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Journal of Controlled Release, ISSN 0168-3659, 03/2011, Volume 150, Issue 2, pp. 229 - 234
Transplantation of islets of Langerhans is a promising method for treating patients with insulin-dependent diabetes mellitus. The major obstacle in clinical... 
Poly(ethylene glycol)–lipid | Urokinase | Surface modification | Thiol | Islet of Langerhans | Maleimide | Thrombomodulin | Poly(ethylene glycol)-lipid | CELLS | ENCAPSULATION | INTRAPORTAL TRANSPLANTATION | PREVENTS | CHEMISTRY, MULTIDISCIPLINARY | INSULIN | ENGRAFTMENT | PHARMACOLOGY & PHARMACY | HUMAN BLOOD | TISSUE FACTOR | LANGERHANS | Enzymes, Immobilized - metabolism | Islets of Langerhans - drug effects | Fluorescein-5-isothiocyanate - metabolism | Polyethylene Glycols - chemistry | Succinimides - chemistry | Sulfhydryl Compounds - metabolism | Thrombomodulin - metabolism | Fluorescein-5-isothiocyanate - chemistry | Islets of Langerhans - metabolism | Mesocricetus | Enzymes, Immobilized - chemical synthesis | Female | Serum Albumin, Bovine - chemistry | Sulfhydryl Compounds - chemistry | Urokinase-Type Plasminogen Activator - chemistry | Cell Membrane - metabolism | Polyethylene Glycols - metabolism | Cricetinae | Islets of Langerhans - enzymology | Fluorescein-5-isothiocyanate - analogs & derivatives | Graft Survival | Glucose - pharmacology | Islets of Langerhans Transplantation - methods | Serum Albumin, Bovine - metabolism | Thrombomodulin - chemistry | Fibrinolysis | Cell Membrane - enzymology | Insulin - metabolism | Animals | Urokinase-Type Plasminogen Activator - metabolism | Enzyme Activation | Phosphatidylethanolamines - metabolism | Protein C - metabolism | Thrombin - metabolism | Maleimides - chemistry | Phosphatidylethanolamines - chemistry | Microscopy, Fluorescence | Glucose metabolism | Ethylene glycol | Phospholipids | Diabetes | Glucose | Dextrose | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2015, Volume 35, Issue 11, pp. 2412 - 2422
OBJECTIVE—Thrombomodulin (TM), a glycoprotein constitutively expressed in the endothelium, is well known for its anticoagulant and anti-inflammatory... 
monocytes | macrophages | myeloid cells | abdominal aortic aneurysm | thrombomodulin | OXIDATIVE STRESS | ACTIVATION | LECTIN-LIKE DOMAIN | LEWIS Y | DEFICIENT MICE | PROTEIN-C | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | CALCIUM-CHLORIDE | HEMATOLOGY | EXPRESSION | Aortic Aneurysm, Abdominal - chemically induced | Aortitis - immunology | Aortic Aneurysm, Abdominal - immunology | Human Umbilical Vein Endothelial Cells - metabolism | Muscle, Smooth, Vascular - metabolism | Oxidative Stress | Humans | Human Umbilical Vein Endothelial Cells - immunology | Muscle, Smooth, Vascular - immunology | Aortitis - chemically induced | Aortic Aneurysm, Abdominal - metabolism | Matrix Metalloproteinase 9 - metabolism | Thrombomodulin - metabolism | Transfection | RNA Interference | Time Factors | Inflammation Mediators - metabolism | Thrombomodulin - deficiency | Cell Membrane - metabolism | Retrospective Studies | Thrombomodulin - genetics | Angiotensin II | Aorta, Abdominal - metabolism | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Elastin - metabolism | Calcium Chloride | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Aortitis - genetics | Macrophages, Peritoneal - immunology | Aortic Aneurysm, Abdominal - genetics | Chemotaxis | Mice, Knockout | Aorta, Abdominal - immunology | Aortitis - metabolism | Animals | Myocytes, Smooth Muscle - immunology | Cell Membrane - immunology | Macrophages, Peritoneal - metabolism | Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 12/2012, Volume 56, Issue 6, pp. 2071 - 2081
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 10/2014, Volume 58, Issue 10, pp. 2036 - 2045
Scope: Vitamin D-3, its biologically most active metabolite 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3), and the vitamin D receptor (VDR) are important... 
