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science & technology (445) 445
life sciences & biomedicine (388) 388
animals (337) 337
thioctic acid - pharmacology (258) 258
lipoic acid (189) 189
rats (180) 180
male (167) 167
thioctic acid - chemistry (167) 167
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antioxidants - chemistry (39) 39
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gold - chemistry (22) 22
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1. Full Text Proline Catalyzed α‑Aminoxylation Reaction in the Synthesis of Biologically Active Compounds
by Kumar, Pradeep and Dwivedi, Namrata
Accounts of chemical research, ISSN 0001-4842, 02/2013, Volume 46, Issue 2, pp. 289 - 299
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Thioctic Acid - chemical synthesis | Proline - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Lactones - chemical synthesis | Pyrones - chemistry | Furans - chemistry | Pentanoic Acids - chemistry | Catalysis | Furans - chemical synthesis | Pyrones - chemical synthesis | Pentanoic Acids - chemical synthesis | Thioctic Acid - chemistry | Lactones - chemistry | Index Medicus | Proteins | Toxicology | Synthesis | Asymmetry | Chemists | Chemical reactions | Strategy
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2. Full Text A silver complex of hyaluronan–lipoate (SHLS12): Synthesis, characterization and biological properties
by Sacco, Pasquale and Sechi, Alessandra and Trevisan, Antonia and Picotti, Fabrizio and Gianni, Rita and Stucchi, Luca and Fabbian, Matteo and Bosco, Marco and Paoletti, Sergio and Marsich, Eleonora
Carbohydrate polymers, ISSN 0144-8617, 01/2016, Volume 136, pp. 418 - 426
Hyaluronan | Hyaluronan–lipoate | Bacteria barrier effect | Silver complex | Gel | Hyaluronan-lipoate | Physical Sciences | Chemistry | Chemistry, Organic | Polymer Science | Chemistry, Applied | Science & Technology | Biofilms - drug effects | Gels - chemical synthesis | Biocompatible Materials - chemistry | Humans | Hyaluronic Acid - chemistry | Silver - chemistry | Biocompatible Materials - pharmacology | Thioctic Acid - chemical synthesis | Anti-Bacterial Agents - chemical synthesis | Biocompatible Materials - chemical synthesis | Animals | Anti-Bacterial Agents - chemistry | Hyaluronic Acid - analogs & derivatives | Hyaluronic Acid - chemical synthesis | Thioctic Acid - analogs & derivatives | Anti-Bacterial Agents - pharmacology | Mice | Gels - chemistry | 3T3 Cells | Thioctic Acid - chemistry | Gels - pharmacology | Hyaluronic acid | Sulfur compounds | Chemical properties | Enzymes | Biological products | Analysis | Bacteria | Antibacterial agents | Blood proteins | Index Medicus
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3. Full Text Design and Synthesis of Novel Quinolinone-3-aminoamides and Their α-Lipoic Acid Adducts as Antioxidant and Anti-inflammatory Agents
by Detsi, Anastasia and Bouloumbasi, Dionysia and Prousis, Kyriakos C and Koufaki, Maria and Athanasellis, Giorgos and Melagraki, Georgia and Afantitis, Antreas and Igglessi-Markopoulou, Olga and Kontogiorgis, Christos and Hadjipavlou-Litina, Dimitra J
Journal of medicinal chemistry, ISSN 0022-2623, 05/2007, Volume 50, Issue 10, pp. 2450 - 2458
Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Amides - chemical synthesis | Dimethyl Sulfoxide - chemistry | Rats, Inbred F344 | Male | Quinolones - pharmacology | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Hydrazines - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Quinolones - chemical synthesis | Hydroxyl Radical - chemistry | Female | Picrates | Biphenyl Compounds - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Amides - pharmacology | Oxidation-Reduction | Rats | Thioctic Acid - pharmacology | Edema - drug therapy | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Thioctic Acid - chemical synthesis | Animals | Thioctic Acid - analogs & derivatives | Carrageenan | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | Index Medicus
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4. Full Text Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions
by Wu, Liangliang and Zou, Yan and Deng, Chao and Cheng, Ru and Meng, Fenghua and Zhong, Zhiyuan
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 21, pp. 5262 - 5272
