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threonine-trna ligase - genetics (103) 103
threonine-trna ligase - metabolism (102) 102
index medicus (69) 69
molecular sequence data (61) 61
humans (58) 58
escherichia coli - genetics (55) 55
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base sequence (48) 48
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transfer rna (37) 37
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threonine-trna ligase (30) 30
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crystallography, x-ray (19) 19
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discrimination (18) 18
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aminoacyl-trna synthetase (17) 17
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zinc ion (16) 16
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Methods, ISSN 1046-2023, 01/2017, Volume 113, pp. 64 - 71
•AARS protein stability can be evaluated by differential scanning fluorimetry (DSF).•DSF can be used for determining the stability of AARS enzyme... 
Amino acid | tRNA | Differential scanning fluorimetry | Aminoacyl-tRNA synthetase | Histidyl-tRNA synthetase | SYPRO Orange | CRYSTALLIZATION | CARBONIC-ANHYDRASE | PROTEIN | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | THERMAL SHIFT ASSAYS | BOMBYX-MORI | INHIBITION | STRUCTURAL BASIS | PURIFICATION | BINDING | Histidine-tRNA Ligase - antagonists & inhibitors | Protein Unfolding | Amino Acids - chemistry | RNA, Transfer, Amino Acid-Specific - metabolism | Substrate Specificity | Fluorometry - methods | Threonine-tRNA Ligase - genetics | Phase Transition | Histidine-tRNA Ligase - genetics | Threonine-tRNA Ligase - antagonists & inhibitors | Benzopyrans - chemistry | Amino Acids - metabolism | Threonine-tRNA Ligase - chemistry | Alanine-tRNA Ligase - genetics | Enzyme Inhibitors - chemistry | Escherichia coli Proteins - antagonists & inhibitors | Alanine-tRNA Ligase - metabolism | Fluorescent Dyes - chemistry | Transfer RNA Aminoacylation | Histidine-tRNA Ligase - metabolism | Escherichia coli - enzymology | Alanine-tRNA Ligase - antagonists & inhibitors | Muramidase - chemistry | Enzyme Stability | RNA, Transfer, Amino Acid-Specific - genetics | Escherichia coli Proteins - metabolism | Muramidase - metabolism | Histidine-tRNA Ligase - chemistry | Alanine-tRNA Ligase - chemistry | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Protein Binding | Escherichia coli Proteins - chemistry | Threonine-tRNA Ligase - metabolism | Ligases | Transfer RNA | Amino acids | Usage | Analysis
Journal Article
Human mutation, ISSN 1059-7794, 2014, Volume 35, Issue 8, pp. 983 - 989
ABSTRACT By way of whole‐exome sequencing, we identified a homozygous missense mutation in VARS2 in one subject with microcephaly and epilepsy associated with... 
aminoacyl tRNA syntethases | TARS2 | encephalomyopathy | VARS2 | OXPHOS defect | mitochondrial disease | Encephalomyopathy | Aminoacyl tRNA syntethases | Mitochondrial disease | CELLS | INVOLVEMENT | BRAIN-STEM | LEUKOENCEPHALOPATHY | GENE | DNA | GENETICS & HEREDITY | Mitochondria - enzymology | Saccharomyces cerevisiae - genetics | Humans | Mitochondrial Encephalomyopathies - enzymology | Infant | Male | Threonine-tRNA Ligase - genetics | HLA Antigens - genetics | RNA, Messenger - metabolism | Electron Transport Complex I - metabolism | Saccharomyces cerevisiae - metabolism | RNA, Transfer, Val - genetics | DNA, Mitochondrial - genetics | Mitochondria - genetics | Electron Transport Complex I - genetics | Isoenzymes - metabolism | Valine-tRNA Ligase - metabolism | Valine-tRNA Ligase - genetics | Child | RNA, Transfer, Thr - genetics | Fibroblasts - metabolism | Cell Line | DNA, Mitochondrial - metabolism | RNA, Transfer, Thr - metabolism | Isoenzymes - genetics | Mitochondrial Encephalomyopathies - genetics | RNA, Messenger - genetics | Mitochondria - pathology | HLA Antigens - metabolism | Polymorphism, Genetic | Mitochondrial Encephalomyopathies - pathology | RNA, Transfer, Val - metabolism | Homozygote | Heterozygote | Fibroblasts - cytology | Mutation | Threonine-tRNA Ligase - metabolism | Proteins | Care and treatment | Analysis | Epilepsy | Genetic aspects | Single nucleotide polymorphisms | Aminoacyl-tRNA synthetases | Transfer RNA
Journal Article
Molecular Biology and Evolution, ISSN 0737-4038, 11/2008, Volume 25, Issue 11, pp. 2369 - 2389
A comparative genomic analysis of 35 cyanobacterial strains has revealed that the gene complement of aminoacyl-tRNA synthetases (AARSs) and routes for... 
