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Journal of Neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 11, pp. 2852 - 2861
Glutamate receptor (GluR) ion channels mediate fast synaptic transmission in the mammalian CNS. Numerous crystallographic studies, the majority on the... 
Glutamate receptor | Kainate | Antagonist | Structure | Crystallography | Gating | ACTIVATION | NMDA RECEPTORS | MECHANISM | MODEL | kainate | antagonist | NEUROSCIENCES | structure | GLUTAMATE-RECEPTOR | crystallography | AMPA RECEPTORS | glutamate receptor | gating | DYNAMICS | PARTIAL AGONIST ACTION | ION CHANNELS | SUBUNIT | Excitatory Amino Acid Antagonists - metabolism | Receptors, Kainic Acid - chemistry | Protein Conformation - drug effects | Thymine - analogs & derivatives | Receptors, AMPA - chemistry | Alanine - chemistry | Crystallography, X-Ray | Receptors, Kainic Acid - antagonists & inhibitors | Oocytes | Quinoxalines - pharmacology | Alanine - analogs & derivatives | Recombinant Fusion Proteins - antagonists & inhibitors | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Excitatory Amino Acid Antagonists - chemistry | Thymine - pharmacology | Binding Sites | Alanine - pharmacology | Thymine - metabolism | Thymine - chemistry | Glutamic Acid - pharmacology | Xenopus laevis | Models, Molecular | Rats | Alanine - metabolism | Excitatory Amino Acid Antagonists - pharmacology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - metabolism | Recombinant Fusion Proteins - chemistry | Patch-Clamp Techniques | Animals | Hydrogen Bonding | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - chemistry | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | Protein Binding | Glutamic Acid - metabolism | Glutamic Acid - chemistry | Receptors, AMPA - antagonists & inhibitors | BIOLOGY | GENES | CRYSTAL STRUCTURE | MATERIALS SCIENCE | CHAINS | DIMERS | CONFORMATIONAL CHANGES
Journal Article
Phytomedicine, ISSN 0944-7113, 01/2015, Volume 22, Issue 1, pp. 213 - 222
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2001, Volume 276, Issue 26, pp. 23616 - 23623
Mitochondrial toxicity can result hom antiviral nucleotide analog therapy used to control human immunodeficiency virus type 1 infection. We evaluated the... 
INTRACELLULAR PHOSPHORYLATION | EXONUCLEASE ACTIVITY | SUBSTRATE-SPECIFICITY | NUCLEOSIDE ANALOGS | (-)-2'-DEOXY-3'-THIACYTIDINE 3TC | BIOCHEMISTRY & MOLECULAR BIOLOGY | REVERSE-TRANSCRIPTASE | ANTI-HIV DEOXYNUCLEOTIDES | INSERTION FIDELITY | HUMAN-IMMUNODEFICIENCY-VIRUS | MITOCHONDRIAL-DNA | Anti-HIV Agents - pharmacology | DNA Polymerase gamma | Zidovudine - metabolism | Deoxyribonucleotides - pharmacology | DNA Replication - drug effects | Humans | Cytidine Triphosphate - metabolism | Reverse Transcriptase Inhibitors - pharmacology | Substrate Specificity | Zalcitabine - pharmacology | Exodeoxyribonucleases - antagonists & inhibitors | Lamivudine - analogs & derivatives | Nucleic Acid Synthesis Inhibitors | Stavudine - pharmacology | Thymine Nucleotides - metabolism | DNA - biosynthesis | Deoxyguanine Nucleotides - metabolism | Anti-HIV Agents - metabolism | Thymine Nucleotides - pharmacology | Cytidine Triphosphate - pharmacology | Deoxyguanine Nucleotides - pharmacology | Lamivudine - metabolism | Zidovudine - pharmacology | Zalcitabine - metabolism | Stavudine - metabolism | Deoxyribonucleotides - metabolism | Zidovudine - analogs & derivatives | Exodeoxyribonucleases - metabolism | Cytidine Triphosphate - analogs & derivatives | Lamivudine - pharmacology | Reverse Transcriptase Inhibitors - metabolism | DNA-Directed DNA Polymerase - metabolism | Dideoxynucleotides | Kinetics
Journal Article
Biomacromolecules, ISSN 1525-7797, 09/2012, Volume 13, Issue 9, pp. 3004 - 3012
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2007, Volume 51, Issue 1, pp. 48 - 53
Journal Article
Endocrinology, ISSN 0013-7227, 11/2015, Volume 156, Issue 11, pp. 4105 - 4114
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 10/2018, Volume 19, Issue 10, p. 2915
Salvage chemotherapy for refractory metastatic colorectal cancer using trifluridine/tipiracil (FTD/TPI) and regorafenib has shown survival benefits. We... 
Regorafenib | TAS-102 | Tipiracil hydrochloride | Trifluridine | Colorectal cancer | MULTICENTER | colorectal cancer | MECHANISM | trifluridine | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRIFLUOROTHYMIDINE | regorafenib | tipiracil hydrochloride | ANTITUMOR-ACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | TRIAL | PRECLINICAL MODELS | DNA | INHIBITOR | THYMIDINE PHOSPHORYLASE | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Apoptosis - drug effects | Humans | Pyrrolidines - administration & dosage | Male | Trifluridine - administration & dosage | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Colorectal Neoplasms - drug therapy | Antineoplastic Agents - pharmacology | Thymine - administration & dosage | Thymine - pharmacology | Pyridines - therapeutic use | Trifluridine - pharmacology | Pyridines - administration & dosage | Thymine - therapeutic use | Phenylurea Compounds - therapeutic use | Trifluridine - therapeutic use | Animals | Phenylurea Compounds - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Cell Line, Tumor | Phenylurea Compounds - pharmacology | Pyridines - pharmacology | Colorectal Neoplasms - pathology
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2009, Volume 29, Issue 2, pp. 563 - 574
Kainate receptors (KARs) contribute to postsynaptic excitation in only a select subset of neurons. To define the parameters that specify the postsynaptic... 
