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Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173916
Damaged lung grafts obtained after circulatory death (DCD lungs) and warm ischemia may be at high risk of reperfusion injury after transplantation. Such lungs... 
OXIDATIVE STRESS | ACTIVATION | ALVEOLAR EPITHELIAL-CELLS | CIRCULATORY DEATH | MULTIDISCIPLINARY SCIENCES | PRIMARY GRAFT DYSFUNCTION | REPERFUSION INJURY | IN-VIVO | FACTOR-KAPPA-B | INTERLEUKIN-6 | TRANSPLANTATION | Bronchoalveolar Lavage Fluid - immunology | Pyrrolidines - administration & dosage | Male | Transplantation Immunology | Disease Models, Animal | Reperfusion Injury - rehabilitation | NF-kappa B - antagonists & inhibitors | Thiocarbamates - administration & dosage | Cytokines - metabolism | Immunity, Innate - drug effects | Lung Injury - rehabilitation | Rats | Tissue and Organ Procurement | Lung - physiopathology | Lung Transplantation - adverse effects | Rats, Sprague-Dawley | Lung Injury - physiopathology | Animals | Perfusion | Warm Ischemia - adverse effects | Reperfusion Injury - immunology | Antioxidants - administration & dosage | Reperfusion Injury - physiopathology | Lung Transplantation - methods | Tissue Donors | In Vitro Techniques | Lung Injury - immunology | Lung - immunology | Complications and side effects | Care and treatment | Lungs | Dosage and administration | Transplantation | Research | Chemical compounds | Reperfusion injury | Risk factors | Phosphorylation | Thoracic surgery | Intensive care | Transplants & implants | Lung transplantation | Biology | Activation | Kinases | Interleukin 6 | Proteins | Respiratory tract | Reperfusion | Ischemia | Bronchoalveolar lavage | Rodents | Surgery | Tumor necrosis factor-TNF | Damage | Alveoli | Pyrrolidine | Injuries | Edema | Ventilators | NF-κB protein | Immune response | Cytokines | Blood & organ donations | Pulmonary arteries | Weight gain measurement | Health risks | Bronchus | Pharmacology | Permeability | Tumor necrosis factor-α | Medicine | Hypotheses | Hospitals | Inhibitors | Grafts | In vivo methods and tests | Rehabilitation | Laboratory animals | Oxygenation | Pyrrolidine dithiocarbamate
Journal Article
Journal Article
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 11/2018, Volume 70, Issue 11, pp. 1461 - 1473
Objectives To evaluate the effects of a topical emulsion containing pyrrolidine dithiocarbamate (PDTC) (EcPDTC) in skin oxidative stress and inflammation... 
topical emulsion | antioxidant | inflammation | ultraviolet B | oxidative stress | pyrrolidine dithiocarbamate | ANTIOXIDANT ACTIVITY | LIPID-PEROXIDATION | COLONIC ANASTOMOSES | INDUCED COLITIS | INDUCED INFLAMMATION | FACTOR-KAPPA-B | NECROSIS-FACTOR-ALPHA | INDUCED OXIDATIVE STRESS | PHARMACOLOGY & PHARMACY | PIMENTA-PSEUDOCARYOPHYLLUS EXTRACT | TRANS-CHALCONE | Emulsions | Antioxidants - chemistry | Skin - metabolism | Pyrrolidines - administration & dosage | Administration, Cutaneous | Sunburn - pathology | Sunburn - prevention & control | Ultraviolet Rays | Inflammation Mediators - metabolism | Lipid Peroxidation - drug effects | Drug Compounding | Anti-Inflammatory Agents - administration & dosage | Skin - pathology | Disease Models, Animal | Thiocarbamates - administration & dosage | Cytokines - metabolism | Mice, Hairless | Thiocarbamates - chemistry | Pyrrolidines - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - administration & dosage | Oxidative Stress - drug effects | Skin - drug effects | Sunburn - metabolism | Antioxidants | Alkaloids | Sunburn | Collagen | Superoxide | Skin | Inflammation | Oxidative stress | Collagens | Lipid peroxidation | Lipids | Quantitation | Matrix metalloproteinase | Skin injuries | Anions | Fluorescence recovery after photobleaching | Catalase | Peroxidase | Oxidation | Metalloproteinase | Inhibition | Pyrrolidine | Glutathione | Peroxidation | Edema | Cytokines | U.V. radiation | Scavenging | Neutrophils | Hairless | Sulfonic acid | Radiation dosage | Tumor necrosis factor | Irradiation | Pyrrolidine dithiocarbamate | Radiation damage
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e84248
Since the serendipitous discovery of cisplatin, platinum-based drugs have become well-established antitumor agents, despite the fact that their clinical use is... 