Gene duplication | Phylogeny | Aminoacyl-tRNA synthetase | Cyanobacteria | Domain shuffling | Horizontal gene transfer | ASPARAGINE SYNTHETASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COLI YADB GENE | domain shuffling | MITOCHONDRIAL-DNA | horizontal gene transfer | MULTIPLE SEQUENCE ALIGNMENT | EVOLUTIONARY BIOLOGY | COMPLETE GENOME STRUCTURE | MOLECULAR PHYLOGENETICS | aminoacyl-tRNA synthetase | gene duplication | GLUTAMINYL-TRANSFER-RNA | HISTIDYL-TRANSFER-RNA | cyanobacteria | GENETICS & HEREDITY | phylogeny | HORIZONTAL GENE-TRANSFER | NUCLEOTIDE-SEQUENCE | Cyanobacteria - genetics | Gene Duplication | Cyanobacteria - classification | Threonine-tRNA Ligase - genetics | RNA, Transfer, Gln - metabolism | RNA, Transfer, Asn - metabolism | Histidine-tRNA Ligase - genetics | Genetic Variation | Arginine-tRNA Ligase - genetics | Aspartate-tRNA Ligase - metabolism | RNA, Transfer, Amino Acyl - metabolism | Amino Acyl-tRNA Synthetases - metabolism | RNA, Bacterial - metabolism | Amino Acyl-tRNA Synthetases - genetics | Protein Structure, Tertiary | Genome, Bacterial | Histidine-tRNA Ligase - metabolism | Bacterial Proteins - genetics | Arginine-tRNA Ligase - metabolism | RNA, Transfer, Amino Acyl - genetics | Cyanobacteria - enzymology | Amino Acid Motifs | Aspartate-tRNA Ligase - genetics | Glutamate-tRNA Ligase - metabolism | Glutamate-tRNA Ligase - genetics | Threonine-tRNA Ligase - metabolism | Evolution, Molecular | Proteins | Bacteria | Evolutionary biology | Molecular biology | Genomics
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e81734
Twenty different aminoacyl-tRNA synthetases (ARSs) link each amino acid to their cognate tRNAs. Individual ARSs are also associated with various non-canonical... 
BREAST-CANCER | TARGET | SIGNAL | AIMP2 | PROTEIN INTERACTIONS | FANCD2 | INTERACTS | MULTIDISCIPLINARY SCIENCES | C-MYC | ASSIGNMENT | TRANSLATION | Humans | Molecular Sequence Data | Neoplasm Proteins - metabolism | Cytokines - chemistry | Mass Spectrometry | HEK293 Cells | Carrier Proteins - chemistry | Amino Acyl-tRNA Synthetases - chemistry | Amino Acyl-tRNA Synthetases - metabolism | Amino Acid Sequence | Computational Biology - methods | Threonine-tRNA Ligase - analysis | Cytokines - metabolism | RNA-Binding Proteins - chemistry | Neoplasm Proteins - chemistry | Nuclear Proteins | Protein Interaction Mapping - methods | Algorithms | Carrier Proteins - metabolism | Chromatography, Affinity | Threonine-tRNA Ligase - isolation & purification | Lysine-tRNA Ligase - metabolism | Protein Processing, Post-Translational | RNA-Binding Proteins - metabolism | Threonine-tRNA Ligase - metabolism | Physiological aspects | Usage | Research | Aminoacyl-tRNA synthetases | Mass spectrometry | Multiple sclerosis | Biomedical research | Peptides | Amino acids | Kinases | Proteins | Signal transduction | Cell growth | Tumor necrosis factor-TNF | Life sciences | Spectroscopy | Purification | tRNA | Threonine-tRNA ligase | Cloning | Mass spectroscopy | Topology | Precipitates | Computer science | Contaminants | Affinity | Scientific imaging | Autoimmune diseases | Aminoacyl-tRNA ligase | Cancer | Apoptosis
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 1357 - 15
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2016, Volume 36, Issue 4, pp. 655 - 662
OBJECTIVE—Understanding the mechanisms regulating normal and pathological angiogenesis is of great scientific and clinical interest. In this report, we show... 
