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1. Full Text Membrane‐permeable Triphosphate Prodrugs of Nucleoside Analogues
by Gollnest, Tristan and Dinis de Oliveira, Thiago and Rath, Anna and Hauber, Ilona and Schols, Dominique and Balzarini, Jan and Meier, Chris
Angewandte Chemie (International ed.), ISSN 1433-7851, 04/2016, Volume 55, Issue 17, pp. 5255 - 5258
nucleoside analogues | biological activity | prodrugs | cell uptake | triphosphate | Anti-HIV Agents - pharmacology | Polyphosphates - pharmacology | Humans | Nucleosides - pharmacokinetics | Cell Membrane Permeability | Prodrugs - chemistry | HIV - drug effects | Prodrugs - metabolism | Swine | Thymine Nucleotides - metabolism | Nucleosides - pharmacology | Nucleosides - metabolism | Anti-HIV Agents - metabolism | CD4-Positive T-Lymphocytes - virology | Thymine Nucleotides - pharmacology | Cell Line | Nucleosides - chemistry | Esterases - metabolism | Thymine Nucleotides - chemical synthesis | Thymine Nucleotides - chemistry | Polyphosphates - metabolism | Anti-HIV Agents - chemistry | Animals | Prodrugs - pharmacokinetics | Anti-HIV Agents - pharmacokinetics | HIV Infections - drug therapy | Polyphosphates - pharmacokinetics | Prodrugs - pharmacology | Polyphosphates - chemistry | Phosphates | Nucleosides | Enzymes | Metabolites | Liver | Phosphonates | Protease inhibitors | Antiretroviral drugs | Drugs | Prodrugs | Series (mathematics) | Fluorescence | Lymphocytes T | Thymidine | Permeability | Derivatives | Chemical compounds | Conversion | Bearing | Polymerase chain reaction | Chemistry | Esterase | Phosphate | Antiviral activity | Nucleoside analogs | Index Medicus
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2. Full Text Synthesis and evaluation of the anti-hepatitis B virus activity of 4′-Azido-thymidine analogs and 4′-Azido-2′-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent
by Onitsuka, Kengo and Tokuda, Ryoh and Kuwata-Higashi, Nobuyo and Kumamoto, Hiroki and Aoki, Manabu and Amano, Masayuki and Kohgo, Satoru and Das, Debananda and Haraguchi, Kazuhiro and Mitsuya, Hiroaki and Imoto, Shuhei
Nucleosides, nucleotides & nucleic acids, ISSN 1525-7770, 04/2020, Volume 39, Issue 4, pp. 518 - 529
4′-azido nucleoside | modified pyrimidines | Anti-HBV nucleoside | Antiviral Agents - pharmacology | Cytidine - chemistry | Stereoisomerism | Humans | Molecular Conformation | Cytidine - pharmacology | Zidovudine - pharmacology | Cytidine - analogs & derivatives | Zidovudine - chemistry | Cytidine - chemical synthesis | Hep G2 Cells | Microbial Sensitivity Tests | Hepatitis B virus - drug effects | Antiviral Agents - chemistry | Zidovudine - analogs & derivatives | Antiviral Agents - chemical synthesis | Zidovudine - chemical synthesis | Hepatitis | Cytotoxicity | Thymidine | Antiviral activity | Thymine | Hepatitis B | Index Medicus
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3. Full Text Thymidine analogues for tracking DNA synthesis
by Cavanagh, Brenton L and Walker, Tom and Norazit, Anwar and Meedeniya, Adrian C.B
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2011, Volume 16, Issue 9, pp. 7980 - 7993
DNA synthesis | Nucleoside analogues | EdU (5-ethynyl-2'-deoxyuridine) | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Fluorescent Dyes - chemistry | Cell Proliferation | Stem Cell Niche | Click Chemistry | Humans | Cells, Cultured | DNA - chemistry | Animals | Deoxyuridine - analogs & derivatives | Thymidine - analogs & derivatives | Deoxyuridine - chemistry | Staining and Labeling | Bromodeoxyuridine - chemistry | DNA - biosynthesis | Thymidine - chemistry | Index Medicus | nucleoside analogues | EdU (5-ethynyl-2′-deoxyuridine)
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4. Full Text 2′-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743
by McGuigan, Christopher and Derudas, Marco and Quintiliani, Maurizio and Andrei, Graciela and Snoeck, Robert and Henson, Geoffrey and Balzarini, Jan
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2009, Volume 19, Issue 22, pp. 6264 - 6267
