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1. Full Text SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury
by Niswander, Lisa M and Fegan, Katherine H and Kingsley, Paul D and McGrath, Kathleen E and Palis, James
Blood, ISSN 0006-4971, 07/2014, Volume 124, Issue 2, pp. 277 - 286
Megakaryocyte (MK) development in the bone marrow progresses spatially from the endosteal niche, which promotes MK progenitor proliferation, to the sinusoidal... 
DIPROTIN-A | TRANSENDOTHELIAL MIGRATION | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | CHEMOKINE RECEPTOR | FACTOR-I | PLATELET PRODUCTION | HEMATOLOGY | PROPLATELET FORMATION | OSTEOBLASTIC NICHE | MARROW VASCULAR NICHE | Chemokine CXCL12 - physiology | Stem Cell Niche - radiation effects | Bone Marrow Cells - physiology | Cell Movement - genetics | Thrombopoiesis - genetics | Cell Differentiation - genetics | Megakaryocyte Progenitor Cells - radiation effects | Bone Marrow Cells - drug effects | Female | Megakaryocytes - cytology | Megakaryocytes - radiation effects | Thrombopoiesis - drug effects | Stem Cell Niche - genetics | Chemokine CXCL12 - administration & dosage | Megakaryocyte Progenitor Cells - cytology | Radiation Injuries, Experimental - genetics | Cell Differentiation - radiation effects | Megakaryocyte Progenitor Cells - drug effects | Bone Marrow Cells - cytology | Megakaryocyte Progenitor Cells - physiology | Mice, Inbred C57BL | Cells, Cultured | Megakaryocytes - physiology | Receptors, CXCR4 - administration & dosage | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Cell Movement - radiation effects | Receptors, CXCR4 - metabolism | Cell Movement - drug effects | Thrombopoiesis - radiation effects | Animals | Cell Differentiation - drug effects | Mice | Stem Cell Niche - drug effects | Megakaryocytes - drug effects | Platelets and Thrombopoiesis
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2. Full Text Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis
by Machlus, Kellie R and Wu, Stephen K and Vijey, Prakrith and Soussou, Thomas S and Liu, Zhi-Jian and Shacham, Eran and Unger, T.J and Kashyap, Trinayan and Klebanov, Boris and Sola-Visner, Martha and Crochiere, Marsha and Italiano, Joseph E and Landesman, Yosef
Blood, ISSN 0006-4971, 08/2017, Volume 130, Issue 9, pp. 1132 - 1143
Selinexor is the first oral selective inhibitor of nuclear export compound tested for cancer treatment. Selinexor has demonstrated a safety therapy profile... 
INDUCED IMMUNE THROMBOCYTOPENIA | ACTIVATION | GROUND-STATE PLURIPOTENCY | CONGENITAL AMEGAKARYOCYTIC THROMBOCYTOPENIA | EMBRYONIC STEM-CELLS | IN-VIVO | SELF-RENEWAL | C-MPL | HEMATOLOGY | NUCLEAR EXPORT INHIBITORS | PROPLATELET FORMATION | Blood Platelets - pathology | Triazoles - adverse effects | Apoptosis - drug effects | Cell Count | Fetus - pathology | Stem Cells - cytology | Liver - embryology | Dose-Response Relationship, Drug | Blood Platelets - drug effects | Megakaryocytes - metabolism | Thrombopoiesis - drug effects | Bone Marrow - drug effects | Thrombopoietin - metabolism | Megakaryocytes - ultrastructure | Thrombocytopenia - chemically induced | Thrombocytopenia - blood | Thrombocytopenia - metabolism | Mice, Knockout | Megakaryocytes - pathology | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Bone Marrow - pathology | Platelet Activation - drug effects | Megakaryocytes - drug effects | Hydrazines - adverse effects | 101 | Platelets and Thrombopoiesis
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3. Full Text Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
by Duerschmied, Daniel and Suidan, Georgette L and Demers, Melanie and Herr, Nadine and Carbo, Carla and Brill, Alexander and Cifuni, Stephen M and Mauler, Maximilian and Cicko, Sanja and Bader, Michael and Idzko, Marco and Bode, Christoph and Wagner, Denisa D
Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 6, pp. 1008 - 1015
The majority of peripheral serotonin is stored in platelets, which secrete it on activation. Serotonin releases Weibel-Palade bodies (WPBs) and we asked... 
