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Biochemistry, ISSN 0006-2960, 06/2018, Volume 57, Issue 22, pp. 3155 - 3166
Thiolases are a class of carbon-carbon bond forming enzymes with important applications in biotechnology and metabolic engineering as they provide a general... 
OXIDATION CYCLE | MECHANISM | ACETOACETYL-COA THIOLASE | ACTIVE-SITE BASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-KETOACYL THIOLASE | ZOOGLOEA-RAMIGERA | ESCHERICHIA-COLI | RALSTONIA-EUTROPHA | BIOSYNTHETIC THIOLASE | Index Medicus
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2019, Volume 17, Issue 6, pp. 1375 - 1378
Economical and environmentally-friendly routes to convert feedstock chemicals like acetate into valuable chiral products such as (R)-3-hydroxybutyrate are in... 
Journal Article
ACS Catalysis, ISSN 2155-5435, 03/2018, Volume 8, Issue 3, pp. 1973 - 1989
Cytosolic thiolase (CT) catalyzes the reversible Claisen condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA. The reaction cycle proceeds... 
acetoacetyl-CoA | Claisen condensation | monovalent cation activation | tetrahedral reaction intermediate | biosynthetic thiolase | CRYSTAL-STRUCTURE | ZOOGLOEA-RAMIGERA | CHEMISTRY, PHYSICAL | COENZYME-A | SUBSTRATE-BINDING | ACETOACETYL-COA THIOLASE | AZOLE RESISTANCE | 3-KETOACYL-COA THIOLASE | MICROBIAL-PRODUCTION | EFFECTIVE IONIC-RADII
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 08/2016, Volume 84, Issue 8, pp. 1075 - 1096
ABSTRACT Bioinformatics studies have shown that the genomes of trypanosomatid species each encode one SCP2‐thiolase‐like protein (SLP), which is characterized... 
gene knockout | SCP2‐thiolase | SCP2‐thiolase‐like protein | crystal structure | malonyl‐CoA:ACP transacylase | Trypanosoma brucei | mitochondrial lipid metabolism | malonyl‐CoA decarboxylase | SCP2-thiolase | SCP2-thiolase-like protein | malonyl-CoA decarboxylase | malonyl-CoA:ACP transacylase | MAXIMUM-LIKELIHOOD | 3-OXOACYL-COA THIOLASE | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACYL CARRIER PROTEIN | BIOPHYSICS | SUCCINATE COA-TRANSFERASE | MALONYL-COA | STRUCTURAL BASIS | 3-KETOACYL-COA THIOLASE | FATTY-ACID SYNTHASE | Substrate Specificity | Crystallography, X-Ray | Green Fluorescent Proteins - genetics | Mitochondrial Proteins - genetics | Acyltransferases - metabolism | Protozoan Proteins - genetics | Trypanosoma brucei brucei - chemistry | Trypanosoma brucei brucei - enzymology | Acyltransferases - genetics | Recombinant Fusion Proteins - metabolism | Protozoan Proteins - metabolism | Malonates - chemistry | Malonates - metabolism | Mitochondrial Proteins - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Protein Domains | Protozoan Proteins - chemistry | Green Fluorescent Proteins - chemistry | Acyl Coenzyme A - metabolism | Genes, Reporter | Acetyl Coenzyme A - chemistry | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Gene Expression | Protein Structure, Secondary | Lipid Metabolism | Recombinant Fusion Proteins - chemistry | Acetyl Coenzyme A - metabolism | Acyl Coenzyme A - chemistry | Sequence Homology, Amino Acid | Sequence Alignment | Escherichia coli - genetics | Mitochondrial Proteins - chemistry | Recombinant Fusion Proteins - genetics | Acyltransferases - chemistry | Kinetics | Enzymes | Analysis | Genes | Genomics | Crystals | Physiological aspects | Fluorescence | Glucose | Structure | Dextrose | Life Sciences
Journal Article
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 02/2019, Volume 17, Issue 6, pp. 1375 - 1378
Economical and environmentally-friendly routes to convert feed-stock chemicals like acetate into valuable chiral products such as (R)-3-hydroxybutyrate are in... 
