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The FEBS Journal, ISSN 1742-464X, 09/2017, Volume 284, Issue 18, pp. 2981 - 2999
We determined the crystal structure of Thr1, the self‐standing adenylation domain involved in the nonribosomal‐like biosynthesis of free 4‐chlorothreonine in... 
crystallography | kinetic analysis | nonribosomal code | adenylation domain | substrate specificity | NONRIBOSOMAL PEPTIDE SYNTHETASE | FIREFLY LUCIFERASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARRIER PROTEIN DOMAINS | PSEUDOMONAS-SYRINGAE | COENZYME-A | NRPS ADENYLATION | AMINO-ACID | SUCCINYLBENZOYL-COA SYNTHETASE | SYRINGAE PV SYRINGAE | Threonine - chemistry | Bacterial Proteins - chemistry | Substrate Specificity | Crystallography, X-Ray | Threonine - metabolism | Peptide Synthases - genetics | Peptide Synthases - chemistry | Adenosine Triphosphate - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Streptomyces - chemistry | Bacterial Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Peptide Synthases - metabolism | Threonine - analogs & derivatives | Sequence Homology, Amino Acid | Sequence Alignment | Threonine - biosynthesis | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | Bacterial Proteins - metabolism | Streptomyces - enzymology | Kinetics | Adenosine Triphosphate - chemistry | Stereoisomers | Physiological aspects | Structure | Analysis | Crystals | Surgical implants | Threonine | Cocrystallization | Biosynthesis | Crystallography | Monomers | Substrates | Biomedical materials | Substrate specificity | Adenylation | Protein structure | ATP | Crystal structure
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2015, Volume 290, Issue 22, pp. 13710 - 13724
Journal Article
PLoS Biology, ISSN 1544-9173, 12/2015, Volume 13, Issue 12, p. e1002309
Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest as an antineoplastic agent. Recent work suggests that metformin... 
DIABETES-MELLITUS | LKB1-AMPK PATHWAY | ATP CITRATE LYASE | RESPIRATORY-CHAIN | ACTIVATED PROTEIN-KINASE | REDUCTIVE GLUTAMINE-METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | COMPLEX 1 | ALPHA-KETOGLUTARATE | AMPK | TUMOR-GROWTH | Neoplasms - metabolism | AMP-Activated Protein Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Phosphoproteins - metabolism | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Metformin - pharmacology | Cells, Cultured | Citric Acid Cycle - drug effects | Protein-Serine-Threonine Kinases - genetics | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Phosphoproteins - genetics | Hypoglycemic Agents - pharmacology | Mice, Knockout | Neoplasms - drug therapy | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Embryo, Mammalian - cytology | Electron Transport Chain Complex Proteins - metabolism | Lipid Metabolism - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mutation | Neoplasms - pathology | AMP-Activated Protein Kinases - genetics | Life Sciences | Cellular Biology | Cancer | Cell growth | Insulin-like growth factors | Kinases | Cancer therapies
Journal Article