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The Journal of Physiology, ISSN 0022-3751, 07/2010, Volume 588, Issue 14, pp. 2605 - 2619
In vertebrate retina, melatonin regulates various physiological functions. In this work we investigated the mechanisms underlying melatonin‐induced... 
CIRCADIAN CLOCK | XENOPUS-LAEVIS | BIPOLAR CELLS | PROTEIN-KINASE-C | PHYSIOLOGY | FISH RETINA | PHOSPHOLIPASE-C | VISUAL PATHWAY | FUNCTIONAL-ROLE | MT2 MELATONIN | RECEPTORS | NEUROSCIENCES | Cyclic GMP - pharmacology | Receptor, Melatonin, MT2 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Male | Calcium - analysis | Melatonin - physiology | Type C Phospholipases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Isoquinolines - pharmacology | Cyclic GMP - analogs & derivatives | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Bridged-Ring Compounds - pharmacology | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Guanosine Diphosphate - pharmacology | Pertussis Toxin - pharmacology | Retinal Ganglion Cells - physiology | Protein Kinase C - physiology | Retinal Ganglion Cells - enzymology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Receptor, Melatonin, MT2 - physiology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Glycine - physiology | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Tetrahydronaphthalenes - pharmacology | Thiones - pharmacology | Carbazoles - pharmacology | Type C Phospholipases - physiology | Melatonin | Phospholipids | Glycine | Ganglion | Gross domestic product | Protein kinases | Kinases | Retina | Physiology | Neuroscience
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 12/2015, Volume 153, pp. 49 - 59
Heart tissue becomes zinc-depleted and the capacity to mobilize labile zinc is diminished, indicating zinc dyshomeostasis during ischemia/reperfusion (I/R).... 
Hypoxia | Reoxygenation | Proteolysis | Caspase-3 | Zinc | Apoptosis | ACTIVATION | RAT | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | CARDIOMYOPATHY | CARDIAC-CELLS | DEATH | INTRACELLULAR ZINC | CHEMISTRY, INORGANIC & NUCLEAR | ACUTE MYOCARDIAL-INFARCTION | Receptor, Epidermal Growth Factor - genetics | Caspase Inhibitors - pharmacology | Phosphorylation | Receptor, ErbB-2 - genetics | Protein Multimerization | Caspase 3 - metabolism | Receptor, ErbB-2 - metabolism | RNA, Messenger - metabolism | Cell Hypoxia | Receptor, Epidermal Growth Factor - metabolism | Zinc Compounds - pharmacology | Amino Acid Chloromethyl Ketones - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Benzothiazoles - pharmacology | Chlorides - pharmacology | Down-Regulation | RNA, Messenger - genetics | Rats | Tyrphostins - pharmacology | Cardiotonic Agents - pharmacology | Leupeptins - pharmacology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Thiones - pharmacology | Quinazolines - pharmacology | Organometallic Compounds - pharmacology | Proteins | Membrane lipids | Inositol | RNA | Antifungal agents | Permeability | Antibacterial agents | Phosphotransferases | Tyrosine | Cell death
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9108 - 9123
Here, we describe the most promising small synthetic organic compounds that act as potent Sortase A inhibitors and cater the potential to be developed as... 