Glutamate receptor | Interneurons | Synaptic | Glutamate transporters | Kainic acid | Hippocampus | kainic acid | hippocampus | SYNAPTIC-TRANSMISSION | GAMMA-OSCILLATIONS | NEUROSCIENCES | synaptic | THALAMOCORTICAL SYNAPSES | BIPOLAR CELLS | AMPA RECEPTORS | PYRAMIDAL CELLS | glutamate receptor | MULTIVESICULAR RELEASE | EXCITATORY SYNAPSES | MOSSY-FIBER SYNAPSES | glutamate transporters | FEEDFORWARD INHIBITION | interneurons | Interneurons - physiology | Thymine - analogs & derivatives | Galactolipids - pharmacology | Receptors, Kainic Acid - antagonists & inhibitors | Receptors, Kainic Acid - genetics | Receptors, Kainic Acid - agonists | Excitatory Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - physiology | Alanine - analogs & derivatives | Thymine - pharmacology | Electric Stimulation - methods | Alanine - pharmacology | Baclofen - pharmacology | Interneurons - drug effects | Rats | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Hippocampus - cytology | Benzothiadiazines - pharmacology | Rats, Sprague-Dawley | Receptors, Kainic Acid - metabolism | Patch-Clamp Techniques | Animals | GABA Agonists - pharmacology | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology | In Vitro Techniques | Aspartic Acid - pharmacology
Journal Article
Neuroscience, ISSN 0306-4522, 2012, Volume 221, pp. 157 - 169
Highlights ► GluK1 receptors facilitate presynaptic glutamate release in the basolateral amygdala. ► Activation of GluK1 receptors in the basolateral amygdala... 
Neurology | anxiety | seizures | presynaptic glutamate release | GluK1 kainate receptors | basolateral amygdala | Basolateral amygdala | Anxiety | Presynaptic glutamate release | Seizures | SOCIAL ANXIETY DISORDER | HYPERPOLARIZATION-ACTIVATED CURRENTS | NEUROSCIENCES | KAINATE RECEPTORS | IN-VITRO | ELECTRICAL-STIMULATION | LIMBIC STATUS EPILEPTICUS | INHIBITORY SYNAPTIC-TRANSMISSION | RAT HIPPOCAMPAL SLICES | GABA(A) RECEPTORS | PRINCIPAL NEURONS | Sensory Gating - drug effects | Amygdala - drug effects | Thymine - analogs & derivatives | Biophysical Phenomena - drug effects | Male | Neurons - cytology | Alanine - analogs & derivatives | Excitatory Amino Acid Agents - pharmacology | Exploratory Behavior - drug effects | Tetrodotoxin - pharmacology | Thymine - pharmacology | Neurons - drug effects | Alanine - pharmacology | GABA-A Receptor Antagonists - pharmacology | Membrane Potentials - drug effects | Presynaptic Terminals - drug effects | Acoustic Stimulation | Rats | Amygdala - cytology | Sodium Channel Blockers - pharmacology | Bicuculline - pharmacology | Membrane Potentials - physiology | Rats, Sprague-Dawley | Receptors, Kainic Acid - metabolism | Patch-Clamp Techniques | Animals | Presynaptic Terminals - metabolism | Glutamic Acid - metabolism | In Vitro Techniques | Physiological aspects | Neurosciences | Pyrimidines | Phenylalanine | Marine toxins | Glutamate
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e107113
Aptamers are nucleic acid based molecular recognition elements with a high potential for the theranostics. Some of the aptamers are under development for... 
IN-VITRO | ACTIVATION | INITIATION | MULTIDISCIPLINARY SCIENCES | COAGULATION | ANTICOAGULANT | ARTERIAL THROMBOSIS | VON-WILLEBRAND-FACTOR | FACTOR XA INHIBITOR | RAT MODEL | DISCOVERY | Recombinant Proteins - therapeutic use | Thrombin - antagonists & inhibitors | Male | Peptide Fragments - pharmacology | Antithrombins - pharmacology | Fibrinolytic Agents - therapeutic use | G-Quadruplexes | Drug Evaluation, Preclinical | Disease Models, Animal | Fibrinogen - drug effects | Aptamers, Nucleotide - pharmacology | Antithrombins - therapeutic use | Mice, Inbred C57BL | Aptamers, Nucleotide - chemistry | Anticoagulants - therapeutic use | Aptamers, Nucleotide - therapeutic use | Antithrombins - chemistry | Recombinant Proteins - pharmacology | Fibrinolytic Agents - pharmacology | Thrombosis - pathology | Animals | Blood Coagulation - drug effects | Anticoagulants - pharmacology | Fibrinogen - metabolism | Mice | Peptide Fragments - therapeutic use | Thrombosis - drug therapy | Hirudins - pharmacology | Fibrin | Analysis | DNA | Fibrinogen | Thrombin | Anticoagulants (Medicine) | Health aspects | Thrombosis | Blood clot | Blood coagulation | Physiological effects | Animal models | Drug delivery systems | Intravenous administration | Coagulation | Biology | Experiments | Blood | PharmacoPhores | Physiology | Thromboembolism | Deoxyribonucleic acid--DNA | Anticoagulants | Therapeutic applications | Research & development--R&D | Thymine | Pharmacology | Blood clots | Inhibitors | Aptamers | In vivo methods and tests | Research & development | Deoxyribonucleic acid | R&D
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2013, Volume 86, Issue 9, pp. 1376 - 1396
Journal Article