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thioredoxin reductase (325) 325
thioredoxin-disulfide reductase - antagonists & inhibitors (277) 277
apoptosis (227) 227
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glutathione - metabolism (91) 91
selenium (90) 90
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reactive oxygen species (73) 73
chemistry, medicinal (71) 71
nf-kappa-b (71) 71
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thioredoxins - genetics (70) 70
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auranofin - pharmacology (68) 68
signal transduction (68) 68
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biophysics (55) 55
hydrogen-peroxide (55) 55
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thioredoxin reductase 1 - antagonists & inhibitors (54) 54
thioredoxin reductase 1 - metabolism (54) 54
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gene-expression (52) 52
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Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2011, Volume 50, Issue 6, pp. 689 - 699
Journal Article
Journal of biological inorganic chemistry, ISSN 0949-8257, 09/2015, Volume 20, Issue 6, pp. 1005 - 1020
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e50683
Mitochondria are considered major generators of cellular reactive oxygen species (ROS) which are implicated in the pathogenesis of neurodegenerative diseases... 
APOPTOSIS | SUPEROXIDE | INHIBITION | ANTIOXIDANT | MULTIDISCIPLINARY SCIENCES | ANIMAL-MODELS | HUMAN SUBSTANTIA-NIGRA | HYDROGEN-PEROXIDE | 6-HYDROXYDOPAMINE | PARKINSONS-DISEASE | METALLOPORPHYRINS | Mitochondria - enzymology | RNA, Small Interfering - genetics | Mesencephalon - cytology | Peroxiredoxins - metabolism | RNA, Messenger - metabolism | Dopaminergic Neurons - cytology | Gene Knockdown Techniques | Cell Respiration - genetics | Oxidopamine - pharmacology | Cell Death - genetics | Dopaminergic Neurons - metabolism | Cell Respiration - drug effects | Dopaminergic Neurons - drug effects | Lentivirus - genetics | Cell Death - drug effects | Energy Metabolism - genetics | Paraquat - pharmacology | Auranofin - pharmacology | Cell Line | RNA, Messenger - genetics | Enzyme Inhibitors - pharmacology | Oxidative Stress - genetics | Rats | Mitochondria - metabolism | Thioredoxin Reductase 2 - antagonists & inhibitors | Mitochondria - drug effects | Mitochondria - pathology | Thioredoxin Reductase 2 - genetics | Hydrogen Peroxide - metabolism | Drug Synergism | Thioredoxin Reductase 2 - metabolism | Animals | Thioredoxin Reductase 2 - deficiency | Oxidative Stress - drug effects | Energy Metabolism - drug effects | Nervous system diseases | Biochemistry | Hydrogen peroxide | Thioredoxin | Cell death | Peroxiredoxin | Brain | Oxidative stress | Cell culture | Neurosciences | Basal ganglia | Parkinson's disease | Pathogenesis | Kinases | Proteins | Antioxidants | Mitochondria | Toxicants | Neurodegeneration | Rodents | Penicillin | Aging | Inhibition | Movement disorders | Dopamine receptors | Cellular manufacture | Medical research | Dopamine | Incubation | Neurodegenerative diseases | Mortality | 6-Hydroxydopamine | Central nervous system diseases | Oxygen consumption | Cultures | Pharmacology | Steady state | Substrates | Neurological diseases | Paraquat | Electron transport | Apoptosis | Reductase | Oxygen
Journal Article
Placenta, ISSN 0143-4004, 2012, Volume 33, Issue 12, pp. 1012 - 1019
Abstract Oxidative stress is a key feature in the pathogenesis of pre-eclampsia and antioxidants have been proposed as a potential therapy in the treatment of... 
Internal Medicine | Obstetrics and Gynecology | Antioxidants | Oxidative stress | Reactive oxygen species | Trophoblast | Selenium | WOMEN | REPRODUCTIVE BIOLOGY | THIOREDOXIN | PREECLAMPSIA | DEVELOPMENTAL BIOLOGY | DEFICIENCY | OBSTETRICS & GYNECOLOGY | Oxidants - pharmacology | Oxidative Stress | Glutathione Peroxidase - antagonists & inhibitors | Humans | Protective Agents - metabolism | Protective Agents - chemistry | Protective Agents - therapeutic use | Selenomethionine - therapeutic use | Trophoblasts - drug effects | Pre-Eclampsia - prevention & control | Sodium Selenite - metabolism | Osmolar Concentration | Sodium Selenite - antagonists & inhibitors | Enzyme Induction - drug effects | Female | Auranofin - pharmacology | Cell Line | Glutathione Peroxidase - metabolism | Selenium - chemistry | Selenomethionine - antagonists & inhibitors | Selenomethionine - metabolism | Trophoblasts - metabolism | Enzyme Inhibitors - pharmacology | Thioredoxin Reductase 2 - antagonists & inhibitors | Thioredoxin Reductase 2 - genetics | Glutathione Peroxidase - genetics | Pregnancy | Selenium - therapeutic use | Thioredoxin Reductase 2 - metabolism | Selenium - metabolism | Thioredoxin Reductase 1 - antagonists & inhibitors | Thioredoxin Reductase 1 - genetics | Dietary Supplements | Sodium Selenite - therapeutic use | Thioredoxin Reductase 1 - metabolism
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2016, Volume 6, Issue 1, p. 23071
The mitochondrial thioredoxin system (NADPH, thioredoxin reductase, thioredoxin) is a major redox regulator. Here we have investigated the redox correlation... 