Chromatin immunoprecipitation | Adipose tissue | Vitamin D | Vitamin D receptor | Vitamin D target genes | CHIP-SEQ | ADIPOCYTES | FOOD SCIENCE & TECHNOLOGY | MECHANISMS | ADIPOGENESIS | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | OBESITY | INFLAMMATION | RECEPTOR KNOCKOUT MICE | 1,25-DIHYDROXYVITAMIN D-3 | 3T3-L1 CELLS | Adaptor Proteins, Signal Transducing - chemistry | Up-Regulation | Humans | Adaptor Proteins, Vesicular Transport - genetics | Male | RNA, Messenger - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Receptors, Calcitriol - genetics | Adipose Tissue - metabolism | Thrombomodulin - metabolism | Cholecalciferol - administration & dosage | Cholecalciferol - therapeutic use | Dual-Specificity Phosphatases - genetics | Conserved Sequence | Vitamin D Deficiency - pathology | Adaptor Proteins, Vesicular Transport - chemistry | Calcitriol - metabolism | Seasons | Thrombomodulin - genetics | Mitogen-Activated Protein Kinase Phosphatases - chemistry | Nuclear Proteins - genetics | Vitamin D Response Element | Adaptor Proteins, Vesicular Transport - agonists | Biomarkers - metabolism | Cell Line | Nuclear Proteins - agonists | Dual-Specificity Phosphatases - metabolism | Adipose Tissue - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Receptors, Calcitriol - metabolism | Thrombomodulin - chemistry | Adaptor Proteins, Signal Transducing - agonists | Nuclear Proteins - chemistry | Mitogen-Activated Protein Kinase Phosphatases - genetics | Cholecalciferol - deficiency | Dual-Specificity Phosphatases - chemistry | Cholecalciferol - metabolism | Receptors, Calcitriol - agonists | Adaptor Proteins, Signal Transducing - genetics | Finland | Aged | Vitamin D Deficiency - diet therapy | Thrombomodulin - agonists | Vitamin D Deficiency - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Dietary Supplements | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Adipose tissues | Metabolites | RNA | Genes | Genomics | Calcifediol | Alfacalcidol | Gene expression | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2018, Volume 141, pp. 201 - 213
Given our recent evidence for the role of high mobility group box 1 (HMGB1) in chemotherapy-induced peripheral neuropathy (CIPN) in rats, we examined the... 
Chemotherapy-induced peripheral neuropathy | Paclitaxel | Reactive oxygen species (ROS) | High mobility group box 1 (HMGB1) | Macrophage | CELLS | OXIDATIVE STRESS | SOLUBLE THROMBOMODULIN | RAT | ROOT GANGLION NEURONS | ALLODYNIA | NEUROSCIENCES | CHEMOTHERAPY | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | EXPRESSION | HYPERSENSITIVITY | Hyperalgesia - chemically induced | Peripheral Nervous System Diseases - chemically induced | Pyruvates - pharmacology | Reactive Oxygen Species - metabolism | Clodronic Acid - pharmacology | Minocycline - pharmacology | Coculture Techniques | Male | Phosphoproteins - metabolism | Paclitaxel - antagonists & inhibitors | Thrombomodulin - metabolism | Thiocarbamates - pharmacology | HMGB1 Protein - metabolism | Proline - pharmacology | Membrane Proteins - metabolism | Neurons - metabolism | Sciatic Nerve - drug effects | Phosphorylation - drug effects | Peripheral Nervous System Diseases - complications | Peripheral Nervous System Diseases - immunology | Recombinant Proteins - metabolism | Proline - analogs & derivatives | Hyperalgesia - complications | Receptor for Advanced Glycation End Products - metabolism | Cells, Cultured | Hyperalgesia - prevention & control | Paclitaxel - adverse effects | Imidazoles - pharmacology | Antibodies - pharmacology | Up-Regulation - drug effects | p300-CBP Transcription Factors - metabolism | Macrophages - metabolism | Animals | Acetylcysteine - pharmacology | Macrophages - drug effects | Mice | Pyridines - pharmacology | Receptors, CXCR4 | Ganglia, Spinal - metabolism | Chemotherapy | Cysteine | Chromosomal proteins | Macrophages | Cancer | Cystine | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 11/2011, Volume 92, Issue 2, pp. 317 - 327
Journal Article
Oncogene, ISSN 0950-9232, 11/2017, Volume 36, Issue 44, pp. 6097 - 6108
The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis.... 
