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Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 04/2016, Volume 8, Issue 334, pp. 334ra51 - 334ra51
Journal Article
Hypertension, ISSN 0194-911X, 04/2012, Volume 59, Issue 4, pp. 818 - 824
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e58371 - e58371
Background: The present study investigates the effects and mechanisms of alpha-Lipoic acid (LA) on myocardial infarct size, cardiac function and cardiomyocyte... 
ISCHEMIA-REPERFUSION INJURY | CELLS | OXIDATIVE STRESS | HEME OXYGENASE-1 EXPRESSION | NRF2 | PHOSPHORYLATION | PROTEIN-KINASE | ANTIOXIDANT | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | ERYTHROID 2-RELATED FACTOR-2 | Tumor Necrosis Factor-alpha - metabolism | Thioctic Acid - administration & dosage | Apoptosis - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | Protein Transport - drug effects | Heme Oxygenase-1 - genetics | Myocardial Reperfusion Injury - pathology | Cell Nucleus - metabolism | Myocardial Infarction - pathology | Transcription, Genetic | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Neutrophils - pathology | Creatine Kinase - blood | Ventricular Function, Left - drug effects | Rats | Thioctic Acid - pharmacology | Cardiotonic Agents - pharmacology | Myocardial Reperfusion Injury - physiopathology | Gene Expression Regulation - drug effects | Myocardial Reperfusion Injury - metabolism | Animals | Cardiotonic Agents - administration & dosage | Myocytes, Cardiac - drug effects | Signal Transduction - drug effects | L-Lactate Dehydrogenase - blood | NF-E2-Related Factor 2 - metabolism | Myocytes, Cardiac - metabolism | Myocardial infarction | Lipoic acid | Oxidative stress | Phosphorylation | Dehydrogenases | Heart surgery | AKT protein | Myocardial ischemia | Activation | Kinases | Heart function | Accumulation | Antioxidants | Signal transduction | Reperfusion | Ischemia | Rodents | Inhibition | Pretreatment | Cardiology | Heart diseases | Translocation | Coronary artery | Cardiomyocytes | Inflammation | Tumor necrosis factor-α | Nuclear transport | 1-Phosphatidylinositol 3-kinase | Injury prevention | Acids | Nitric oxide | Myocardium | In vivo methods and tests | Diabetes | Laboratory animals | Apoptosis | Index Medicus
Journal Article
Inflammation, ISSN 0360-3997, 4/2015, Volume 38, Issue 2, pp. 510 - 519
Sepsis is often initiated by invasive infection, characterized by overwhelming induction of pro-inflammatory cytokines. The incidence and mortality of sepsis... 
Pathology | nuclear factor kappa B signaling pathway | alpha-lipoic acid | Medicine & Public Health | inflammation | Rheumatology | Internal Medicine | acute kidney injury | Pharmacology/Toxicology | sepsis | PROTECTS MICE | ACTIVATION | HUMAN-DISEASE | COX-2 | IMMUNOLOGY | CELL BIOLOGY | SEPTIC SHOCK | INFLAMMATORY RESPONSE | UP-REGULATION | EXPRESSION | Dinoprostone - secretion | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Nitric Oxide Synthase Type II - biosynthesis | Phosphorylation | I-kappa B Proteins - metabolism | Lipopolysaccharides | Mesangial Cells - drug effects | Cyclooxygenase 2 - biosynthesis | Sepsis - pathology | I-kappa B Kinase - metabolism | Inflammation - drug therapy | Interleukin-1beta - metabolism | Interleukin-6 - metabolism | Cell Line | Cell Survival - drug effects | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Sepsis - immunology | Signal Transduction | Acute Kidney Injury - drug therapy | Acute Kidney Injury - pathology | Anti-Inflammatory Agents - pharmacology | Mesangial Cells - immunology | Rats | Thioctic Acid - pharmacology | Inflammation - immunology | Antioxidants - pharmacology | Interleukin-6 - secretion | Acute Kidney Injury - prevention & control | Dinoprostone - metabolism | Animals | Transcription Factor RelA - metabolism | Acetylcysteine - pharmacology | Nitric Oxide - metabolism | Medicine, Experimental | Medical research | Research | Anti-inflammatory drugs | Index Medicus
Journal Article
Journal Article
European journal of pharmacology, ISSN 0014-2999, 03/2017, Volume 799, pp. 41 - 47
Leukotriene A hydrolase is a soluble enzyme with epoxide hydrolase and aminopeptidase activities catalysing the conversion of leukotriene A to leukotriene B... 
Dose-Response Relationship, Drug | Cytosol - enzymology | Neutrophils - cytology | Humans | Enzyme Inhibitors - pharmacology | Thioctic Acid - pharmacology | Epoxide Hydrolases - metabolism | Epoxide Hydrolases - antagonists & inhibitors
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 07/2018, Volume 19, Issue 7, p. 2050
Platinum(II) drugs are activated intracellularly by aquation of the leaving groups and then bind to DNA, forming DNA adducts capable to activate various... 
Kiteplatin | Mitochondria | DNA | α-lipoic acid | Platinum(IV) complexes | Cisplatin | Tumor spheroids | PT(IV) PRODRUGS | APOPTOSIS | kiteplatin | alpha-lipoic acid | platinum(IV) complexes | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | ANTITUMOR-ACTIVITY | tumor spheroids | CANCER | CHEMISTRY, MULTIDISCIPLINARY | METABOLISM | ANTIOXIDANT | ANTICANCER DRUGS | cisplatin | T-CELLS | Platinum - metabolism | Reactive Oxygen Species - metabolism | Humans | Prodrugs - chemistry | Platinum - chemistry | Organoplatinum Compounds - pharmacology | Prodrugs - metabolism | Thioctic Acid - metabolism | Antineoplastic Agents - metabolism | Mitochondrial Membranes - drug effects | Cisplatin - chemistry | MCF-7 Cells | Organoplatinum Compounds - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | Platinum - pharmacology | Thioctic Acid - chemistry | Organoplatinum Compounds - chemistry | Cell Survival - drug effects | Thioctic Acid - pharmacology | Mitochondria - metabolism | Cisplatin - pharmacology | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Mitochondrial Membranes - metabolism | Cisplatin - metabolism | Cell Line, Tumor | Prodrugs - pharmacology | Drug Screening Assays, Antitumor | Drugs | Lipoic acid | Dehydrogenases | Prodrugs | Pyruvate dehydrogenase (lipoamide) | Pyruvic acid | Tumor cell lines | Chemical compounds | Depolarization | Antioxidants | Signal transduction | Oxaliplatin | Platinum | Cell lines | Glycolysis | Ligands | Transduction | Membrane potential | DNA adducts | Deoxyribonucleic acid--DNA | Adducts | Cancer | Index Medicus
Journal Article