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1. Full Text Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy
by Pieroni, Marco and Machado, Diana and Azzali, Elisa and Santos Costa, Sofia and Couto, Isabel and Costantino, Gabriele and Viveiros, Miguel
Journal of medicinal chemistry, ISSN 0022-2623, 07/2015, Volume 58, Issue 15, pp. 5842 - 5853
Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Humans | Antitubercular Agents - pharmacology | Thioridazine - analogs & derivatives | Mycobacterium tuberculosis - drug effects | Drug Synergism | Microbial Sensitivity Tests | Thioridazine - pharmacology | Drug Design | Mycobacterium smegmatis - drug effects | Thioridazine - chemistry | Macrophages - drug effects | Thioridazine - chemical synthesis | Index Medicus
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2. Full Text An optical sensor with specific binding sites for the detection of thioridazine hydrochloride based on ZnO-QDs coated with molecularly imprinted polymer
by Ensafi, Ali A and Zakery, Maryam and Rezaei, Behzad
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, ISSN 1386-1425, 01/2019, Volume 206, pp. 460 - 465
Fluorimetric sensor | Molecularly imprinted polymers | Thioridazine hydrochloride | ZnO quantum dots | Spectroscopy | Technology | Science & Technology | Spectrometry, Fluorescence - methods | Limit of Detection | Reproducibility of Results | Quantum Dots - chemistry | Nanocomposites | Zinc Oxide - chemistry | Humans | Thioridazine - chemistry | Linear Models | Thioridazine - blood | Molecular Imprinting - methods | Circuit components | Polymerization | Zinc oxide | Thioridazine | Sensors | Polymers | Index Medicus
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3. Full Text Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells
by Ke, Xi-Yu and Lin Ng, Victor Wee and Gao, Shu-Jun and Tong, Yen Wah and Hedrick, James L and Yang, Yi Yan
Biomaterials, ISSN 0142-9612, 2013, Volume 35, Issue 3, pp. 1096 - 1108
Advanced Basic Science | Dentistry | Co-delivery | Thioridazine | Cancer stem cells | Doxorubicin | Polycarbonates | Polymeric micelles | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Doxorubicin - therapeutic use | Neoplastic Stem Cells - drug effects | Humans | Polyethylene Glycols - chemistry | Thioridazine - administration & dosage | Dopamine Antagonists - administration & dosage | Drug Carriers - chemistry | Micelles | Neoplastic Stem Cells - pathology | Female | Breast - pathology | Doxorubicin - administration & dosage | Thioridazine - therapeutic use | Polycarboxylate Cement - chemistry | Dopamine Antagonists - therapeutic use | Breast Neoplasms - drug therapy | Antibiotics, Antineoplastic - administration & dosage | Animals | Antibiotics, Antineoplastic - therapeutic use | Breast - drug effects | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Ethylene glycol | Urea | Usage | Anthracyclines | Antipsychotic drugs | Cancer cells | Stem cells | Carbonates | Cancer | Index Medicus
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4. Full Text Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis
by Scalacci, Nicolò and Brown, Alistair K and Pavan, Fernando R and Ribeiro, Camila M and Manetti, Fabrizio and Bhakta, Sanjib and Maitra, Arundhati and Smith, Darren L and Petricci, Elena and Castagnolo, Daniele
European journal of medicinal chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 147 - 158
MDR-TB | Thioridazine | Tuberculosis | Indole | Efflux pump | Antitubercular Agents - chemical synthesis | Cell Line | Antitubercular Agents - chemistry | Chemistry Techniques, Synthetic | Drug Resistance, Multiple - drug effects | Humans | Antitubercular Agents - pharmacology | Structure-Activity Relationship | Mycobacterium tuberculosis - drug effects | Thioridazine - pharmacology | Drug Design | Thioridazine - chemistry | Thioridazine - chemical synthesis | Medical colleges | Drug resistance in microorganisms | Analysis | Pharmacy | Antitubercular agents | Research institutes | Drug therapy | Derivatives (Financial instruments) | Phenothiazine | Antipsychotic drugs | Index Medicus
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5. Full Text Environmental fate and effect assessment of thioridazine and its transformation products formed by photodegradation