MOLECULAR CHARACTERIZATION | MARKER | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | TUMOR ANGIOGENESIS | CELL BIOLOGY | IN-VITRO | ELEVATED EXPRESSION | ONCOLOGY | COLORECTAL-CANCER | GROWTH | GENETICS & HEREDITY | SPROUTING ANGIOGENESIS | ENDOSIALIN | Human Umbilical Vein Endothelial Cells | Cell Adhesion Molecules - genetics | Membrane Glycoproteins - metabolism | Humans | Lectins, C-Type - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Neovascularization, Pathologic - pathology | Receptors, Complement - metabolism | Lectins, C-Type - metabolism | Thrombomodulin - metabolism | Pericytes - pathology | Receptors, Complement - genetics | Antigens, Neoplasm - metabolism | Antigens, Surface - metabolism | Thrombomodulin - genetics | Antigens, Neoplasm - genetics | Endothelial Cells - metabolism | Pancreatic Neoplasms - pathology | Pericytes - metabolism | Antigens, Surface - genetics | Pancreatic Neoplasms - genetics | Cell Adhesion Molecules - metabolism | Membrane Glycoproteins - genetics | Animals | Protein Binding | Ligands | Neovascularization, Pathologic - genetics | Mice | Endothelial Cells - pathology | Care and treatment | Pancreatic cancer | Analysis | Lectins | Extracellular matrix | Diagnosis | Research | Protein-protein interactions | Animal models | Peptides | Cell surface | Endothelial cells | Endothelium | Angiogenesis | Rodents | Fibroblasts | Pericytes | Matrix protein | Thrombomodulin | Protein interaction | Umbilical vein | Tumors | Index Medicus | Original
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2016, Volume 36, Issue 2, pp. 361 - 369
OBJECTIVE—Thrombomodulin is highly expressed on the lumenal surface of vascular endothelial cells (ECs) and possesses potent anticoagulant, antifibrinolytic,... 
anticoagulants | endothelial cells | thrombosis | tumor necrosis factor | thrombomodulin | NUCLEAR RECEPTOR NUR77 | ATHEROSCLEROSIS | ALPHA | SCHIZOPHRENIA | PROLIFERATION | KAPPA-B | THROMBIN ACTIVATABLE FIBRINOLYSIS | PROTEIN-C | DISSEMINATED INTRAVASCULAR COAGULATION | PERIPHERAL VASCULAR DISEASE | KRUPPEL-LIKE FACTOR-2 | HEMATOLOGY | Up-Regulation | Carotid Stenosis - prevention & control | Receptors, Steroid - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Male | RNA, Messenger - metabolism | Carotid Stenosis - metabolism | DNA-Binding Proteins - metabolism | Thrombomodulin - metabolism | Receptors, Thyroid Hormone - genetics | Transfection | RNA Interference | Time Factors | Carotid Stenosis - genetics | Blood Coagulation | Thrombomodulin - genetics | Thrombosis - prevention & control | Disease Models, Animal | Promoter Regions, Genetic | Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics | Transduction, Genetic | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | DNA-Binding Proteins - genetics | RNA Stability | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Receptors, Thyroid Hormone - metabolism | Thrombosis - metabolism | Animals | Receptors, Steroid - genetics | Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism | Thrombosis - genetics | Protein C - metabolism | Index Medicus
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 04/2018, Volume 46, Issue 2, pp. 765 - 780
Background/Aims: Based on the protective effect of crocin against cardiovascular diseases, we hypothesize that crocin could improve endothelial function... 
