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The Journal of Cell Biology, ISSN 0021-9525, 3/2004, Volume 164, Issue 5, pp. 769 - 779
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases.... 
EGF receptor | Growth factor signaling | EGF receptor ligands | ADAMs | Ectodomain shedding | CELLS | ectodomain shedding | HB-EGF | TACE | PROTEIN-COUPLED RECEPTORS | ALPHA-CONVERTING-ENZYME | growth factor signaling | MICE LACKING | FAMILY | CELL BIOLOGY | EPIDERMAL-GROWTH-FACTOR | TGF-ALPHA | METALLOPROTEASE-DISINTEGRIN | ADAM17 Protein | Metalloendopeptidases - genetics | Phenylalanine - analogs & derivatives | Glycoproteins - metabolism | Metalloendopeptidases - metabolism | Thiophenes - metabolism | Epiregulin | Amphiregulin | Disintegrins - genetics | ADAM12 Protein | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | EGF Family of Proteins | Embryo, Mammalian - anatomy & histology | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Muscle Proteins - metabolism | Membrane Proteins - metabolism | Transforming Growth Factor alpha - metabolism | Fibroblasts - metabolism | Tetradecanoylphorbol Acetate - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Phenylalanine - metabolism | Disintegrins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Epidermal Growth Factor - metabolism | Genotype | Protease Inhibitors - metabolism | ADAM Proteins | Mice, Knockout | Muscle Proteins - genetics | Heparin-binding EGF-like Growth Factor | Animals | Endopeptidases - genetics | Betacellulin | Ligands | Fibroblasts - cytology | Mice | Cytology | Research | Proteins | Enzymes | Cellular biology | Rodents | Index Medicus | EGF receptor; EGF receptor ligands; ADAMs; ectodomain shedding; growth factor signaling
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e87548 - e87548
Background: Inhibition of the transporter-mediated hepatobiliary elimination of bile salts is a putative mechanism for liver toxicity observed with some... 
BILE-ACID TRANSPORT | IN-VITRO | RAT HEPATOCYTES | PULMONARY ARTERIAL-HYPERTENSION | SALT EXPORT PUMP | BILIARY-EXCRETION | MULTIDISCIPLINARY SCIENCES | HEPATIC-UPTAKE | KNOCKOUT MICE | FAMILIAL INTRAHEPATIC CHOLESTASIS | P-GLYCOPROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Bile - metabolism | Male | Hepatocytes - metabolism | Pyridazines - pharmacology | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Liver - drug effects | Organic Anion Transporters, Sodium-Independent - metabolism | ATP-Binding Cassette Transporters - metabolism | Adult | Female | Membrane Transport Proteins - metabolism | Endothelin Receptor Antagonists | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Taurocholic Acid - pharmacology | Liver - metabolism | Receptors, Endothelin - metabolism | Thiophenes - pharmacology | Bile Acids and Salts - metabolism | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Symporters - metabolism | Isoxazoles - pharmacology | Phenylpropionates - pharmacology | Bile - drug effects | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Drug resistance in microorganisms | Endothelin | Bile acids | Research | Analysis | Salts | Transplants & implants | Toxicity | Pathogenesis | Liver | Gallbladder diseases | Accumulation | Bioaccumulation | Rodents | Inhibition | Protein transport | P-Glycoprotein | Efflux | Polypeptides | Mortality | Multidrug resistance | Glycoprotein | Substrate inhibition | Breast cancer | Substrates | Bile salts | Organic anion transporting polypeptide | Molecular modelling | Acids | Sodium | Hepatocytes | Transporter | Cancer | Bile | Index Medicus
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 06/2010, Volume 88, Issue 6, pp. 682 - 691
To evaluate potential mechanisms of clinical hepatotoxicity, 4 endothelin receptor antagonists (ERAs) were examined for substrate activity and inhibition of... 
