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Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 09/2008, Volume 21, Issue 9, pp. 1814 - 1822
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a... 
ACYL GLUCURONIDES | CHEMISTRY, MEDICINAL | PROTEIN | RAT | REACTIVE METABOLITES | TIENILIC ACID | HEPATIC-NECROSIS | BIOACTIVATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | MASS-SPECTROMETRY | TOXICOLOGY | HUMAN URINE | Buspirone - chemistry | Raloxifene Hydrochloride - pharmacology | Thiazoles - metabolism | Acetaminophen - metabolism | Humans | Microsomes, Liver - metabolism | Indomethacin - metabolism | Simvastatin - pharmacology | Diclofenac - chemistry | Thiazines - metabolism | Propranolol - pharmacology | Toxicity Tests - methods | Binding Sites | Simvastatin - metabolism | Microsomes, Liver - chemistry | Indomethacin - pharmacology | Paroxetine - metabolism | Raloxifene Hydrochloride - metabolism | Triazoles - metabolism | Ticrynafen - metabolism | Paroxetine - pharmacology | Diclofenac - metabolism | Paroxetine - chemistry | Diphenhydramine - pharmacology | Diclofenac - pharmacology | Triazoles - chemistry | Buspirone - metabolism | Ticrynafen - pharmacology | Structure-Activity Relationship | Buspirone - pharmacology | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Carbamazepine - chemistry | Diphenhydramine - metabolism | Acetaminophen - pharmacology | Microsomes, Liver - drug effects | Propranolol - metabolism | Carbamazepine - metabolism | Thiazines - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Hepatocytes - drug effects | Carbamazepine - pharmacology | Simvastatin - chemistry | Acetaminophen - chemistry | Ticrynafen - chemistry | Propranolol - chemistry | Diphenhydramine - chemistry | Thiazines - chemistry | Triazoles - pharmacology | Indomethacin - chemistry | Thiazoles - chemistry | Thiazoles - pharmacology | Raloxifene Hydrochloride - chemistry | Index Medicus
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 2008, Volume 46, Issue 1, pp. 73 - 81
Journal Article
Journal of Endodontics, ISSN 0099-2399, 2011, Volume 37, Issue 6, pp. 793 - 798
Abstract Introduction The purpose of the present study was to evaluate the biocompatibility of 2 root-end filling materials, Endosequence Root Repair Material... 
Endocrinology & Metabolism | Dentistry | biocompatibility | cell adhesion | Bioceramic | mineral trioxide aggregate | human gingival fibroblast | cytotoxicity | root repair material | PHOSPHATE-CONTAINING FLUID | WHITE PORTLAND-CEMENT | ENDODONTICS | DENTISTRY, ORAL SURGERY & MEDICINE | SCANNING-ELECTRON-MICROSCOPE | MTA | BIOLOGIC PROPERTIES | PERIODONTAL-LIGAMENT FIBROBLASTS | END FILLING MATERIALS | Methylmethacrylates - chemistry | Biocompatible Materials - chemistry | Coloring Agents | Humans | Oxides - chemistry | Dental Cements - chemistry | Silicates - chemistry | Crystallography | Biocompatible Materials - toxicity | Tantalum - chemistry | Tetrazolium Salts | Aluminum Compounds - chemistry | Gingiva - drug effects | Time Factors | Zinc Oxide - chemistry | Spectrometry, X-Ray Emission | Surface Properties | Zirconium - chemistry | Tantalum - toxicity | Thiazoles | Zinc Oxide-Eugenol Cement - chemistry | Calcium Compounds - chemistry | Root Canal Filling Materials - chemistry | Zirconium - toxicity | Cell Survival - drug effects | Microscopy, Electron, Scanning | Calcium Phosphates - toxicity | Cells, Cultured | Oxides - toxicity | Calcium Phosphates - chemistry | Materials Testing | Cell Adhesion - drug effects | Fibroblasts - drug effects | Retrograde Obturation | Gingiva - cytology | Silicates - toxicity | Polyvinyls - chemistry | Root Canal Filling Materials - toxicity | Drug Combinations
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9108 - 9123
Here, we describe the most promising small synthetic organic compounds that act as potent Sortase A inhibitors and cater the potential to be developed as... 
