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1. Full Text Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy
by Pieroni, Marco and Machado, Diana and Azzali, Elisa and Santos Costa, Sofia and Couto, Isabel and Costantino, Gabriele and Viveiros, Miguel
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2015, Volume 58, Issue 15, pp. 5842 - 5853
Tuberculosis, caused by Mycobacterium tuberculosis, is still one of the leading infectious diseases globally. Therefore, novel approaches are needed to face... 
CHEMISTRY, MEDICINAL | ATP SYNTHASE | EFFLUX PUMPS | RESISTANT MYCOBACTERIUM-TUBERCULOSIS | BIOLOGICAL EVALUATION | ANTIBIOTIC-RESISTANCE | DRUG DEVELOPMENT | INHIBITORS | COMBINATION | DERIVATIVES | DISCOVERY | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Humans | Antitubercular Agents - pharmacology | Thioridazine - analogs & derivatives | Mycobacterium tuberculosis - drug effects | Drug Synergism | Microbial Sensitivity Tests | Thioridazine - pharmacology | Drug Design | Mycobacterium smegmatis - drug effects | Thioridazine - chemistry | Macrophages - drug effects | Thioridazine - chemical synthesis
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2. Full Text Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells
by Ke, Xi-Yu and Lin Ng, Victor Wee and Gao, Shu-Jun and Tong, Yen Wah and Hedrick, James L and Yang, Yi Yan
Biomaterials, ISSN 0142-9612, 2013, Volume 35, Issue 3, pp. 1096 - 1108
Abstract In this study, thioridazine (THZ), which was reported to kill cancer stem cells, was used in a combination therapy with doxorubicin (DOX) to eradicate... 
Advanced Basic Science | Dentistry | Co-delivery | Thioridazine | Cancer stem cells | Doxorubicin | Polycarbonates | Polymeric micelles | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | OVERDOSE | IDENTIFICATION | TUMORS | CHEMOTHERAPY | BREAST-CANCER | THERAPY | RESISTANCE | KINETIC STABILITY | Doxorubicin - therapeutic use | Neoplastic Stem Cells - drug effects | Humans | Polyethylene Glycols - chemistry | Thioridazine - administration & dosage | Dopamine Antagonists - administration & dosage | Drug Carriers - chemistry | Micelles | Neoplastic Stem Cells - pathology | Female | Breast - pathology | Doxorubicin - administration & dosage | Thioridazine - therapeutic use | Polycarboxylate Cement - chemistry | Dopamine Antagonists - therapeutic use | Breast Neoplasms - drug therapy | Antibiotics, Antineoplastic - administration & dosage | Animals | Antibiotics, Antineoplastic - therapeutic use | Breast - drug effects | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Ethylene glycol | Urea | Usage | Anthracyclines | Antipsychotic drugs | Cancer cells | Stem cells | Carbonates | Cancer
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3. Full Text Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis
by Scalacci, Nicolò and Brown, Alistair K and Pavan, Fernando R and Ribeiro, Camila M and Manetti, Fabrizio and Bhakta, Sanjib and Maitra, Arundhati and Smith, Darren L and Petricci, Elena and Castagnolo, Daniele
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 147 - 158
The neuroleptic drug thioridazine has been recently repositioned as possible anti-tubercular drug. Thioridazine showed anti-tubercular activity against drug... 
MDR-TB | Thioridazine | Tuberculosis | Indole | Efflux pump | MYCOBACTERIUM-TUBERCULOSIS | MULTIDRUG-RESISTANT | DESIGN | CHEMISTRY, MEDICINAL | PHENOTHIAZINES | SQ109 | IDENTIFICATION | THERAPY | Antitubercular Agents - chemical synthesis | Cell Line | Antitubercular Agents - chemistry | Chemistry Techniques, Synthetic | Drug Resistance, Multiple - drug effects | Humans | Antitubercular Agents - pharmacology | Structure-Activity Relationship | Mycobacterium tuberculosis - drug effects | Thioridazine - pharmacology | Drug Design | Thioridazine - chemistry | Thioridazine - chemical synthesis | Medical colleges | Drug resistance in microorganisms | Analysis | Pharmacy | Antitubercular agents | Research institutes | Drug therapy | Derivatives (Financial instruments) | Phenothiazine | Antipsychotic drugs
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4. Full Text Environmental fate and effect assessment of thioridazine and its transformation products formed by photodegradation
by Wilde, Marcelo L and Menz, Jakob and Trautwein, Christoph and Leder, Christoph and Kümmerer, Klaus
Environmental Pollution, ISSN 0269-7491, 06/2016, Volume 213, pp. 658 - 670
An experimental and quantitative structure-activity relationship (QSAR) approach was applied to assess the environmental fate and effects of the antipsychotic... 