PULMONARY-HYPERTENSION | PERMEABILITY | 5-HYDROXYTRYPTAMINE | ENDOTHELIAL-CELLS | MAST-CELLS | P-SELECTIN | RECEPTOR | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | VON-WILLEBRAND-FACTOR | SELECTIN-DEFICIENT MICE | Blood Platelets - immunology | Endothelium, Vascular - drug effects | Male | Shock, Septic - immunology | Lipopolysaccharides | Serotonin - blood | Inflammation - metabolism | L-Selectin - immunology | Leukocytosis - metabolism | Weibel-Palade Bodies - metabolism | Chemotaxis - immunology | Neutrophils - metabolism | Serotonin - immunology | Serotonin Uptake Inhibitors - immunology | Endothelium, Vascular - immunology | Neutrophil Infiltration - immunology | Fluoxetine - pharmacology | Acute Disease | Neutrophils - drug effects | Leukocytosis - immunology | Chemotaxis - drug effects | Mice, Knockout | Blood Platelets - metabolism | Endothelium, Vascular - metabolism | Mice | Serotonin Uptake Inhibitors - pharmacology | Leukocyte Rolling - drug effects | Weibel-Palade Bodies - immunology | Histamine - immunology | L-Selectin - metabolism | Flow Cytometry | Tryptophan Hydroxylase - deficiency | Blood Platelets - drug effects | Fluoxetine - immunology | Shock, Septic - genetics | Leukocyte Rolling - genetics | Histamine - pharmacology | Shock, Septic - chemically induced | Mice, Inbred C57BL | Kaplan-Meier Estimate | Neutrophils - immunology | Inflammation - immunology | Leukocyte Rolling - immunology | Tryptophan Hydroxylase - genetics | Weibel-Palade Bodies - drug effects | Animals | Serotonin - metabolism | Inflammation - genetics | Leukocytosis - genetics | Phagocytes, Granulocytes, and Myelopoiesis | Platelets and Thrombopoiesis
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4. Full Text Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival
by Debrincat, MA and Josefsson, EC and James, C and Henley, KJ and Ellis, S and Lebois, M and Betterman, KL and Lane, RM and Rogers, KL and White, MJ and Roberts, AW and Harvey, NL and Metcalf, D and Kile, BT
BLOOD, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5850 - 5858
Mature megakaryocytes depend on the function of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of... 
IDIOPATHIC THROMBOCYTOPENIC PURPURA | BLOOD-PLATELETS | BCL-2 | APOPTOSIS | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | IN-VIVO | PLATELET SENESCENCE | INHIBITOR | HEMATOLOGY | FAMILY | Blood Platelets - pathology | Embryo, Mammalian - drug effects | Organ Specificity - drug effects | Piperazines - administration & dosage | Liver - pathology | Cell Count | Fetus - metabolism | Fetus - pathology | Liver - embryology | Dose-Response Relationship, Drug | Lymphatic Vessels - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Liver - drug effects | Nitrophenols - pharmacology | Gene Deletion | Cell Death - drug effects | Blood Platelets - drug effects | Megakaryocytes - metabolism | Thrombopoiesis - drug effects | Cell Survival - drug effects | Embryo, Mammalian - pathology | Liver - metabolism | Mice, Inbred C57BL | Megakaryocytes - ultrastructure | Cell Size | Nitrophenols - administration & dosage | Sulfonamides - pharmacology | Piperazines - pharmacology | Blood Cell Count | Proto-Oncogene Proteins c-bcl-2 - deficiency | Fetus - drug effects | Megakaryocytes - pathology | Animals | Blood Platelets - metabolism | Lymphatic Vessels - pathology | Myeloid Cell Leukemia Sequence 1 Protein | Alleles | Biphenyl Compounds - administration & dosage | Mice | Megakaryocytes - drug effects | bcl-X Protein - metabolism | Hemorrhage - pathology | Sulfonamides - administration & dosage
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5. Full Text Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP
by Bussel, James B and Kuter, David J and Pullarkat, Vinod and Lyons, Roger M and Guo, Matthew and Nichol, Janet L
Blood, ISSN 0006-4971, 03/2009, Volume 113, Issue 10, pp. 2161 - 2171
Chronic immune thrombocytopenic purpura (ITP) is characterized by low platelet counts and mucocutaneous bleeding. In previous studies romiplostim (AMG531), a... 