LISTERIA-MONOCYTOGENES | SRTA GENE | CHEMISTRY, MEDICINAL | CELL-WALL | STREPTOCOCCUS-PNEUMONIAE | SORTING SIGNAL | STAPHYLOCOCCUS-AUREUS SORTASE | SURFACE-PROTEINS | IMIDAZOLIUM ION-PAIR | A INHIBITORS | PROTEIN ANCHORING TRANSPEPTIDASE | Aminoacyltransferases - antagonists & inhibitors | Cysteine Endopeptidases - chemistry | Small Molecule Libraries - pharmacology | Staphylococcus aureus - enzymology | Nitriles - pharmacology | Benzoates - chemistry | Humans | Bacterial Proteins - chemistry | Carbolines - chemistry | Cysteine Endopeptidases - metabolism | Rhodanine - analogs & derivatives | Rhodanine - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Staphylococcal Infections - microbiology | Bacterial Adhesion - drug effects | Adamantane - analogs & derivatives | Aminoacyltransferases - chemistry | Bacterial Proteins - antagonists & inhibitors | Adamantane - pharmacology | Staphylococcal Infections - drug therapy | Thiones - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Staphylococcus aureus - pathogenicity | Small Molecule Libraries - chemistry | Animals | Nitriles - chemistry | Benzoates - pharmacology | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Protein Conformation | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Thiazoles - pharmacology | Thiones - pharmacology | Staphylococcus aureus - drug effects | Carbolines - pharmacology
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2007, Volume 9, Issue 3, pp. 299 - 309
Non-muscle myosin II has diverse functions in cell contractility, cytokinesis and locomotion, but the specific contributions of its different isoforms have yet... 
ORGANIZATION | ADHESION | TRANSLOCATION | MIGRATING CELLS | CONTRACTILITY | CYTOSKELETON | RAC | DYNAMICS | MITOTIC KINESIN EG5 | INHIBITORS | CELL BIOLOGY | Nonmuscle Myosin Type IIA - antagonists & inhibitors | Embryonic Stem Cells - metabolism | RNA, Small Interfering - genetics | Embryonic Stem Cells - cytology | Humans | Nocodazole - pharmacology | Cercopithecus aethiops | Cell Movement - physiology | Heterocyclic Compounds, 4 or More Rings - pharmacology | Microtubules - metabolism | Nonmuscle Myosin Type IIB - antagonists & inhibitors | Transfection | Nonmuscle Myosin Type IIA - physiology | Guanine Nucleotide Exchange Factors - metabolism | Microtubules - drug effects | Nonmuscle Myosin Type IIA - genetics | Kinesin - genetics | Aminoquinolines - pharmacology | Kinesin - antagonists & inhibitors | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | Nonmuscle Myosin Type IIB - physiology | Fibroblasts - metabolism | Guanine Nucleotide Exchange Factors - genetics | Nonmuscle Myosin Type IIB - genetics | Enzyme Inhibitors - pharmacology | Pyrimidines - pharmacology | Actomyosin - metabolism | Kinesin - metabolism | Naphthalenes - pharmacology | Azepines - pharmacology | Cell Movement - drug effects | Animals | Embryonic Stem Cells - drug effects | Cell Adhesion - physiology | Fibroblasts - drug effects | rac1 GTP-Binding Protein - antagonists & inhibitors | Fibroblasts - cytology | Mice | Vinblastine - pharmacology | Thiones - pharmacology | COS Cells | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Evaluation | Motility | Microtubules | Myosin | Physiological aspects | Genetic aspects | Properties | Health aspects | Cells
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 2/2007, Volume 59, Issue 2, pp. 157 - 164
The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs... 
Biomedicine | Chemosensitivity | Oncology | Cancer Research | Confocal microscopy | Human glioblastoma cells | Pharmacology/Toxicology | Kinesin inhibitors | Monastrol analogues | monastrol analogues | PROTEIN | P-GLYCOPROTEIN | PACLITAXEL | kinesin inhibitors | POTENT | ONCOLOGY | confocal microscopy | IN-VIVO | BIOLOGICAL EVALUATION | human glioblastoma cells | PHARMACOLOGY & PHARMACY | chemosensitivity | MULTIDRUG-RESISTANCE | BRAIN | Fluoresceins - pharmacology | Cysteine - analogs & derivatives | Flow Cytometry - methods | Paclitaxel - pharmacology | Tubulin Modulators - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Tubulin - metabolism | Spindle Apparatus - metabolism | Time Factors | Cysteine - pharmacology | Rotenone - pharmacology | Glioblastoma - metabolism | Molecular Structure | Kinesin - antagonists & inhibitors | Quinazolines - chemistry | Insecticides - pharmacology | Cell Survival - drug effects | Tetrahydroisoquinolines - pharmacology | Thiones - chemistry | Pyrimidines - pharmacology | Kinesin - metabolism | Acridines - pharmacology | Glioblastoma - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Spindle Apparatus - drug effects | Vinblastine - pharmacology | Thiones - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Quinazolines - pharmacology | Brain tumors
Journal Article
Journal of Biochemical and Molecular Toxicology, ISSN 1095-6670, 02/2018, Volume 32, Issue 2, p. e22019
The conversion reactions of pyrimidine-thiones with nucleophilic reagent were studied during this scientific research. For this purpose, new compounds were... 
