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Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 128 - 132
.... This in part reflects the need for mitochondria to generate one-carbon units and export them to the cytosol for anabolic metabolism(2,9... 
CHAIN | HYPERTROPHIC CARDIOMYOPATHY | SERINE HYDROXYMETHYLTRANSFERASE | METABOLISM | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | DEFECT | LACTIC-ACIDOSIS | MUTATIONS | IDENTIFICATION | ANTICODON WOBBLE NUCLEOTIDE | Mitochondria - enzymology | Electron Transport | Protein Biosynthesis | Humans | Ribosomes - metabolism | Sarcosine - metabolism | Multifunctional Enzymes - metabolism | Thymine Nucleotides - biosynthesis | Oxidative Phosphorylation - drug effects | Glycine Hydroxymethyltransferase - deficiency | HEK293 Cells | RNA, Transfer - genetics | Codon - genetics | RNA, Transfer - chemistry | Leucine - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Biocatalysis | RNA, Transfer - metabolism | HCT116 Cells | Mitochondria - metabolism | Mitochondria - drug effects | Glycine Hydroxymethyltransferase - metabolism | Guanosine - metabolism | Tetrahydrofolates - metabolism | Lysine - genetics | Carrier Proteins - metabolism | Methylation - drug effects | Folic Acid - metabolism | Aminohydrolases - metabolism | Folic Acid Antagonists - pharmacology | GTP-Binding Proteins - metabolism | Mitochondria | Physiological aspects | Genetic aspects | Methylation | Observations | Genetic translation | Folic acid | Transfer RNA | Phosphorylation | Inborn errors of metabolism | Peptides | Serine | Biosynthesis | Mitochondrial DNA | Thymidine | Catalytic activity | Leucine | Cytosol | Experiments | Anticancer properties | Proteins | Purines | Antitumor agents | Metabolites | Lymphocytes | Vitamin B | Catalysis | Enzymes | Translation | tRNA Ala | tRNA | Methionine | Metabolism | Carbon | Immunosuppression | Oxidative phosphorylation | Lysine | Proteomics | Electron transport | Respiration | Codons | Cancer
Journal Article
Nature neuroscience, ISSN 1546-1726, 2004, Volume 7, Issue 11, pp. 1233 - 1241
Establishing the cellular identity in vivo of adult multipotent neural progenitors is fundamental to understanding their biology. We used two transgenic... 
SITE-SPECIFIC RECOMBINATION | NEURAL STEM-CELLS | RADIAL GLIAL-CELLS | FIBRILLARY ACIDIC PROTEIN | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | SUBVENTRICULAR ZONE | MAMMALIAN FOREBRAIN | NEUROSCIENCES | INTERMEDIATE-FILAMENT PROTEIN | TRANSGENIC MICE | Glial Fibrillary Acidic Protein - genetics | Microtubule-Associated Proteins - metabolism | Phosphopyruvate Hydratase - metabolism | Prosencephalon - physiology | Olfactory Bulb - metabolism | Hippocampus - drug effects | Glial Fibrillary Acidic Protein - metabolism | Prosencephalon - drug effects | Tubulin - metabolism | Neurons - physiology | beta-Galactosidase - metabolism | Ganciclovir - pharmacology | Integrases - metabolism | Bromodeoxyuridine - metabolism | Neural Cell Adhesion Molecule L1 - metabolism | Cell Differentiation - physiology | Olfactory Bulb - cytology | Green Fluorescent Proteins - metabolism | Thymidine Kinase - genetics | Neuroglia - physiology | Sialic Acids - metabolism | Gene Expression Regulation - physiology | Cell Size | Mice, Transgenic | Neuropeptides - metabolism | Hippocampus - cytology | Gene Expression Regulation - drug effects | Immunohistochemistry - methods | Hippocampus - metabolism | Animals | Cell Count - methods | Analysis of Variance | Cell Differentiation - drug effects | Prosencephalon - cytology | Stem Cells - drug effects | Stem Cells - physiology | Mice | Olfactory Bulb - drug effects | Physiological aspects | Brain | Cellular proteins | Research | Neurons
Journal Article
Cancer Biology & Therapy, ISSN 1555-8576, 2012, Volume 13, Issue 13, pp. 1284 - 1289
Journal Article
Journal Article
British journal of pharmacology, ISSN 1476-5381, 2007, Volume 152, Issue 1, pp. 141 - 150
Background and purpose: ARL 67156, 6‐N,N‐Diethyl‐D‐β‐γ‐dibromomethylene adenosine triphosphate, originally named FPL 67156, is the only commercially available... 
