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Expert Opinion on Drug Metabolism & Toxicology, ISSN 1742-5255, 04/2016, Volume 12, Issue 4, pp. 423 - 431
Journal Article
Journal Article
Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 801 - 804
New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new... 
Enzymes | Antibacterials | Tuberculosis | Mycobacterium tuberculosis | Cell walls | Antituberculars | Bacteria | Reports | Biochemistry | Enantiomers | Codons | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | CELL-WALL | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Thiazines - therapeutic use | Ethambutol - pharmacology | Drug Resistance, Bacterial | Molecular Sequence Data | Spiro Compounds - therapeutic use | Tuberculosis - microbiology | Mycobacterium tuberculosis - drug effects | Polysaccharides - biosynthesis | Microbial Sensitivity Tests | Racemases and Epimerases - metabolism | Enzyme Inhibitors - chemistry | Spiro Compounds - chemical synthesis | Tuberculosis - drug therapy | Arabinose - metabolism | Thiazines - pharmacology | Molecular Structure | Mycobacterium tuberculosis - metabolism | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Amino Acid Sequence | Genes, Bacterial | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Racemases and Epimerases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Thiazines - chemical synthesis | Thiazines - chemistry | Mycobacterium - genetics | Mycobacterium - drug effects | Gene Expression Regulation, Bacterial - drug effects | Animals | Cell Wall - metabolism | Enzyme Inhibitors - cerebrospinal fluid | Mice | Mice, Inbred BALB C | Spiro Compounds - pharmacology | Mycobacterium tuberculosis - genetics | Antitubercular agents | Dosage and administration | Drug therapy | Genetics | Pharmacology | Chemical synthesis
Journal Article
Journal Article
Embo Molecular Medicine, ISSN 1757-4676, 2014, Volume 6, Issue 3, pp. 372 - 383
The benzothiazinone lead compound, BTZ043, kills Mycobacterium tuberculosis by inhibiting the essential flavo-enzyme DprE1, decaprenylphosphoryl-beta-D-ribose... 
DprE1 | combination regimens | benzothiazinones | tuberculosis | Benzothiazinones | Tuberculosis | Combination regimens | MYCOBACTERIUM-TUBERCULOSIS | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | PA-824 | GRANULOMA-FORMATION | BTZ043 | Antitubercular Agents - chemical synthesis | Thiazines - therapeutic use | Humans | Bacterial Proteins - chemistry | Crystallography, X-Ray | Spiro Compounds - therapeutic use | Piperazines - chemistry | Embryo, Nonmammalian - drug effects | Mycobacterium tuberculosis - drug effects | Tuberculosis - drug therapy | Thiazines - pharmacology | Lung - metabolism | Binding Sites | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Disease Models, Animal | Thiazines - pharmacokinetics | Catalytic Domain | Antitubercular Agents - pharmacology | Alcohol Oxidoreductases - metabolism | Piperazines - therapeutic use | Piperazines - pharmacology | Thiazines - chemistry | Zebrafish - growth & development | Molecular Dynamics Simulation | Spiro Compounds - pharmacokinetics | Hep G2 Cells | Animals | Spleen - metabolism | Alcohol Oxidoreductases - chemistry | Bacterial Proteins - metabolism | Mice | Spiro Compounds - pharmacology | Chronic diseases | Enzymes | Analysis | Sugars | Monosaccharides | Drugs | Animal models | Acquired immune deficiency syndrome--AIDS | Ribose | Piperazine | New combinations | Clinical trials | Pyrazinamide | Epimerase | Crystal structure
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 12/2011, Volume 16, Issue 12, pp. 1177 - 1188
Recent research suggests an involvement of hippocampal neurogenesis in behavioral effects of antidepressants. However, the precise mechanisms through which... 
stress | immediate early gene | depression | hypothalamopituitary-adrenal axis | antidepressant | hippocampal neurogenesis | PROGENITOR CELLS | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRITICAL PERIOD | ADULT HIPPOCAMPAL NEUROGENESIS | PITUITARY-ADRENOCORTICAL AXIS | MAJOR DEPRESSION | NEUROSCIENCES | ENHANCED SYNAPTIC PLASTICITY | CHRONIC FLUOXETINE | RAT DENTATE GYRUS | MOOD DISORDERS | GENERATED GRANULE CELLS | hypothalamo-pituitary-adrenal axis | Depression - physiopathology | Thiazines - therapeutic use | Humans | Male | Hippocampus - drug effects | Hippocampus - diagnostic imaging | Pituitary-Adrenal Function Tests - methods | Depression - drug therapy | Cell Count - statistics & numerical data | Thiazines - pharmacology | Antidepressive Agents - pharmacology | Neurogenesis - drug effects | Corticosterone - blood | Fluoxetine - therapeutic use | Hydrocarbons, Halogenated - pharmacology | Hypothalamo-Hypophyseal System - physiopathology | Disease Models, Animal | Fluoxetine - pharmacology | Hypothalamo-Hypophyseal System - drug effects | Pituitary-Adrenal System - physiopathology | Dexamethasone | Pituitary-Adrenal System - drug effects | Stress, Psychological - drug therapy | Antidepressive Agents - therapeutic use | Radiography | Hydrocarbons, Halogenated - therapeutic use | Animals | Cell Count - methods | Neurogenesis - physiology | Corticosterone - metabolism | Mice | Mice, Inbred BALB C | Hippocampus - physiopathology | Stress, Psychological - physiopathology | Antidepressants | Neurons | Cellular control mechanisms | Physiological aspects | Dosage and administration | Research | Management | Stress (Psychology) | Original
Journal Article
Arthritis Care & Research, ISSN 0004-3591, 05/2009, Volume 61, Issue 5, pp. 658 - 666
Objective To develop and validate a composite disease activity score for juvenile idiopathic arthritis (JIA), the Juvenile Arthritis Disease Activity Score... 
RHEUMATOID-ARTHRITIS | TRIALS | RESPONSIVENESS | QUALITY | RHEUMATOLOGY | ACTIVITY INDEX | CLINICAL-PRACTICE | HEALTH-STATUS | CHILDREN
Journal Article
Life Sciences, ISSN 0024-3205, 03/2013, Volume 92, Issue 6-7, pp. 383 - 392
Journal Article