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Nature Neuroscience, ISSN 1097-6256, 01/2010, Volume 13, Issue 1, pp. 22 - 24
In cultured rat hippocampal neurons, we found that thrombospondin 1 (TSP1) increased the speed of synapse formation in young neurons, but not the final density... 
SYNAPSE FORMATION | RECEPTOR | CNS | NEUROSCIENCES | Disks Large Homolog 4 Protein | Embryo, Mammalian | Humans | Mutagenesis, Site-Directed - methods | Neurons - cytology | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Synapsins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - pharmacology | Cell Adhesion Molecules, Neuronal | Transfection - methods | Thrombospondin 1 - genetics | Membrane Proteins - metabolism | Receptors, LDL - genetics | Synapses - drug effects | Immunoprecipitation - methods | Membrane Proteins - genetics | Synapses - physiology | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Expression Regulation - physiology | Rats | Receptors, LDL - metabolism | Hippocampus - cytology | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Guanylate Kinases | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Protein Binding | Thrombospondin 1 - pharmacology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Luminescent Proteins - genetics | Mice | Physiological aspects | Parahippocampal region | Neural transmission | Genetic aspects | Research | Blood coagulation factors | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 09/2006, Volume 38, Issue 9, pp. 1060 - 1065
Human adenocarcinomas commonly harbor mutations in the KRAS and MYC proto-oncogenes and the TP53 tumor suppressor gene. All three genetic lesions are... 
EPITHELIAL-CELLS | GENE | RAS | IN-VIVO | THROMBOSPONDIN-1 | GENETICS & HEREDITY | C-MYC | CELL-PROLIFERATION | EXPRESSION | CANCER | FIBROBLASTS | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - metabolism | Stem Cells - cytology | Vascular Endothelial Growth Factor A - metabolism | RNA, Neoplasm - metabolism | Transplantation, Homologous | Culture Media, Conditioned - analysis | Immediate-Early Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Proto-Oncogene Proteins c-myc - physiology | Retroviridae - genetics | Thrombospondin 1 - genetics | Cell Line | Oligonucleotides, Antisense - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Neoplasms - blood supply | Vascular Endothelial Growth Factor A - analysis | Animals | Immediate-Early Proteins - genetics | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Proto-Oncogene Proteins c-myc - genetics | Thrombospondin 1 - metabolism | Genetic Vectors | In Vitro Techniques | Neoplasms - pathology | Cell Line, Transformed | Cell Transformation, Viral | Connective Tissue Growth Factor | Physiological aspects | Genetic aspects | Neovascularization | Research | Oncogenes | Risk factors | Tumors | Signal transduction | Genotype & phenotype | Ribonucleic acid | Rodents | Oncology | Gene expression | Ribonucleic acid--RNA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 8, pp. 5492 - 5506
Decorin, a small leucine-rich proteoglycan, inhibits tumor growth by antagonizing multiple receptor tyrosine kinases including EGFR and Met. Here, we... 
CYCLIN-DEPENDENT KINASES | SIGNAL-TRANSDUCTION | BREAST-CANCER | MATRIX METALLOPROTEINASES | LEUCINE-RICH PROTEOGLYCANS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | DOWN-REGULATION | DEFICIENT MICE | FACTOR RECEPTOR | HYPOXIA-INDUCIBLE FACTOR-1 | Transcription, Genetic - drug effects | Humans | Transcriptional Activation - drug effects | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - pathology | Thrombospondin 1 - genetics | Tissue Inhibitor of Metalloproteinase-3 - metabolism | Enzyme Induction - drug effects | Female | Decorin - pharmacology | Matrix Metalloproteinases - biosynthesis | Tissue Inhibitor of Metalloproteinase-3 - genetics | Decorin - therapeutic use | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Down-Regulation - drug effects | Proto-Oncogene Proteins c-met - genetics | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Thrombospondin 1 - metabolism | Proteoglycan | Angiogenesis | Small Leucine-rich Proteoglycan | Vascular Endothelial Growth Factor (VEGF) | Myc | β-Catenin | Glycobiology and Extracellular Matrices | Cancer Biology | Breast Cancer | Cell Biology | Thrombospondin
Journal Article
Human Reproduction, ISSN 0268-1161, 5/2014, Volume 29, Issue 5, pp. 978 - 988
Journal Article
Aging Cell, ISSN 1474-9718, 2011, Volume 10, Issue 5, pp. 769 - 779
Journal Article
Blood, ISSN 0006-4971, 01/2008, Volume 111, Issue 2, pp. 613 - 623
Platelet a-granules constitute the major rapidly releasable reservoir of thrombospondin-1 in higher animals. Although some fragments and peptides derived from... 