extracellular nucleotide | CD39 | FPL 67156 | ARL 67156 | NTPDase | Ecto‐5′‐nucleotidase | ecto‐ATPase | NPP | Ecto-ATPase | Extracellular nucleotide | Ecto-5′-nucleotidase | DIPHOSPHOHYDROLASE | NEUROTRANSMISSION | ecto-ATPase | PHOSPHODIESTERASE-I | HYDROLYSIS | RECEPTOR | GUINEA-PIG | ecto-5'-nucleotidase | CLONING | PHARMACOLOGY & PHARMACY | ISOLATED VAS-DEFERENS | AUTOTAXIN NPP2 | DIADENOSINE POLYPHOSPHATES | 5'-Nucleotidase - antagonists & inhibitors | Nucleotidases - genetics | Uridine Triphosphate - metabolism | Humans | Substrate Specificity | Nucleotidases - antagonists & inhibitors | Antigens, CD - metabolism | Adenosine Triphosphate - pharmacology | Pyrophosphatases - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Phosphoric Diester Hydrolases - metabolism | Thymidine Monophosphate - metabolism | Apyrase - antagonists & inhibitors | Adenosine Monophosphate - metabolism | Apyrase - metabolism | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Dinucleoside Phosphates - metabolism | Thymidine Monophosphate - analogs & derivatives | Adenosine Triphosphate - analogs & derivatives | Hydrolysis | Pyrophosphatases - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | Nucleotidases - metabolism | Animals | Adenosine Triphosphatases - genetics | Mice | Adenosine Diphosphate - metabolism | Kinetics | 5'-Nucleotidase - metabolism | Research Papers
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2009, Volume 29, Issue 37, pp. 11511 - 11522
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 15057
Journal Article
Nature neuroscience, ISSN 1546-1726, 2004, Volume 7, Issue 11, pp. 1222 - 1232
Although netrins are an important family of neuronal guidance proteins, intracellular mechanisms that mediate netrin function are not well understood. Here we... 
SIGNAL-TRANSDUCTION | RECEPTOR DCC | CAENORHABDITIS-ELEGANS | FLOOR PLATE | GROWTH CONE GUIDANCE | COLORECTAL-CANCER | COMMISSURAL AXONS | SPINAL-CORD | C-ELEGANS | PROTEIN-TYROSINE KINASE | NEUROSCIENCES | Glial Fibrillary Acidic Protein - genetics | Microtubule-Associated Proteins - metabolism | Phosphopyruvate Hydratase - metabolism | Prosencephalon - physiology | Olfactory Bulb - metabolism | Hippocampus - drug effects | Glial Fibrillary Acidic Protein - metabolism | Prosencephalon - drug effects | Tubulin - metabolism | Neurons - physiology | beta-Galactosidase - metabolism | Ganciclovir - pharmacology | Integrases - metabolism | Bromodeoxyuridine - metabolism | Neural Cell Adhesion Molecule L1 - metabolism | Cell Differentiation - physiology | Olfactory Bulb - cytology | Green Fluorescent Proteins - metabolism | Thymidine Kinase - genetics | Neuroglia - physiology | Sialic Acids - metabolism | Gene Expression Regulation - physiology | Cell Size | Mice, Transgenic | Neuropeptides - metabolism | Hippocampus - cytology | Gene Expression Regulation - drug effects | Immunohistochemistry - methods | Hippocampus - metabolism | Animals | Cell Count - methods | Analysis of Variance | Cell Differentiation - drug effects | Prosencephalon - cytology | Stem Cells - drug effects | Stem Cells - physiology | Mice | Olfactory Bulb - drug effects | Physiological aspects | Cellular proteins | Axons | Genetic aspects | Research | Protein kinases
Journal Article
The Journal of pathology, ISSN 0022-3417, 2018, Volume 244, Issue 4, pp. 485 - 498
Pulmonary vascular remodeling is the main pathological hallmark of pulmonary hypertension disease. We undertook a comprehensive and multilevel approach to... 
