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European Journal of Pharmacology, ISSN 0014-2999, 01/2017, Volume 794, pp. 209 - 215
N-arachidonoyl glycine (NAGLY), is the endogenous lipid that activates the G protein-couple receptor 18 (GPR18) with vasodilatory activity in resistance... 
Na+/Ca2+ exchanger | Vasorelaxation | Nitric oxide | N-arachidonoyl glycine | Hypotensive | Ca | exchanger | ANANDAMIDE-INDUCED VASORELAXATION | RAT | IDENTIFICATION | VASCULAR ENDOTHELIUM | CORONARY-ARTERIES | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | ABNORMAL-CANNABIDIOL | GPR18 | Glycine - analogs & derivatives | Kidney - blood supply | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Endothelium, Vascular - drug effects | Male | Thiourea - pharmacology | Quinoxalines - pharmacology | Phenylephrine - pharmacology | Regional Blood Flow - drug effects | Piperidines - pharmacology | Oxadiazoles - pharmacology | Blood Pressure - drug effects | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Kidney - drug effects | Rats | Capsaicin - analogs & derivatives | Arachidonic Acids - pharmacology | Hypertension - physiopathology | Hypertension - metabolism | Carbachol - pharmacology | Animals | Cyclic GMP - metabolism | Glycine - pharmacology | Endothelium, Vascular - metabolism | Anilides - pharmacology | Endothelium, Vascular - pathology | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Nitric Oxide - metabolism | Thiourea - analogs & derivatives | Medical colleges | Dilatation | Vasodilators | Blood vessels | Indomethacin | Glycine | Endothelium
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 01/2000, Volume 28, Issue 1, pp. 55 - 63
Reactive oxygen species have been shown to be involved in the mutagenicity, clastogenicity, and apoptosis of mammalian cells treated with arsenic or cadmium.... 
Excision repair | Reactive oxygen species | Peroxynitrite | Hydrogen peroxide | Free radicals | Nitric oxide | nitric oxide | free radicals | OXIDATIVE STRESS | peroxynitrite | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | hydrogen peroxide | SODIUM ARSENITE | STRAND BREAKS | excision repair | CHINESE-HAMSTER CELLS | reactive oxygen species | HEAT-SHOCK RESPONSE | L-ARGININE | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | WELL WATER | MALIGNANT NEOPLASMS | Cadmium Chloride - toxicity | Catalase - pharmacology | Free Radical Scavengers - pharmacology | Amitrole - pharmacology | Mutagens - toxicity | Citrulline - analogs & derivatives | Reactive Oxygen Species - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Molsidomine - analogs & derivatives | Thiourea - pharmacology | Endothelium, Vascular - chemistry | Phenanthrolines - pharmacology | Chromans - pharmacology | Arsenites - toxicity | Cattle | Superoxides - metabolism | Nitric Oxide Donors - pharmacology | Superoxide Dismutase - pharmacology | N-Glycosyl Hydrolases - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Sodium Selenite - pharmacology | Antioxidants - pharmacology | Onium Compounds - pharmacology | Hydrogen Peroxide - metabolism | Nitroarginine - pharmacology | Nitrates - metabolism | Bacterial Proteins - pharmacology | DNA-Formamidopyrimidine Glycosylase | Animals | Citrulline - pharmacology | Ditiocarb - pharmacology | Escherichia coli Proteins | Sodium Compounds - toxicity | Uric Acid - pharmacology | Molsidomine - pharmacology | Thiomalates - pharmacology | Aorta - cytology | DNA Damage | Nitric Oxide - metabolism | Thiourea - analogs & derivatives | formamidopyrimidine-DNA glycosylase | formamidopyrimidine | 3-morpholinosydnonimine | 8-oxoguanine
Journal Article
Circulation, ISSN 0009-7322, 09/2006, Volume 114, Issue 13, pp. 1372 - 1379
Background - At birth, the increase in oxygen causes contraction of the ductus arteriosus, thus diverting blood flow to the lungs. Although this contraction is... 