20S PROTEASOME | DESIGN | CANCER CELLS | MULTIDISCIPLINARY SCIENCES | COMPLEXES | OLIGOPEPTIDES | BORTEZOMIB | GOLD(III) DITHIOCARBAMATE DERIVATIVES | PROTEASOME INHIBITORS | COUPLED PEPTIDE TRANSPORTERS | APOPTOSIS INDUCERS | Free Radical Scavengers - pharmacology | Apoptosis - drug effects | Humans | Antineoplastic Agents - administration & dosage | Molecular Targeted Therapy | Peptidomimetics - administration & dosage | Thiocarbamates - pharmacology | Chromans - pharmacology | Organogold Compounds - administration & dosage | Drug Design | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Organogold Compounds - chemistry | Disease Models, Animal | Peptidomimetics - pharmacology | Thiocarbamates - administration & dosage | Proteasome Inhibitors - pharmacology | Peptidomimetics - chemistry | Cisplatin - pharmacology | Thiocarbamates - chemistry | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Organogold Compounds - pharmacology | Tumor Burden - drug effects | Breast Neoplasms - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Chemotherapy | Peptides | Health aspects | Cancer | Drugs | Delivery systems | Clinical trials | Homeostasis | Oncology | Biochemistry | Metastasis | Kinases | Cancer therapies | Anticancer properties | Proteins | Antitumor agents | Platinum | Xenografts | Cell cycle | Inhibition | Sulfur | Gold | Enzymes | Medical research | Departments | Cultures | Breast cancer | Pharmacology | Shrinkage | Cisplatin | Medicine | Pathology | Chemistry | Side effects | Peptidomimetics | Breast | Ligands | Drug discovery | Prostate cancer | Apoptosis
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 04/2017, Volume 268, pp. 1 - 12
Cutaneous leishmaniasis (CL) is the most common form of the leishmaniasis in humans. Ulcerative painless skin lesions are predominant clinical features of CL.... 
L. (L.) amazonensis | TNFα | Spinal cord | Pain | NFκB | Hyperalgesia | L. (L.) amazonensis | TNF alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | INFLAMMATORY HYPERALGESIA | ANION-INDUCED PAIN | NECROSIS-FACTOR-ALPHA | VIANNIA-BRAZILIENSIS | CUTANEOUS LEISHMANIASIS | NEUROPATHIC PAIN | KNEE-JOINT INCAPACITATION | NITRIC-OXIDE | REDUCES HYPERALGESIA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | UP-REGULATION | NF kappa B | Tumor Necrosis Factor-alpha - metabolism | Hyperalgesia - parasitology | Spinal Cord - metabolism | Etanercept - administration & dosage | Tumor Necrosis Factor-alpha - genetics | Pyrrolidines - administration & dosage | Male | NF-kappa B - metabolism | Leishmania mexicana - physiology | Receptors, Tumor Necrosis Factor, Type I - metabolism | RNA, Messenger - metabolism | Pyrrolidines - therapeutic use | Receptors, Tumor Necrosis Factor, Type II - metabolism | NF-kappa B - antagonists & inhibitors | Thiocarbamates - administration & dosage | Hyperalgesia - metabolism | Parasite Load | Thiocarbamates - therapeutic use | Leishmaniasis, Cutaneous - drug therapy | Receptors, Tumor Necrosis Factor, Type I - genetics | Receptors, Tumor Necrosis Factor, Type II - genetics | Hyperalgesia - physiopathology | Adalimumab - therapeutic use | Adalimumab - administration & dosage | Animals | Hyperalgesia - drug therapy | Leishmaniasis, Cutaneous - parasitology | NF-kappa B - genetics | Tumor Necrosis Factor-alpha - administration & dosage | Mice, Inbred BALB C | Spinal Cord - physiopathology | Leishmaniasis, Cutaneous - physiopathology | Morphine - therapeutic use | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Etanercept - therapeutic use
Journal Article
Cardiovascular Toxicology, ISSN 1530-7905, 10/2016, Volume 16, Issue 4, pp. 345 - 354
High-salt-induced inflammation and oxidative stress in the hypothalamic paraventricular nucleus (PVN) contribute to the pathogenesis of salt-sensitive... 