AUTOIMMUNE THROMBOCYTOPENIA | ADULT PATIENTS | INTRAVENOUS GAMMA-GLOBULIN | IN-VITRO | PURPURA | AMG-531 | BONE-MARROW | SPLENECTOMY | PLATELET PRODUCTION | HEMATOLOGY | THROMBOPOIETIN LEVELS | Humans | Middle Aged | Male | Recombinant Fusion Proteins | Thrombopoietin | Purpura, Thrombocytopenic, Idiopathic - drug therapy | Carrier Proteins - adverse effects | Platelet Count | Receptors, Fc - administration & dosage | Carrier Proteins - administration & dosage | Female | Blood Platelets - drug effects | Thrombopoiesis - drug effects
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6. Full Text Idiopathic thrombocytopenic purpura: Current concepts in pathophysiology and management
by Roberto Stasi and Maria Laura Evangelista and Elisa Stipa and Francesco Buccisano and Adriano Venditti and Sergio Amadori
Thrombosis and Haemostasis, ISSN 0340-6245, 01/2008, Volume 99, Issue 1, pp. 4 - 13
Summary Idiopathic thrombocytopenic purpura (ITP) is characterized by a low platelet count, which is the result of both increased platelet destruction and... 
Thrombocytopenia | Platelet immunology | immunity | Review Article | Immunity | FC-GAMMA RECEPTORS | thrombocytopenia | platelet immunology | COMMON VARIABLE IMMUNODEFICIENCY | HIGH-DOSE DEXAMETHASONE | AUTOIMMUNE THROMBOCYTOPENIA | IN-VITRO | ANTI-CD20 MONOCLONAL-ANTIBODY | INTRAVENOUS IMMUNOGLOBULIN-G | CIRCULATING THROMBOPOIETIN | AUTOREACTIVE T-CELLS | IMMUNE THROMBOCYTOPENIA | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Glucocorticoids - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Blood Platelets - immunology | Autoantibodies - blood | Humans | Recombinant Fusion Proteins | Thrombopoietin | Purpura, Thrombocytopenic, Idiopathic - blood | Receptors, Fc - therapeutic use | Splenectomy | Purpura, Thrombocytopenic, Idiopathic - therapy | Purpura, Thrombocytopenic, Idiopathic - immunology | T-Lymphocytes - drug effects | Treatment Failure | Blood Platelets - drug effects | Carrier Proteins - therapeutic use | Thrombopoiesis - drug effects | Hematologic Agents - pharmacology | Immune Tolerance - drug effects | Purpura, Thrombocytopenic, Idiopathic - physiopathology | Hydrazines - therapeutic use | Hematologic Agents - therapeutic use | B-Lymphocytes - drug effects | Animals | Platelet Count | Immunoglobulins, Intravenous - therapeutic use | Cell Communication - drug effects | Immunologic Factors - pharmacology | Immunologic Factors - therapeutic use
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7. Full Text Interleukin 1 Receptor 1 and Interleukin 1β Regulate Megakaryocyte Maturation, Platelet Activation, and Transcript Profile During Inflammation in Mice and Humans
by Beaulieu, Lea M and Lin, Elaine and Mick, Eric and Koupenova, Milka and Weinberg, Ellen O and Kramer, Carolyn D and Genco, Caroline A and Tanriverdi, Kahraman and Larson, Martin G and Benjamin, Emelia J and Freedman, Jane E
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 03/2014, Volume 34, Issue 3, pp. 552 - 564
OBJECTIVE—Interleukin 1 Receptor 1 (IL1R1) and its ligand, IL1β, are upregulated in cardiovascular disease, obesity, and infection. Previously, we reported a... 