Oxygen | Ion channels | Vasoconstriction | Ductus arteriosus, patent | Heart defects, congenital | heart defects | CARDIAC & CARDIOVASCULAR SYSTEMS | ductus arteriosus, patent | TRPC1 | RECEPTOR | CLOSURE | congenital | CAPACITATIVE CA2+ ENTRY | PULMONARY VASOCONSTRICTION | CYTOSOLIC CALCIUM | ion channels | CONSTRICTION | PERIPHERAL VASCULAR DISEASE | vasoconstriction | SMOOTH-MUSCLE-CELLS | RABBIT | oxygen | Oxygen - pharmacology | Tetraethylammonium - pharmacology | Calcium Signaling - physiology | Maleimides - pharmacology | Potassium Channels - physiology | Thiourea - pharmacology | Polyunsaturated Alkamides | Isoquinolines - pharmacology | rho-Associated Kinases | Niflumic Acid - pharmacology | Indoles - pharmacology | Endocannabinoids | Ductus Arteriosus - physiology | Boron Compounds - pharmacology | Mibefradil - pharmacology | Nifedipine - pharmacology | Calcium - pharmacology | Oxidation-Reduction | Protein-Serine-Threonine Kinases - physiology | Rabbits - embryology | Calcium Channels, L-Type - physiology | Imidazoles - pharmacology | Calcium Channel Blockers - pharmacology | Potassium Channels - drug effects | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Ductus Arteriosus - embryology | Patch-Clamp Techniques | Animals | Menthol - pharmacology | Ruthenium Red - pharmacology | Muscle Contraction - drug effects | Calcium Channels, L-Type - drug effects | Muscle Contraction - physiology | Thapsigargin - pharmacology | Cytosol - metabolism | In Vitro Techniques | Intracellular Signaling Peptides and Proteins - physiology | Thiourea - analogs & derivatives
Journal Article
BJU International, ISSN 1464-4096, 03/2008, Volume 101, Issue 6, pp. 775 - 780
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2008, Volume 294, Issue 5, pp. 2031 - 2039
This study determined the role of a slowly inactivating component of sodium current (INa), late INa, to induce delayed afterdepolarizations (DADs) and... 
Calcium overload | Action potential | Transient inward current | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | PIG VENTRICULAR MYOCYTES | HEART-FAILURE | NA+ CHANNELS | transient inward current | ANTIANGINAL AGENT | action potential | PURKINJE-FIBERS | TOXIN ATX-II | DOG HEART | RANOLAZINE | PERIPHERAL VASCULAR DISEASE | LONG QT SYNDROME | calcium overload | Up-Regulation | Calcium - metabolism | Anti-Arrhythmia Agents - pharmacology | Ryanodine Receptor Calcium Release Channel - metabolism | Sodium - metabolism | Thiourea - pharmacology | Cnidarian Venoms - pharmacology | Ranolazine | Action Potentials | Time Factors | Sodium-Calcium Exchanger - metabolism | Egtazic Acid - analogs & derivatives | Sodium Channels - metabolism | Tachycardia, Supraventricular - metabolism | Sodium-Calcium Exchanger - antagonists & inhibitors | Tetrodotoxin - pharmacology | Ryanodine - pharmacology | Acetanilides - pharmacology | Guinea Pigs | Heart Conduction System - metabolism | Heart Atria - cytology | Sodium Channel Blockers - pharmacology | Ryanodine Receptor Calcium Release Channel - drug effects | Sodium Channels - drug effects | Cardiotonic Agents - pharmacology | Chelating Agents - pharmacology | Piperazines - pharmacology | Heart Atria - metabolism | Patch-Clamp Techniques | Animals | Egtazic Acid - pharmacology | Myocytes, Cardiac - drug effects | Heart Conduction System - physiopathology | Myocytes, Cardiac - metabolism | Tachycardia, Supraventricular - physiopathology | Thiourea - analogs & derivatives | Proteins | Cardiovascular system | Toxins | Sodium | Calcium | Cells | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2010, Volume 30, Issue 30, pp. 10205 - 10219
The neuropeptide kisspeptin is necessary for reproduction, fertility, and puberty. Here, we show strong kisspeptin innervation of hypothalamic anorexigenic... 