Thymidine kinase | VZV | Zoster | Shingles | Nucleosides | Herpes | Fluorosugars | Cf 1743 | BCNAs | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Antiviral agents | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Nucleosides - chemistry | Bridged Bicyclo Compounds - pharmacology | Humans | Models, Molecular | Substrate Specificity | Structure-Activity Relationship | Microbial Sensitivity Tests | Bridged Bicyclo Compounds - chemistry | Fluorides - chemistry | Herpesvirus 3, Human - drug effects | Drug Interactions | Bromodeoxyuridine - pharmacology | Herpesvirus 3, Human - metabolism | Pyrimidine Nucleosides - administration & dosage | Bromodeoxyuridine - chemistry | Drug Design | Thymidine Kinase - metabolism | Nucleosides - pharmacology | HeLa Cells | Pyrimidine Nucleosides - pharmacology | Virus Replication - physiology | Virus diseases | Heterocyclic compounds | Index Medicus
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5. Full Text Synthesis and Duplex‐Stabilizing Properties of Fluorinated N‐Methanocarbathymidine Analogues Locked in the C3′‐endo Conformation
by Jung, Michael E and Dwight, Timothy A and Vigant, Frederic and Østergaard, Michael E and Swayze, Eric E and Seth, Punit P
Angewandte Chemie (International ed.), ISSN 1433-7851, 09/2014, Volume 53, Issue 37, pp. 9893 - 9897
fluorination | modified nucleosides | asymmetric synthesis | diastereoselectivity | duplex thermal stability | Oligonucleotides - chemistry | Thymidine - analogs & derivatives | Molecular Conformation | Models, Molecular | Molecular Structure | Nucleic Acid Conformation | Thymidine - chemistry | Oligonucleotides - chemical synthesis | Index Medicus | Synthesis | Fluorine | Analogue | Fluorination | Scaffolds | Isomers | Thermal stability
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6. Full Text Evaluating the Genotoxic and Cytotoxic Effects of Thymidine Analogs, 5-Ethynyl-2 '-Deoxyuridine and 5-Bromo-2 '-Deoxyurdine to Mammalian Cells
by Haskins, Jeremy S and Su, Cathy and Maeda, Junko and Walsh, Kade D and Haskins, Alexis H and Allum, Allison J and Froning, Coral E and Kato, Takamitsu A
International journal of molecular sciences, ISSN 1422-0067, 09/2020, Volume 21, Issue 18, p. 6631
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Toxicity | Anemia | DNA damage | Sister chromatid exchange | Homologous recombination | Genotoxicity | Cytotoxicity | Bromodeoxyuridine | Homology | Photons | Thymidine | DNA repair | Mammalian cells | DNA biosynthesis | Homologous recombination repair | Accident prevention | Hypoxanthine | Mutation | Repair | Chromosomes | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus | radiosensitizer | BrdU | EdU
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7. Full Text Rational Design and 3D-Pharmacophore Mapping of 5′-Thiourea-Substituted α-Thymidine Analogues as Mycobacterial TMPK Inhibitors
by Andrade, Carolina H and Pasqualoto, Kerly F. M and Ferreira, Elizabeth I and Hopfinger, Anton J
Journal of Chemical Information and Modeling, ISSN 1549-9596, 04/2009, Volume 49, Issue 4, pp. 1070 - 1078
Pharmaceutical Modeling | Computer Science, Information Systems | Physical Sciences | Computer Science, Interdisciplinary Applications | Chemistry | Life Sciences & Biomedicine | Technology | Computer Science | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Antitubercular Agents - chemical synthesis | Reproducibility of Results | Antitubercular Agents - chemistry | Thymidine - chemical synthesis | Molecular Conformation | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Models, Molecular | Thiourea - chemistry | Enzyme Inhibitors - chemical synthesis | Mycobacterium tuberculosis - drug effects | Algorithms | Thymidine - analogs & derivatives | Thymidine - pharmacology | Enzyme Inhibitors - chemistry | Mycobacterium tuberculosis - enzymology | Drug Design | Ligands | Quantitative Structure-Activity Relationship | Index Medicus
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8. Full Text Synthesis, Biological Evaluation, and Radioiodination of Halogenated closo-Carboranylthymidine Analogues
by Tiwari, Rohit and Toppino, Antonio and Agarwal, Hitesh K and Huo, Tianyao and Byun, Youngjoo and Gallucci, Judith and Hasabelnaby, Sherifa and Khalil, Ahmed and Goudah, Ayman and Baiocchi, Robert A and Darby, Michael V and Barth, Rolf F and Tjarks, Werner