Photodegradation | Transformation products | Thioridazine | Toxicity | QSAR | Risk assessment | IN-VITRO PHOTOTOXICITY | LC-MSN | SIMULATED SUNLIGHT | PHOTOLYSIS PRODUCTS | ENVIRONMENTAL SCIENCES | WASTE-WATER | DEGRADATION | RISK-ASSESSMENT | PHENOTHIAZINE DRUGS | SURFACE WATERS | ULTRA EXPERT-SYSTEM | Antipsychotic Agents - radiation effects | Biodegradation, Environmental | Antipsychotic Agents - toxicity | Environmental Monitoring | Chromatography, High Pressure Liquid | Water Pollutants, Chemical - analysis | Water Pollutants, Chemical - toxicity | Aliivibrio fischeri - drug effects | Antipsychotic Agents - analysis | Photolysis | Thioridazine - radiation effects | Mass Spectrometry | Water Pollutants, Chemical - radiation effects | Thioridazine - analysis | Quantitative Structure-Activity Relationship | Thioridazine - toxicity | Bacteria | Liquid chromatography | Antipsychotic drugs | Mass spectrometry | Green technology | Index Medicus
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5. Full Text Antibacterial properties of thioridazine
by N. Hrynchuk and N. Vrynchanu
Фармацевтичний журнал, ISSN 0367-3057, 09/2019, Volume 4, Issue 4, pp. 96 - 104
The emergence and spread of antibiotic-resistant strains of microorganisms reduces the effectiveness of antibiotic therapy and requires finding solutions to... 
microorganisms | thioridazine derivatives | antibacterial action | thioridazine
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6. Full Text In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment
by Parumasivam, T and Chan, J.G.Y and Chan, H.K and Pang, A and Quan, D.H and Triccas, J.A and Britton, W.J
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 10/2016, Volume 107, pp. 205 - 214
Thioridazine is an orally administered antipsychotic drug with potential for treatment of drug-resistant tuberculosis (TB). However, drug-induced adverse... 
Thioridazine | Tuberculosis | Cardiotoxicity | Rifapentine | Inhalation | PULMONARY DRUG-DELIVERY | MULTIDRUG-RESISTANT | PARTICLES | PHENOTHIAZINES | COMBINATION | CORRUGATION | THERAPEUTIC EFFECTIVENESS | RESISTANT MYCOBACTERIUM-TUBERCULOSIS | PHARMACOLOGY & PHARMACY | DERIVATIVES | EFFICIENCY | Rifampin - analogs & derivatives | Powders | Thioridazine - therapeutic use | Humans | Antitubercular Agents - pharmacology | Administration, Inhalation | Thioridazine - administration & dosage | Thioridazine - pharmacology | Tuberculosis - drug therapy | Antitubercular Agents - administration & dosage | Rifampin - therapeutic use | Rifampin - administration & dosage | Rifampin - pharmacology | In Vitro Techniques | Powder Diffraction | Antitubercular Agents - therapeutic use | Antipsychotic drugs | Drug therapy | Analysis | Drugs | Drug resistance in microorganisms | Drug delivery systems | Vehicles | Index Medicus
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7. Full Text A Randomized Evaluation of the Effects of Six Antipsychotic Agents on QTc, In the Absence and Presence of Metabolic Inhibition
by Harrigan, Edmund P and Miceli, Jeffrey J and Anziano, Richard and Watsky, Eric and Reeves, Karen R and Cutler, Neal R and Sramek, John and Shiovitz, Thomas and Middle, Michelle
Journal of Clinical Psychopharmacology, ISSN 0271-0749, 02/2004, Volume 24, Issue 1, pp. 62 - 69
Many drugs have been associated with QTc prolongation and, in some cases, this is augmented by concomitant administration with metabolic inhibitors. The... 