by Wilde, Marcelo L and Menz, Jakob and Trautwein, Christoph and Leder, Christoph and Kümmerer, Klaus
Environmental pollution (1987), ISSN 0269-7491, 06/2016, Volume 213, pp. 658 - 670
Photodegradation | Transformation products | Thioridazine | Toxicity | QSAR | Risk assessment | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Antipsychotic Agents - radiation effects | Biodegradation, Environmental | Antipsychotic Agents - toxicity | Environmental Monitoring | Chromatography, High Pressure Liquid | Water Pollutants, Chemical - analysis | Water Pollutants, Chemical - toxicity | Aliivibrio fischeri - drug effects | Antipsychotic Agents - analysis | Photolysis | Thioridazine - radiation effects | Mass Spectrometry | Water Pollutants, Chemical - radiation effects | Thioridazine - analysis | Quantitative Structure-Activity Relationship | Thioridazine - toxicity | Bacteria | Liquid chromatography | Antipsychotic drugs | Mass spectrometry | Green technology | Index Medicus
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6. Full Text In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment
by Parumasivam, T and Chan, J.G.Y and Pang, A and Quan, D.H and Triccas, J.A and Britton, W.J and Chan, H.K
European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, 10/2016, Volume 107, pp. 205 - 214
Thioridazine | Tuberculosis | Cardiotoxicity | Rifapentine | Inhalation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Rifampin - analogs & derivatives | Powders | Thioridazine - therapeutic use | Humans | Antitubercular Agents - pharmacology | Administration, Inhalation | Thioridazine - administration & dosage | Thioridazine - pharmacology | Tuberculosis - drug therapy | Antitubercular Agents - administration & dosage | Rifampin - therapeutic use | Rifampin - administration & dosage | Rifampin - pharmacology | In Vitro Techniques | Powder Diffraction | Antitubercular Agents - therapeutic use | Antipsychotic drugs | Drug therapy | Analysis | Drugs | Drug resistance in microorganisms | Drug delivery systems | Vehicles | Index Medicus
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7. Full Text Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide
by Johannessen, Tor‐Christian and Hasan‐Olive, Md Mahdi and Zhu, Huaiyang and Denisova, Oxana and Grudic, Amra and Latif, Md Abdul and Saed, Halala and Varughese, Jobin K and Røsland, Gro Vatne and Yang, Ning and Sundstrøm, Terje and Nordal, Anne and Tronstad, Karl Johan and Wang, Jian and Lund‐Johansen, Morten and Simonsen, Anne and Janji, Bassam and Westermarck, Jukka and Bjerkvig, Rolf and Prestegarden, Lars
International journal of cancer, ISSN 0020-7136, 04/2019, Volume 144, Issue 7, pp. 1735 - 1745
temozolomide | glioblastoma | autophagy | drug resistance | thioridazine | Life Sciences & Biomedicine | Oncology | Science & Technology | Lysosomes - drug effects | Cell Survival - drug effects | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Brain Neoplasms - genetics | Thioridazine - administration & dosage | Synthetic Lethal Mutations | Brain Neoplasms - drug therapy | Autophagy - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Drug Synergism | Temozolomide - therapeutic use | Xenograft Model Antitumor Assays | Autophagosomes - drug effects | Animals | Glioblastoma - genetics | Temozolomide - administration & dosage | Thioridazine - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Glioblastoma - drug therapy | Drug Resistance, Neoplasm - drug effects | RNA | Genes | Brain tumors | Genomics | Drug resistance | Antineoplastic agents | Gene expression | Glioblastoma multiforme | Antimitotic agents | Chemotherapy | Analysis | Health aspects | Phenothiazine | Cancer | Brain | Neuroleptics | Toxicity | Brain cancer | Glioblastoma | Radiation | Phagosomes | Lysosomes | Genomes | Lethality | Drug development | Autophagy | Psychotropic drugs | Surgery | Biocompatibility | RNA-mediated interference | Feasibility studies | Pharmacology | Ribonucleic acid--RNA | Sensitivity | Thioridazine | Neural networks | Medical prognosis | Glioblastoma cells | Temozolomide | Phagocytosis | Tumors | Index Medicus
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8. Full Text In vitro and in vivo toxicity evaluation of non-neuroleptic phenothiazines, antitubercular drug candidates
by Salie, Sumayah and Labuschagné, Antoinette and Walters, Avril and Geyer, Sohair and Jardine, Anwar and Jacobs, Muazzam and Hsu, Nai-Jen
