitors - chemistry | Humans | Carbonic Anhydrase II - metabolism | Crystallography, X-Ray | Thiophenes - metabolism | Structure-Activity Relationship | Carbonic Anhydrases - chemistry | Antigens, Neoplasm - chemistry | Carbonic Anhydrases - metabolism | Thiazines - metabolism | Thermodynamics | Antigens, Neoplasm - metabolism | Binding Sites | Carbonic Anhydrase II - genetics | Carbonic Anhydrase IX | Catalytic Domain | Mutagenesis, Site-Directed | Sulfonamides - chemistry | Thiazines - chemistry | Sulfonamides - metabolism | Protein Binding | Molecular Docking Simulation | Kinetics | Carbonic Anhydrase Inhibitors - metabolism | Thiophenes - chemistry | Carbonic Anhydrase II - chemistry | Ophthalmic drugs | Index Medicus
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9. Full Text Investigation and Mathematical Description of the Real Driving Force of Passive Transport of Drug Molecules from Supersaturated Solutions
by Borbás, Enikő and Sinkó, Bálint and Tsinman, Oksana and Tsinman, Konstantin and Kiserdei, Éva and Démuth, Balázs and Balogh, Attila and Bodák, Brigitta and Domokos, András and Dargó, Gergő and Balogh, György T and Nagy, Zsombor K
Molecular pharmaceutics, ISSN 1543-8384, 11/2016, Volume 13, Issue 11, pp. 3816 - 3826
cosolvent | microflux | meloxicam | DMSO | electrospinning | nanofiber | flux | Soluplus | supersaturation | in vitro dissolution-permeation test | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Models, Theoretical | Nanofibers - chemistry | Povidone - chemistry | beta-Cyclodextrins - chemistry | Dimethyl Sulfoxide - chemistry | Polyethylene Glycols - chemistry | Polymers - chemistry | Thiazoles - chemistry | Molecular Structure | Polyvinyls - chemistry | Thiazines - chemistry | Solutions - chemistry | Index Medicus
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10. Full Text Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune
by Vullo, Daniela and De Luca, Viviana and Del Prete, Sonia and Carginale, Vincenzo and Scozzafava, Andrea and Capasso, Clemente and Supuran, Claudiu T
Bioorganic & medicinal chemistry, ISSN 0968-0896, 04/2015, Volume 23, Issue 8, pp. 1728 - 1734
Carbonic anhydrase | Metalloenzymes | Hydratase activity | Antarctic carbonic anhydrase | Cyanobacteria | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Nostoc commune - chemistry | Amino Acid Sequence | Sulfanilamides - chemistry | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Molecular Sequence Data | Thiophenes - pharmacology | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrases - chemistry | Sulfonamides - pharmacology | Thiazines - chemistry | Carbonic Anhydrases - metabolism | Sequence Alignment | Nostoc commune - enzymology | Thiazines - pharmacology | Nostoc commune - drug effects | Thiophenes - chemistry | Sulfanilamides - pharmacology | Index Medicus
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