Original Paper | Endothelial nitric oxide synthase | Endothelial function | Intermediate-conductance Ca | Activated K+ channels | Crocin | conductance Ca2+ activated K+ channels | OXIDATIVE STRESS | PHYSIOLOGY | SUBCHRONIC EXPOSURE | CELL BIOLOGY | BREAST-CANCER CELLS | K-CA-CHANNELS | INDUCED CARDIOTOXICITY | Intermediate | HYPERPOLARIZING FACTOR | CORPUS CAVERNOSUM | NITRIC-OXIDE | INFLAMMATORY RESPONSE | HYPERTENSIVE-RATS | Human Umbilical Vein Endothelial Cells | Intermediate-Conductance Calcium-Activated Potassium Channels - genetics | Calcium - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - metabolism | Aorta - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism | Carotenoids - pharmacology | Thrombomodulin - metabolism | RNA Interference | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Flavonoids - pharmacology | Nitric Oxide Synthase Type III - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Pyrazoles - pharmacology | Aorta - drug effects | Rats | Down-Regulation - drug effects | Rats, Sprague-Dawley | Aorta - pathology | Cell Movement - drug effects | Intercellular Adhesion Molecule-1 - metabolism | Animals | Signal Transduction - drug effects | Cell Proliferation - drug effects | Nitric Oxide - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA, Small Interfering - metabolism | Cell growth | Nitric oxide | Rodents | Cell adhesion & migration | Index Medicus | Intermediate-conductance Ca2+-activated K+ channels
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 505 - 505
Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2) are ligands for Tie2, an endothelial-specific receptor tyrosine kinase that is an essential regulator of... 
CATALYZED ACTIVATION | PROTEIN-C ACTIVATION | RECEPTOR TYROSINE KINASES | FIBRINOLYSIS INHIBITOR | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | BLOOD-VESSELS | ENDOTHELIAL-CELL COFACTOR | GROWTH-FACTOR | TIE2 RECEPTOR | Human Umbilical Vein Endothelial Cells | Angiopoietin-2 - genetics | Humans | Cercopithecus aethiops | Recombinant Proteins - biosynthesis | Angiopoietin-1 - metabolism | Angiopoietin-2 - metabolism | Carboxypeptidase B2 - metabolism | Thrombomodulin - metabolism | Thrombin - pharmacology | RNA Interference | Angiopoietin-1 - blood | Receptor, TIE-2 - metabolism | Thrombomodulin - genetics | Blood Platelets - drug effects | Receptor, TIE-2 - antagonists & inhibitors | Mice, Inbred C57BL | Recombinant Proteins - genetics | Receptor, TIE-2 - genetics | Angiopoietin-1 - genetics | Animals | Blood Platelets - metabolism | Thrombin - chemistry | Protein Binding | Mice | Platelet Factor 4 - metabolism | Protein C - metabolism | Thrombin - metabolism | COS Cells | RNA, Small Interfering - metabolism | Tyrosine | Angiopoietin | Cloning | Coagulation | Wounds | Thrombin | Protein C | Activated protein C | Fibrinolysis | Cell surface | Endothelial cells | Proteins | Angiogenesis | Hemostasis | Protein-tyrosine kinase receptors | Thrombomodulin | Platelets | Protein-tyrosine kinase | Index Medicus
Journal Article