carbonic anhydrase | acetylcholinesterase | enzyme inhibition | pyrimidine-thiones | antioxidant activity | ANTIRADICAL ACTIVITIES | ISOENZYMES I | ENZYME-ACTIVITY | ANALGESIC ACTIVITIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHENETHYL ESTER CAPE | ERYTHROCYTES IN-VITRO | STRUCTURE-ACTIVITY INSIGHT | LYOPHILIZED AQUEOUS EXTRACT | CHIONANTHUS-VIRGINICUS L | CAFFEIC ACID | TOXICOLOGY | Antioxidants - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Pyrimidines - chemical synthesis | Acetazolamide - chemistry | Humans | Cholinesterase Inhibitors - chemistry | Carbonic Anhydrases - isolation & purification | Cholinesterase Inhibitors - chemical synthesis | Carbonic Anhydrases - chemistry | Iron Chelating Agents - chemical synthesis | Iron Chelating Agents - chemistry | Pyrimidines - chemistry | Carbonic Anhydrases - metabolism | Isoenzymes - isolation & purification | Isoenzymes - metabolism | Drug Design | Molecular Structure | Acetazolamide - pharmacology | Thiones - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Thiones - chemical synthesis | Acetylcholinesterase - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Carbonic Anhydrase Inhibitors - pharmacology | Nootropic Agents - chemical synthesis | Pyrimidines - pharmacology | Nootropic Agents - chemistry | Cholinesterase Inhibitors - pharmacology | Iron Chelating Agents - pharmacology | Kinetics | Thiones - pharmacology | Transition Temperature | Acetylcholinesterase - metabolism | Isoenzymes - antagonists & inhibitors | Nootropic Agents - pharmacology | Antioxidants | Pyrimidines | Chemical tests and reagents | Analysis | Investigations | Butane | Carbonic anhydrase | Isoforms | Acetazolamide | Chelation | Butanol | Inhibition | Derivatives | Acetylcholinesterase | Chemical synthesis | Conversion | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 2013, Volume 126, Issue 17, pp. 3873 - 3883
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2003, Volume 161, Issue 2, pp. 281 - 294
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small... 
Mitosis | Kinetochores | Chromatids | Microtubules | HeLa cells | Cellular immunity | Chromosomes | Anaphase | Cells | Mitotic spindle apparatus | Chemical biology | Spindle assembly checkpoint | Chromosome segregation | KINASE-ACTIVITY | MAD2 | BUDDING YEAST | spindle assembly checkpoint | TENSION | G/M TRANSITION | mitosis | HISTONE H3 PHOSPHORYLATION | MAMMALIAN-CELLS | CELL BIOLOGY | kinetochores | chromosome segregation | chemical biology | VERTEBRATE SOMATIC-CELLS | Cell Cycle Proteins - drug effects | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Paclitaxel - pharmacology | Humans | Nocodazole - pharmacology | Chromosome Segregation - drug effects | Mitosis - genetics | Aurora Kinase B | Microtubules - drug effects | Spindle Apparatus - genetics | Cell Cycle Proteins - genetics | Genes, cdc - physiology | Indoles - pharmacology | Kinetochores - enzymology | Protein-Serine-Threonine Kinases - metabolism | Aneugens - pharmacology | Eukaryotic Cells - enzymology | Polyploidy | Protein Kinases - drug effects | Separase | Protein-Serine-Threonine Kinases - genetics | Genes, cdc - drug effects | Aurora Kinases | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Anaphase - drug effects | Phenotype | Anaphase - genetics | Animals | Eukaryotic Cells - drug effects | Mitosis - drug effects | Microtubules - genetics | Microtubules - enzymology | Protein-Serine-Threonine Kinases - drug effects | Eukaryotic Cells - cytology | Kinetochores - drug effects | Spindle Apparatus - drug effects | HeLa Cells | Thiones - pharmacology | Endopeptidases | Chromosome Segregation - genetics | Spindle Apparatus - enzymology | Research | mitosis; chromosome segregation; kinetochores; spindle assembly checkpoint; chemical biology
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2001, Volume 134, Issue 5, pp. 1055 - 1065
Although accumulating studies have identified IκB kinase (IKK) to be essential for controlling NF‐κB activity in response to several cytokines, the upstream... 