ENERGY-BALANCE | HORMONE PULSE-GENERATOR | HYPOTHALAMIC KISS-1 SYSTEM | REPRODUCTIVE FUNCTION | MESSENGER-RNA | FOOD-INTAKE | MORPHOLOGICAL EVIDENCE | NA+/CA2+ EXCHANGE INHIBITOR | ARCUATE NUCLEUS | NEUROSCIENCES | LUTEINIZING-HORMONE | Receptors, G-Protein-Coupled - metabolism | Arcuate Nucleus of Hypothalamus - cytology | Male | Neurons - cytology | Green Fluorescent Proteins - genetics | Thiourea - pharmacology | RNA, Messenger - metabolism | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Kisspeptins | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Neuropeptide Y - metabolism | Egtazic Acid - analogs & derivatives | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Female | Sodium-Calcium Exchanger - antagonists & inhibitors | Neurons - metabolism | Neurons - drug effects | Membrane Potentials - drug effects | Tumor Suppressor Proteins - metabolism | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Axons - metabolism | Mice, Transgenic | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Imidazoles - pharmacology | Chelating Agents - pharmacology | Calcium Channel Blockers - pharmacology | Gene Expression Regulation - drug effects | Pro-Opiomelanocortin - metabolism | Renilla - genetics | Animals | Egtazic Acid - pharmacology | Tumor Suppressor Proteins - pharmacology | Mice | Receptors, G-Protein-Coupled - genetics | In Vitro Techniques | Receptors, Kisspeptin-1 | Thiourea - analogs & derivatives
Journal Article
The Journal of Comparative Neurology, ISSN 0021-9967, 03/2005, Volume 483, Issue 3, pp. 278 - 291
Journal Article
Investigative ophthalmology & visual science, ISSN 0146-0404, 01/2019, Volume 60, Issue 1, pp. 265 - 273
Journal Article
Journal Article
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 02/2018, Volume 96, Issue 2, pp. 253 - 264
Oxidative stress and neural degeneration have been shown to be involved in the pathogenesis of Parkinson's disease (PD). The P2Y6 purinergic receptor (P2Y6R)... 
Parkinson's disease | P2Y6R | MPP | oxidative stress | SH‐SY5Y | SH-SY5Y | LIPID-PEROXIDATION | SIGNALING MOLECULE | SUBSTANTIA-NIGRA | NEUROSCIENCES | PROTECTS | INHIBITION | PATHWAY | P2Y RECEPTOR | SUPEROXIDE-DISMUTASE | PARKINSONS-DISEASE | Malondialdehyde - metabolism | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | 1-Methyl-4-phenylpyridinium - pharmacology | Humans | Herbicides - pharmacology | Thiourea - pharmacology | Transfection | Apyrase - pharmacology | Receptors, Purinergic P2 - genetics | Receptors, Purinergic P2 - metabolism | Superoxide Dismutase-1 - metabolism | Cell Line, Tumor | Purinergic P2 Receptor Antagonists - pharmacology | Purinergic P2 Receptor Agonists - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Oxidative Stress - drug effects | Uridine Diphosphate - pharmacology | Isothiocyanates - pharmacology | Neuroblastoma - pathology | Thiourea - analogs & derivatives | Nitric Oxide Synthase Type II - metabolism | RNA, Small Interfering - metabolism | Oxidative stress | Neurons | Cell death | Nitric oxide | Biochemistry | Superoxide | Mitogens | Reactive oxygen species | Pathogenesis | Superoxide dismutase | Kinases | Neurodegeneration | Down-regulation | Degeneration | Inhibition | Movement disorders | Neurodegenerative diseases | Extracellular signal-regulated kinase | Pharmacology | Inflammation | siRNA | Malondialdehyde | Nitric-oxide synthase | Microglia | Signaling | Protein kinase | Apyrase | Viability | Apoptosis
Journal Article
Nitric Oxide, ISSN 1089-8603, 04/2016, Volume 54, pp. 38 - 50
Journal Article
Plant Cell Reports, ISSN 0721-7714, 05/2016, Volume 35, Issue 5, pp. 1155 - 1168
Journal Article