NF-κB | Oxidative stress | Biomedicine | Hypothalamic paraventricular nucleus | Salt-sensitive hypertension | NLRP3 | Pharmacology/Toxicology | Cardiology | SYMPATHETIC AFFERENT REFLEX | CARDIAC & CARDIOVASCULAR SYSTEMS | INFLAMMASOME ACTIVATION | HEART-FAILURE | ENDOPLASMIC-RETICULUM STRESS | PROINFLAMMATORY CYTOKINES | II-INDUCED HYPERTENSION | NF-kappa B | RENIN-ANGIOTENSIN SYSTEM | MODULATES NEUROTRANSMITTERS | TOXICOLOGY | ATTENUATES HYPERTENSION | Phosphorylation | Transcription Factor RelA - antagonists & inhibitors | Sympathetic Nervous System - drug effects | Antihypertensive Agents - administration & dosage | Pyrrolidines - administration & dosage | Caspase 1 - metabolism | Male | Paraventricular Hypothalamic Nucleus - enzymology | Sympathetic Nervous System - physiopathology | Sympathetic Nervous System - metabolism | Paraventricular Hypothalamic Nucleus - physiopathology | I-kappa B Kinase - metabolism | Interleukin-1beta - metabolism | Arterial Pressure - drug effects | Hypertension - prevention & control | Anti-Inflammatory Agents - administration & dosage | Rats, Inbred Dahl | Hypertension - enzymology | Disease Models, Animal | Thiocarbamates - administration & dosage | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Infusions, Parenteral | Biomarkers - blood | Sodium Chloride, Dietary | Hypertension - physiopathology | Norepinephrine - blood | Paraventricular Hypothalamic Nucleus - drug effects | Animals | Transcription Factor RelA - metabolism | Epinephrine - blood | Antioxidants - administration & dosage | Oxidative Stress - drug effects | Index Medicus
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 03/2009, Volume 8, Issue 6, pp. 514 - 521
The progression of breast cancer is associated with oxidative stress.  However, the effects of pyrrolidine dithiocarbamate (PDTC), a known antioxidant, on the... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Oxidative stress | Migration | Vascular endothelial growth factor (VEGF) | Tumor angiogenesis | Breast cancer | Mice | Proliferation | Pyrrolidine dithocarbamate (PDTC) | SU5416 | APOPTOSIS | pyrrolidine dithocarbamate (PDTC) | proliferation | CARCINOMA CELLS | SENSITIVITY | breast cancer | vascular endothelial growth factor (VEGF) | CELL-LINES | mice | REACTIVE OXYGEN | ONCOLOGY | ANTIOXIDANT | tumor angiogenesis | migration | NF-KAPPA-B | oxidative stress | PROGRESSION | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Humans | Pyrrolidines - administration & dosage | Vascular Endothelial Growth Factor A - metabolism | Antineoplastic Agents - administration & dosage | Vascular Endothelial Growth Factor A - genetics | Breast Neoplasms - metabolism | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Angiogenesis Inhibitors - administration & dosage | Female | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | NF-kappa B - antagonists & inhibitors | Thiocarbamates - administration & dosage | Mice, Inbred C57BL | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Breast Neoplasms - drug therapy | Drug Synergism | Cell Movement - drug effects | Pyrroles - pharmacology | Animals | Breast Neoplasms - genetics | Estrogen Receptor alpha - genetics | Tumor Burden - drug effects | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Neovascularization, Pathologic - metabolism
Journal Article
Journal Article