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Blood, ISSN 0006-4971, 07/2014, Volume 124, Issue 2, pp. 277 - 286
Megakaryocyte (MK) development in the bone marrow progresses spatially from the endosteal niche, which promotes MK progenitor proliferation, to the sinusoidal... 
DIPROTIN-A | TRANSENDOTHELIAL MIGRATION | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | CHEMOKINE RECEPTOR | FACTOR-I | PLATELET PRODUCTION | HEMATOLOGY | PROPLATELET FORMATION | OSTEOBLASTIC NICHE | MARROW VASCULAR NICHE | Chemokine CXCL12 - physiology | Stem Cell Niche - radiation effects | Bone Marrow Cells - physiology | Cell Movement - genetics | Thrombopoiesis - genetics | Cell Differentiation - genetics | Megakaryocyte Progenitor Cells - radiation effects | Bone Marrow Cells - drug effects | Female | Megakaryocytes - cytology | Megakaryocytes - radiation effects | Thrombopoiesis - drug effects | Stem Cell Niche - genetics | Chemokine CXCL12 - administration & dosage | Megakaryocyte Progenitor Cells - cytology | Radiation Injuries, Experimental - genetics | Cell Differentiation - radiation effects | Megakaryocyte Progenitor Cells - drug effects | Bone Marrow Cells - cytology | Megakaryocyte Progenitor Cells - physiology | Mice, Inbred C57BL | Cells, Cultured | Megakaryocytes - physiology | Receptors, CXCR4 - administration & dosage | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Cell Movement - radiation effects | Receptors, CXCR4 - metabolism | Cell Movement - drug effects | Thrombopoiesis - radiation effects | Animals | Cell Differentiation - drug effects | Mice | Stem Cell Niche - drug effects | Megakaryocytes - drug effects | Platelets and Thrombopoiesis
Journal Article
Blood, ISSN 0006-4971, 08/2017, Volume 130, Issue 9, pp. 1132 - 1143
Journal Article
Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 6, pp. 1008 - 1015
The majority of peripheral serotonin is stored in platelets, which secrete it on activation. Serotonin releases Weibel-Palade bodies (WPBs) and we asked... 
PULMONARY-HYPERTENSION | PERMEABILITY | 5-HYDROXYTRYPTAMINE | ENDOTHELIAL-CELLS | MAST-CELLS | P-SELECTIN | RECEPTOR | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | VON-WILLEBRAND-FACTOR | SELECTIN-DEFICIENT MICE | Blood Platelets - immunology | Endothelium, Vascular - drug effects | Male | Shock, Septic - immunology | Lipopolysaccharides | Serotonin - blood | Inflammation - metabolism | L-Selectin - immunology | Leukocytosis - metabolism | Weibel-Palade Bodies - metabolism | Chemotaxis - immunology | Neutrophils - metabolism | Serotonin - immunology | Serotonin Uptake Inhibitors - immunology | Endothelium, Vascular - immunology | Neutrophil Infiltration - immunology | Fluoxetine - pharmacology | Acute Disease | Neutrophils - drug effects | Leukocytosis - immunology | Chemotaxis - drug effects | Mice, Knockout | Blood Platelets - metabolism | Endothelium, Vascular - metabolism | Mice | Serotonin Uptake Inhibitors - pharmacology | Leukocyte Rolling - drug effects | Weibel-Palade Bodies - immunology | Histamine - immunology | L-Selectin - metabolism | Flow Cytometry | Tryptophan Hydroxylase - deficiency | Blood Platelets - drug effects | Fluoxetine - immunology | Shock, Septic - genetics | Leukocyte Rolling - genetics | Histamine - pharmacology | Shock, Septic - chemically induced | Mice, Inbred C57BL | Kaplan-Meier Estimate | Neutrophils - immunology | Inflammation - immunology | Leukocyte Rolling - immunology | Tryptophan Hydroxylase - genetics | Weibel-Palade Bodies - drug effects | Animals | Serotonin - metabolism | Inflammation - genetics | Leukocytosis - genetics | Phagocytes, Granulocytes, and Myelopoiesis | Platelets and Thrombopoiesis
Journal Article
BLOOD, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5850 - 5858
Mature megakaryocytes depend on the function of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of... 
