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European Journal of Medicinal Chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 2, pp. 738 - 742
Considering that some thiopyrimidines were previously reported as potential therapeutics, the present study achieved novel analogs of bioactive 2-substituted... 
2-Thiouracil | Cytotoxicity | Antimicrobial activity | 2-Thiopyrimidine-4-one | Alkylation | Structure–activity relationship | Structure-activity relationship | CHEMISTRY, MEDICINAL | 1-ADAMANTANETHIOL | COMPLEXES | PYRIMIDINES | ANTIMALARIALS | DEOXYDATIVE SUBSTITUTION | THIOURACIL | PYRIDINE 1-OXIDES | ACETIC-ANHYDRIDE | INHIBITORS | DERIVATIVES | Parasitic Sensitivity Tests | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Structure-Activity Relationship | Moraxella (Branhamella) catarrhalis - drug effects | Plasmodium falciparum - drug effects | Pyrimidinones - chemistry | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Candida albicans - drug effects | Anti-Bacterial Agents - chemistry | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Pyrimidinones - chemical synthesis | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Streptococcus pyogenes - drug effects | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Animals | Antimalarials - chemistry | Cell Line, Tumor | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Mice | Drug Screening Assays, Antitumor | Antimitotic agents | Drug resistance in microorganisms | Care and treatment | Pyrimidines | Lung cancer | Universities and colleges | Data mining | Antineoplastic agents | Cancer
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 159 - 165
A series of novel thiouracil derivatives containing a triazolo-thiadiazole moiety ( ) have been synthesized by structural modifications on a lead SecA... 
SecA inhibitors | Molecular simulation | Antibacterial activity | Triazolo-thiadiazole | Thiouracil | INSERTION | CHEMISTRY, MEDICINAL | CONFORMER GENERATION | ANALOGS | IDENTIFICATION | COLI PREPROTEIN TRANSLOCASE | PROTEIN SECRETION | BACTERIAL-RESISTANCE | Staphylococcus aureus - enzymology | Triazoles - chemistry | Bacterial Proteins - chemistry | Enzyme Inhibitors - chemical synthesis | Thiadiazoles - chemistry | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Drug Design | SEC Translocation Channels - chemistry | Thiouracil - chemical synthesis | SEC Translocation Channels - metabolism | SEC Translocation Channels - antagonists & inhibitors | Bacterial Proteins - antagonists & inhibitors | Thiouracil - chemistry | Chemistry Techniques, Synthetic | Enzyme Inhibitors - metabolism | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Anti-Bacterial Agents - metabolism | Bacillus subtilis - enzymology | Anti-Bacterial Agents - chemical synthesis | Adenosine Triphosphatases - antagonists & inhibitors | Thiouracil - metabolism | Adenosine Triphosphatases - chemistry | Bacterial Proteins - metabolism | Protein Conformation | Anti-Bacterial Agents - pharmacology | Molecular Docking Simulation | Staphylococcus aureus - drug effects | Thiouracil - pharmacology | Bacillus subtilis - drug effects | Adenosine triphosphatase | Triazoles | Antibacterial agents
Journal Article
Profiles of Drug Substances, Excipients and Related Methodology, ISSN 1871-5125, 2019, Volume 44, p. 293
Thiouracil, 2-sulfanylidene-1H-pyrimidin-4-one, has been used as anti-thyroid, coronary vasodilator, and in congestive heart failure. It was found to cause... 
Analytical methods | Pharmacology | Anti-thyroid | Preparation methods | Thiouracil | Thermal and spectral behavior | Methimazole | Thiouracil - chemistry | Thyroxine | Propylthiouracil | Antithyroid Agents - chemistry | Antithyroid Agents - pharmacology | Thiouracil - pharmacology
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 2002, Volume 90, Issue 1, pp. 22 - 37
A new antimetabolite of adenine, viz. 5-dimethylaminomethyl-2-thiouracil, was synthesized using the Mannich reaction. Owing to the biological importance of... 
Antimetabolite chelate | Antifungal | 5-Dimethylamino methyl-2-thiouracil | Antitumor | Thermal analyses | Antibacterial | Mannich base | Antimetabolite | Structure–activity relationship | Structure-activity relationship | antifungal | thermal analyses | antitumor | BIOCHEMISTRY & MOLECULAR BIOLOGY | antimetabolite | antimetabolite chelate | COMPLEXES | antibacterial | structure-activity relationship | 5-dimethylamino methyl-2-thiouracil | CHEMISTRY, INORGANIC & NUCLEAR | Thiouracil - analogs & derivatives | Antineoplastic Agents - chemical synthesis | Escherichia coli - drug effects | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Spectroscopy, Fourier Transform Infrared | Cobalt - pharmacology | Anti-Bacterial Agents - chemistry | Mice, Inbred DBA | Antineoplastic Agents - pharmacology | Nickel - pharmacology | Thiouracil - chemical synthesis | Antifungal Agents - pharmacology | Thiouracil - chemistry | Magnetic Resonance Spectroscopy | Antineoplastic Agents - chemistry | Lymphoma | Leukemia P388 - drug therapy | Anti-Bacterial Agents - chemical synthesis | Animals | Organometallic Compounds - chemical synthesis | Electrochemistry | Organometallic Compounds - chemistry | Anti-Bacterial Agents - pharmacology | Mice | Staphylococcus aureus - drug effects | Chelating Agents | Organometallic Compounds - pharmacology | Thiouracil - pharmacology
Journal Article
Molecular Diversity, ISSN 1381-1991, 11/2017, Volume 21, Issue 4, pp. 967 - 983
Journal Article
Journal Article