Inorganic chemistry, ISSN 0020-1669, 01/2012, Volume 51, Issue 1, pp. 629 - 639
Physical Sciences | Chemistry, Inorganic & Nuclear | Chemistry | Science & Technology | Cell Line | Thymidine Kinase - chemistry | Humans | Models, Molecular | Crystallography, X-Ray | Animals | Thymidine - analogs & derivatives | Thymidine - pharmacology | Halogenation | Thymidine Kinase - metabolism | Iodine Radioisotopes - chemistry | Protein Binding | Mice | Phosphorylation - drug effects | Thymidine - pharmacokinetics | Borane | Phosphorylation | Analysis | Cancer cells | Physiological aspects | Thymidine | Chemical properties | Structure | Decomposition (Chemistry) | Index Medicus
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9. Full Text Evaluation of anti-HIV-1 mutagenic nucleoside analogues
by Vivet-Boudou, Valérie and Isel, Catherine and El Safadi, Yazan and Smyth, Redmond P and Laumond, Géraldine and Moog, Christiane and Paillart, Jean-Christophe and Marquet, Roland
The Journal of biological chemistry, ISSN 0021-9258, 01/2015, Volume 290, Issue 1, pp. 371 - 383
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Anti-HIV Agents - pharmacology | Predictive Value of Tests | Deoxycytidine - chemistry | Mutagens - metabolism | HIV Reverse Transcriptase - antagonists & inhibitors | Molecular Sequence Data | Reverse Transcriptase Inhibitors - pharmacology | Deoxycytidine - pharmacology | HIV Reverse Transcriptase - genetics | Base Pair Mismatch | Reverse Transcriptase Inhibitors - chemistry | Reverse Transcription | Thermodynamics | Deoxycytidine - metabolism | Time Factors | Thymidine - pharmacology | Base Sequence | Drug Design | Anti-HIV Agents - metabolism | Thymidine - chemistry | HIV Reverse Transcriptase - chemistry | Thymidine - metabolism | Mutagens - chemistry | Nucleic Acid Denaturation | HIV-1 - drug effects | Mutagens - pharmacology | High-Throughput Screening Assays - economics | HIV-1 - genetics | Anti-HIV Agents - chemistry | Thymidine - analogs & derivatives | Base Pairing | Mutagenesis | HIV-1 - enzymology | Reverse Transcriptase Inhibitors - metabolism | Deoxycytidine - analogs & derivatives | Index Medicus | Human Immunodeficiency Virus (HIV) | Molecular Biophysics | Antiviral Agent | Nucleoside | Nucleotide Analogue | Lethal
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10. Full Text Diadenosine 5′,5′′-(Boranated)polyphosphonate Analogues as Selective Nucleotide Pyrophosphatase/Phosphodiesterase Inhibitors
by Eliahu, Shay and Lecka, Joanna and Reiser, Georg and Haas, Michael and Bigonnesse, François and Lévesque, Sébastien A and Pelletier, Julie and Sévigny, Jean and Fischer, Bilha
Journal of medicinal chemistry, ISSN 0022-2623, 12/2010, Volume 53, Issue 24, pp. 8485 - 8497
Purinergic P2Y Receptor Agonists - chemical synthesis | Adenine Nucleotides - pharmacology | Calcium - metabolism | Humans | Boranes - chemistry | Substrate Specificity | Adenine Nucleotides - chemistry | Dinucleoside Phosphates - chemical synthesis | Structure-Activity Relationship | Dinucleoside Phosphates - chemistry | Adenine Nucleotides - chemical synthesis | Pyrophosphatases - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Cell Line | Thymidine Monophosphate - metabolism | Purinergic P2Y Receptor Agonists - chemistry | Boranes - pharmacology | Dinucleoside Phosphates - metabolism | Thymidine Monophosphate - analogs & derivatives | Receptors, Purinergic P2Y - physiology | Purinergic P2Y Receptor Agonists - pharmacology | Hydrolysis | Phosphoric Diester Hydrolases | Nucleotidases - metabolism | Boranes - chemical synthesis | Dinucleoside Phosphates - pharmacology | Drug Screening Assays, Antitumor | Index Medicus
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11. Full Text Synthesis and Evaluation of α‑Thymidine Analogues as Novel Antimalarials
by Cui, Huaqing and Carrero-Lérida, Juana and Silva, Ana P. G and Whittingham, Jean L and Brannigan, James A and Ruiz-Pérez, Luis M and Read, Kevin D and Wilson, Keith S and González-Pacanowska, Dolores and Gilbert, Ian H
Journal of medicinal chemistry, ISSN 0022-2623, 12/2012, Volume 55, Issue 24, pp. 10948 - 10957
