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Oncogene, ISSN 0950-9232, 11/2002, Volume 21, Issue 53, pp. 8196 - 8205
Sonic Hedgehog is a secreted morphogen involved in patterning a wide range of structures in the developing embryo. Disruption of the Hedgehog signalling... 
C3H/10T1/2 | Microarray | Downstream target genes | Sonic Hedgehog | downstream target genes | CDNA MICROARRAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANIMAL DEVELOPMENT | MOUSE EMBRYO | DROSOPHILA | CELL BIOLOGY | microarray | THROMBOMODULIN | FLOOR PLATE | ONCOLOGY | GENETICS & HEREDITY | GLI PROTEINS | CANDIDATE GENE | DIFFERENTIATION | HUMAN HOMOLOG | Cytoskeletal Proteins | Protein Biosynthesis | Testicular Hormones - biosynthesis | Oligonucleotide Array Sequence Analysis | Cell Count | Recombinant Fusion Proteins - physiology | Nuclear Receptor Subfamily 4, Group A, Member 1 | Testicular Hormones - genetics | Mesoderm - cytology | Receptors, Cytoplasmic and Nuclear | Thrombomodulin - biosynthesis | Trans-Activators - physiology | Hedgehog Proteins | Insulin-Like Growth Factor II - genetics | Transfection | Neoplasm Proteins | Anti-Mullerian Hormone | Insulin-Like Growth Factor II - biosynthesis | Nerve Tissue Proteins - biosynthesis | Trans-Activators - genetics | Growth Inhibitors - biosynthesis | Thrombomodulin - genetics | Growth Inhibitors - genetics | Glycoproteins - genetics | Homeodomain Proteins - biosynthesis | LIM Domain Proteins | Signal Transduction | Gene Expression Regulation | Myelin Proteins - biosynthesis | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Myelin Proteins - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Mice, Inbred C3H | Glycoproteins - biosynthesis | Membrane Proteins | Pluripotent Stem Cells - metabolism | Proteins - genetics | Receptors, Steroid | Animals | Mice | DNA-Binding Proteins - biosynthesis | Forkhead Transcription Factors | Embryonic development | Stem cells | Physiological aspects | Genetic aspects | Research | Gene expression | Identification and classification | Health aspects | Cancer
Journal Article
Circulation Research, ISSN 0009-7330, 03/2005, Volume 96, Issue 5, pp. e48 - e57
The vascular endothelium maintains blood fluidity by inhibiting blood coagulation, inhibiting platelet aggregation, and promoting fibrinolysis. Endothelial... 
endothelium | CATALYZED ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | transcription | HUMAN VASCULAR ENDOTHELIUM | PROTEIN-C | coagulation | TUMOR-NECROSIS-FACTOR | THROMBOMODULIN GENE | PLASMINOGEN-ACTIVATOR | thrombomodulin | SHEAR-STRESS | CELL COFACTOR | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | TRANSCRIPTION FACTOR | TISSUE FACTOR | Humans | DNA, Complementary - genetics | Recombinant Fusion Proteins - physiology | von Willebrand Factor - biosynthesis | von Willebrand Factor - genetics | Hemorheology | Nitric Oxide Synthase - genetics | Thrombomodulin - biosynthesis | Trans-Activators - physiology | RNA, Messenger - biosynthesis | Thrombin - pharmacology | Transfection | Cattle | Trans-Activators - genetics | Aorta | Nitric Oxide Synthase - biosynthesis | Trans-Activators - biosynthesis | Plasminogen Activator Inhibitor 1 - genetics | Thrombomodulin - genetics | Binding Sites | Promoter Regions, Genetic | Endothelial Cells - metabolism | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Nitric Oxide Synthase Type III | Gene Expression Regulation - physiology | Umbilical Veins | Interleukin-1 - pharmacology | Gene Expression Regulation - drug effects | Kruppel-Like Transcription Factors | Plasminogen Activator Inhibitor 1 - biosynthesis | Tumor Necrosis Factor-alpha - pharmacology | Thrombosis - metabolism | Transcription, Genetic - physiology | Animals | Blood Coagulation - genetics | Cells, Cultured - metabolism | Blood Coagulation - physiology | Thromboplastin - metabolism
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e96005
Statins exert atheroprotective effects through the induction of specific transcriptional factors in multiple organs. In endothelial cells, statin-dependent... 