TORSADES-DE-POINTES | MULTIPLE-DOSE PHARMACOKINETICS | HALOPERIDOL | PSYCHIATRY | KETOCONAZOLE | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY | PSYCHOTIC DISORDERS | RISPERIDONE | OLANZAPINE | CLINICAL PHARMACOKINETICS | THIORIDAZINE | Clozapine - metabolism | Aryl Hydrocarbon Hydroxylases - biosynthesis | Antipsychotic Agents - adverse effects | Clozapine - administration & dosage | Humans | Middle Aged | Haloperidol - administration & dosage | Long QT Syndrome - chemically induced | Male | Thioridazine - administration & dosage | Long QT Syndrome - physiopathology | Dibenzothiazepines - adverse effects | Haloperidol - metabolism | Heart Conduction System - physiology | Risperidone - adverse effects | Dibenzothiazepines - metabolism | Adult | Female | Aryl Hydrocarbon Hydroxylases - pharmacokinetics | Benzodiazepines - metabolism | Thioridazine - adverse effects | Quetiapine Fumarate | Risperidone - administration & dosage | Electrocardiography - drug effects | Heart Conduction System - drug effects | Haloperidol - adverse effects | Dibenzothiazepines - administration & dosage | Biotransformation - drug effects | Adolescent | Antipsychotic Agents - metabolism | Benzodiazepines - administration & dosage | Risperidone - metabolism | Benzodiazepines - adverse effects | Clozapine - adverse effects | Thioridazine - metabolism
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8. Full Text Systemic thioridazine in combination with dicloxacillin against early aortic graft infections caused by Staphylococcus aureus in a porcine model: In vivo results do not reproduce the in vitro synergistic activity
by Stenger, Michael and Behr-Rasmussen, Carsten and Klein, Kasper and Grønnemose, Rasmus B and Andersen, Thomas Emil and Klitgaard, Janne K and Kolmos, Hans Jørn and Lindholt, Jes S
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173362
Introduction Conservative treatment solutions against aortic prosthetic vascular graft infection (APVGI) for inoperable patients are limited. The combination... 
DIAGNOSIS | ANTIBIOTICS | EFFLUX PUMP | MANAGEMENT | METABOLISM | EFFICACY | ENANTIOMERS | MULTIDISCIPLINARY SCIENCES | RESISTANCE | PREVENTION | POLYESTER | Staphylococcal Infections - drug therapy | Thioridazine - adverse effects | Thioridazine - therapeutic use | Body Temperature - drug effects | Staphylococcus aureus - physiology | Body Weight - drug effects | Hemoglobins - metabolism | Vascular Grafting - adverse effects | Haptoglobins - metabolism | Drug Synergism | Dicloxacillin - therapeutic use | Animals | Time Factors | Swine | Thioridazine - pharmacology | Dicloxacillin - pharmacology | Female | Leukocyte Count | Dicloxacillin - adverse effects | Staphylococcus aureus - drug effects | Staphylococcal Infections - blood | Disease Models, Animal | Staphylococcal Infections - metabolism | Care and treatment | Dicloxacillin | Thioridazine | Staphylococcus aureus infections | Dosage and administration | Research | Drug therapy, Combination | Health aspects | Prostheses | Surgical implants | Temperature | Infections | Statistical methods | Antibacterial materials | Experiments | Grafting | Synergism | Blood | Methicillin | Psychotropic drugs | Inoculation | Aorta | Doublecortin protein | Bacteria | Pigs | Vascular surgery | Statistical analysis | Staphylococcus infections | Antimicrobial agents | Pharmacology | Metabolism | Statistics | Hogs | Biofilms | Grafts | Antibiotics | Samples | Coronary vessels | Viability
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9. Full Text Genetic response of Salmonella enterica serotype Enteritidis to thioridazine rendering the organism resistant to the agent
by Spengler, Gabriella and Rodrigues, Liliana and Martins, Ana and Martins, Marta and McCusker, Matthew and Cerca, Pedro and Machado, Lisa and Costa, Sofia Santos and Ntokou, Eleni and Couto, Isabel and Viveiros, Miguel and Fanning, Séamus and Molnar, Joseph and Amaral, Leonard
International Journal of Antimicrobial Agents, ISSN 0924-8579, 2011, Volume 39, Issue 1, pp. 16 - 21
Abstract Thioridazine (TZ)-induced accumulation of the universal efflux pump substrate ethidium bromide and its subsequent efflux by Salmonella strains with... 