ACTIVATION | CELL RESPONSES | FACTOR MULTIMER SIZE | L-ARGININE | GLYCOPROTEIN-IV | MONOCLONAL-ANTIBODY | TERMINAL PEPTIDE | KINASE-I | HEMATOLOGY | INTEGRIN-ASSOCIATED PROTEIN | VON-WILLEBRAND-FACTOR | Cyclic GMP - pharmacology | Immunologic Capping - physiology | Cell Adhesion Molecules - genetics | CD36 Antigens - genetics | Peptides - genetics | Secretory Vesicles - metabolism | Fibrinolytic Agents - metabolism | Phosphoproteins - metabolism | Platelet Adhesiveness - genetics | Secretory Vesicles - genetics | Peptides - metabolism | Thrombin - pharmacology | CD36 Antigens - metabolism | Blood Platelets - cytology | Arginine - genetics | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Thrombospondin 1 - genetics | Immunologic Capping - drug effects | Microfilament Proteins - metabolism | Platelet Aggregation - drug effects | Platelet Glycoprotein GPIIb-IIIa Complex - genetics | Microfilament Proteins - genetics | CD47 Antigen - genetics | rap1 GTP-Binding Proteins - metabolism | Shear Strength | Nitric Oxide - antagonists & inhibitors | Platelet Aggregation - physiology | CD47 Antigen - metabolism | Phosphoproteins - genetics | Cell Adhesion Molecules - metabolism | Thrombin - genetics | Mice, Knockout | Peptides - pharmacology | Platelet Adhesiveness - drug effects | Fibrinolytic Agents - pharmacology | Animals | Cyclic GMP - metabolism | Blood Platelets - metabolism | Nitric Oxide - genetics | Cyclic GMP - genetics | Thrombospondin 1 - pharmacology | Mice | Thrombin - metabolism | Thrombospondin 1 - metabolism | Nitric Oxide - metabolism | rap1 GTP-Binding Proteins - genetics | Arginine - metabolism | Cyclic GMP - antagonists & inhibitors | Hemostasis, Thrombosis, and Vascular Biology
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 23, pp. 20778 - 20787
Activation of oncogenes or inactivation of tumor suppressors in urothelium is considered critical for development of urothelial cancer. Here we report cloning... 
METASTASIS | TRANSITIONAL-CELL CARCINOMA | VEGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR ANGIOGENESIS | MESENCHYMAL TRANSITION | IDENTIFICATION | CANCER | EXPRESSION | TUMORIGENESIS | ENDOTHELIAL GROWTH-FACTOR | Humans | MicroRNAs - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | RNA, Neoplasm - metabolism | Tumor Suppressor Protein p53 - genetics | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Carcinoma in Situ - genetics | Urinary Bladder Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Thrombospondin 1 - genetics | Neoplasms, Experimental - genetics | Urinary Bladder Neoplasms - pathology | Urinary Bladder Neoplasms - metabolism | Gene Expression Regulation, Neoplastic - genetics | Carcinoma in Situ - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Neoplasm Invasiveness | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Signal Transduction - genetics | Animals | RNA, Neoplasm - genetics | Neovascularization, Pathologic - genetics | Mice | MicroRNAs - genetics | Neovascularization, Pathologic - metabolism | Neoplasms, Experimental - metabolism | Thrombospondin 1 - metabolism | Carcinoma in Situ - metabolism | Molecular Bases of Disease | Angiogenesis | Bladder Carcinoma | MicroRNA | Transgenic | Hypoxia | Tumor | Uroplakin II | p53 | Urothelium
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 19, pp. 3349 - 3358
Journal Article