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International journal of molecular sciences, ISSN 1422-0067, 07/2018, Volume 19, Issue 7, p. 2050
... (1,1-cyclobutanedicarboxylate) analogue the antioxidant α-Lipoic acid (ALA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase (PDK). The new compounds (cis,trans,cis-[Pt(CBDCA)(ALA)2(cis-1,4-DACH... 
Kiteplatin | Mitochondria | DNA | α-lipoic acid | Platinum(IV) complexes | Cisplatin | Tumor spheroids | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Platinum - metabolism | Reactive Oxygen Species - metabolism | Humans | Prodrugs - chemistry | Platinum - chemistry | Organoplatinum Compounds - pharmacology | Prodrugs - metabolism | Thioctic Acid - metabolism | Antineoplastic Agents - metabolism | Mitochondrial Membranes - drug effects | Cisplatin - chemistry | MCF-7 Cells | Organoplatinum Compounds - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | Platinum - pharmacology | Thioctic Acid - chemistry | Organoplatinum Compounds - chemistry | Cell Survival - drug effects | Thioctic Acid - pharmacology | Mitochondria - metabolism | Cisplatin - pharmacology | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Mitochondrial Membranes - metabolism | Cisplatin - metabolism | Cell Line, Tumor | Prodrugs - pharmacology | Drug Screening Assays, Antitumor | Drugs | Lipoic acid | Dehydrogenases | Prodrugs | Pyruvate dehydrogenase (lipoamide) | Pyruvic acid | Tumor cell lines | Chemical compounds | Depolarization | Antioxidants | Signal transduction | Oxaliplatin | Platinum | Glycolysis | Ligands | Membrane potential | DNA adducts | Deoxyribonucleic acid--DNA | Adducts | Cancer | Index Medicus | kiteplatin | platinum(IV) complexes | mitochondria | cisplatin | tumor spheroids
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