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Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/2017, Volume 76, Issue 5, pp. 811 - 820
Journal Article
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, ISSN 0277-0008, 09/2018, Volume 38, Issue 9, pp. 935 - 946
The emergence and spread of antimicrobial resistance have led to a global public health emergency requiring development of new antimicrobial classes. Lefamulin... 
lefamulin | gram‐positive | pleuromutilin | drug‐resistant gram‐positive cocci | gram-positive | drug-resistant gram-positive cocci | ACUTE BACTERIAL SKIN | STREPTOCOCCUS-PNEUMONIAE | SURVEILLANCE | PHARMACOLOGY & PHARMACY | BC-3781 | ANTIMICROBIAL ACTIVITY | RESPIRATORY-TRACT INFECTIONS | Diterpenes - pharmacology | Thioglycolates - adverse effects | Diterpenes - therapeutic use | Humans | Microbial Sensitivity Tests - statistics & numerical data | Thioglycolates - therapeutic use | Anti-Bacterial Agents - therapeutic use | Diterpenes - pharmacokinetics | Drug Resistance, Microbial | Thioglycolates - pharmacokinetics | Thioglycolates - pharmacology | Community-Acquired Infections - drug therapy | Anti-Bacterial Agents - pharmacokinetics | Anti-Bacterial Agents - adverse effects | Anti-Bacterial Agents - pharmacology | Diterpenes - adverse effects | Drug Resistance | Drug resistance in microorganisms | Pneumonia | Sexually transmitted diseases | Bacterial infections | RNA | Bacterial pneumonia | Protein biosynthesis | Antibacterial agents | Protein binding | Linezolid | Sexually transmitted diseases--STD | Intravenous administration | Clinical trials | Infections | Moxifloxacin | Vancomycin | Streptococcus infections | Methicillin | Proteins | Time dependence | Bacteria | Antibacterial activity | Public health | Binding | Formulations | Exploration | Antimicrobial agents | Pharmacology | Ribonucleic acid--RNA | Infectious diseases | Reviews | Antibiotics | Lungs | Protein synthesis | Minimum inhibitory concentration | Skin | Antimicrobial resistance | Legionnaires' disease bacterium
Journal Article
Rheumatology (Oxford, England), ISSN 1462-0324, 12/2014, Volume 53, Issue 12, pp. 2167 - 2174
Journal Article
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 02/2019, Volume 47, Issue 2, pp. 104 - 113
Lesinurad [Zurampic; 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H- 1,2,4-triazol-3-ylthio)], a selective inhibitor of uric acid reabsorption transporters... 
AXIAL CHIRALITY | WARFARIN | ENANTIOMERS | RECEPTOR | PHARMACOLOGY & PHARMACY | FLUOXETINE | DISCOVERY | Organic Anion Transporters, Sodium-Independent - antagonists & inhibitors | Stereoisomerism | Triazoles - chemistry | Humans | Middle Aged | Gout - drug therapy | Male | Structure-Activity Relationship | Healthy Volunteers | Organic Anion Transporters - metabolism | Uric Acid - urine | Young Adult | Kidney - metabolism | Organic Cation Transport Proteins - antagonists & inhibitors | Renal Reabsorption - drug effects | Organic Anion Transporters, Sodium-Independent - metabolism | HEK293 Cells | Adult | Uric Acid - blood | Triazoles - therapeutic use | Organic Anion Transporters - antagonists & inhibitors | Uricosuric Agents - chemistry | Kidney - drug effects | Uric Acid - metabolism | Organic Cation Transport Proteins - metabolism | Administration, Oral | Thioglycolates - chemistry | Thioglycolates - metabolism | Uricosuric Agents - metabolism | Thioglycolates - therapeutic use | Triazoles - pharmacology | Triazoles - metabolism | Thioglycolates - pharmacology | Uricosuric Agents - pharmacology | Microsomes, Liver | Uricosuric Agents - therapeutic use | Hydroxylation | Liver | Dealkylation | Gout | Oral administration | Reabsorption | Pharmacology | Uric acid | Metabolism | Microsomes | Stereoselectivity | Dihydrodiol | Proteins | Metabolites | Acids | Pharmacokinetics | Recombinant
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 07/2015, Volume 9, pp. 3423 - 3434
Lesinurad is a selective uric acid reabsorption inhibitor under investigation for the treatment of gout. Single and multiple ascending dose studies were... 