PROINFLAMMATORY ACTIVATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BIOLOGY | ATHEROSCLEROSIS | CHROMOSOME CONFORMATION | KRUPPEL-LIKE FACTOR-2 | INHIBITORS | TARGETED DELETION | TRANSCRIPTION FACTOR | STATINS | Chromatin - metabolism | Kruppel-Like Transcription Factors - biosynthesis | MEF2 Transcription Factors - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Response Elements | Gene Expression Regulation - genetics | Humans | Nitric Oxide Synthase Type III - biosynthesis | Nitric Oxide Synthase Type III - genetics | Chromatin Assembly and Disassembly - drug effects | Quinolines - pharmacology | Gene Knockdown Techniques | Thrombomodulin - biosynthesis | Gene Expression Regulation - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Human Umbilical Vein Endothelial Cells - cytology | MEF2 Transcription Factors - metabolism | Thrombomodulin - genetics | Chromatin - genetics | Kruppel-Like Transcription Factors - genetics | Chromatin | DNA microarrays | Nitric oxide | Genes | Genomics | Luciferase | Statins | Endothelium | Transcription factors | Nephrology | Immunoprecipitation | Laboratories | Gene regulation | Spatial discrimination | Science | Fluorescence | Cardiovascular disease | Genomes | Kinases | KLF4 gene | Gene sequencing | KLF4 protein | Myocyte-specific enhancer-binding factor 2 | Rodents | Fluorescence in situ hybridization | Thrombomodulin | Chromosomes | Kruppel protein | Organs | Gene expression | Nitric-oxide synthase | Endothelial cells | Medicine | NOS3 protein | Umbilical vein | Binding sites | Endocrinology | Conformation
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 12/2016, Volume 439, pp. 67 - 73
CD93 belongs to the group XIV C-type lectin like domain (CTLD) and is closely related to thrombomodulin (CD141). Although CD93 is known to be involved in the... 
DsbC | Erv1p | Inflammation | CD93 | Disulfide bond | C-type like domain (CTLD) | THROMBOMODULIN | BIOCHEMICAL RESEARCH METHODS | IMMUNOLOGY | PROTEINS | Disulfides - metabolism | Tumor Necrosis Factor-alpha - metabolism | Calcium - metabolism | Humans | Membrane Glycoproteins - biosynthesis | Membrane Glycoproteins - chemistry | Cytoplasm - metabolism | Monocytes - metabolism | Monocytes - immunology | Structure-Activity Relationship | Recombinant Proteins - biosynthesis | Inflammation - metabolism | Receptors, Complement - biosynthesis | Disulfides - chemistry | Escherichia coli Proteins - biosynthesis | Cloning, Molecular - methods | Escherichia coli - metabolism | Receptors, Complement - genetics | Tumor Necrosis Factor-alpha - immunology | Nuclear Magnetic Resonance, Biomolecular | Protein Domains | Binding Sites | Oxidoreductases - biosynthesis | Cell Line | Oxidoreductases - genetics | Membrane Glycoproteins - pharmacology | Inflammation - immunology | Membrane Glycoproteins - genetics | Monocytes - drug effects | Receptors, Complement - chemistry | Protein Disulfide-Isomerases - genetics | Protein Disulfide-Isomerases - biosynthesis | Escherichia coli - genetics | Lipopolysaccharides - pharmacology | Escherichia coli Proteins - genetics | Protein Binding | Gene Expression Regulation, Bacterial | Oxidases | Lectins | Recombinant proteins | Analysis | Escherichia coli | Protein binding | Life Sciences
Journal Article
European Journal of Vascular & Endovascular Surgery, ISSN 1078-5884, 2009, Volume 38, Issue 1, pp. 20 - 25
Abstract Objectives Thrombomodulatory factors have been implicated in plaque instability. The aim was to examine the relationship between thrombomodulatory... 