macrophages | CaMK | NF‐κB | P2Y receptor | IKK | PKC | p38 MAPK | ERK | NF-κB | Macrophages | TRANSCRIPTIONAL ACTIVITY | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | J774 MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | P65 SUBUNIT | NF-kappa B | PATHWAY | GENE-EXPRESSION | T-CELL ACTIVATION | PHARMACOLOGY & PHARMACY | Transcription Factor RelA | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Macrophages, Peritoneal - cytology | Time Factors | Protein Kinase C - metabolism | Bridged-Ring Compounds - pharmacology | Indoles - pharmacology | Flavonoids - pharmacology | Phosphorylation - drug effects | Macrophages, Peritoneal - drug effects | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Uridine Triphosphate - pharmacology | Enzyme Inhibitors - pharmacology | Receptors, Purinergic P2 - physiology | Imidazoles - pharmacology | Protein Kinase C - antagonists & inhibitors | Macrophages - cytology | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Enzyme Activation - drug effects | I-kappa B Kinase | Sulfonamides - pharmacology | Macrophages - enzymology | Animals | Lipopolysaccharides - pharmacology | Protein-Serine-Threonine Kinases - drug effects | Thapsigargin - pharmacology | Macrophages - drug effects | Pyridines - pharmacology | Thiones - pharmacology | Macrophages, Peritoneal - metabolism | Benzylamines - pharmacology | Mitogen-Activated Protein Kinases - drug effects | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - drug effects | Papers
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2006, Volume 14, Issue 24, pp. 8582 - 8589
4-Aryl-3,4-dihydropyrimidin-2(1 )-thiones were synthesized by Lewis acid-catalyzed Biginelli condensation (Methods B and C). Dihydropyrimidin-2-thiones were... 
Ferric chloride | Boric acid | Dihydropyrimidin-2-thiones (DHPM-2-thiones) | Biginelli reaction | Calcium channel blocker activity | boric acid | ANTIHYPERTENSIVE AGENTS | CHEMISTRY, MEDICINAL | BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS | SOLVENT-FREE CONDITIONS | ONE-POT SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CHROMATOGRAPHIC RESOLUTION | calcium channel blocker activity | ADRENOCEPTOR-SELECTIVE ANTAGONISTS | IMPROVED PROTOCOL CONDITIONS | CONDENSATION REACTION | ferric chloride | dihydropyrimidin-2-thiones (DHPM-2-thiones) | ACID-ESTERS | PHARMACOLOGICAL-PROPERTIES | Calcium Channel Blockers - chemical synthesis | Dihydropyridines - chemistry | Vasodilator Agents - pharmacology | Chlorides - pharmacology | Thiones - chemistry | Rats | Male | Thiones - chemical synthesis | Calcium Channel Blockers - pharmacology | Parasympatholytics - pharmacology | Barium Compounds - pharmacology | Dihydropyridines - chemical synthesis | Ileum - drug effects | Animals | Calcium Channels - chemistry | Potassium Chloride - pharmacology | Calcium Channel Blockers - chemistry | Dihydropyridines - pharmacology | Vasodilator Agents - chemical synthesis | Female | Vasodilator Agents - chemistry | Aorta, Thoracic - drug effects | Thiones - pharmacology | Iron salts | Universities and colleges | Condensation | Calcium channel blockers
Journal Article