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PLoS Genetics, ISSN 1553-7390, 01/2010, Volume 6, Issue 1, pp. e1000805 - e1000805
Polycomb (PcG) regulation has been thought to produce stable long-term gene silencing. Genomic analyses in Drosophila and mammals, however, have shown that it... 
BITHORAX COMPLEX | TRANSCRIPTIONAL ACTIVITY | STEM-CELLS | ASH1 | HISTONE METHYLTRANSFERASE COMPLEX | DROSOPHILA TRITHORAX PROTEIN | HOMEOTIC GENE | GENETICS & HEREDITY | PCG PROTEINS | MLL | EXPRESSION | Cell Line | Chromatin - metabolism | Membrane Proteins - genetics | Epigenesis, Genetic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Transcription Factors - metabolism | Animals | Polycomb Repressive Complex 1 | Thioredoxins - genetics | Protein Binding | Drosophila melanogaster - growth & development | Thioredoxins - metabolism | Membrane Proteins - metabolism | Acetylation | Drosophila Proteins - genetics | Chromatin - genetics | Physiological aspects | Embryonic development | Epigenetic inheritance | Gene silencing | Genetic aspects | Research | Index Medicus | ASH1 protein | Chromatin | Genomic analysis | Immunoprecipitation | Transcription | RNA-mediated interference | Embryo cells | polycomb group proteins | Promoters | epigenetics | Polymerase chain reaction | Polycomb gene | MLL protein | histone methyltransferase | Repressors | Stem cells | Development | Histones | Genetik | Biological Sciences | Genetics | Naturvetenskap | Natural Sciences | Biologiska vetenskaper | Proteins | Insects | Epigenetics | Gene expression | Experiments | Polyclonal antibodies
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2016, Volume 25, Issue 20, pp. 4556 - 4565
Lipid traits (total, low-density and high-density lipoprotein cholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is... 
DENSITY-LIPOPROTEIN CHOLESTEROL | THIOREDOXIN INTERACTING PROTEIN | GENE PROMOTER | RISK-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | FAMILIAL COMBINED HYPERLIPIDEMIA | BODY-MASS INDEX | ASSOCIATION | CORONARY-ARTERY-DISEASE | LOWERING DRUGS | BLOOD | Carnitine O-Palmitoyltransferase - genetics | Cholesterol - blood | Epigenesis, Genetic | Humans | Amino Acid Transport System y+ - genetics | Male | Genetic Loci | ATP Binding Cassette Transporter, Subfamily G, Member 1 - metabolism | Cardiovascular Diseases - enzymology | Cardiovascular Diseases - genetics | Cholesterol - chemistry | ras GTPase-Activating Proteins - genetics | DNA Methylation | Amino Acid Transport System y+ - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | Carnitine O-Palmitoyltransferase - metabolism | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Genetic Predisposition to Disease | Phosphoric Monoester Hydrolases - genetics | ras GTPase-Activating Proteins - metabolism | Cardiovascular Diseases - metabolism | Genetic Association Studies | Ubiquitin-Protein Ligases - metabolism | Cholesterol - metabolism | Sequence Analysis, DNA | Triglycerides - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Sterol Regulatory Element Binding Protein 1 - genetics | Triglycerides - blood | CpG Islands | Triglycerides - genetics | Phosphoric Monoester Hydrolases - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus | Epigènesi | ADN
Journal Article
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, ISSN 1552-4841, 04/2017, Volume 174, Issue 3, pp. 269 - 282
Journal Article
Genes and Development, ISSN 0890-9369, 08/2006, Volume 20, Issue 15, pp. 2041 - 2054
Polycomb group (PcG) and trithorax group (trxG) proteins act as antagonistic regulators to maintain transcriptional OFF and ON states of HOX and other target... 