Infection | Diet, high-fat | Megakaryocytes | Blood platelets | IL1R1 protein, human | THROMBOPOIESIS | CELLS | blood platelets | infection | megakaryocytes | HIGH-FAT DIET | CANAKINUMAB | ATHEROSCLEROSIS | IL1R1 protein | ARTERIES | CYTOKINE PRODUCTION | INHIBITION | high-fat | PERIPHERAL VASCULAR DISEASE | IL-1-BETA | diet | HEMATOLOGY | human | EXPRESSION | Inflammation - pathology | Transcription, Genetic - drug effects | Interleukin-1beta - pharmacology | Receptors, Interleukin-1 Type I - physiology | Humans | Platelet Activation - physiology | Platelet Adhesiveness - physiology | NF-kappa B - metabolism | Gene Expression Profiling | Obesity - blood | Obesity - genetics | Atherosclerosis - etiology | Bacteroidaceae Infections - blood | Thrombin - pharmacology | Protein Processing, Post-Translational - drug effects | Collagen - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Megakaryocytes - cytology | Proto-Oncogene Proteins c-akt - metabolism | Bacteroidaceae Infections - pathology | Disease Models, Animal | Receptors, Interleukin-1 Type I - deficiency | Porphyromonas gingivalis | Cell Line | Interleukin-1beta - physiology | Obesity - complications | Imidazoles - pharmacology | Inflammation - etiology | Mice, Knockout | Platelet Adhesiveness - drug effects | Transcription, Genetic - physiology | Animals | MAP Kinase Signaling System - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Receptors, Interleukin-1 Type I - genetics | Inflammation - genetics | Mice | Platelet Activation - drug effects | Pyridines - pharmacology | Dietary Fats - toxicity
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8. Full Text Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents
by Bao, Weili and Bussel, James B and Heck, Susanne and He, Wu and Karpoff, Marissa and Boulad, Nayla and Yazdanbakhsh, Karina
Blood, ISSN 0006-4971, 11/2010, Volume 116, Issue 22, pp. 4639 - 4645
Immune thrombocytopenia (ITP) is an autoantibody-mediated bleeding disorder with both accelerated platelet destruction and impaired platelet production. We and... 
GROWTH-FACTOR-BETA | ACTIVATION | HUMAN-PLATELETS | PURPURA | ROMIPLOSTIM | CD40 LIGAND | ELTROMBOPAG | MECHANISMS | SUPPRESSION | HEMATOLOGY | CUTTING EDGE | CD40 Ligand - blood | Cell Count | Humans | Middle Aged | Thrombocytopenia - immunology | Male | T-Lymphocytes, Regulatory - immunology | Young Adult | Receptors, Thrombopoietin - agonists | T-Lymphocytes, Regulatory - drug effects | Thrombocytopenia - drug therapy | Blood Platelets - cytology | Adolescent | Adult | Female | Aged | Cell Proliferation - drug effects | Thrombopoiesis - drug effects | Transforming Growth Factor beta1 - blood | Chronic Disease | Cohort Studies | Platelets and Thrombopoiesis
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9. Full Text High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)-mediated inhibition of platelet production
by Thon, Jonathan N and Devine, Matthew T and Begonja, Antonija Jurak and Tibbitts, Jay and Italiano Jr, Joseph E
Blood, ISSN 0006-4971, 09/2012, Volume 120, Issue 10, pp. 1975 - 1984
Proplatelet production represents a terminal stage of megakaryocyte development during which long, branching processes composed of platelet-sized swellings are... 
