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Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 03/2006, Volume 20, Issue 3, pp. 542 - 544
It is widely believed that the potencies of nonsteroid anti-inflammatory drugs ( NSAIDs) as inhibitors of cyclooxygenase ( COX) are influenced by protein... 
SITE | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | nonsteroid anti-inflammatory drugs | coxibs | PROSTAGLANDIN H-2 SYNTHASE | CELL BIOLOGY | CYCLO-OXYGENASE-2 | THERAPY | FLUID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BIOLOGY | prostaglandins | SELECTIVITY | Organic Chemicals - cerebrospinal fluid | Humans | Naproxen - pharmacology | Synovial Fluid - metabolism | Pyrazoles - cerebrospinal fluid | Sodium Salicylate - pharmacology | Lactones - pharmacology | Aspirin - cerebrospinal fluid | Cell Line - drug effects | Calcium - physiology | Pyrazoles - blood | Organic Chemicals - pharmacology | Dinoprostone - cerebrospinal fluid | Diclofenac - cerebrospinal fluid | Aspirin - pharmacology | Sulfones - cerebrospinal fluid | Aspirin - blood | Thiazines - blood | Sulfonamides - pharmacology | Indomethacin - cerebrospinal fluid | Indomethacin - pharmacology | Cyclooxygenase 1 - drug effects | Cyclooxygenase Inhibitors - adverse effects | Cyclooxygenase Inhibitors - blood | Diclofenac - pharmacology | Thiazoles - blood | Thromboxane A2 - blood | Cerebrospinal Fluid Proteins - pharmacology | Dinoprostone - biosynthesis | Lactones - cerebrospinal fluid | Blood Platelets - enzymology | Cyclooxygenase 2 Inhibitors - cerebrospinal fluid | Sodium Salicylate - cerebrospinal fluid | Sulfones - pharmacology | Blood Proteins - pharmacology | Cyclooxygenase 2 Inhibitors - adverse effects | Sulfonamides - blood | Lactones - blood | Naproxen - cerebrospinal fluid | Sodium Salicylate - blood | Thiazines - pharmacology | Cyclooxygenase 2 Inhibitors - blood | Cyclooxygenase Inhibitors - cerebrospinal fluid | Blood Platelets - drug effects | Sulfones - blood | Organic Chemicals - blood | Ionophores - pharmacology | Pyrazoles - pharmacology | Sulfonamides - cerebrospinal fluid | Cyclooxygenase 2 Inhibitors - pharmacology | Thiazoles - cerebrospinal fluid | Celecoxib | Diclofenac - blood | Dinoprostone - blood | Naproxen - blood | Organ Specificity | Calcimycin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Indomethacin - blood | Protein Binding | Thiazines - cerebrospinal fluid | Thiazoles - pharmacology
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/2004, Volume 141, Issue 7, pp. 1175 - 1184
This study characterises some of the mechanisms and mediators involved in the orofacial nociception triggered by injection of formalin into the upper lip of... 
Formalin | bradykinin | prostaglandins | cytokines | noradrenaline | Prostaglandins | Cytokines | Noradrenaline | Bradykinin | THERMAL HYPERALGESIA | CYCLOOXYGENASE-2 | INFLAMMATORY HYPERALGESIA | NECROSIS-FACTOR-ALPHA | B-2 RECEPTOR | NERVE GROWTH-FACTOR | PAIN | formalin | PHARMACOLOGY & PHARMACY | INHIBITOR | UP-REGULATION | ANALGESIC EFFICACY | Bradykinin - analogs & derivatives | Bradykinin B1 Receptor Antagonists | Captopril - pharmacology | Rats, Wistar | Nociceptors - physiology | Male | Cytokines - physiology | Facial Pain - physiopathology | Cytokines - chemistry | Dose-Response Relationship, Drug | Facial Pain - chemically induced | Tyramine - chemistry | Arachidonic Acids - metabolism | Injections, Subcutaneous | Formaldehyde - administration & dosage | Thiazines - pharmacology | Behavior, Animal - drug effects | Interleukin-8 - pharmacology | Biogenic Amines - physiology | Bradykinin - pharmacology | Atenolol - pharmacology | Pyrazoles - pharmacology | Lip - drug effects | Tyramine - physiology | Rats | Behavior, Animal - physiology | Hindlimb - innervation | Receptor, Bradykinin B2 - physiology | Bradykinin B2 Receptor Antagonists | Celecoxib | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Drug Synergism | Bradykinin - physiology | Tumor Necrosis Factor-alpha - pharmacology | Prostaglandins - physiology | Animals | Interleukin-6 - pharmacology | Lip - innervation | Receptor, Bradykinin B1 - physiology | Hindlimb - drug effects | Thiazoles - pharmacology | Guanethidine - pharmacology | Nociceptors - drug effects | Facial Pain - drug therapy | Papers
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2008, Volume 105, Issue 21, pp. 7606 - 7611
Acetylcholine-binding proteins (AChBPs) from mollusks are suitable structural and functional surrogates of the nicotinic acetylcholine receptors when combined... 