THIOLASE | POLYKETIDE | CHEMISTRY, ORGANIC | CRYSTAL-STRUCTURE | BIOSYNTHESIS
Journal Article
Metabolic Brain Disease, ISSN 0885-7490, 12/2017, Volume 32, Issue 6, pp. 2063 - 2071
Hydroxysteroid (17β) dehydrogenase 10 (HSD10) and mitochondrial acetoacetyl-CoA thiolase (β-KT) are two adjacent enzymes for the degradation of isoleucine,... 
Biochemistry, general | Acetoacetyl-CoA thiolase (β-KT) | Neurology | Neurosciences | Biomedicine | Hydroxysteroid (17β) dehydrogenase 10 (HSD10) | Metabolic Diseases | Oncology | Mutation | Isoleucine metabolism | MITOCHONDRIAL ACETOACETYL-COENZYME | DIAGNOSIS | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 10 | Hydroxysteroid (17 beta) | T2 DEFICIENCY | BETA-KETOTHIOLASE DEFICIENCY | FAILURE | NEUROSCIENCES | dehydrogenase 10 (HSD10) | HSD10 DISEASE | Acetoacetyl-CoA thiolase (beta-KT) | ENDOCRINOLOGY & METABOLISM | MHBD DEFICIENCY | 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE-DEFICIENCY | COA THIOLASE DEFICIENCY | Acetyl-CoA C-Acyltransferase - genetics | Brain - diagnostic imaging | Humans | Child, Preschool | Epilepsy - metabolism | Infant | Male | 3-Hydroxyacyl CoA Dehydrogenases - genetics | Amino Acid Metabolism, Inborn Errors - diagnosis | Amino Acid Metabolism, Inborn Errors - metabolism | Mental Retardation, X-Linked - genetics | Amino Acid Metabolism, Inborn Errors - genetics | China | Mental Retardation, X-Linked - diagnosis | Epilepsy - genetics | Female | Retrospective Studies | Dyskinesias - genetics | Diagnosis, Differential | Dyskinesias - diagnostic imaging | Models, Molecular | Dyskinesias - metabolism | Isoleucine - metabolism | Acetyl-CoA C-Acetyltransferase - genetics | Amino Acid Metabolism, Inborn Errors - diagnostic imaging | Dyskinesias - diagnosis | Acetyl-CoA C-Acyltransferase - metabolism | Mental Retardation, X-Linked - diagnostic imaging | Acetyl-CoA C-Acyltransferase - deficiency | Mental Retardation, X-Linked - metabolism | Enzymes | Medical colleges | Metabolites | Genes | Physiological aspects | Genetic aspects | Glutamine | Urine | Degradation | Mitochondria | Pathogenesis | Thiolase | Disorders | Metabolism | Patients | Deoxyribonucleic acid--DNA | Isoleucine
Journal Article
Pediatrics International, ISSN 1328-8067, 02/2015, Volume 57, Issue 1, pp. 41 - 48
Journal Article
Acta Crystallographica Section F, ISSN 2053-230X, 01/2018, Volume 74, Issue 1, pp. 6 - 13
Journal Article
by Kim, EJ and Son, HF and Kim, S and Ahn, JW and Kim, KJ
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 02/2014, Volume 444, Issue 3, pp. 365 - 369
ReBktB is a beta-keto thiolase from Ralstonia eutropha H16 that catalyzes condensation reactions between acetyl-CoA with acyl-CoA molecules that contains... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | ZOOGLOEA-RAMIGERA | ESCHERICHIA-COLI | Beta-keto thiolase | PHB | IDENTIFICATION | Ralstonia eutropha | BIOPHYSICS | PATHWAY | CLONING | GENES | BIOSYNTHETIC THIOLASE | Polyhydroxyalkanoates | Crystal structure
Journal Article
Journal of Molecular Catalysis. B, Enzymatic, ISSN 1381-1177, 11/2015, Volume 121, Issue C, pp. 113 - 121
Thiolases catalyze the formation of carbon–carbon bonds in diverse biosynthetic pathways. The promiscuous β-ketoacyl thiolase B of ( BktB) has been utilized in... 
In vitro biocatalysis | Rational engineering | Enzyme mechanism | Thiolase | Crystal structure | ZOOGLOEA-RAMIGERA | CHEMISTRY, PHYSICAL | BIOCHEMICAL-CHARACTERIZATION | 3-KETOACYL-COA THIOLASE | POLYHYDROXYALKANOATES | BIOSYNTHETIC THIOLASE | BINDING | INSIGHTS
Journal Article