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Clinical Pharmacokinetics, ISSN 0312-5963, 2008, Volume 47, Issue 3, pp. 203 - 216
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 09/2013, Volume 76, Issue 3, pp. 455 - 466
AimsThe anticoagulant rivaroxaban is an oral, direct Factor Xa inhibitor for the management of thromboembolic disorders. Metabolism and excretion involve... 
cytochrome | glycoprotein | rivaroxaban | drug interactions | healthy subjects | 450 | P-glycoprotein | Rivaroxaban | Healthy subjects | Cytochrome P450 | Drug interactions | BAY-59-7939 | SAFETY | PREVENTION | PHARMACODYNAMICS | cytochrome P450 | PROTEASE INHIBITORS | IN-VITRO | FACTOR-XA INHIBITOR | ERYTHROMYCIN | PHARMACOLOGY & PHARMACY | LIVER-MICROSOMES | Anticoagulants - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Erythromycin - pharmacology | Ketoconazole - administration & dosage | Humans | Middle Aged | Cytochrome P-450 Enzyme System - metabolism | Midazolam - administration & dosage | Substrate Specificity | Metabolic Clearance Rate | Thiophenes - administration & dosage | Ketoconazole - pharmacology | Enzyme Inhibitors - administration & dosage | Young Adult | Drug Interactions | Enzyme Inhibitors - pharmacokinetics | Clarithromycin - pharmacokinetics | Clarithromycin - administration & dosage | Adult | Morpholines - administration & dosage | Enzyme Inhibitors - pharmacology | Ketoconazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP3A - administration & dosage | Erythromycin - administration & dosage | ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors | ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism | Thiophenes - pharmacokinetics | Erythromycin - pharmacokinetics | Cytochrome P-450 CYP3A - metabolism | Adolescent | Anticoagulants - pharmacokinetics | Morpholines - pharmacokinetics | Clarithromycin - pharmacology | Midazolam - pharmacology | Ketoconazole | Protease inhibitors | Fluconazole | Proteases | Cytochrome P-450 | Dosage and administration | Anticoagulants (Medicine) | Erythromycin | Thromboembolism | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 05/2009, Volume 119, Issue 19, pp. 2553 - 2560
Background-Both clopidogrel and prasugrel require biotransformation to active metabolites by cytochrome P450 (CYP) enzymes. Among persons treated with... 
Drugs | Cardiovascular diseases | Genetics | 2007 FOCUSED UPDATE | CARDIAC & CARDIOVASCULAR SYSTEMS | drugs | STENT THROMBOSIS | OF-FUNCTION POLYMORPHISM | cardiovascular diseases | PERCUTANEOUS CORONARY INTERVENTION | genetics | PLATELET INHIBITION | ASSOCIATION TASK-FORCE | PERIPHERAL VASCULAR DISEASE | ELEVATION MYOCARDIAL-INFARCTION | THIENOPYRIDINE ANTIPLATELET AGENT | CLOPIDOGREL RESPONSIVENESS | ACTIVE METABOLITE | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Myocardial Infarction - mortality | Cardiovascular Diseases - drug therapy | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Biotransformation - genetics | Cytochrome P-450 Enzyme System - metabolism | Male | Young Adult | Receptors, Purinergic P2Y12 | Cardiovascular Diseases - mortality | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Microsomes, Liver - enzymology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Piperazines - pharmacokinetics | Stroke - mortality | Platelet Aggregation Inhibitors - therapeutic use | Stroke - prevention & control | Purinergic P2 Receptor Antagonists | Thiophenes - pharmacology | Genotype | Treatment Outcome | Piperazines - therapeutic use | Piperazines - pharmacology | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | Thiophenes - pharmacokinetics | Prodrugs - pharmacokinetics | Cytochrome P-450 CYP2C19 | Cytochrome P-450 Enzyme System - genetics | Aged | Myocardial Infarction - prevention & control | Prodrugs - therapeutic use | Prodrugs - pharmacology | Care and treatment | Demographic aspects | Patient outcomes | Cytochrome P-450 | Genetic aspects | Research | Genetic polymorphisms | Heart attack | Index Medicus | Abridged Index Medicus
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 08/2013, Volume 62, Issue 6, pp. 505 - 512
Journal Article
British Journal of Surgery, ISSN 0007-1323, 06/2014, Volume 101, Issue 7, pp. 742 - 749
Journal Article
Journal Article
Journal Article