protein kinases | unfolded protein response | zebrafish | vascular endothelial growth factor A | pathologic neovascularization | endoplasmic reticulum | VASCULAR DEVELOPMENT | FACTOR VEGF | A EXPRESSION | ENDOTHELIAL-GROWTH-FACTOR | ER STRESS | TUMOR ANGIOGENESIS | INDUCTION | HYPOXIA | FRAGMENT | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ZEBRAFISH DEVELOPMENT | Endoplasmic Reticulum - metabolism | Threonine-tRNA Ligase - genetics | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Activating Transcription Factor 6 - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Isoleucine-tRNA Ligase - genetics | Gene Expression Regulation, Developmental | Isoleucine-tRNA Ligase - deficiency | Signal Transduction | Animals, Genetically Modified | Threonine-tRNA Ligase - deficiency | Activating Transcription Factor 4 - genetics | Genotype | Zebrafish | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Unfolded Protein Response | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Phenotype | Zebrafish Proteins - deficiency | Animals | Activating Transcription Factor 4 - metabolism | Endoplasmic Reticulum Stress | Mutation | Zebrafish Proteins - genetics | Neovascularization, Physiologic
Journal Article
PLoS neglected tropical diseases, ISSN 1935-2735, 02/2020, Volume 14, Issue 2, pp. e0007983 - e0007983
The development of chemotherapies against eukaryotic pathogens is especially challenging because of both the evolutionary conservation of drug targets between... 
IDENTITY | EVOLUTION | ESCHERICHIA-COLI | GENES | TRNASCAN-SE | CRYSTAL-STRUCTURES | DRUG-RESISTANCE | COMBINATION | PROGRAM | PARASITOLOGY | TROPICAL MEDICINE | Alanine-tRNA Ligase - metabolism | Trypanosomiasis - parasitology | Alanine-tRNA Ligase - antagonists & inhibitors | Protozoan Proteins - antagonists & inhibitors | Trypanosoma - genetics | Humans | Enzyme Inhibitors - pharmacology | Threonine-tRNA Ligase - genetics | Antiprotozoal Agents - chemistry | Protozoan Proteins - genetics | Antiprotozoal Agents - pharmacology | Threonine-tRNA Ligase - antagonists & inhibitors | Leishmania - enzymology | Protozoan Proteins - metabolism | Trypanosoma - drug effects | Alanine-tRNA Ligase - genetics | Enzyme Inhibitors - chemistry | Leishmania - drug effects | Leishmaniasis - parasitology | Trypanosoma - enzymology | Leishmania - genetics | Threonine-tRNA Ligase - metabolism | Drugs | Funding | Genes | Homology | Amino acids | Identification | Genomes | Parasites | Drug resistance | Annotations | Evolutionary conservation | Evolution | Supervision | Trypanosome | Pathogens | Enzymes | Threonine-tRNA ligase | tRNA | Developmental biology | Molecular interactions | Macromolecules | Cross-reactivity | Coevolution | Chemotherapy | Alanine-tRNA ligase | Natural products | Software | Aminoacyl-tRNA ligase | Methods | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article
Journal Article
Journal Article