X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (48705) 48705
Publication (9880) 9880
Book Review (289) 289
Book Chapter (215) 215
Conference Proceeding (55) 55
Dissertation (17) 17
Newsletter (14) 14
Book / eBook (13) 13
Reference (6) 6
Data Set (5) 5
Magazine Article (3) 3
Government Document (1) 1
Streaming Audio (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (25832) 25832
animals (24705) 24705
biochemistry & molecular biology (23572) 23572
protein-serine-threonine kinases - metabolism (19714) 19714
index medicus (19364) 19364
phosphorylation (17129) 17129
cell biology (12756) 12756
mice (11356) 11356
protein-serine-threonine kinases - genetics (10220) 10220
signal transduction (9441) 9441
molecular sequence data (8081) 8081
amino acid sequence (7871) 7871
cell line (6277) 6277
proteins (6274) 6274
male (5489) 5489
activation (5419) 5419
mutation (5311) 5311
apoptosis (5201) 5201
rats (5168) 5168
protein binding (4986) 4986
expression (4903) 4903
female (4868) 4868
threonine (4605) 4605
research (4435) 4435
cell line, tumor (4370) 4370
cells, cultured (4169) 4169
protein-serine-threonine kinases (4119) 4119
article (4090) 4090
cancer (4059) 4059
kinases (4045) 4045
enzyme activation (3995) 3995
tor serine-threonine kinases - metabolism (3937) 3937
protein-serine-threonine kinases - chemistry (3753) 3753
protein kinases - metabolism (3716) 3716
research article (3669) 3669
proto-oncogene proteins - metabolism (3629) 3629
protein-serine-threonine kinases - antagonists & inhibitors (3616) 3616
oncology (3435) 3435
biophysics (3400) 3400
base sequence (3303) 3303
gene expression (3253) 3253
cell cycle proteins - metabolism (3249) 3249
binding sites (3187) 3187
genetics & heredity (3178) 3178
analysis (3081) 3081
transfection (3072) 3072
cells (3014) 3014
protein-kinase (3008) 3008
physiological aspects (2981) 2981
signal transduction - drug effects (2934) 2934
protein structure, tertiary (2928) 2928
cell cycle (2865) 2865
protein (2836) 2836
hela cells (2813) 2813
dna-binding proteins - metabolism (2808) 2808
threonine - metabolism (2737) 2737
proto-oncogene proteins c-akt (2721) 2721
kinetics (2690) 2690
protein kinases (2654) 2654
multidisciplinary sciences (2645) 2645
identification (2634) 2634
enzyme inhibitors - pharmacology (2624) 2624
protein-serine-threonine kinases - physiology (2611) 2611
phosphatidylinositol 3-kinases - metabolism (2589) 2589
biochemistry (2496) 2496
kinase (2418) 2418
blotting, western (2412) 2412
gene (2402) 2402
genetic aspects (2371) 2371
models, molecular (2358) 2358
biology (2328) 2328
models, biological (2322) 2322
growth (2303) 2303
signal transduction - physiology (2219) 2219
sequence homology, amino acid (2216) 2216
saccharomyces-cerevisiae (2213) 2213
recombinant proteins - metabolism (2157) 2157
pathway (2151) 2151
gene-expression (2106) 2106
serine (2092) 2092
time factors (2060) 2060
proto-oncogene proteins c-akt - metabolism (2038) 2038
inhibition (2019) 2019
transcription factors - metabolism (2016) 2016
tumor cells, cultured (2009) 2009
apoptosis - drug effects (1949) 1949
amino acids (1923) 1923
in-vivo (1894) 1894
phosphorylation - drug effects (1892) 1892
cell proliferation (1891) 1891
binding (1882) 1882
mtor (1876) 1876
dna damage (1871) 1871
cloning, molecular (1837) 1837
substrate specificity (1836) 1836
medicine (1835) 1835
serine - metabolism (1811) 1811
gene expression regulation (1804) 1804
life sciences (1797) 1797
ataxia telangiectasia mutated proteins (1789) 1789
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (48528) 48528
Japanese (61) 61
French (59) 59
Chinese (56) 56
German (33) 33
Russian (29) 29
Polish (8) 8
Italian (4) 4
Korean (3) 3
Hungarian (2) 2
Ukrainian (2) 2
Portuguese (1) 1
Romanian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2005, Volume 280, Issue 37, pp. 32291 - 32300
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9312 - 9330
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer’s... 