Advanced Basic Science | Dentistry | Anticancer drug | Intracellular drug release | Reduction-sensitive | pH-Sensitive | Polypeptide | Micelles | PH-Sensitive | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Dicarboxylic Acids - chemical synthesis | Colloids | Cross-Linking Reagents - pharmacology | Humans | Polyethylene Glycols - chemistry | Hydrogen-Ion Concentration - drug effects | Oxidation-Reduction - drug effects | Antineoplastic Agents - pharmacology | Thioctic Acid - chemistry | Lysine - analogs & derivatives | Microscopy, Electron, Transmission | Intracellular Space - drug effects | Magnetic Resonance Spectroscopy | Peptides - chemistry | Cyclohexanecarboxylic Acids - chemical synthesis | Thioctic Acid - chemical synthesis | Hep G2 Cells | Peptides - pharmacology | Dicarboxylic Acids - chemistry | Hydrolysis | Particle Size | Intracellular Space - metabolism | Lysine - chemical synthesis | Polyethylene Glycols - chemical synthesis | HeLa Cells | Lysine - chemistry | Cyclohexanecarboxylic Acids - chemistry | Doxorubicin - pharmacology | Phosphates | Ethylene glycol | Crosslinked polymers | Anthracyclines | Hydrogen-ion concentration | Block copolymers | Index Medicus | Reduction | Polypeptides | Crosslinking | Nanostructure | Doxorubicin
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5. Full Text Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts
by Melagraki, Georgia and Afantitis, Antreas and Igglessi-Markopoulou, Olga and Detsi, Anastasia and Koufaki, Maria and Kontogiorgis, Christos and Hadjipavlou-Litina, Dimitra J
European journal of medicinal chemistry, ISSN 0223-5234, 2009, Volume 44, Issue 7, pp. 3020 - 3026
Coumarins | Lipoic acid | Antioxidant | Anti-inflammatory | Biological and medical sciences | Medical sciences | General and cellular metabolism. Vitamins | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Antioxidants - chemistry | Anti-Inflammatory Agents - pharmacology | Lipoxygenase Inhibitors - therapeutic use | Rats | Coumarins - chemistry | Male | Edema - drug therapy | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antioxidants - therapeutic use | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Animals | Anti-Inflammatory Agents - chemistry | Lipoxygenase Inhibitors - chemistry | Soybeans - enzymology | Anti-Inflammatory Agents - therapeutic use | Female | Anti-Inflammatory Agents - chemical synthesis | Edema - chemically induced | Lipoxygenase Inhibitors - pharmacology | Thioctic Acid - chemistry | Anti-inflammatory drugs | Analysis | Index Medicus
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6. Full Text Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation
by Pagoni, Aikaterini and Marinelli, Lisa and Di Stefano, Antonio and Ciulla, Michele and Turkez, Hasan and Mardinoglu, Adil and Vassiliou, Stamatia and Cacciatore, Ivana
European journal of medicinal chemistry, ISSN 0223-5234, 01/2020, Volume 186, pp. 111880 - 111880
Hybrid | Lipoic acid | Polyphenol | Alzheimer’s disease | Antioxidants - chemistry | Phenols - chemical synthesis | Humans | Structure-Activity Relationship | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Amyloid beta-Peptides - metabolism | Molecular Structure | Tumor Cells, Cultured | Thioctic Acid - chemistry | Phenols - pharmacology | Protein Aggregates - drug effects | Peptide Fragments - metabolism | Neuroprotective Agents - chemistry | Alzheimer Disease - drug therapy | Thioctic Acid - pharmacology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Thioctic Acid - chemical synthesis | Amyloid beta-Peptides - antagonists & inhibitors | Neuroprotective Agents - chemical synthesis | Peptide Fragments - antagonists & inhibitors | Alzheimer Disease - metabolism | Phenols - chemistry | Cell Proliferation - drug effects | Index Medicus
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7. Full Text Bioorganic synthesis, characterization and antioxidant activity of esters of natural phenolics and α-lipoic acid
by Kaki, Shiva Shanker and Grey, Carl and Adlercreutz, Patrick
Journal of biotechnology, ISSN 0168-1656, 01/2012, Volume 157, Issue 2, pp. 344 - 349
