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Oncogene, ISSN 0950-9232, 11/2014, Volume 33, Issue 45, pp. 5262 - 5273
Inhibition of type 1 insulin-like growth factor receptor (IGF-1R) enhances tumor cell sensitivity to ionizing radiation. It is not clear how this effect is... 
CYCLIN D1 | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOTIC CATASTROPHE | DOWN-REGULATION | DEPENDENT PROTEIN-KINASE | TUMOR-CELLS | DNA repair | PTEN WILD-TYPE | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | homologous recombination | ONCOLOGY | radiosensitization | PROSTATE-CANCER CELLS | GENETICS & HEREDITY | double-strand break | non-homologous end joining | IGF-1R | IONIZING-RADIATION | Cell Cycle - genetics | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Homologous Recombination - drug effects | Apoptosis - drug effects | Apoptosis - radiation effects | DNA End-Joining Repair - radiation effects | Humans | Apoptosis - genetics | DNA Breaks, Double-Stranded | Pyrones - pharmacology | Quinolines - pharmacology | Histones - radiation effects | HEK293 Cells | Recombinational DNA Repair - drug effects | Fibroblasts - metabolism | DNA End-Joining Repair - drug effects | Homologous Recombination - radiation effects | DNA End-Joining Repair - genetics | Recombinational DNA Repair - genetics | Cell Cycle - radiation effects | Morpholines - pharmacology | Pyrimidines - pharmacology | Receptor, IGF Type 1 - genetics | Blotting, Western | Histones - drug effects | Mice, Knockout | Isoxazoles - pharmacology | Radiation Tolerance - drug effects | Animals | Fibroblasts - radiation effects | Fibroblasts - drug effects | Cell Line, Tumor | Homologous Recombination - genetics | Recombinational DNA Repair - radiation effects | Thiazoles - pharmacology | Histones - metabolism | Cell Cycle - drug effects | Cell receptors | Physiological aspects | Genetic research | Genetic aspects | Research | Genetic recombination | Insulin-like growth factor 1 | Proteins | Oncology | Kinases | non-homologous end-joining
Journal Article
Molecular Plant, ISSN 1674-2052, 05/2012, Volume 5, Issue 3, pp. 642 - 652
Light is emerging as a central regulator of plant immune responses against herbivores and pathogens. Solar UV-B radiation plays an important role as a positive... 
photomorphogenesis | plant–microbe interactions | defense | jasmonate | photoreceptor | phenylpropanoids | phenolics | plant-microbe interactions | SECONDARY METABOLITES | CHLOROPHYLL FLUORESCENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLISTER BLIGHT DISEASE | PSEUDOMONAS-SYRINGAE | NICOTIANA-LONGIFLORA | PLANT SCIENCES | SIGNAL-TRANSDUCTION | HERBIVOROUS INSECTS | LEAF EPIDERMAL TRANSMITTANCE | SALICYLIC-ACID | ULTRAVIOLET-RADIATION | Thiazoles - metabolism | Coumaric Acids - chemistry | Plant Diseases - immunology | Arabidopsis - immunology | Glucosinolates - metabolism | Plant Diseases - microbiology | Disease Resistance - immunology | Botrytis - physiology | Arabidopsis Proteins - metabolism | Arabidopsis - radiation effects | Indoles - metabolism | Ultraviolet Rays | Botrytis - radiation effects | Signal Transduction - radiation effects | Gene Expression Regulation, Plant - radiation effects | Chromosomal Proteins, Non-Histone - metabolism | Coumaric Acids - metabolism | Disease Resistance - drug effects | Signal Transduction - genetics | Cyclopentanes - pharmacology | Phenols - metabolism | Mutation - genetics | Disease Resistance - radiation effects | Arabidopsis - genetics | Arabidopsis - microbiology | Gene Expression Regulation, Plant - drug effects | Botrytis - drug effects | Signal Transduction - drug effects | Oxylipins - pharmacology
Journal Article
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 83, Issue 1, pp. 235 - 242
Purpose To define the roles of radiotherapy and chemotherapy on the risk of Grade 3+ mucositis during intensity-modulated radiation therapy (IMRT) for... 