INDUCED IMMUNE THROMBOCYTOPENIA | BREAST-CANCER | IN-VITRO | COLLAGEN | GROWTH | HEMATOLOGY | EXPRESSION | GAMMA-CHAIN | Humans | Molecular Imaging | Blood Platelets - physiology | Maytansine - pharmacology | Tubulin - metabolism | Flow Cytometry | Liver - drug effects | Microtubules - drug effects | Antibodies, Monoclonal, Humanized - pharmacology | Microtubules - ultrastructure | Biological Assay | Fetus | Blood Platelets - drug effects | Thrombopoiesis - drug effects | Cell Differentiation - physiology | Thrombopoiesis - physiology | Maytansine - analogs & derivatives | Megakaryocytes - ultrastructure | Megakaryocytes - physiology | Thrombocytopenia - chemically induced | Animals | Platelet Count | Cell Differentiation - drug effects | Blood Platelets - ultrastructure | Liver - physiology | Thrombocytopenia - prevention & control | Liver - cytology | Mice | Primary Cell Culture | Megakaryocytes - drug effects | Microscopy, Fluorescence | Trastuzumab | Plenary Paper | Platelets and Thrombopoiesis
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10. Full Text Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia
by Gerrits, Anja J and Leven, Emily A and Frelinger, Andrew L and Brigstocke, Sophie L and Berny-Lang, Michelle A and Mitchell, W. Beau and Revel-Vilk, Shoshana and Tamary, Hannah and Carmichael, Sabrina L and Barnard, Marc R and Michelson, Alan D and Bussel, James B
Blood, ISSN 0006-4971, 09/2015, Volume 126, Issue 11, pp. 1367 - 1378
Because Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT) patients have microthrombocytopenia, hemorrhage is a major problem. We asked whether... 
LONG-TERM | PERSISTENT | CHRONIC IMMUNE THROMBOCYTOPENIA | PROTEIN | CLOPIDOGREL | INHIBITION | GENE | PRASUGREL | MUTATIONS | HEMATOLOGY | WASP | Hydrazines - therapeutic use | Pyrazoles - therapeutic use | Benzoates - therapeutic use | Humans | Child, Preschool | Infant | Male | Case-Control Studies | Thrombocytopenia - blood | Young Adult | Receptors, Thrombopoietin - agonists | Thrombocytopenia - drug therapy | Genetic Diseases, X-Linked - drug therapy | Platelet Count | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Wiskott-Aldrich Syndrome - drug therapy | Adolescent | Mean Platelet Volume | P-Selectin - blood | Adult | Platelet Activation - drug effects | Wiskott-Aldrich Syndrome - blood | Child | Genetic Diseases, X-Linked - blood | 100 | 101 | Platelets and Thrombopoiesis
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11. Full Text An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis
by Yang, Mo and Chan, Godfrey C.F and Deng, Ruixia and Ng, Margaret H and Cheng, Sau Wan and Lau, Ching Po and Ye, Jie Yu and Wang, Liangjie and Liu, Chang
Journal of Ethnopharmacology, ISSN 0378-8741, 07/2009, Volume 124, Issue 1, pp. 87 - 97
A decoction containing and (Danggui Buxue Tang, DBT) has been used to raise the “Qi” and nourish the “Blood”. However, its effects on haematopoiesis and... 