α-Lipoic acid | Synthesis | Antioxidant | Lipase | Phenolics | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Antioxidants - chemistry | Oxidation-Reduction | Phenols - chemical synthesis | Free Radical Scavengers - chemistry | Thioctic Acid - pharmacology | Antioxidants - chemical synthesis | Thioctic Acid - chemical synthesis | Esters - chemical synthesis | Animals | Esters - chemistry | Thiobarbituric Acid Reactive Substances - chemistry | Phenols - chemistry | Thioctic Acid - analogs & derivatives | Molecular Structure | Biphenyl Compounds - chemistry | Lipid Peroxidation | Fish Oils - chemistry | Esters - pharmacology | Thioctic Acid - chemistry | Antioxidants | Emulsions | Scavenging | Fish | Esters | Derivatives | Radicals | Index Medicus | Engineering and Technology | Industrial Biotechnology | alpha-Lipoic acid | Industriell bioteknik | Teknik
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8. Full Text Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction
by Benchekroun, Mohamed and Pachón-Angona, Irene and Luzet, Vincent and Martin, Helene and Oset-Gasque, María-Jesús and Marco-Contelles, José and Ismaili, Lhassane
Bioorganic chemistry, ISSN 0045-2068, 04/2019, Volume 85, pp. 221 - 228
Antioxidants | Aβ1−40 self-aggregation inhibition | Multicomponent reactions | Benzyl isocyanide | (R)-Lipoic acid | Benzylamine | Ugi four-component reaction | Caffeic acid | Ferulic acid | self-aggregation inhibition | Free Radical Scavengers - pharmacology | Coumaric Acids - chemistry | Free Radical Scavengers - chemistry | Humans | Caffeic Acids - pharmacology | Structure-Activity Relationship | Neuroprotective Agents - pharmacology | Amyloid beta-Peptides - metabolism | Free Radical Scavengers - chemical synthesis | Molecular Structure | Thioctic Acid - chemistry | Peptide Fragments - metabolism | Neuroprotective Agents - chemistry | Hydrogen Peroxide - pharmacology | Caffeic Acids - chemical synthesis | Thioctic Acid - pharmacology | Caffeic Acids - chemistry | Coumaric Acids - chemical synthesis | Thioctic Acid - chemical synthesis | Neuroprotective Agents - chemical synthesis | Cell Line, Tumor | Thioctic Acid - analogs & derivatives | Oxidative Stress - drug effects | Protein Multimerization - drug effects | Coumaric Acids - pharmacology | Index Medicus
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9. Full Text Lipoyl Ester Terminated Star PLGA as a Simple and Smart Material for Controlled Drug Delivery Application
by Wang, Xiuxiu and Cheng, Ru and Cheng, Liang and Zhong, Zhiyuan
Biomacromolecules, ISSN 1525-7797, 04/2018, Volume 19, Issue 4, pp. 1368 - 1373
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Polymer Science | Science & Technology | Doxorubicin - therapeutic use | Antioxidants - chemistry | Nanoparticles - chemistry | Humans | Polylactic Acid-Polyglycolic Acid Copolymer - chemistry | Doxorubicin - chemistry | Antioxidants - chemical synthesis | Thioctic Acid - chemical synthesis | Drug Liberation - drug effects | Drug Delivery Systems | Neoplasms - drug therapy | Flow Cytometry | Nanoparticles - therapeutic use | Biodegradable Plastics - chemical synthesis | Glutathione - chemistry | Dioxanes - chemistry | Polylactic Acid-Polyglycolic Acid Copolymer - chemical synthesis | Thioctic Acid - chemistry | Biodegradable Plastics - chemistry | Index Medicus
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10. Full Text A Multifunctional Polypeptide via Ugi Reaction for Compact and Biocompatible Quantum Dots with Efficient Bioconjugation
by Zhang, Hang and Chen, Jinlong and Xiao, Chunsheng and Tao, Youhua and Wang, Xianhong
Bioconjugate chemistry, ISSN 1043-1802, 04/2018, Volume 29, Issue 4, pp. 1335 - 1343
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Multidisciplinary | Science & Technology | Optical Imaging | Chemistry Techniques, Synthetic | Peptides - chemistry | Pyridines - chemistry | Biocompatible Materials - chemistry | Humans | Pyridines - chemical synthesis | Thioctic Acid - chemical synthesis | DNA - chemical synthesis | Biocompatible Materials - chemical synthesis | DNA - chemistry | Peptides - chemical synthesis | Quantum Dots - chemistry | Hydrophobic and Hydrophilic Interactions | Ligands | HeLa Cells | Microscopy, Fluorescence | Thioctic Acid - chemistry | Organic chemistry | Pyridines | Lipoic acid | Biomedical materials | Polypeptides | Quantum dots | Chemical reactions | Biocompatibility | Coupling | Continuity (mathematics) | Deoxyribonucleic acid--DNA | Index Medicus
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11. Full Text Hyaluronic acid lipoate: Synthesis and physicochemical properties
by Picotti, Fabrizio and Fabbian, Matteo and Gianni, Rita and Sechi, Alessandra and Stucchi, Luca and Bosco, Marco