IDIOPATHIC THROMBOCYTOPENIC PURPURA | BLOOD-PLATELETS | BCL-2 | APOPTOSIS | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | IN-VIVO | PLATELET SENESCENCE | INHIBITOR | HEMATOLOGY | FAMILY | Blood Platelets - pathology | Embryo, Mammalian - drug effects | Organ Specificity - drug effects | Piperazines - administration & dosage | Liver - pathology | Cell Count | Fetus - metabolism | Fetus - pathology | Liver - embryology | Dose-Response Relationship, Drug | Lymphatic Vessels - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Liver - drug effects | Nitrophenols - pharmacology | Gene Deletion | Cell Death - drug effects | Blood Platelets - drug effects | Megakaryocytes - metabolism | Thrombopoiesis - drug effects | Cell Survival - drug effects | Embryo, Mammalian - pathology | Liver - metabolism | Mice, Inbred C57BL | Megakaryocytes - ultrastructure | Cell Size | Nitrophenols - administration & dosage | Sulfonamides - pharmacology | Piperazines - pharmacology | Blood Cell Count | Proto-Oncogene Proteins c-bcl-2 - deficiency | Fetus - drug effects | Megakaryocytes - pathology | Animals | Blood Platelets - metabolism | Lymphatic Vessels - pathology | Myeloid Cell Leukemia Sequence 1 Protein | Alleles | Biphenyl Compounds - administration & dosage | Mice | Megakaryocytes - drug effects | bcl-X Protein - metabolism | Hemorrhage - pathology | Sulfonamides - administration & dosage
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 01/2008, Volume 99, Issue 1, pp. 4 - 13
Summary Idiopathic thrombocytopenic purpura (ITP) is characterized by a low platelet count, which is the result of both increased platelet destruction and... 
Thrombocytopenia | Platelet immunology | immunity | Review Article | Immunity | FC-GAMMA RECEPTORS | thrombocytopenia | platelet immunology | COMMON VARIABLE IMMUNODEFICIENCY | HIGH-DOSE DEXAMETHASONE | AUTOIMMUNE THROMBOCYTOPENIA | IN-VITRO | ANTI-CD20 MONOCLONAL-ANTIBODY | INTRAVENOUS IMMUNOGLOBULIN-G | CIRCULATING THROMBOPOIETIN | AUTOREACTIVE T-CELLS | IMMUNE THROMBOCYTOPENIA | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Glucocorticoids - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Blood Platelets - immunology | Autoantibodies - blood | Humans | Recombinant Fusion Proteins | Thrombopoietin | Purpura, Thrombocytopenic, Idiopathic - blood | Receptors, Fc - therapeutic use | Splenectomy | Purpura, Thrombocytopenic, Idiopathic - therapy | Purpura, Thrombocytopenic, Idiopathic - immunology | T-Lymphocytes - drug effects | Treatment Failure | Blood Platelets - drug effects | Carrier Proteins - therapeutic use | Thrombopoiesis - drug effects | Hematologic Agents - pharmacology | Immune Tolerance - drug effects | Purpura, Thrombocytopenic, Idiopathic - physiopathology | Hydrazines - therapeutic use | Hematologic Agents - therapeutic use | B-Lymphocytes - drug effects | Animals | Platelet Count | Immunoglobulins, Intravenous - therapeutic use | Cell Communication - drug effects | Immunologic Factors - pharmacology | Immunologic Factors - therapeutic use
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2014, Volume 34, Issue 3, pp. 552 - 564
OBJECTIVE—Interleukin 1 Receptor 1 (IL1R1) and its ligand, IL1β, are upregulated in cardiovascular disease, obesity, and infection. Previously, we reported a... 
Infection | Diet, high-fat | Megakaryocytes | Blood platelets | IL1R1 protein, human | THROMBOPOIESIS | CELLS | blood platelets | infection | megakaryocytes | HIGH-FAT DIET | CANAKINUMAB | ATHEROSCLEROSIS | IL1R1 protein | ARTERIES | CYTOKINE PRODUCTION | INHIBITION | high-fat | PERIPHERAL VASCULAR DISEASE | IL-1-BETA | diet | HEMATOLOGY | human | EXPRESSION | Inflammation - pathology | Transcription, Genetic - drug effects | Interleukin-1beta - pharmacology | Receptors, Interleukin-1 Type I - physiology | Humans | Platelet Activation - physiology | Platelet Adhesiveness - physiology | NF-kappa B - metabolism | Gene Expression Profiling | Obesity - blood | Obesity - genetics | Atherosclerosis - etiology | Bacteroidaceae Infections - blood | Thrombin - pharmacology | Protein Processing, Post-Translational - drug effects | Collagen - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Megakaryocytes - cytology | Proto-Oncogene Proteins c-akt - metabolism | Bacteroidaceae Infections - pathology | Disease Models, Animal | Receptors, Interleukin-1 Type I - deficiency | Porphyromonas gingivalis | Cell Line | Interleukin-1beta - physiology | Obesity - complications | Imidazoles - pharmacology | Inflammation - etiology | Mice, Knockout | Platelet Adhesiveness - drug effects | Transcription, Genetic - physiology | Animals | MAP Kinase Signaling System - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Receptors, Interleukin-1 Type I - genetics | Inflammation - genetics | Mice | Platelet Activation - drug effects | Pyridines - pharmacology | Dietary Fats - toxicity
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 07/2009, Volume 124, Issue 1, pp. 87 - 97
Journal Article