Molecules | Hydrogen bonds | Atomic interactions | Drug interactions | Ligands | Agonists | Kinetics | Nicotinic receptors | Binding sites | Crystal structure | Acetylcholine-binding protein | Imidacloprid | Nicotinic receptor | Thiacloprid | SITE | DOMAIN | MULTIDISCIPLINARY SCIENCES | COMPLEXES | thiacloprid | MODEL | imidacloprid | ACETYLCHOLINE-BINDING-PROTEIN | CONFORMATIONAL-CHANGES | crystal structure | nicotinic receptor | acetylcholine-binding protein | SELECTIVITY | REVEALS | Imidazolines - metabolism | Pyridines - chemistry | Imidazoles - chemistry | Nitro Compounds - chemistry | Neonicotinoids | Crystallography, X-Ray | Nicotinic Agonists - chemistry | Nicotine - pharmacology | Aplysia | Receptors, Nicotinic - chemistry | Nitro Compounds - pharmacology | Thiazines - pharmacology | Nicotinic Agonists - pharmacology | Receptors, Nicotinic - drug effects | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Imidazolines - pharmacology | Imidazoles - pharmacology | Thiazines - chemistry | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Imidazolines - chemistry | Animals | Pyridines - metabolism | Nicotine - chemistry | Protein Conformation | Pyridines - pharmacology | Evaluation | Cell receptors | Pharmacology, Experimental | Crystals | Electronegativity | Binding proteins | Properties | Structure | Index Medicus | TRYPTOPHAN | SPECIFICITY | ACETYLCHOLINE | RESOLUTION | CRYSTAL STRUCTURE | TOXICITY | INTERACTIONS | 60 APPLIED LIFE SCIENCES | FLUORESCENCE | LIGANDS | QUENCHING | AMINO ACIDS | KINETICS | ORIENTATION | EQUILIBRIUM | INTERFACES | INSECTS | AROMATICS | POSITIONING | PROTEINS | RECEPTORS | INSECTICIDES | FUNCTIONALS | Biological Sciences | Physical Sciences
Journal Article
Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 801 - 804
New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new... 
Enzymes | Antibacterials | Tuberculosis | Mycobacterium tuberculosis | Cell walls | Antituberculars | Bacteria | Reports | Biochemistry | Enantiomers | Codons | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | CELL-WALL | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Thiazines - therapeutic use | Ethambutol - pharmacology | Drug Resistance, Bacterial | Molecular Sequence Data | Spiro Compounds - therapeutic use | Tuberculosis - microbiology | Mycobacterium tuberculosis - drug effects | Polysaccharides - biosynthesis | Microbial Sensitivity Tests | Racemases and Epimerases - metabolism | Enzyme Inhibitors - chemistry | Spiro Compounds - chemical synthesis | Tuberculosis - drug therapy | Arabinose - metabolism | Thiazines - pharmacology | Molecular Structure | Mycobacterium tuberculosis - metabolism | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Amino Acid Sequence | Genes, Bacterial | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Racemases and Epimerases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Thiazines - chemical synthesis | Thiazines - chemistry | Mycobacterium - genetics | Mycobacterium - drug effects | Gene Expression Regulation, Bacterial - drug effects | Animals | Cell Wall - metabolism | Enzyme Inhibitors - cerebrospinal fluid | Mice | Mice, Inbred BALB C | Spiro Compounds - pharmacology | Mycobacterium tuberculosis - genetics | Antitubercular agents | Dosage and administration | Drug therapy | Genetics | Pharmacology | Chemical synthesis
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e91364
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. 16401 - 16406
Journal Article