Hepatic transport | BSEP | Endothelin | Transporter substrate | Pulmonary artery hypertension | Endothelin receptor antagonists | OATP | PHARMACOKINETIC INTERACTION | PHYSIOLOGY | pulmonary artery hypertension | RAT HEPATOCYTES | PULMONARY ARTERIAL-HYPERTENSION | SALT EXPORT PUMP | transporter substrate | HEPATIC-UPTAKE | endothelin receptor antagonists | CLINICAL-PRACTICE GUIDELINES | endothelin | CYCLOSPORINE-A | THERAPY | BILIARY-EXCRETION | KETOCONAZOLE | PHARMACOLOGY & PHARMACY | hepatic transport | Antihypertensive Agents - pharmacology | Estradiol - analogs & derivatives | Taurocholic Acid - metabolism | Humans | Middle Aged | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | Thiophenes - metabolism | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Pyridazines - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Young Adult | Phenylpropionates - metabolism | Symporters - antagonists & inhibitors | ATP-Binding Cassette Transporters - metabolism | Adult | Female | Pyridazines - metabolism | Biological Transport - drug effects | Cell Culture Techniques | Endothelin Receptor Antagonists | Hepatocytes - drug effects | Estradiol - metabolism | Organic Anion Transporters - antagonists & inhibitors | Isoxazoles - metabolism | Organic Anion Transporters, Sodium-Dependent - antagonists & inhibitors | Cells, Cultured | Thiophenes - pharmacology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Symporters - metabolism | Isoxazoles - pharmacology | Phenylpropionates - pharmacology | ATP Binding Cassette Subfamily B Member 11 | Enkephalin, D-Penicillamine (2,5)- - metabolism | Adolescent | Sulfonamides - metabolism | Aged | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Cell receptors | Genetic aspects | Research | Diagnosis | Properties | Health aspects | Liver cells | Pulmonary hypertension | Studies | Drugs | Pathology | Medical treatment | Liver | Index Medicus
Journal Article
Clinical & Experimental Metastasis, ISSN 0262-0898, 12/2008, Volume 25, Issue 8, pp. 843 - 854
NSCLC cells with a mesenchymal phenotype have shown a marked reduction in sensitivity to EGFR inhibitors, though the molecular rationale has remained obscure.... 
Biomedicine | Hematology | NSCLC | PDGFR | Oncology | Cancer Research | Epithelial mesenchymal transition | TGF beta | Surgical Oncology | FGFR | Biomedicine general | EGFR | CARCINOMA-CELLS | TUMOR PROGRESSION | DOWN-REGULATION | E-CADHERIN | ANTITUMOR-ACTIVITY | GEFITINIB RESISTANCE | TRANSITION | GROWTH-FACTOR RECEPTOR | IN-VITRO | ONCOLOGY | NEXT-GENERATION | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Receptor, ErbB-3 - metabolism | Receptor, ErbB-2 - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Drug Resistance, Neoplasm | Immunoblotting | Mesoderm - cytology | RNA, Messenger - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Chromatography, Liquid | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Respiratory Mucosa - cytology | Carcinoma, Non-Small-Cell Lung - metabolism | Receptors, Platelet-Derived Growth Factor - genetics | Thiophenes - pharmacology | Pyrimidines - pharmacology | Receptor, ErbB-3 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Signal Transduction - drug effects | Receptors, Platelet-Derived Growth Factor - metabolism | Benzimidazoles - pharmacology | Mitogen-Activated Protein Kinases - genetics | Quinazolines - pharmacology | Erlotinib Hydrochloride | Mitogen-Activated Protein Kinase Kinases - genetics | Receptor, ErbB-2 - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-akt - genetics | Quinolines - pharmacology | Protein-Tyrosine Kinases - genetics | Receptor, Epidermal Growth Factor - metabolism | Spectrometry, Mass, Electrospray Ionization | Receptors, Fibroblast Growth Factor - genetics | Tumor Cells, Cultured | Carcinoma, Non-Small-Cell Lung - pathology | RNA, Messenger - genetics | Receptors, Fibroblast Growth Factor - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Mesoderm - metabolism | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Respiratory Mucosa - metabolism | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinases - metabolism | Tyrosine | Transforming growth factors | Lung cancer, Non-small cell | Phosphotransferases | Analysis | Stem cells | Index Medicus
Journal Article
FEBS Letters, ISSN 0014-5793, 2005, Volume 579, Issue 14, pp. 3029 - 3036
Understanding the molecular pathway(s) of antioxidant gene regulation is of crucial importance for developing antioxidant-inducing agents for the intervention... 