Urate lowering | Food effect | Clearance | Single and multiple doses | URAT1 | Urinary excretion | DIAGNOSIS | single and multiple doses | CHEMISTRY, MEDICINAL | MANAGEMENT | GOUT | ESCISIT | EVIDENCE BASED RECOMMENDATIONS | urinary excretion | HYPERURICEMIA | food effect | TASK-FORCE | DISEASE | clearance | PHARMACOLOGY & PHARMACY | urate lowering | Triazoles - administration & dosage | Triazoles - adverse effects | Triazoles - blood | Humans | Biological Availability | Male | Healthy Volunteers | Organic Anion Transporters - metabolism | Pharmaceutical Solutions | Uric Acid - urine | Young Adult | Thioglycolates - pharmacokinetics | Capsules | Organic Cation Transport Proteins - antagonists & inhibitors | Thioglycolates - administration & dosage | Thioglycolates - blood | Adult | Triazoles - pharmacokinetics | Uric Acid - blood | Thioglycolates - adverse effects | Organic Anion Transporters - antagonists & inhibitors | Gastrointestinal Absorption | Uricosuric Agents - blood | Double-Blind Method | Organic Cation Transport Proteins - metabolism | Administration, Oral | Uricosuric Agents - administration & dosage | Renal Elimination - drug effects | Cross-Over Studies | Uricosuric Agents - pharmacokinetics | Adolescent | Uricosuric Agents - adverse effects | Dose-response relationship (Biochemistry) | Drug metabolism | Models | Testing | Dosing | Task forces | Excretion | Pharmacodynamics | Tablets | Blood & organ donations | Gout | Reabsorption | Pharmacology | Arthritis | Uric acid | Family medical history | Bioavailability | Males | Metabolism | Annual reports | Studies | Inhibitors | Acids | Rheumatism | Kidney diseases | Safety | Pharmacokinetics | Drug dosages
Journal Article
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2010, Volume 107, Issue 6, pp. 2568 - 2573
Journal Article
Surgical and Cosmetic Dermatology, ISSN 1984-5510, 2016, Volume 7, Issue 4, pp. 350 - 352
Journal Article
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 07/2014, Volume 392, Issue 1-2, pp. 14 - 22
Poly(ADP-ribose) polymerase-1 (PARP-1) enzyme, as a sensor of DNA damage, could convert nicotinamide adenine dinucleotide (NAD) into long poly(ADP-ribose)... 
NAD | Cardiac hypertrophy | SIRT6 | 6014 | PARP-1 | ACTIVATION | HEART-FAILURE | MYOCYTE CELL-DEATH | MOLECULAR DOCKING | CELL BIOLOGY | IN-VITRO | CARDIAC-HYPERTROPHY | ENDOCRINOLOGY & METABOLISM | NAD(+) | STRESS | EXPRESSION | POLY(ADP-RIBOSE) POLYMERASE-1 INHIBITORS | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Humans | NADPH Oxidases - metabolism | Xanthines - pharmacology | Cardiotonic Agents - therapeutic use | Myocytes, Cardiac - enzymology | Xanthines - chemistry | Enzyme Inhibitors - chemistry | Cytoprotection - drug effects | Inhibitory Concentration 50 | Angiotensin II | Drug Evaluation, Preclinical | NAD - metabolism | Recombinant Proteins - metabolism | Xanthines - analysis | Thioglycolates - chemistry | Enzyme Inhibitors - pharmacology | Enzyme Inhibitors - analysis | Thioglycolates - analysis | Cardiomegaly - enzymology | Cardiotonic Agents - pharmacology | NADPH Oxidase 4 | Enzyme Activation - drug effects | NADPH Oxidase 2 | Poly(ADP-ribose) Polymerase Inhibitors | Rats, Sprague-Dawley | Up-Regulation - drug effects | Myocytes, Cardiac - pathology | Poly(ADP-ribose) Polymerases - metabolism | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Thioglycolates - pharmacology | Molecular Docking Simulation | Sirtuins - metabolism | Enzymes | Silver | Cellular | Depletion | Inhibitors | Deoxyribonucleic acid | Attenuation | Inhibition
Journal Article