Regulatory toxicology and pharmacology, ISSN 0273-2300, 12/2019, Volume 109, pp. 104508 - 104508
Cytotoxicity | Thioridazine | Drug development | Pharmacokinetics | Phenothiazines | Toxicity | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Medicine, Legal | Legal Medicine | Science & Technology | Cells, Cultured | Phenothiazines - administration & dosage | Thioridazine - administration & dosage | Toxicity Tests, Acute | Phenothiazines - toxicity | Animals | Toxicity Tests, Subacute | Antitubercular Agents - administration & dosage | Female | Macrophages - drug effects | Antitubercular Agents - toxicity | Mice | Primary Cell Culture | Thioridazine - toxicity | Index Medicus
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9. Full Text Differential effects of thioridazine enantiomers on action potential duration in rabbit papillary muscle
by Jensen, Ask Schou and Pennisi, Cristian Pablo and Sevcencu, Cristian and Christensen, Jørn Bolstad and Kristiansen, Jette Elisabeth and Struijk, Johannes Jan
European journal of pharmacology, ISSN 0014-2999, 01/2015, Volume 747, pp. 7 - 12
Reversal of resistance | Thioridazine | QT prolongation | APD prolongation | Isolated papillary muscle | Ventricular action potential | Ventricular actionpotential | Reversalofresistance | Isolated papillarymuscle | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Rabbits | Animals | Time Factors | Stereoisomerism | Thioridazine - pharmacology | Papillary Muscles - physiology | Thioridazine - chemistry | Female | Structure-Activity Relationship | Papillary Muscles - drug effects | Action Potentials - drug effects | Enantiomers | Analysis | Antipsychotic drugs | Index Medicus
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10. Full Text The anticancer activity of the old neuroleptic phenothiazine-type drug thioridazine
by Spengler, Gabriella and Csonka, Ákos and Molnár, Joseph and Amaral, Leonard
Anticancer research, ISSN 0250-7005, 11/2016, Volume 36, Issue 11, pp. 5701 - 5706
Induction of apoptosis | Multidrug-resistant cancer cell lines | Thioridazine | Phenothiazines | Thioridazine derivatives | Inhibition of replication | Resistance to doxorubicin | Reversal of multidrug resistance | Review | Inhibition of P-glycoprotein (ABCB1) | Life Sciences & Biomedicine | Oncology | Science & Technology | Thioridazine - therapeutic use | Antipsychotic Agents - therapeutic use | Humans | Phenothiazines - therapeutic use | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | DNA Damage | Neoplasms - pathology | Apoptosis | Neoplasms - drug therapy | Index Medicus
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11. Full Text Genetic response of Salmonella enterica serotype Enteritidis to thioridazine rendering the organism resistant to the agent
by Spengler, Gabriella and Rodrigues, Liliana and Martins, Ana and Martins, Marta and McCusker, Matthew and Cerca, Pedro and Machado, Lisa and Costa, Sofia Santos and Ntokou, Eleni and Couto, Isabel and Viveiros, Miguel and Fanning, Séamus and Molnar, Joseph and Amaral, Leonard
International journal of antimicrobial agents, ISSN 0924-8579, 2011, Volume 39, Issue 1, pp. 16 - 21
Infectious Disease | Real-time RT-PCR | soxS | rob | Salmonella enterica serotype Enteritidis | AcrAB efflux pump | marA | Thioridazine | ramA | Developed resistance to thioridazine during culture | pmrA | pmrB | Activation of genes by thioridazine | acrB | Pharmacology & Pharmacy | Infectious Diseases | Life Sciences & Biomedicine | Microbiology | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Salmonella enteritidis - drug effects | Humans | Bacterial Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Microbial Sensitivity Tests | Culture Media | Membrane Transport Proteins - genetics | Thioridazine - pharmacology | Salmonella enteritidis - growth & development | Bacterial Proteins - metabolism | Membrane Transport Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Drug Resistance, Bacterial - genetics | Gene Expression Regulation, Bacterial | Salmonella enteritidis - genetics | Thioridazine - metabolism | Salmonella | Anopheles | Safety and security measures | Genes | Genetic aspects | Bacterial genetics | Saturated fatty acids | Ionophores | Phenothiazine | Food | Index Medicus
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