Megakaryocytopoiesis | Thrombopoiesis | Danggui Buxue Tang (DBT) | Hematopoiesis | Radix angelicae sinensis | Radix astragali | Thrombopoietin | Apoptosis | CHEMISTRY, MEDICINAL | GLYCOSAMINOGLYCANS | STIMULATES MEGAKARYOCYTOPOIESIS | BIOLOGICAL ASSESSMENT | PROLIFERATION | PLANT SCIENCES | THROMBOCYTOPOIESIS | INTEGRATIVE & COMPLEMENTARY MEDICINE | MOLECULAR-WEIGHT HEPARIN | PHARMACOLOGY & PHARMACY | MICE | GROWTH-FACTOR | EXPRESSION | MARROW STROMAL CELLS | Apoptosis - drug effects | Plant Extracts - pharmacology | Caspase 3 - metabolism | Body Weight - drug effects | Drugs, Chinese Herbal - pharmacology | Male | Angelica sinensis | Thrombopoietin - blood | Hematopoiesis - drug effects | Plant Roots | Radiation Injuries, Experimental - drug therapy | Phytotherapy | Megakaryocytes - metabolism | Thrombopoiesis - drug effects | Drugs, Chinese Herbal - therapeutic use | Bone Marrow - drug effects | Disease Models, Animal | Radiation Injuries, Experimental - metabolism | Cell Line | Astragalus Plant | Mitochondria - drug effects | Annexin A5 - metabolism | Organ Size - drug effects | Animals | Platelet Count | Stem Cells - drug effects | Intracellular Membranes - drug effects | Mice | Mice, Inbred BALB C | Megakaryocytes - drug effects | Plant Extracts - therapeutic use | Universities and colleges | Index Medicus
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12. Full Text Revealing eltrombopag's promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation
by Di Buduo, CA and Currao, M and Pecci, A and Kaplan, DL and Balduini, CL and Balduini, A
HAEMATOLOGICA, ISSN 0390-6078, 12/2016, Volume 101, Issue 12, pp. 1479 - 1488
Eltrombopag is a small, non-peptide thrombopoietin mimetic that has been approved for increasing platelet count not only in immune thrombocytopenia and... 
MARROW FAILURE SYNDROMES | HUMAN MEGAKARYOCYTES | SEVERE APLASTIC-ANEMIA | ACUTE MYELOID-LEUKEMIA | PLATELET PRODUCTION | EX-VIVO | HEMATOLOGY | THROMBOPOIETIN-RECEPTOR AGONISTS | PROPLATELET FORMATION | HEPATITIS-C | MYELODYSPLASTIC SYNDROMES | Hematopoietic Stem Cells - drug effects | Hydrazines - pharmacology | Humans | Hematopoietic Stem Cells - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptors, Thrombopoietin - metabolism | Phenotype | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Blood Platelets - cytology | Blood Platelets - metabolism | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Benzoates - pharmacology | Biomarkers | Megakaryocytes - cytology | Megakaryocytes - drug effects | Megakaryocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Thrombopoiesis - drug effects | Pyrazoles - pharmacology
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13. Full Text Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature
by Kavanagh, David and McGlasson, Sarah and Jury, Alexa and Williams, Jac and Scolding, Neil and Bellamy, Chris and Gunther, Claudia and Ritchie, Diane and Gale, Daniel P and Kanwar, Yashpal S and Challis, Rachel and Buist, Holly and Overell, James and Weller, Belinda and Flossmann, Oliver and Blunden, Mark and Meyer, Eric P and Krucker, Thomas and Evans, Stephen J. W and Campbell, Iain L and Jackson, Andrew P and Chandran, Siddharthan and Hunt, David P. J
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 24, pp. 2824 - 2833
Many drugs have been reported to cause thrombotic microangiopathy (TMA), yet evidence supporting a direct association is often weak. In particular, TMA has... 
AICARDI-GOUTIERES-SYNDROME | SYSTEMIC-LUPUS-ERYTHEMATOSUS | HEMOLYTIC-UREMIC SYNDROME | MULTIPLE-SCLEROSIS PATIENTS | NEUROLOGICAL DISEASE | THROMBOCYTOPENIC PURPURA | ALPHA | MUTATIONS | HEMATOLOGY | ASSOCIATION | BETA | Microvessels - ultrastructure | Kidney - drug effects | Kidney - pathology | Species Specificity | Humans | Microvessels - drug effects | Mice, Transgenic | Interferon Type I - adverse effects | Animals | Signal Transduction - drug effects | Biopsy | Multiple Sclerosis - pathology | Thrombotic Microangiopathies - chemically induced | Platelets and Thrombopoiesis
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