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Current Opinion in Hematology, ISSN 1065-6251, 09/2007, Volume 14, Issue 5, pp. 511 - 514
PURPOSE OF REVIEWThis article summarizes recent insights into the pathophysiology of immune thrombocytopenic purpura, a disorder in which autoantibodies... 
T lymphocytes | Autoantibody | Immune thrombocytopenic purpura | Platelets | ANTIBODIES | autoantibody | REACTIVITY | CHRONIC ITP | MECHANISMS | platelets | ANTIPLATELET AUTOANTIBODIES | IN-VITRO | immune thrombocytopenic purpura | KINETICS | IIIA | PLATELET-MEMBRANE | HEMATOLOGY | T-CELLS | Blood Platelets - pathology | Blood Platelets - immunology | CD8-Positive T-Lymphocytes - pathology | Cell Proliferation | Purpura, Thrombocytopenic, Idiopathic - genetics | Humans | CD4-Positive T-Lymphocytes - pathology | CD4-Positive T-Lymphocytes - immunology | Thrombopoiesis - genetics | Receptors, IgG - genetics | Thrombopoietin - immunology | Purpura, Thrombocytopenic, Idiopathic - immunology | Purpura, Thrombocytopenic, Idiopathic - pathology | B-Lymphocytes - pathology | Purpura, Thrombocytopenic, Idiopathic - physiopathology | Platelet Glycoprotein GPIIb-IIIa Complex - immunology | Platelet Membrane Glycoproteins - immunology | Immunity, Cellular - genetics | Polymorphism, Genetic - immunology | Thrombopoiesis - immunology | Receptors, IgG - immunology | Thrombopoietin - genetics | Autoantibodies - immunology | Megakaryocytes - pathology | B-Lymphocytes - immunology | Autoantibodies - genetics | CD8-Positive T-Lymphocytes - immunology | Chronic Disease | Antibody Formation - genetics | Platelet Glycoprotein GPIb-IX Complex - immunology
Journal Article
Advances in experimental medicine and biology, ISSN 0065-2598, 2016, Volume 909, pp. 69 - 138
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1431 - 13
Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions. The... 
EXTRACELLULAR HSP27 | POLYCYTHEMIA-VERA | HSP90 INHIBITOR | ACTIVATION | SHOCK-PROTEIN 27 | MULTIDISCIPLINARY SCIENCES | MYELOPROLIFERATIVE NEOPLASMS | SERUM | MESENCHYMAL TRANSITION | TYROSINE-PHOSPHATASE | BONE-MARROW FIBROSIS | Leukocytes - pathology | Whole-Body Irradiation | Humans | STAT5 Transcription Factor - immunology | Primary Myelofibrosis - pathology | Molecular Targeted Therapy | HSP27 Heat-Shock Proteins - genetics | Leukocytes - immunology | STAT5 Transcription Factor - genetics | Thrombopoietin - immunology | Oligonucleotides - pharmacology | Bone Marrow Cells - immunology | Bone Marrow Transplantation | HEK293 Cells | Female | Disease Models, Animal | Primary Myelofibrosis - drug therapy | Janus Kinase 2 - immunology | Transduction, Genetic | Mice, Inbred C57BL | Primary Myelofibrosis - immunology | Bone Marrow Cells - pathology | Janus Kinase 2 - genetics | Mice, Transgenic | HSP27 Heat-Shock Proteins - immunology | Thrombopoietin - genetics | Primary Myelofibrosis - genetics | Animals | K562 Cells | Cell Line, Tumor | Leukocytes - drug effects | Mice | Mutation | Spleen | CD34 antigen | Cell proliferation | Animal models | Myelofibrosis | Therapeutic applications | Lung diseases | Heat shock proteins | Antisense oligonucleotides | Stat5 protein | Disease control | Patients | Neoplasms | Thrombopoietin | Janus kinase 2 | Hsp27 protein | Fibrosis | Weight reduction | Apoptosis | Cancer | Heat shock | Tumors | Life Sciences
Journal Article
Infection and Immunity, ISSN 0019-9567, 05/2007, Volume 75, Issue 5, pp. 2283 - 2290
Journal Article
The Journal of Immunology, ISSN 0022-1767, 01/2003, Volume 170, Issue 1, pp. 421 - 429
Journal Article
Immunity, ISSN 1074-7613, 2000, Volume 13, Issue 4, pp. 549 - 560
To assess the role of the Janus kinase (Jak) family member Tyk2, we have generated Tyk2(-/-) mice. In contrast to other Jaks, where inactivation leads to a... 