Surgery | Carotid plaque | Plaque instability | Thrombomodulation | Atherosclerosis | SURGERY | LOCALIZATION | ATHEROSCLEROTIC PLAQUES | STENOSIS | CORONARY-ARTERIES | LESIONS | VESSELS | PLASMINOGEN-ACTIVATOR | PERIPHERAL VASCULAR DISEASE | UNSTABLE ANGINA | FACTOR PATHWAY INHIBITOR | Carotid Arteries - metabolism | Factor Xa Inhibitors | Follow-Up Studies | Antigens, CD - biosynthesis | Blood Coagulation Factors - biosynthesis | Lipoproteins - genetics | Humans | Middle Aged | Male | Carotid Artery Thrombosis - metabolism | Macrophages | Tissue Plasminogen Activator - genetics | Antigens, CD - genetics | Cadherins - biosynthesis | Thrombomodulin - biosynthesis | Endarterectomy, Carotid | Aged, 80 and over | Female | Carotid Artery Thrombosis - surgery | Plasminogen Activator Inhibitor 1 - genetics | Thrombomodulin - genetics | Cadherins - genetics | Thromboplastin - biosynthesis | Antigens, Differentiation, Myelomonocytic - biosynthesis | Genetic Predisposition to Disease | Gene Expression Regulation | Blood Coagulation Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Antigens, Differentiation, Myelomonocytic - genetics | DNA - genetics | Lipoproteins - biosynthesis | Plasminogen Activator Inhibitor 1 - biosynthesis | Phenotype | Tissue Plasminogen Activator - biosynthesis | Endothelium, Vascular - metabolism | Thromboplastin - genetics | Carotid Arteries - surgery | Aged | Carotid Artery Thrombosis - genetics | Gene expression | Genetic aspects
Journal Article
Development, ISSN 0950-1991, 04/1998, Volume 125, Issue 8, pp. 1457 - 1468
The cardiovascular system develops early in embryogenesis from cells of mesodermal origin. To study the molecular and cellular processes underlying this... 
Cardiovascular system | Mouse | Endothelial cell progenitor | tie-2 | Endocardium | Vasculogenesis | thrombomodulin (TM) | VASCULAR DEVELOPMENT | vasculogenesis | cardiovascular system | ANGIOGENESIS | DEVELOPMENTAL BIOLOGY | CARDIAC DEVELOPMENT | DEVELOPING HEART | endothelial cell progenitor | mouse | GENE | endocardium | GROWTH-FACTOR | TRANSCRIPTION FACTOR | EXPRESSION | RECEPTOR TYROSINE KINASE | Endothelium, Vascular - cytology | Receptors, Vascular Endothelial Growth Factor | Receptor, TIE-2 | Golgi Apparatus - drug effects | Receptor Protein-Tyrosine Kinases - biosynthesis | Cytoplasmic Granules - physiology | Endothelium, Vascular - drug effects | von Willebrand Factor - biosynthesis | Fibroblast Growth Factors - biosynthesis | Stem Cells - cytology | Golgi Apparatus - physiology | Mesoderm - cytology | Proto-Oncogene Proteins - biosynthesis | Thrombomodulin - biosynthesis | Endoplasmic Reticulum, Rough - drug effects | Female | Golgi Apparatus - ultrastructure | Endothelium, Vascular - embryology | Tretinoin - pharmacology | Zinc Fingers | GATA4 Transcription Factor | Cell Separation | Cytoplasmic Granules - drug effects | Gene Expression Regulation | Endoplasmic Reticulum, Rough - ultrastructure | Transcription Factors - biosynthesis | Gestational Age | Cyclic AMP - pharmacology | Pregnancy | GATA6 Transcription Factor | Endoplasmic Reticulum, Rough - physiology | Animals | Cytoplasmic Granules - ultrastructure | Fibroblast Growth Factor 3 | Cell Differentiation - drug effects | Receptors, Growth Factor - biosynthesis | Mesoderm - physiology | Stem Cells - drug effects | Stem Cells - physiology | Mice | DNA-Binding Proteins - biosynthesis
Journal Article
Journal of Infection, ISSN 0163-4453, 2009, Volume 58, Issue 5, pp. 368 - 374
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2007, Volume 282, Issue 18, pp. 13769 - 13779
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 06/2010, Volume 207, Issue 6, pp. 1247 - 1260
Journal Article