HOX gene | PcG/trxG | Histone methylation | Polycomb response element | Drosophila | Quantitative chromatin immunoprecipitation | RNA-POLYMERASE-II | BITHORAX COMPLEX | CHROMATIN-STRUCTURE | DROSOPHILA-MELANOGASTER | METHYLTRANSFERASE ACTIVITY | DEVELOPMENTAL BIOLOGY | quantitative chromatin | CELL BIOLOGY | TRITHORAX GROUP PROTEINS | histone methylation | POLYCOMB-RESPONSE ELEMENT | HOMEOTIC GENE | immunoprecipitation | IN-VIVO | GENETICS & HEREDITY | BINDING SITES | Homeodomain Proteins - metabolism | Drosophila Proteins - immunology | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Thioredoxins - genetics | Immunoglobulin G - immunology | Chromatin - physiology | Thioredoxins - metabolism | Transcription, Genetic | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Promoter Regions, Genetic | Rabbits | Histone-Lysine N-Methyltransferase - genetics | Response Elements | Animals, Genetically Modified | Membrane Proteins - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Lysine - genetics | Animals | Polycomb Repressive Complex 1 | Histone-Lysine N-Methyltransferase - metabolism | Histones - physiology | Repressor Proteins - immunology | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Lysine - chemistry | Methylation | Gene Silencing - physiology | Chromatin | Analysis | Histones | Genetic aspects | Research | Index Medicus
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 04/2018, Volume 217, Issue 4, pp. 1287 - 1301
In mammalian pancreatic beta cells, the IRE1 alpha-XBP1 pathway is constitutively and highly activated under physiological conditions. To elucidate the precise... 
DIABETES-MELLITUS | DISULFIDE-ISOMERASE | XBP1 | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | ER-STRESS | INSULIN-SECRETION | IRE1 | ENDOPLASMIC-RETICULUM STRESS | TRANSCRIPTION FACTOR | CELL BIOLOGY | Diabetes Mellitus - blood | Diabetes Mellitus - enzymology | Protein-Serine-Threonine Kinases - deficiency | Endoribonucleases - genetics | Phosphorylation | Molecular Chaperones - metabolism | Proinsulin - chemistry | Proinsulin - metabolism | Diabetes Mellitus - genetics | Protein Disulfide-Isomerases - metabolism | eIF-2 Kinase - metabolism | Insulinoma - genetics | Male | Thioredoxins - genetics | Thioredoxins - metabolism | Membrane Proteins - metabolism | Endoribonucleases - deficiency | Insulin - genetics | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Promoter Regions, Genetic | Endoribonucleases - metabolism | Oxidation-Reduction | Signal Transduction | Membrane Proteins - genetics | Molecular Chaperones - genetics | Pancreatic Neoplasms - enzymology | Protein-Serine-Threonine Kinases - genetics | Pancreatic Neoplasms - genetics | Proinsulin - genetics | Insulinoma - enzymology | Protein Folding | Mice, Knockout | Activating Transcription Factor 6 - metabolism | Insulin - metabolism | Protein Disulfide-Isomerases - genetics | Animals | X-Box Binding Protein 1 - metabolism | Cell Line, Tumor | Blood Glucose - metabolism | X-Box Binding Protein 1 - genetics | Insulin-Secreting Cells - enzymology | Index Medicus
Journal Article
Neurotoxicology, ISSN 0161-813X, 2009, Volume 30, Issue 6, pp. 926 - 933
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57327 - e57327
The q arm of chromosome 1 is frequently amplified at the gene level in breast cancer. Since the significance of this is unclear we investigated whether 1q... 
DISULFIDE BOND FORMATION | CELLS | HUMAN URINARY PROTEOME | THIOREDOXIN DOMAIN | METASTASIS | MULTIDISCIPLINARY SCIENCES | CANDIDATE GENES | IDENTIFICATION | EXPRESSION | PROGRESSION | FAMILY | Carcinoma, Ductal, Breast - genetics | Oxidoreductases Acting on Sulfur Group Donors - metabolism | Alternative Splicing - genetics | Humans | RNA, Messenger - genetics | DNA, Complementary - genetics | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Up-Regulation - genetics | Open Reading Frames - genetics | RNA, Messenger - metabolism | Breast Neoplasms - enzymology | Breast Neoplasms - genetics | Carcinoma, Ductal, Breast - enzymology | Base Sequence | Oxidoreductases Acting on Sulfur Group Donors - genetics | Cell Line, Tumor | Female | Transcription, Genetic | Protein Biosynthesis - genetics | Genes, Neoplasm - genetics | Real-Time Polymerase Chain Reaction | Expressed Sequence Tags | Oxidases | RNA | Genes | Development and progression | Breast cancer | Genetic aspects | Genetic transcription | Comparative analysis | Cancer | Transcription | Genomics | Estrogens | Oxidase | Estrogen receptors | Biochemistry | Metastasis | Neuroblastoma | Sulfhydryl oxidase | Expressed sequence tags | Breast carcinoma | Epidermal growth factor | Race | Chemical bonds | Enzymes | Nucleotide sequence | ErbB protein | Serial analysis of gene expression | Gene expression | ErbB-2 protein | Chromosome 1 | Polymerase chain reaction | Studies | Medical prognosis | Breast | Gene mapping | Tumors | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 05/2017, Volume 36, Issue 18, pp. 2515 - 2528
CD40, a member of the tumour necrosis factor receptor (TNFR) superfamily, has the capacity to cause extensive apoptosis in carcinoma cells, while sparing... 