Radiology | Hematology, Oncology and Palliative Medicine | Intensity-modulated radiation therapy | Chemotherapy | Mucositis | HEAD | MUCOSAL REACTIONS | IMRT | PHASE-III | NECK-CANCER | ALTERED FRACTIONATION | ONCOLOGY | CONFORMAL RADIOTHERAPY | ORAL MUCOSITIS | QUALITY-OF-LIFE | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Confidence Intervals | Radiotherapy Planning, Computer-Assisted - methods | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Thiazoles - administration & dosage | Oropharyngeal Neoplasms - pathology | Radiotherapy, Intensity-Modulated - adverse effects | Cisplatin - administration & dosage | Mouth Mucosa - drug effects | Antibodies, Monoclonal, Humanized | Mouth Mucosa - radiation effects | Fluorouracil - administration & dosage | Fluorouracil - adverse effects | Stomatitis - pathology | Aged, 80 and over | Adult | Female | Cetuximab | Mouth Mucosa - pathology | Odds Ratio | Taxoids - adverse effects | Radiotherapy Dosage | Dasatinib | Oropharyngeal Neoplasms - drug therapy | Pyrimidines - administration & dosage | Induction Chemotherapy - methods | Oropharyngeal Neoplasms - radiotherapy | Tumor Burden | Stomatitis - etiology | Induction Chemotherapy - adverse effects | Radiography | Taxoids - administration & dosage | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Organs at Risk - diagnostic imaging | Cisplatin - adverse effects | Aged | Care and treatment | Nuclear radiation | Radiation | Radiotherapy | Throat cancer | Health aspects | Cancer | Index Medicus | Acute toxicity | MULTIVARIATE ANALYSIS | PATIENTS | NEOPLASMS | RADIOLOGY AND NUCLEAR MEDICINE | MEDICAL PERSONNEL | RADIATION DOSES | TOXICITY | NECK | RADIOTHERAPY | CHEMOTHERAPY | HAZARDS | MUCOUS MEMBRANES
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 03/2007, Volume 6, Issue 3, pp. 935 - 944
VRX0466617 is a novel selective small-molecule inhibitor for Chk2 discovered through a protein kinase screening program. In this study, we provide a detailed... 
Cell cycle checkpoints | inhibitors | ATM | kinases | Chk2 | DNA damage responses | POTENT | ONCOLOGY | PHOSPHORYLATION | DNA-DAMAGE RESPONSE | PROTEIN-KINASE | DOUBLE-STRAND BREAKS | CYCLE CHECKPOINTS | HUMAN CANCER-CELLS | IONIZING-RADIATION | ATAXIA-TELANGIECTASIA | Protein Kinases - genetics | Threonine - chemistry | Cells, Cultured - radiation effects | Apoptosis - drug effects | Humans | Benzimidazoles - chemistry | Cell Nucleus - metabolism | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Radiation, Ionizing | Cells, Cultured - drug effects | Recombinant Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cell Cycle - radiation effects | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Ataxia Telangiectasia Mutated Proteins | Phosphorylation - radiation effects | Benzimidazoles - pharmacology | Mice | Cell Cycle - drug effects | Protein Kinases - metabolism | Immunoprecipitation | Paclitaxel - pharmacology | Tumor Suppressor Proteins - antagonists & inhibitors | Apoptosis - radiation effects | Protein Kinases - chemistry | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Cell Nucleus - radiation effects | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Molecular Structure | DNA Damage - drug effects | Recombinant Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - genetics | Cisplatin - pharmacology | DNA-Binding Proteins - genetics | Serine - chemistry | Animals | Checkpoint Kinase 2 | Checkpoint Kinase 1 | Thiazoles - chemistry | Cell Proliferation - drug effects | Thiazoles - pharmacology | Cell Nucleus - drug effects | DNA Damage - radiation effects | Doxorubicin - pharmacology | Cell Proliferation - radiation effects
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2016, Volume 479, Issue 4, pp. 847 - 852
It is well known that radiation exposure to the heart and the use of non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of myocardial infarction... 