Reactive oxygen species | Reactive nitrogen species | Cardiac cell | Cytotoxicity | Antioxidant | Nrf2 signaling | 3 H-1,2-Dithiole-3-thione | 1,2-dithiole-3-thione | D3T | glutathione | CDNB | MTT | FBS | 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide | glutathione reductase | GSH | xanthine oxidase | polymerase chain reaction | PBS | NQO1 | 1-chloro-2,4-dinitrobenzene | SOD | GST | transferase | GPx | fetal bovine serum | superoxide dismutase | phosphate buffered saline | NAD(P)H:quinone oxidoreductase-1 | 2,6-dichloroindophenol | DCIP | PCR | glutathione peroxidase | 3H-1,2-Dithiole-3-thione | 3H-1 | antioxidant | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | OXIDATIVE STRESS | cardiac cell | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | GENE-REGULATION | nrf2 signaling | GLUTATHIONE S-TRANSFERASES | INDUCTION | FREE-RADICALS | CELL BIOLOGY | BIOPHYSICS | 2-dithiole-3-thione | reactive oxygen species | CARDIOVASCULAR-DISEASE | reactive nitrogen species | INDUCED CYTOTOXICITY | SUPEROXIDE-DISMUTASE | cytotoxicity | Fibroblasts - enzymology | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Glutathione Reductase - metabolism | Antioxidants - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | RNA, Messenger - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Myocardium - metabolism | Trans-Activators - genetics | Xanthine - pharmacology | Superoxide Dismutase - metabolism | Fibroblasts - metabolism | Glutathione Peroxidase - metabolism | Signal Transduction | Reactive Nitrogen Species - metabolism | RNA, Messenger - genetics | Cells, Cultured | Enzyme Induction | Thiophenes - pharmacology | DNA-Binding Proteins - genetics | Mice, Knockout | Myocardium - cytology | Catalase - metabolism | Myocardium - enzymology | Animals | Trans-Activators - deficiency | Heart - drug effects | NAD(P)H Dehydrogenase (Quinone) - metabolism | NF-E2-Related Factor 2 | Trans-Activators - metabolism | Mice | Thiones - pharmacology | Antioxidants | Superoxide dismutase | Superoxide | Glutathione transferase | Quinone | Glutathione | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e65403 - e65403
Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor in many human malignancies. Signal strength, target gene... 
ACTIVATED PROTEIN-KINASE | PATHWAY | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PHENOTYPE | DEGRADATION | MECHANISMS | COOPERATION | CANCER | SONIC-HEDGEHOG | Interleukin-8 - genetics | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation | Membrane Glycoproteins - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Hedgehog Proteins - metabolism | Gene Expression Profiling | Vascular Endothelial Growth Factor A - metabolism | Hedgehog Proteins - agonists | Vascular Endothelial Growth Factor A - genetics | Dermis - drug effects | Matrix Metalloproteinase 7 - metabolism | Medulloblastoma - pathology | Biomarkers, Tumor - metabolism | Cerebellar Neoplasms - pathology | Interleukin-8 - metabolism | Patched Receptors | Phosphorylation - drug effects | Real-Time Polymerase Chain Reaction | Cerebellar Neoplasms - metabolism | Fibroblasts - metabolism | Cerebellar Neoplasms - drug therapy | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Medulloblastoma - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Synergism | Fibroblasts - drug effects | Biomarkers, Tumor - genetics | Fibroblasts - cytology | Zinc Finger Protein GLI1 | Patched-1 Receptor | Receptors, Cell Surface - genetics | Receptor, Epidermal Growth Factor - metabolism | Hedgehog Proteins - genetics | Cyclohexylamines - pharmacology | HEK293 Cells | Veratrum Alkaloids - pharmacology | Dermis - cytology | Dermis - metabolism | Enzyme-Linked Immunosorbent Assay | RNA, Messenger - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Matrix Metalloproteinase 7 - genetics | Carrier Proteins - metabolism | Protein Array Analysis | Medulloblastoma - drug therapy | Genetic aspects | Epidermal growth factor | Medulloblastoma | Pancreatic cancer | Genes | Skin cancer | Regulators | Transcription factors | Transcription | Brain cancer | Genomics | Crosstalk | Signal strength | AKT protein | Genomes | Insulin-like growth factors | Amphiregulin | Kinases | Synergism | Proteins | Synergistic effects | Signal transduction | Immunology | Pancreatic carcinoma | Etiology | Rodents | Genetics | Physiology | Trends | Interleukin 8 | Medical research | Gli1 protein | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Gene expression | Insulin | Signaling | Hypotheses | Hedgehog protein | Aberration | Molecular biology | Human behavior | Cancer | Matrilysin | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7396, pp. 62 - 68
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2011, Volume 31, Issue 5, pp. 1919 - 1933
During early telencephalic development, the major portion of the ventral telencephalic (subpallial) region becomes subdivided into three regions, the lateral... 