SRTA GENE | IN-VITRO | CHEMISTRY, MEDICINAL | CELL-WALL | STREPTOCOCCUS-PNEUMONIAE | ACTIVE-SITE | STAPHYLOCOCCUS-AUREUS SORTASE | SURFACE-PROTEINS | IMIDAZOLIUM ION-PAIR | A INHIBITORS | PROTEIN ANCHORING TRANSPEPTIDASE | Aminoacyltransferases - antagonists & inhibitors | Cysteine Endopeptidases - chemistry | Small Molecule Libraries - pharmacology | Staphylococcus aureus - enzymology | Nitriles - pharmacology | Benzoates - chemistry | Humans | Bacterial Proteins - chemistry | Carbolines - chemistry | Cysteine Endopeptidases - metabolism | Rhodanine - analogs & derivatives | Rhodanine - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Staphylococcal Infections - microbiology | Bacterial Adhesion - drug effects | Adamantane - analogs & derivatives | Aminoacyltransferases - chemistry | Bacterial Proteins - antagonists & inhibitors | Adamantane - pharmacology | Staphylococcal Infections - drug therapy | Thiones - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Staphylococcus aureus - pathogenicity | Small Molecule Libraries - chemistry | Animals | Nitriles - chemistry | Benzoates - pharmacology | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Protein Conformation | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Thiazoles - pharmacology | Thiones - pharmacology | Staphylococcus aureus - drug effects | Carbolines - pharmacology | Index Medicus
Journal Article
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2015, Volume 11, Issue 11, pp. 837 - 839
Phytoalexins are abundant in edible crucifers and have important biological activities, yet no dedicated gene for their biosynthesis is known. Here, we report... 
ARABIDOPSIS-THALIANA | INHIBITION | CANCER CELLS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRESS METABOLITES | BRASSICACEAE | YEAST EXPRESSION | BRASSININ | GLUCOSINOLATE METABOLISM | CRUCIFEROUS PHYTOALEXINS | Microsomes - metabolism | Thiazoles - metabolism | Sesquiterpenes - metabolism | Thiocarbamates - metabolism | Brassica rapa - enzymology | Cytochrome P-450 Enzyme System - metabolism | Molecular Sequence Data | Isoenzymes - chemistry | Brassica rapa - genetics | RNA, Messenger - metabolism | Indoles - metabolism | Vegetables - chemistry | Isoenzymes - metabolism | Plant Proteins - chemistry | Base Sequence | Escherichia coli - metabolism | Vegetables - metabolism | Plant Proteins - metabolism | Spiro Compounds - chemistry | Plant Leaves - chemistry | Recombinant Proteins - metabolism | Gene Expression | Biocatalysis | Sesquiterpenes - chemistry | Isoenzymes - genetics | RNA, Messenger - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Thiocarbamates - chemistry | Brassicaceae - genetics | Microsomes - chemistry | Plant Proteins - genetics | Cytochrome P-450 Enzyme System - chemistry | Cyclization | Plant Leaves - metabolism | Escherichia coli - genetics | Cytochrome P-450 Enzyme System - genetics | Thiazoles - chemistry | High-Throughput Nucleotide Sequencing | Kinetics | Indoles - chemistry | Brassicaceae - enzymology | Spiro Compounds - metabolism | Genetics | Biosynthesis | Biochemistry | Metabolites | Index Medicus
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 2014, Volume 58, Issue 7, pp. 928 - 936
Background. Several combinations of 2 or 3 direct-acting antivirals (DAAs) can cure hepatitis C virus (HCV) in the majority of treatment-naive patients. DAAs... 
sofosbuvir | faldaprevir | ribavirin | simeprevir | daclatasvir | INFECTIOUS DISEASES | MICROBIOLOGY | IMMUNOLOGY | POTENT | BI 201335 | HIV | INHIBITOR | ANTIRETROVIRAL TREATMENT | Heterocyclic Compounds, 3-Ring - economics | Simeprevir | Oligopeptides - economics | Hepatitis C - drug therapy | Ribavirin - economics | Humans | Imidazoles - chemistry | Uridine Monophosphate - chemistry | Uridine Monophosphate - economics | Thiazoles - therapeutic use | Health Services Accessibility - economics | Oligopeptides - therapeutic use | Antiviral Agents - chemistry | Drug Industry - economics | Imidazoles - therapeutic use | Drug Therapy, Combination | Oligopeptides - chemistry | Thiazoles - economics | Uridine Monophosphate - therapeutic use | Sulfonamides - chemistry | Antiviral Agents - therapeutic use | Ribavirin - therapeutic use | Ribavirin - chemistry | Anti-HIV Agents - chemistry | Sulfonamides - therapeutic use | Imidazoles - economics | Heterocyclic Compounds, 3-Ring - chemistry | Heterocyclic Compounds, 3-Ring - therapeutic use | Sulfonamides - economics | Uridine Monophosphate - analogs & derivatives | Thiazoles - chemistry | Developing Countries | Antiviral Agents - economics | Hepacivirus | Sofosbuvir | Economic aspects | Antiviral agents | Production management | Care and treatment | Hepatitis C | Hepatitis | Antiviral drugs | Medical treatment | Developing countries--LDCs | Index Medicus | and Commentaries
Journal Article