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Environmental Toxicology and Chemistry, ISSN 0730-7268, 12/2014, Volume 33, Issue 12, pp. 2767 - 2774
In the present study, effect-directed analysis was used to identify teratogenic compounds in porewater collected from a Superfund site along the Elizabeth... 
Zebrafish | Porewater | Polycyclic aromatic hydrocarbons (PAHs) | Elizabeth River | Effect‐directed analysis | Effect-directed analysis | CARDIAC TOXICITY | POLYCYCLIC AROMATIC-HYDROCARBONS | RECEPTOR AGONISTS | CONTAMINATED SEDIMENT | SUPERFUND SITE | IDENTIFICATION | KILLIFISH FUNDULUS-HETEROCLITUS | ENVIRONMENTAL SCIENCES | HETEROCYCLES | TOXICOLOGY | MEDAKA ORYZIAS-LATIPES | EMBRYOS | Polycyclic Aromatic Hydrocarbons - toxicity | Benz(a)Anthracenes - toxicity | Pyrenes - isolation & purification | Benz(a)Anthracenes - chemistry | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Fluorenes - toxicity | Benzo(a)pyrene - isolation & purification | Chromatography, High Pressure Liquid | Embryo, Nonmammalian - drug effects | Chromatography, Reverse-Phase | Water Pollutants, Chemical - isolation & purification | Receptors, Aryl Hydrocarbon - metabolism | Pyrenes - toxicity | Fluorenes - isolation & purification | Benzo(a)pyrene - toxicity | Benz(a)Anthracenes - isolation & purification | Water Pollutants, Chemical - chemistry | Benzo(a)pyrene - chemistry | Cardiovascular System - drug effects | Cytochrome P-450 CYP1A1 - metabolism | Zebrafish - growth & development | Receptors, Aryl Hydrocarbon - agonists | Animals | Fluorenes - chemistry | Polycyclic Aromatic Hydrocarbons - metabolism | Pyrenes - chemistry | Water Pollutants, Chemical - toxicity | Polycyclic Aromatic Hydrocarbons - chemistry | Rivers - chemistry | Embryonic Development - drug effects | Fluorenes - metabolism | Virginia | Hazardous waste sites | Thiophene | Benzopyrene | Analysis | High performance liquid chromatography | Estuaries | Rivers | Polycyclic aromatic hydrocarbons | Toxicity | Chromatography | Cytochrome | Superfund | CYP1A protein | Colloid chemistry | Benzo(a)pyrene | Synergism | Teratogenesis | Aromatic compounds | Pore water | Pollution abatement | Pretreatment | Dibenzothiophene | Cytochromes P450 | Fractionation | Cytochrome P450 | Creosote | Liquid chromatography | Embryos | Pyrene | Organic chemistry | Contaminants | Teratogenicity | Acute toxicity | Fluoranthene | Index Medicus | Toxicology | Inhibitors | Toxic
Journal Article
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 10/2012, Volume 64, Issue 1, pp. 95 - 103
► Sitaxentan preclinical safety was assessed in mice, rats, and dogs. ► Coagulopathy, increased serum alkaline phosphatase, hepatic hypertrophy and decreased... 
Carcinogenicity tests | Testis | Toxicology | Drug evaluation | Toxicity | Risk assessment | Drug-induced liver injury | Preclinical | Bile salt export pump | Endothelin receptor | MEDICINE, LEGAL | SALT EXPORT PUMP | INJURY | LIVER TOXICITY | THERAPY | SITAXSENTAN | PHARMACOLOGY & PHARMACY | BOSENTAN | Hypertrophy - chemically induced | Liver - pathology | Species Specificity | Chemical and Drug Induced Liver Injury, Chronic - metabolism | Thiophenes - toxicity | Male | Antihypertensive Agents - classification | Chemical and Drug Induced Liver Injury, Chronic - etiology | Hypertrophy - pathology | Liver - physiopathology | Carcinogens - toxicity | Dose-Response Relationship, Drug | Carcinogens - classification | Antihypertensive Agents - toxicity | Thiophenes - classification | Liver - drug effects | Female | Carcinogens - pharmacokinetics | Hypertension, Pulmonary - drug therapy | Drug Evaluation, Preclinical | Alkaline Phosphatase - blood | Endothelin Receptor Antagonists | Isoxazoles - pharmacokinetics | Liver Function Tests | Isoxazoles - classification | Risk Assessment | Erythrocyte Indices - drug effects | Rats | Antihypertensive Agents - pharmacokinetics | Mice, Inbred Strains | Chemical and Drug Induced Liver Injury, Chronic - pathology | Rats, Sprague-Dawley | Carcinogenicity Tests | Thiophenes - pharmacokinetics | Organ Size - drug effects | Animals | Blood Coagulation - drug effects | Dogs | Mice | Isoxazoles - toxicity | Medical examination | Endothelin | Phosphatases | Hemoglobin | Aspartate | Thrombin | Blood | Pulmonary hypertension | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 02/2014, Volume 724, Issue 1, pp. 31 - 42
Journal Article
Journal Article
Journal of Neural Transmission, ISSN 0300-9564, 6/2015, Volume 122, Issue 6, pp. 779 - 788
Nitrative stress is a key component of the pathogenic process in Parkinson’s disease (PD), but the relative roles of constitutive neuronal nitric oxide... 
n-NOS | Neurology | Neurosciences | i-NOS | Medicine & Public Health | Nitric oxide | Substantia nigra | Dopaminergic cells | Pharmacology/Toxicology | Psychiatry | Parkinson’s disease | Parkinson's disease | MPTP MODEL | TYROSINE-HYDROXYLASE | NITRIC-OXIDE SYNTHASE | SUBSTANTIA-NIGRA | NEUROSCIENCES | CLINICAL NEUROLOGY | DOPAMINERGIC NEURODEGENERATION | VENTRAL MESENCEPHALON | 7-NITROINDAZOLE | INDUCED NEUROTOXICITY | EXPRESSION | PARKINSONS-DISEASE | Microglia - metabolism | Tyrosine 3-Monooxygenase - metabolism | Rats, Wistar | Dopaminergic Neurons - pathology | Cell Count | Parkinson Disease - drug therapy | Glial Fibrillary Acidic Protein - metabolism | Tyrosine - analogs & derivatives | Picolines - toxicity | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Dopaminergic Neurons - drug effects | Mesencephalon - drug effects | Mesencephalon - pathology | Astrocytes - drug effects | Microglia - drug effects | Mesencephalon - enzymology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Dopaminergic Neurons - enzymology | Tyrosine - metabolism | Animals | Nitric Oxide Synthase Type I - metabolism | Parkinson Disease - enzymology | Amidines - pharmacology | Antibodies, Monoclonal - metabolism | Primary Cell Culture | Benzylamines - pharmacology | Astrocytes - metabolism | Nitric Oxide Synthase Type II - metabolism | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2015, Volume 352, Issue 2, pp. 281 - 290
Journal Article