COX inhibitor | ICAM-1 | COX-2 | NSAIDs | Endothelial cells | Radiation | INTERCELLULAR-ADHESION MOLECULE-1 | MYOCARDIAL-INFARCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | RISK | IN-VITRO | HODGKINS-DISEASE | BIOPHYSICS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | TNF-ALPHA | NF-KAPPA-B | Diclofenac - pharmacology | Human Umbilical Vein Endothelial Cells - metabolism | Nitriles - pharmacology | Humans | Thiazines - adverse effects | Up-Regulation - radiation effects | NF-kappa B - metabolism | Sulfones - pharmacology | Thiazoles - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Contraindications | Heart - radiation effects | Myocardium - metabolism | Thiazines - pharmacology | Myocardial Infarction - etiology | Indomethacin - adverse effects | NF-kappa B - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - drug effects | Diclofenac - adverse effects | Risk Factors | E-Selectin - metabolism | Indomethacin - pharmacology | Up-Regulation - drug effects | Intercellular Adhesion Molecule-1 - metabolism | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cyclooxygenase 2 - metabolism | Heart - drug effects | Thiazoles - pharmacology | Human Umbilical Vein Endothelial Cells - radiation effects | Vascular Cell Adhesion Molecule-1 - metabolism | Meloxicam | Medical colleges | Ionizing radiation | Indomethacin | Fluocinolone acetonide | Endothelium | COX-2 inhibitors | Anti-inflammatory drugs | HEART | INHIBITION | MYOCARDIAL INFARCTION | 60 APPLIED LIFE SCIENCES | IONIZING RADIATIONS | HAZARDS
Journal Article
BMC Plant Biology, ISSN 1471-2229, 06/2015, Volume 15, Issue 1, p. 137
Background: Cruciferous plants synthesize a large variety of tryptophan-derived phytoalexins in response to pathogen infection, UV irradiation, or high dosages... 
Eutrema salsugineum | Phytoalexin | Transcriptomics | Thellungiella salsuginea | Glucosinolate biosynthesis | ARABIDOPSIS-THALIANA | ABIOTIC STRESS | SALT TOLERANCE | PLANT SCIENCES | FINAL STEP | METABOLIC-RESPONSES | GENE-EXPRESSION | CAMALEXIN BIOSYNTHESIS | RESISTANCE | B LIGHT | Thiazoles - metabolism | Transcription, Genetic - drug effects | Brassicaceae - drug effects | Sesquiterpenes - metabolism | Cellular Reprogramming - radiation effects | Transcription, Genetic - radiation effects | Transcriptome - radiation effects | RNA, Messenger - metabolism | Brassicaceae - radiation effects | Stress, Physiological - radiation effects | Indoles - metabolism | Biosynthetic Pathways - genetics | Ultraviolet Rays | Stress, Physiological - drug effects | Real-Time Polymerase Chain Reaction | Gene Expression Regulation, Plant - radiation effects | Stress, Physiological - genetics | RNA, Messenger - genetics | Transcriptome - drug effects | Transcriptome - genetics | Gene Knockout Techniques | Silver Nitrate - pharmacology | Brassicaceae - genetics | Cellular Reprogramming - drug effects | Glucosinolates - biosynthesis | Transcription Factors - metabolism | Gene Expression Regulation, Plant - drug effects | Tryptophan - biosynthesis | Metals, Heavy - toxicity | Arabidopsis thaliana | Physiological aspects | Genetic aspects | DNA microarrays | Wasabi | Analysis | RNA sequencing | DNA binding proteins | Genetic transcription | Health aspects
Journal Article
BMC Musculoskeletal Disorders, ISSN 1471-2474, 2012, Volume 13, Issue 1, pp. 94 - 94
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2006, Volume 14, Issue 7, pp. 2409 - 2417
Journal Article
Journal Article