Carbohydrate polymers, ISSN 0144-8617, 03/2013, Volume 93, Issue 1, pp. 273 - 278
Lipoic acid | Radical scavenging properties | Enzymatic degradation | Hydrogel | Hyaluronic acid | Hyaluronic acid lipoate | General and cellular metabolism. Vitamins | Exact sciences and technology | Pharmacology. Drug treatments | Applied sciences | Biological and medical sciences | Physicochemistry of polymers | Medical sciences | Natural polymers | Starch and polysaccharides | Viscosity | Cross-Linking Reagents | Biocatalysis | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Free Radical Scavengers - chemistry | Hyaluronic Acid - chemistry | Imidazoles - chemistry | Spectroscopy, Fourier Transform Infrared | Hyaluronic Acid - physiology | Hyaluronoglucosaminidase - chemistry | Formamides - chemistry | Animals | Ultraviolet Rays | Hyaluronic Acid - analogs & derivatives | Chemical Phenomena | Thioctic Acid - analogs & derivatives | Thioctic Acid - chemistry | Cytokinins | Enzymes | Nuclear magnetic resonance spectroscopy | Index Medicus
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12. Full Text Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD
by Digiacomo, Maria and Chen, Ziwei and Wang, Shengnan and Lapucci, Annalina and Macchia, Marco and Yang, Xiaohong and Chu, Jiaqi and Han, Yifan and Pi, Rongbiao and Rapposelli, Simona
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 02/2015, Volume 25, Issue 4, pp. 807 - 810
BACE1 | Alzheimer’s disease | Multi-targeted ligands | Copper | Amyloid protein | Tacrine | Caffeic acid | Alzheimer's disease | Cell Line | Coumaric Acids - chemistry | Aspartic Acid Endopeptidases - antagonists & inhibitors | Humans | Alzheimer Disease - drug therapy | Models, Molecular | Caffeic Acids - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Tacrine - chemical synthesis | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Tacrine - pharmacology | Cholinesterase Inhibitors - pharmacology | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Drug Design | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Tacrine - analogs & derivatives | Thioctic Acid - chemistry | Index Medicus
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13. Full Text Synthesis and Grafting of Thioctic Acid−PEG−Folate Conjugates onto Au Nanoparticles for Selective Targeting of Folate Receptor-Positive Tumor Cells
by Dixit, Vivechana and Van den Bossche, Jeroen and Sherman, Debra M and Thompson, David H and Andres, Ronald P
Bioconjugate chemistry, ISSN 1043-1802, 05/2006, Volume 17, Issue 3, pp. 603 - 609
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Multidisciplinary | Science & Technology | Gold - chemistry | Neoplasms - metabolism | Microscopy, Electron, Transmission | Nanostructures - ultrastructure | Folate Receptors, GPI-Anchored | Humans | Folic Acid - chemistry | Receptors, Cell Surface - metabolism | Polyethylene Glycols - chemistry | Neoplasms - ultrastructure | Carrier Proteins - metabolism | Cell Line, Tumor | Folic Acid - metabolism | Nanostructures - chemistry | Folic Acid - chemical synthesis | Molecular Structure | Thioctic Acid - chemistry | Nanoparticles | Gold | Medical imaging | Aqueous solutions | Vitamin B | Biochemistry | Cells | Tumors | Index Medicus
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14. Full Text Rational Approach To Discover Multipotent Anti-Alzheimer Drugs
by Rosini, Michela and Andrisano, Vincenza and Bartolini, Manuela and Bolognesi, Maria L and Hrelia, Patrizia and Minarini, Anna and Tarozzi, Andrea and Melchiorre, Carlo
Journal of medicinal chemistry, ISSN 0022-2623, 01/2005, Volume 48, Issue 2, pp. 360 - 363
Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Neurons - cytology | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Tacrine - pharmacology | Butyrylcholinesterase - chemistry | Neurons - drug effects | Tacrine - analogs & derivatives | Tacrine - chemistry | Thioctic Acid - chemistry | Cell Line | Alzheimer Disease - drug therapy | Thioctic Acid - pharmacology | Acetylcholinesterase - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Nootropic Agents - chemical synthesis | Thioctic Acid - chemical synthesis | Nootropic Agents - chemistry | Tacrine - chemical synthesis | Cholinesterase Inhibitors - pharmacology | Thioctic Acid - analogs & derivatives | Amyloid beta-Peptides - chemistry | Nootropic Agents - pharmacology | Index Medicus
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