CARCINOMA-CELLS | BLADDER-CANCER | HUMAN UROTHELIAL CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN B-CELLS | ANTIOXIDANT PATHWAYS | CELL BIOLOGY | IN-VITRO | EPITHELIAL-CELLS | ONCOLOGY | GENETICS & HEREDITY | INDUCED CYTOTOXICITY | C-JUN | TRANSFORMED-CELLS | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Colorectal Neoplasms - genetics | Humans | NADPH Oxidases - metabolism | Apoptosis - genetics | CD40 Antigens - metabolism | CD40 Ligand - metabolism | MAP Kinase Kinase 4 - metabolism | Thioredoxins - genetics | TNF Receptor-Associated Factor 3 - genetics | NADPH Oxidases - genetics | Thioredoxins - metabolism | CD40 Antigens - genetics | MAP Kinase Kinase Kinase 5 - metabolism | Colorectal Neoplasms - metabolism | Cell Proliferation - genetics | MAP Kinase Kinase Kinase 5 - genetics | Oxidation-Reduction | Oxidative Stress - genetics | Epithelial Cells - pathology | TNF Receptor-Associated Factor 3 - metabolism | Signal Transduction - genetics | CD40 Ligand - genetics | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | Colorectal Neoplasms - pathology | Carcinoma | Physiological aspects | Development and progression | Genetic aspects | Cellular signal transduction | Research | Apoptosis | Cancer | Signal transduction | Tumor necrosis factor-TNF | Lymphocytes | Immune system | Index Medicus | Original
Journal Article
Plant Physiology, ISSN 0032-0889, 5/2013, Volume 162, Issue 1, pp. 63 - 73
The NADPH-dependent thioredoxin reductase C (NTRC) is involved in redox-related regulatory processes in chloroplasts and nonphotosynthetic active plastids.... 
Proteins | Enzymes | Chloroplasts | Tetrapyrroles | Biosynthesis | Plants | Physiological regulation | BIOCHEMISTRY AND METABOLISM | Thioredoxin | Plastids | Seedlings | REDOX-MODIFICATION | ARABIDOPSIS-THALIANA | PROTEIN | CHLOROPHYLL BIOSYNTHESIS | MAGNESIUM CHELATASE | LIGHT | PROTOPORPHYRIN-IX METHYLTRANSFERASE | CHLOROPLAST | ADP-GLUCOSE PYROPHOSPHORYLASE | 5-AMINOLEVULINIC ACID SYNTHESIS | PLANT SCIENCES | Chloroplasts - enzymology | Arabidopsis - enzymology | Thioredoxin-Disulfide Reductase - genetics | Seedlings - genetics | Seedlings - enzymology | Arabidopsis Proteins - metabolism | Protoporphyrins - genetics | Thioredoxins - genetics | Thioredoxin-Disulfide Reductase - metabolism | Light | Gene Expression Regulation, Plant | Plastids - genetics | Plastids - metabolism | Thioredoxins - metabolism | NADP - metabolism | Plant Leaves - enzymology | Chloroplasts - genetics | Thioredoxin-Disulfide Reductase - chemistry | Arabidopsis Proteins - genetics | Oxidation-Reduction | Protoporphyrins - metabolism | Tetrapyrroles - metabolism | Chloroplasts - metabolism | Arabidopsis - metabolism | Peroxiredoxins | Arabidopsis - genetics | Plastids - enzymology | Methyltransferases | Plant Leaves - genetics | Plant Leaves - metabolism | Tetrapyrroles - genetics | NADP - genetics | Seedlings - metabolism | Arabidopsis | Pyrrole | Cellular control mechanisms | Physiological aspects | Research | Properties | Observations | Index Medicus | Biochemistry and Metabolism
Journal Article