REDUCTASE INHIBITORS | PERMEABILITY TRANSITION PORE | OXIDATIVE STRESS | ANTICANCER AGENTS | MULTIDISCIPLINARY SCIENCES | ISOMERASE ACTIVITY | CARBENE COMPLEXES | PHOSPHATE CARRIER | HEART-MITOCHONDRIA | ADENINE-NUCLEOTIDE TRANSLOCASE | CELL-DEATH | Oxidants - pharmacology | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Rats, Wistar | Cyclosporine - pharmacology | Humans | Oxidants - metabolism | Cyclophilins - metabolism | Cyclophilins - antagonists & inhibitors | Peroxiredoxin III - chemistry | RNA Interference | Protein Binding - drug effects | Oxidation-Reduction - drug effects | Protein Domains | Thioredoxins - metabolism | Thioredoxins - chemistry | Mitochondria, Heart - genetics | Auranofin - pharmacology | Hydrogen Peroxide - pharmacology | Models, Molecular | Thioredoxin Reductase 2 - antagonists & inhibitors | Thioredoxin Reductase 2 - genetics | Blotting, Western | Hydrogen Peroxide - metabolism | Thioredoxin Reductase 2 - metabolism | Animals | Cell Line, Tumor | Peroxiredoxin III - metabolism | HeLa Cells | Cyclophilins - chemistry | Peroxiredoxin | Reactive oxygen species | Immunoprecipitation | Hydrogen peroxide | Arsenic | Arsenic trioxide | siRNA | Tumor cell lines | Cyclosporin A | Thioredoxin | Mitochondria | Molecular modelling | Thioredoxin 2 | Dinitrobenzene | 1-Chloro-2,4-dinitrobenzene | Rodents | Oxidation | NADP | Redox properties | Apoptosis | Reductase
Journal Article
Biochemistry, ISSN 0006-2960, 07/2009, Volume 48, Issue 26, pp. 6213 - 6223
Journal Article
Brain Pathology, ISSN 1015-6305, 05/2017, Volume 27, Issue 3, pp. 276 - 291
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 01/2010, Volume 298, Issue 1, pp. 194 - 201
The intracellular redox state is stringently maintained by thiol-based antioxidants to establish a balance for the physiological and pathophysiological roles... 
Oxidative stress | Endothelial function | Thioredoxin | Tetrahydrobiopterin | Nitric oxide | Glutathione | endothelial function | GLUTATHIONE-REDUCTASE | nitric oxide | tetrahydrobiopterin | SUPEROXIDE | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | thioredoxin | glutathione | NITRIC-OXIDE SYNTHASE | VASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | GENERATION | DYSFUNCTION | STRESS | oxidative stress | Disulfides - metabolism | Glutathione - metabolism | Glutathione Reductase - metabolism | Biopterin - analogs & derivatives | Glutathione Reductase - genetics | Biopterin - metabolism | Sulfhydryl Compounds - metabolism | Transfection | Cattle | Nitric Oxide Synthase Type III - metabolism | Oxidation-Reduction | RNA, Small Interfering - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Thioredoxin Reductase 2 - antagonists & inhibitors | Thioredoxin Reductase 2 - genetics | Hydrogen Peroxide - metabolism | Nitric Oxide Synthase Type III - antagonists & inhibitors | Thioredoxin Reductase 2 - metabolism | Animals | Proteins - metabolism | Endothelium, Vascular - metabolism | Electrochemistry | Thioredoxin Reductase 1 - antagonists & inhibitors | Thioredoxin Reductase 1 - genetics | Glutathione Reductase - antagonists & inhibitors | Thioredoxin Reductase 1 - metabolism | Blood circulation disorders | Care and treatment | Genetic aspects | Research | Health aspects
Journal Article
Journal Article