pulmonary vascular remodeling | fate mapping | LUNG | RECRUITMENT | PATHOLOGY | MESENCHYMAL TRANSITION | HYPOXIA | ADULT-MOUSE | ONCOLOGY | MARROW-DERIVED CELLS | ARTERIAL-HYPERTENSION | SMOOTH-MUSCLE-CELLS | THYMIDINE-H-3 | EXPRESSION | Vascular Remodeling | Cadherins - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Actins - metabolism | Myocytes, Smooth Muscle - pathology | Antigens, CD - genetics | Muscle, Smooth, Vascular - physiopathology | Respiratory Hypersensitivity - pathology | Familial Primary Pulmonary Hypertension - metabolism | Familial Primary Pulmonary Hypertension - physiopathology | Actins - genetics | Antigens, CD - metabolism | Hypoxia - metabolism | Pulmonary Artery - metabolism | Respiratory Hypersensitivity - physiopathology | Cadherins - genetics | Myocytes, Smooth Muscle - metabolism | Genes, Reporter | Disease Models, Animal | Familial Primary Pulmonary Hypertension - pathology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Respiratory Hypersensitivity - metabolism | Proteoglycans - metabolism | Mice, Transgenic | Antigens - metabolism | Pulmonary Artery - physiopathology | Cell Lineage | Respiratory Hypersensitivity - genetics | Hypoxia - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Hypoxia - pathology | Receptor, Platelet-Derived Growth Factor alpha - genetics | Fluorescent Antibody Technique | Hypoxia - physiopathology | Luminescent Proteins - genetics | Lung - blood supply | Chronic Disease | Proteoglycans - genetics | Pulmonary Artery - pathology | Antigens - genetics | Luminescent Proteins - metabolism | Cell proliferation | Cell culture | Allergens | Flow cytometry | Animal models | Pathogenesis | Smooth muscle | Labelling | Remodeling | Neuronal-glial interactions | Arteries | Vascular diseases | Cell fate | Actin | Rodents | Localization | Thickening | Hypertension | Pulmonary arteries | Lung diseases | Markers | Transgenic mice | Muscles | Blood vessels | Electron microscopy | Pulmonary artery | Endothelial cells | Pulmonary hypertension | Hypoxia | Chondroitin sulfate | Sulfate | Immunofluorescence | Veins & arteries | Original Paper | Original Papers
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 23, pp. 19216 - 19228
Plasmacytoid dendritic cells (pDCs) are characterized by their ability to produce high levels of type 1 interferons in response to ligands that activate TLR7... 
TRANSCRIPTION FACTORS | KAPPA-B KINASE | SYSTEMIC-LUPUS-ERYTHEMATOSUS | AUTOIMMUNE-DISEASES | IMMUNE-RESPONSES | GENE INDUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTORS | I INTERFERON | ALPHA INDUCTION | NUCLEIC-ACIDS | Thymidine Kinase - immunology | Interferon-beta - immunology | Membrane Glycoproteins - metabolism | STAT2 Transcription Factor - immunology | Dendritic Cells - immunology | Humans | NF-kappa B - immunology | Toll-Like Receptor 9 - genetics | NF-kappa B - metabolism | Janus Kinases - metabolism | Toll-Like Receptor 9 - agonists | Toll-Like Receptor 9 - immunology | STAT1 Transcription Factor - metabolism | I-kappa B Kinase - metabolism | Interferon-alpha - genetics | Toll-Like Receptor 7 - immunology | HEK293 Cells | Interferon-beta - genetics | Janus Kinases - immunology | Plasma Cells - metabolism | Membrane Glycoproteins - immunology | Interleukin-6 - metabolism | Dendritic Cells - metabolism | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Interferon-alpha - metabolism | Toll-Like Receptor 7 - metabolism | Interleukin-6 - genetics | Janus Kinases - genetics | Thymidine Kinase - genetics | Membrane Glycoproteins - agonists | I-kappa B Kinase - genetics | STAT1 Transcription Factor - genetics | STAT1 Transcription Factor - immunology | Interferon-alpha - immunology | Membrane Glycoproteins - genetics | Animals | Interferon-beta - metabolism | NF-kappa B - genetics | Interleukin-6 - immunology | STAT2 Transcription Factor - genetics | Thymidine Kinase - metabolism | I-kappa B Kinase - immunology | Mice | STAT2 Transcription Factor - metabolism | Toll-Like Receptor 9 - metabolism | Plasma Cells - immunology | Toll-like Receptors (TLR) | Immunology | Plasmacytoid Dendritic Cells | TAK1 | Innate Immunity | Interferon | Protein Phosphorylation | IKKβ | Kinase Inhibitor
Journal Article