CORTICAL INTERNEURONS | MAMMALIAN BASAL FOREBRAIN | SONIC HEDGEHOG | STRIATAL PROJECTION NEURONS | GROWTH-FACTOR FAMILY | MOUSE FOREBRAIN | RECEPTOR SPECIFICITY | NEUROSCIENCES | CEREBRAL-CORTEX | MEDIAL GANGLIONIC EMINENCE | CAUDAL MIGRATORY STREAM | Immunohistochemistry | Embryonic Stem Cells - metabolism | Fibroblast Growth Factors - genetics | Hedgehog Proteins - metabolism | Fibroblast Growth Factor 8 - metabolism | Fibroblast Growth Factors - metabolism | Flow Cytometry | Hedgehog Proteins - genetics | Time Factors | Cyclohexylamines - pharmacology | Forkhead Transcription Factors - metabolism | Telencephalon - growth & development | Telencephalon - drug effects | Tumor Suppressor Proteins - genetics | Neurons - physiology | Polymerase Chain Reaction | Neurons - metabolism | Fibroblast Growth Factor 8 - genetics | Nuclear Proteins - genetics | Cell Differentiation - physiology | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Telencephalon - metabolism | Telencephalon - cytology | Cells, Cultured | Repressor Proteins - genetics | Thiophenes - pharmacology | Nuclear Proteins - metabolism | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Embryonic Stem Cells - physiology | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Embryonic Stem Cells - drug effects | Signal Transduction - drug effects | Cell Differentiation - drug effects | Signal Transduction - physiology | Mice | Index Medicus
Journal Article
STEM CELLS, ISSN 1066-5099, 11/2012, Volume 30, Issue 11, pp. 2400 - 2411
The floor plate is one of the major organizers of the developing nervous system through its secretion of sonic hedgehog (Shh). Although the floor plate is... 
Human embryonic stem cells | Sonic hedgehog | Floor plate | GLI | FOXA2 | PROGENITORS | HUMAN ES | MOUSE | INDUCTION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | DOPAMINE NEURONS | MAINTENANCE | NEUROECTODERM | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DIFFERENTIATION | HEMATOLOGY | MODULATION | Thyroid Nuclear Factor 1 | Receptors, G-Protein-Coupled - metabolism | Homeodomain Proteins - metabolism | Humans | Activins - antagonists & inhibitors | Activins - metabolism | Glycogen Synthase Kinase 3 beta | Hedgehog Proteins - physiology | Nodal Protein - metabolism | Receptors, G-Protein-Coupled - agonists | Neurogenesis | SOXB1 Transcription Factors - metabolism | Cyclohexylamines - pharmacology | Nodal Protein - antagonists & inhibitors | Dopaminergic Neurons - metabolism | Smoothened Receptor | Body Patterning | Dioxoles - pharmacology | Antigens, Differentiation - metabolism | Benzamides - pharmacology | Neural Tube - cytology | Repressor Proteins - metabolism | Hepatocyte Nuclear Factor 3-beta - metabolism | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Activins - physiology | Cells, Cultured | Thiophenes - pharmacology | Embryonic Stem Cells - enzymology | Nuclear Proteins - metabolism | PAX6 Transcription Factor | Pyrimidines - pharmacology | Glycogen Synthase Kinase 3 - metabolism | Embryonic Stem Cells - physiology | Transcription Factors - metabolism | Cell Lineage | Eye Proteins - metabolism | Neuroepithelial Cells - physiology | Neuroepithelial Cells - metabolism | Pyridines - pharmacology | Nodal Protein - physiology | Paired Box Transcription Factors - metabolism | Index Medicus | Embryonic Stem Cells | Induced Pluripotent Stem Cells
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 01/2010, Volume 30, Issue 2, pp. 470 - 480
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
FORKHEAD TRANSCRIPTION FACTOR | OXIDATIVE STRESS | ATROPHY | JNK | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | P38 MAPK | EXTENDS LIFE-SPAN | SURVIVAL SIGNALS | AKT | UBIQUITIN LIGASES | CELL BIOLOGY | Humans | Muscle Cells - drug effects | Oxidative Stress - physiology | SKP Cullin F-Box Protein Ligases - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Forkhead Transcription Factors - drug effects | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Cell Nucleus - metabolism | Isoquinolines - pharmacology | MAP Kinase Kinase 4 - metabolism | Transfection | Forkhead Transcription Factors - metabolism | Phosphatidylinositol 3-Kinases - drug effects | Muscle Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase 4 - drug effects | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Cell Line | Muscular Atrophy - metabolism | Receptors, Cytoplasmic and Nuclear - drug effects | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Muscle Cells - metabolism | Morpholines - pharmacology | Thiophenes - pharmacology | Muscle Proteins - drug effects | Muscular Atrophy - genetics | MAP Kinase Kinase 3 - drug effects | SKP Cullin F-Box Protein Ligases - metabolism | Sulfonamides - pharmacology | Anthracenes - pharmacology | MAP Kinase Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - drug effects | Animals | Karyopherins - metabolism | Signal Transduction - drug effects | Karyopherins - drug effects | Signal Transduction - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Oxidative Stress - drug effects | Cell Nucleus - drug effects | Forkhead Box Protein O3 | Proto-Oncogene Proteins c-akt - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 12/2016, Volume 1861, Issue 12, pp. 1980 - 1992
Journal Article