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Blood, ISSN 0006-4971, 02/2017, Volume 129, Issue 6, pp. 667 - 679
The genetic landscape of classicalmyelopro-liferative neoplasm (MPN) is in large part elucidated. The MPN-restricted driver mutations, including those in JAK2,... 
POLYCYTHEMIA-VERA | LEUKEMIC TRANSFORMATION | ACTIVATING MUTATION | CLONAL HEMATOPOIESIS | MUTANT CALRETICULIN | ACQUIRED UNIPARENTAL DISOMY | ESSENTIAL THROMBOCYTHEMIA | HEMATOLOGY | SOMATIC MUTATIONS | THROMBOPOIETIN RECEPTOR | HEMATOPOIETIC STEM | Thrombocythemia, Essential - physiopathology | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | STAT Transcription Factors - metabolism | Polycythemia Vera - genetics | Receptors, Granulocyte Colony-Stimulating Factor - genetics | Thrombocythemia, Essential - genetics | Calreticulin - genetics | Receptors, Erythropoietin - genetics | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Polycythemia Vera - metabolism | Janus Kinase 2 - metabolism | Calreticulin - metabolism | Receptors, Granulocyte Colony-Stimulating Factor - metabolism | Polycythemia Vera - physiopathology | Primary Myelofibrosis - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Primary Myelofibrosis - physiopathology | Janus Kinase 2 - genetics | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Receptors, Thrombopoietin - metabolism | Disease Progression | DNA (Cytosine-5-)-Methyltransferases - genetics | Receptors, Thrombopoietin - genetics | Primary Myelofibrosis - genetics | STAT Transcription Factors - genetics | Mutation | Receptors, Erythropoietin - metabolism | Thrombocythemia, Essential - metabolism
Journal Article
Blood, ISSN 0006-4971, 03/2016, Volume 127, Issue 10, pp. 1325 - 1335
Journal Article
Journal Article
Leukemia, ISSN 0887-6924, 03/2016, Volume 30, Issue 3, pp. 728 - 739
The t(8;21) rearrangement, which creates the AML1-ETO fusion protein, represents the most common chromosomal translocation in acute myeloid leukemia (AML).... 
MUTATED C-CBL | CANCER GENOMICS | ONCOLOGY | T(8/21) AML | HEMATOPOIETIC STEM-CELLS | MOUSE MODEL | JUVENILE MYELOMONOCYTIC LEUKEMIA | ACQUIRED UNIPARENTAL DISOMY | SELF-RENEWAL | MYELOPROLIFERATIVE NEOPLASMS | HEMATOLOGY | TYROSINE-PHOSPHATASE | Myeloid Cells - cytology | RNA, Small Interfering - genetics | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Proto-Oncogene Proteins c-cbl - metabolism | Cell Proliferation | Humans | Leukemia, Myeloid, Acute - metabolism | Preleukemia - pathology | MicroRNAs - metabolism | Protein Tyrosine Phosphatases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Protein Tyrosine Phosphatases - genetics | Heterografts | Preleukemia - genetics | src-Family Kinases - metabolism | Myeloid Cells - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Transgenes | Chromosomes, Human, Pair 21 | Proto-Oncogene Proteins c-cbl - genetics | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Chromosomes, Human, Pair 8 | Thrombopoietin - pharmacology | Fetal Blood - cytology | Gene Expression Regulation, Leukemic | Fetal Blood - drug effects | Fetal Blood - metabolism | Mice, SCID | RUNX1 Translocation Partner 1 Protein | Preleukemia - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Myeloid Cells - metabolism | Proto-Oncogene Proteins c-cbl - antagonists & inhibitors | Mice | MicroRNAs - genetics | src-Family Kinases - genetics | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | RNA, Small Interfering - metabolism | Molecular targeted therapy | Gene mutations | Translocation (Genetics) | Health aspects | Innovations | AML1-ETO | miR-9 | UBASH3B | acute myeloid leukemia | CBL | Sts-1
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 12, pp. 2133 - 2146
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 09/2004, Volume 200, Issue 5, pp. 569 - 580
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through its receptor, c-mpl, activates... 
Cell proliferation | Cytokine receptors | Endomitosis | Megakaryocytes | Hematopoiesis | MEDICINE, RESEARCH & EXPERIMENTAL | HEMATOPOIETIC PROGENITOR CELLS | IN-VIVO | CYCLIN D3 | RECEPTOR | C-MPL | DEFICIENT MICE | DIFFERENTIATION | IMMUNOLOGY | THROMBOPOIETIN | ADAPTER PROTEIN | MEGAKARYOPOIESIS | Green Fluorescent Proteins | Mitosis | Platelet Membrane Glycoprotein IIb - biosynthesis | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Retroviridae - genetics | Time Factors | Cell Division | Receptors, Cytokine - metabolism | Megakaryocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Milk Proteins - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Proteins - physiology | Thrombopoietin - metabolism | Signal Transduction | Mice, Inbred C57BL | Receptors, Thrombopoietin | Intracellular Signaling Peptides and Proteins | Genotype | Spleen - cytology | Models, Statistical | Blotting, Western | src Homology Domains | Proto-Oncogene Proteins c-akt | Megakaryocytes - pathology | Animals | STAT5 Transcription Factor | Trans-Activators - metabolism | Mice | Mice, Inbred BALB C | STAT3 Transcription Factor | Genetic Vectors | Bone Marrow Cells - metabolism | Cytokines - biosynthesis | Mitogen-Activated Protein Kinase 3 | Luminescent Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | hematopoiesis | megakaryocytes | endomitosis | cell proliferation | cytokine receptors
Journal Article
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2006, Volume 12, Issue 5, pp. 557 - 567
Journal Article