Infectious Disease | Real-time RT-PCR | soxS | rob | Salmonella enterica serotype Enteritidis | AcrAB efflux pump | marA | Thioridazine | ramA | Developed resistance to thioridazine during culture | pmrA | pmrB | Activation of genes by thioridazine | acrB | MYCOBACTERIUM-TUBERCULOSIS | ESCHERICHIA-COLI | PHENOTHIAZINES | TYPHIMURIUM | MICROBIOLOGY | CELL-WALL | INHIBITION | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | INFECTIOUS DISEASES | BACTERIA | EFFLUX PUMP | CHLORPROMAZINE | Salmonella enteritidis - drug effects | Humans | Bacterial Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Microbial Sensitivity Tests | Culture Media | Membrane Transport Proteins - genetics | Thioridazine - pharmacology | Salmonella enteritidis - growth & development | Bacterial Proteins - metabolism | Membrane Transport Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Drug Resistance, Bacterial - genetics | Gene Expression Regulation, Bacterial | Salmonella enteritidis - genetics | Thioridazine - metabolism | Salmonella | Anopheles | Safety and security measures | Genes | Genetic aspects | Bacterial genetics | Saturated fatty acids | Ionophores | Phenothiazine | Food
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10. Full Text Rifamycin action on RNA polymerase in antibiotictolerant Mycobacterium tuberculosis results in differentially detectable populations
by Saito, Kohta and Warrier, Thulasi and Somersan-Karakaya, Selin and Kaminski, Lina and Mi, Jianjie and Jiang, Xiuju and Park, Suna and Shigyo, Kristi and Gold, Ben and Roberts, Julia and Weber, Elaina and Jacobs, William R and Nathan, Carl F
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2017, Volume 114, Issue 24, pp. E4832 - E4840
Thioridazine | Mycobacterium tuberculosis | Phenotypic tolerance | Differentially detectable | Rifampin
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11. Full Text Assignment of the absolute configuration at the sulfur atom of thioridazine metabolites by the analysis of their chiroptical properties: The case of thioridazine 2-sulfoxide
by Bertucci, Carlo and Guimarães, Luiz Fernando Lopes and Bonato, Pierina Sueli and Borges, Keyller Bastos and Okano, Laura Tiemi and Mazzeo, Giuseppe and Rosini, Carlo
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 2010, Volume 52, Issue 5, pp. 796 - 801
Thioridazine (THD) is a commonly prescribed phenotiazine neuroleptic drug, which is extensively biotransformed in the organism producing as main metabolites... 
Thioridazine metabolites | Thioridazine | Enantioselective HPLC | Enantiomers | Absolute configuration | Circular dichroism | CHEMISTRY, ANALYTICAL | HUMAN PLASMA | THEORETICAL SIMULATION | ELECTRONIC CIRCULAR-DICHROISM | OPTICAL-ROTATION | 5-SULFOXIDE | DENSITY | DEGRADATION | PHARMACOLOGY & PHARMACY | SPECTRA | AB-INITIO CALCULATION | Stereoisomerism | Molecular Conformation | Models, Molecular | Thioridazine - chemistry | Thioridazine - analogs & derivatives | Chromatography, High Pressure Liquid | Circular Dichroism | Thioridazine - metabolism
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12. Full Text Chemotherapeutic efficacy of thioridazine as an adjunct drug in a murine model of latent tuberculosis
by Singh, Amandeep and Sharma, Sadhna
Tuberculosis, ISSN 1472-9792, 2014, Volume 94, Issue 6, pp. 695 - 700
Summary Thioridazine, a potent phenothiazine compound was evaluated for its chemotherapeutic efficacy against experiment model of tuberculosis. Thioridazine... 