Plasmodium falciparum - enzymology | Protozoan Proteins - antagonists & inhibitors | Humans | Microsomes, Liver - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Thiourea - pharmacology | Blood Proteins - metabolism | Urea - chemical synthesis | Nucleoside-Phosphate Kinase - chemistry | Thiourea - chemical synthesis | Thymidine - pharmacology | Urea - analogs & derivatives | Protozoan Proteins - chemistry | Molecular Structure | Antimalarials - chemical synthesis | Cell Line | Recombinant Proteins - antagonists & inhibitors | Thymidine - chemical synthesis | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Models, Molecular | Recombinant Proteins - chemistry | Antimalarials - pharmacology | Thymidine - analogs & derivatives | Antimalarials - chemistry | Protein Binding | Ligands | Thiourea - analogs & derivatives | Urea - pharmacology | Index Medicus
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12. Full Text Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment
by Fung, James and Seto, Wai‐Kay and Lai, Ching‐Lung and Yuen, Man‐Fung
Journal of gastroenterology and hepatology, ISSN 0815-9319, 03/2014, Volume 29, Issue 3, pp. 428 - 434
adefovir | entecavir | telbivudine | tenofovir | antiviral | lamivudine | Tenofovir | Antiviral | Lamivudine | Adefovir | Telbivudine | Entecavir | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Acidosis, Lactic - chemically induced | Humans | Thymidine - adverse effects | Male | Nucleotides - administration & dosage | Arabinofuranosyluracil - adverse effects | Arabinofuranosyluracil - analogs & derivatives | Dose-Response Relationship, Drug | Adenine - adverse effects | Thymidine - administration & dosage | Kidney Diseases - chemically induced | Female | Muscular Diseases - chemically induced | Drug Therapy, Combination | Nucleotides - adverse effects | Adenine - analogs & derivatives | Nucleosides - administration & dosage | Administration, Oral | Organophosphonates - adverse effects | Nucleosides - adverse effects | Pharmacovigilance | Antiviral Agents - administration & dosage | Adenine - administration & dosage | Pregnancy | Organophosphonates - administration & dosage | Hepatitis B, Chronic - drug therapy | Thymidine - analogs & derivatives | Antiviral Agents - adverse effects | Arabinofuranosyluracil - administration & dosage | Nervous System Diseases - chemically induced | Antiviral agents | Analysis | Nucleosides | Bones | Mitochondrial DNA | Biological response modifiers | Drug therapy | Density | Hepatitis B | Index Medicus
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13. Full Text Rational Design of 5‘-Thiourea-Substituted α-Thymidine Analogues as Thymidine Monophosphate Kinase Inhibitors Capable of Inhibiting Mycobacterial Growth
by Van Daele, Ineke and Munier-Lehmann, Hélène and Froeyen, Matheus and Balzarini, Jan and Van Calenbergh, Serge
Journal of medicinal chemistry, ISSN 0022-2623, 11/2007, Volume 50, Issue 22, pp. 5281 - 5292
Biological and medical sciences | Medical sciences | Antibacterial agents | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Nucleosides - chemical synthesis | Stereoisomerism | Humans | Cercopithecus aethiops | Crystallography, X-Ray | Structure-Activity Relationship | Thiourea - pharmacology | Mycobacterium tuberculosis - drug effects | Mycobacterium - growth & development | Mycobacterium bovis - drug effects | Nucleoside-Phosphate Kinase - chemistry | Mycobacterium bovis - enzymology | Thiourea - chemical synthesis | Thymidine - pharmacology | Nucleosides - pharmacology | Mycobacterium - enzymology | Dimerization | Vero Cells | Thymidine - chemical synthesis | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Models, Molecular | Anti-Bacterial Agents - chemical synthesis | Mycobacterium - drug effects | Animals | Thymidine - analogs & derivatives | Mycobacterium tuberculosis - enzymology | Anti-Bacterial Agents - pharmacology | Mycobacterium bovis - growth & development | Thiourea - analogs & derivatives | Mycobacterium tuberculosis - growth & development | Index Medicus | Life Sciences | Microbiology and Parasitology | Biochemistry, Molecular Biology | Chemical Sciences
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14. Full Text