TAU EXON 10 | FUNCTIONAL-LINK | CHEMISTRY, MEDICINAL | DYRK1A OVEREXPRESSION | DOWN-SYNDROME | INTRACELLULAR TARGETS | NEUROFIBRILLARY DEGENERATION | DUAL-SPECIFICITY | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | AFFINITY-CHROMATOGRAPHY | GLYCOGEN-SYNTHASE KINASE | Stereoisomerism | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Dioxoles - chemical synthesis | Protein Kinase Inhibitors - chemistry | Neuroprotective Agents - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Dioxoles - pharmacology | Molecular Structure | Pyramidal Cells - drug effects | Cell Death - drug effects | Imidazoles - chemical synthesis | Porifera - chemistry | Pyramidal Cells - cytology | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Brain - cytology | Recombinant Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Glutamic Acid - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cyclin-Dependent Kinase 2 - chemistry | Imidazoles - pharmacology | Dioxoles - chemistry | Rats, Sprague-Dawley | Brain - drug effects | Neuroprotective Agents - chemical synthesis | Amyloid beta-Protein Precursor - genetics | Animals | Chromatography, Affinity | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | In Vitro Techniques | Alkaloids - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Organic chemistry | Chemical Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e41922
To improve our understanding of uranium toxicity, the determinants of uranyl affinity in proteins must be better characterized. In this work, we analyzed the... 
SPECTROSCOPY | AMINO-ACIDS | PROTEIN-KINASE CK2 | COMPLEXES | CALCIUM | BIOLOGY | GAS-PHASE | COORDINATION | URANYL-ION | SPECTRA | AQUEOUS-SOLUTION | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Calmodulin - genetics | Arabidopsis Proteins - genetics | Phosphorylation | Arabidopsis - chemistry | Calmodulin - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Casein Kinase II - genetics | Uranium - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Uranium - toxicity | Casein Kinase II - chemistry | Arabidopsis Proteins - chemistry | Protein Engineering | Protein Binding | Uranium - chemistry | Calmodulin - chemistry | Casein Kinase II - metabolism | Hydrogen-Ion Concentration | Arabidopsis thaliana | Tyrosine | Uranium | Analysis | Physiological aspects | Fluorescence | Protein kinases | Calmodulin | Protein binding | Protein kinase C | Peptides | Calcium | Toxicity | Physical chemistry | Amino acids | Biochemistry | Kinases | pH effects | Casein kinase II | Proteins | Spectrometry | Hydrogen ions | Calcium-binding protein | Catalysis | Uranium dioxide | Recombinant | Vibration | Threonine | Ion-exchange chromatography | EF-hand | Homogeneity | Affinity | Ligands | Binding sites | Life Sciences | Biomolecules | Environmental Engineering | Biochemistry, Molecular Biology | Environmental Sciences | pH
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 02/2013, Volume 12, Issue 2, pp. 573 - 584
Journal Article
Journal Article
Nature chemical biology, ISSN 1552-4450, 10/2014, Volume 10, Issue 10, pp. 853 - 860
Activation of the ERK pathway is a hallmark of cancer, and targeting of upstream signaling partners led to the development of approved drugs. Recently,... 
POLY(ADP-RIBOSE) POLYMERASE | RAF INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | ACQUIRED-RESISTANCE | MAP KINASE ERK2 | BRAF | CONFORMATION | MEK INHIBITORS | SELECTIVITY | DISCOVERY | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Intracellular Signaling Peptides and Proteins - metabolism | Piperazines - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Enzyme Inhibitors - chemistry | Mitogen-Activated Protein Kinase 1 - genetics | Mitogen-Activated Protein Kinase 8 - genetics | Antineoplastic Agents - pharmacology | Mitogen-Activated Protein Kinase 3 - chemistry | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Indazoles - chemistry | Mitogen-Activated Protein Kinase 3 - genetics | Protein Structure, Secondary | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - chemistry | Mitogen-Activated Protein Kinase 8 - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Indazoles - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Kinetics | Mitogen-Activated Protein Kinase 1 - metabolism | Signal transduction | Binding sites | Pharmaceutical sciences | Cancer
Journal Article
Journal Article
Molecules, ISSN 1420-3049, 10/2014, Volume 19, Issue 10, pp. 15411 - 15439
Journal Article