T-CELL PROLIFERATION | COMPLEMENTS DEFECTS | IFN-GAMMA PRODUCTION | ANTIVIRAL DEFENSE | INTERFERON-GAMMA | JANUS KINASES | NITRIC-OXIDE SYNTHASE | LACKING JAK3 | PROTEIN-TYROSINE KINASE | IMMUNOLOGY | SIGNAL-TRANSDUCTION PATHWAY | Spleen - immunology | Embryo, Mammalian | Humans | Interferon-gamma - metabolism | Protein-Tyrosine Kinases - deficiency | Receptors, Cytokine - physiology | Lymphokines | TYK2 Kinase | Protein-Tyrosine Kinases - physiology | Receptor, Interferon alpha-beta | Lymphocyte Activation - genetics | Interferon Type I - pharmacology | Fibroblasts | Myeloid Progenitor Cells - cytology | Colony-Forming Units Assay | Cytokines - genetics | Interleukin-12 - pharmacology | Nitric Oxide - biosynthesis | Genetic Predisposition to Disease | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | Spleen - cytology | Thrombopoietin - pharmacology | Down-Regulation - genetics | Leukemia Inhibitory Factor Receptor alpha Subunit | Membrane Proteins | Macrophages - metabolism | Trans-Activators - deficiency | Lipopolysaccharides - pharmacology | Rhabdoviridae Infections - genetics | Vaccinia - immunology | Cytokines - deficiency | Mice | Vesicular stomatitis Indiana virus - immunology | Receptors, OSM-LIF | Growth Inhibitors | Lymphocytic Choriomeningitis - immunology | Interleukin-3 - pharmacology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Spleen - enzymology | Interferon Type I - metabolism | Receptors, Interferon - antagonists & inhibitors | Leukemia Inhibitory Factor | Macrophages - immunology | Lymphocytic Choriomeningitis - genetics | Cell Line | Proteins - physiology | Cells, Cultured | Mice, Inbred Strains | Vaccinia - genetics | Proteins - genetics | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Interleukin-6 - pharmacology | Down-Regulation - immunology | Rhabdoviridae Infections - immunology | Receptors, Interferon - physiology | Trans-Activators - metabolism | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Interleukin-10 - pharmacology | Cytokines - biosynthesis
Journal Article
Journal Article
British Journal of Haematology, ISSN 0007-1048, 04/2018, Volume 181, Issue 2, pp. 183 - 195
Journal Article
Experimental Hematology, ISSN 0301-472X, 2015, Volume 43, Issue 2, pp. 125 - 136
Platelets are produced from megakaryocytes (MKs) in the bone marrow. In contrast, most nonmammalian vertebrates have nucleated and spindle-shaped thrombocytes... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | PLATELET-RELEASE | MEDICINE, RESEARCH & EXPERIMENTAL | RAINBOW-TROUT | CHICKEN THROMBOCYTES | CONNECTED CANALICULAR SYSTEM | MEGAKARYOCYTES | RECEPTOR | C-MPL | THROMBOPOIETIN | HEMATOLOGY | LOW-TEMPERATURE | CFU-MK | Thrombopoiesis | Blood Platelets - immunology | Spleen - immunology | Antibodies, Monoclonal - biosynthesis | Male | Spleen - drug effects | Liver - immunology | Lymphocytes - immunology | Thrombin - pharmacology | Liver - drug effects | Blood Platelets - cytology | Platelet Membrane Glycoprotein IIb - immunology | Collagen - pharmacology | Xenopus laevis - genetics | Blood Platelets - drug effects | Biomarkers - metabolism | Gene Expression | Xenopus laevis - immunology | Proto-Oncogene Protein c-fli-1 - genetics | Antibodies, Monoclonal - pharmacology | Thrombocytopenia - immunology | Cells, Cultured | Lymphocytes - cytology | Spleen - cytology | Thrombocytopenia - chemically induced | Organ Specificity | Thrombocytopenia - pathology | Adenosine Diphosphate - pharmacology | Platelet Aggregation | Calcium Chloride - pharmacology | Animals | Lymphocytes - drug effects | Ploidies | Liver - cytology | Mice | Mice, Inbred BALB C | Platelet Membrane Glycoprotein IIb - genetics | Proto-Oncogene Protein c-fli-1 - immunology | Frogs | Analysis | Monoclonal antibodies | Thrombin | Amphibians | Adenosine triphosphatase | Biomedical engineering
Journal Article