Infectious Disease | Pulmonary/Respiratory | Mycobacterium tuberculosis | Latent tuberculosis | Thioridazine | PHENOTHIAZINES | MICROBIOLOGY | IMMUNOLOGY | COMBINATION | EFFLUX PUMP | INHIBITION | RESPIRATORY SYSTEM | RESPIRATION | RESISTANT MYCOBACTERIUM-TUBERCULOSIS | STAPHYLOCOCCUS-AUREUS | INFECTION | COMPLETION | Isoniazid - pharmacology | Thioridazine - therapeutic use | Microbial Viability - drug effects | Antitubercular Agents - pharmacology | Male | Thioridazine - administration & dosage | Colony Count, Microbial | Mycobacterium tuberculosis - drug effects | Dose-Response Relationship, Drug | Animals | Latent Tuberculosis - drug therapy | Thioridazine - pharmacology | Antitubercular Agents - administration & dosage | Female | Isoniazid - therapeutic use | Rifampin - therapeutic use | Mice | Rifampin - pharmacology | Drug Therapy, Combination | Microbial Sensitivity Tests - methods | Antitubercular Agents - therapeutic use | Disease Models, Animal | Mycobacterium tuberculosis - growth & development | Chemotherapy | Tuberculosis | Rifampin | Analysis | Phenothiazine | Cancer
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13. Prolactin response to neuroleptics
: clinical and theoretical implications
by Öhman, Rolf L and Axelsson, Rolf A. A
1980, Journal of neural transmission : Supplementum, ISBN 9780387816050, Volume 17., vii, 74
Side effects | Chemotherapy | Thioridazine | Psychoses | Prolactin
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14. Full Text The anticancer activity of the old neuroleptic phenothiazine-type drug thioridazine
by Spengler, Gabriella and Csonka, Ákos and Molnár, Joseph and Amaral, Leonard
Anticancer Research, ISSN 0250-7005, 11/2016, Volume 36, Issue 11, pp. 5701 - 5706
Thioridazine (TZ), an antipsychotic drug, renders multidrug-resistant (MDR) cancer cells susceptible to cytotoxic agents to which they were initially... 
Induction of apoptosis | Multidrug-resistant cancer cell lines | Thioridazine | Phenothiazines | Thioridazine derivatives | Inhibition of replication | Resistance to doxorubicin | Reversal of multidrug resistance | Review | Inhibition of P-glycoprotein (ABCB1) | MYCOBACTERIUM-TUBERCULOSIS | LEUKEMIC-CELLS | thioridazine derivatives | induction of apoptosis | DOPAMINE-RECEPTOR ANTAGONIST | multidrug-resistant cancer cell lines | INDUCE APOPTOSIS | ANTIPLASMID ACTIVITY | thioridazine | CANCER STEM-CELLS | P-GLYCOPROTEIN | reversal of multidrug resistance | MOUSE LYMPHOMA-CELLS | ONCOLOGY | inhibition of P-glycoprotein (ABCB1) | review | inhibition of replication | MULTIDRUG-RESISTANCE | TUMOR-GROWTH | resistance to doxorubicin | Thioridazine - therapeutic use | Antipsychotic Agents - therapeutic use | Humans | Phenothiazines - therapeutic use | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | DNA Damage | Neoplasms - pathology | Apoptosis | Neoplasms - drug therapy
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15. Mechanism of thioridazine plus medroxyprogesterone in the treatment of endometrial cancer
by Meng, Qiong and Sun, Xiao and Wang, Jing and Wang, Yudong
National Medical Journal of China, ISSN 0376-2491, 05/2015, Volume 95, Issue 19, pp. 1540 - 1543
Endometrial cancer | Medroxyprogesterone | Thioridazine
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16. Full Text Multi-walled carbon nanotubes with immobilised cobalt nanoparticle for modification of glassy carbon electrode: Application to sensitive voltammetric determination of thioridazine
by Shahrokhian, Saeed and Ghalkhani, Masoumeh and Adeli, Mohsen and Amini, Mohammad Kazem
Biosensors and Bioelectronics, ISSN 0956-5663, 2009, Volume 24, Issue 11, pp. 3235 - 3241
Multi-walled carbon nanotubes (MWCNTs) were immobilised with cobalt nanoparticles and analyzed by transmission electron microscopy. This modification procedure... 
Voltammetry | Thioridazine | Immobilised multi-walled carbon nanotubes | Modified electrode | Cobalt nanoparticles | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | FORM | CYCLODEXTRIN | DISPERSION | NANOSCIENCE & NANOTECHNOLOGY | ASCORBIC-ACID | BIOPHYSICS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SPECTROPHOTOMETRIC ASSAY | DOPAMINE | HYDROGEN-PEROXIDE | PHENOTHIAZINE DRUGS | DERIVATIVES | URIC-ACID | Immunoassay | Microelectrodes | Transducers | Flow Injection Analysis | Glass - chemistry | Equipment Design | Nanotubes, Carbon - chemistry | Thioridazine - chemistry | Biological Assay | Biosensing Techniques - instrumentation | Catalysis | Thioridazine - analysis | Cobalt - chemistry | Electrochemistry - instrumentation | Equipment Failure Analysis | Microfluidics | Thin films | Dielectric films | Organic solvents | Cobalt | Nanotubes | Phenothiazine
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