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Cancer, ISSN 0008-543X, 06/2010, Volume 116, Issue 12, pp. 2974 - 2983
BACKGROUND: The follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common histotype among papillary thyroid cancers (PTCs). Although... 
Phosphorylation activation | PAX8-PPARγ translocations | Genetic alterations | Phosphatidylinositol 3-kinase pathway | Follicular variant papillary thyroid cancer | Mitogen-activated protein kinase pathway | RET-PTC rearrangements | RET | follicular variant papillary thyroid cancer | phosphatidylinositol 3-kinase pathway | mitogen-activated protein kinase pathway | PAX8-PPAR gamma translocations | FUSION ONCOGENE | RAS | genetic alterations | CANCER | TUMORS | phosphorylation activation | MOLECULAR PATHWAYS | ONCOLOGY | PAX8-PPAR-GAMMA REARRANGEMENT | BRAF MUTATION | HIGH PREVALENCE | EXPRESSION | Phosphatidylinositol 3-Kinases - genetics | Carcinoma, Papillary, Follicular - genetics | Thyroid Neoplasms - genetics | Translocation, Genetic | ras Proteins - genetics | MAP Kinase Signaling System - genetics | Humans | Signal Transduction - genetics | Mutation | raf Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Genetic markers | Thyroid cancer | Genetic variation | Development and progression | Papilloma | Genetic aspects | Research | Identification and classification | Oncogenes | Glutamic acid | Prognosis | AKT protein | Raf protein | Neuroblastoma | Western blotting | Signal transduction | Ret protein | Transfection | papillary thyroid cancer | Fusion protein | thymoma | Sarcoma | MAP kinase | Ras protein | 1-Phosphatidylinositol 3-kinase | Polymerase chain reaction | Protein kinase | valine | Peroxisome proliferator-activated receptors | Codons | papillary thyroid carcinoma | PTEN protein | Pax8 protein | Proto-oncogenes | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
by Yu, Lei and Ke, Ji and Du, Xin and Yu, Zhen and Gao, Di
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 2369 - 8
Thymoma represents the most common anterior mediastinal compartment neoplasm, originating from the epithelial cell population in the thymus. Various... 
RATS | THYMUS | EXPRESSION | CANCER | MULTIDISCIPLINARY SCIENCES | MCM2 | Thymoma | Epithelial cells | Myc protein | CD36 antigen | Gene expression | Patients | Thymus | Interleukin 6 | Signal transduction | Myasthenia gravis | DNA microarrays | Genetic analysis | Neuromuscular junctions | Myasthenia | Autoimmune diseases
Journal Article
Journal Article
Lung Cancer, ISSN 0169-5002, 2013, Volume 83, Issue 2, pp. 279 - 287
Journal Article
Oncogene, ISSN 0950-9232, 01/2009, Volume 28, Issue 2, pp. 195 - 208
Effective control of both cell survival and cell proliferation is critical to the prevention of oncogenesis and to successful cancer therapy. Using functional... 
Oncogenesis | Breast cancer | Growth arrest | Drug resistance | snoRNA | Apoptosis | HUMAN PROSTATIC-CARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | breast cancer | CELL BIOLOGY | B-CELL LYMPHOMA | IN-VITRO | ONCOLOGY | SNORNA HOST GENE | NONCODING RNAS | SMALL NUCLEOLAR RNAS | FUNCTIONAL EXPRESSION | oncogenesis | GROWTH-ARREST | GENETICS & HEREDITY | growth arrest | MOLECULAR REGULATION | drug resistance | EXPRESSION CLONING REVEALS | Carcinoma, Ductal, Breast - genetics | RNA, Small Nucleolar - physiology | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | Gene Expression Regulation, Neoplastic | RNA, Small Nucleolar - biosynthesis | Cell Line, Tumor - drug effects | Breast Neoplasms - metabolism | Cell Line - drug effects | Dexamethasone - pharmacology | Ultraviolet Rays | Thymus Neoplasms - pathology | Carcinoma, Ductal, Breast - pathology | Female | Antineoplastic Agents - pharmacology | Thymoma - pathology | Carcinoma, Ductal, Breast - metabolism | Cell Line, Tumor - metabolism | Cell Line, Tumor - radiation effects | Expressed Sequence Tags | Cell Line - metabolism | Tumor Stem Cell Assay | RNA, Neoplasm - physiology | Down-Regulation | Radiation Tolerance - genetics | Cell Adhesion | RNA, Small Nucleolar - genetics | Thymus Neoplasms - metabolism | Cell Line - radiation effects | Thymoma - metabolism | Animals | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Breast Neoplasms - pathology | RNA, Neoplasm - genetics | Mice | Control | Care and treatment | RNA | Physiological aspects | Genetic aspects | Research | Health aspects | Oncology | Cell growth | Gene expression | Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2010, Volume 327, Issue 5967, pp. 879 - 883
The LMO2 oncogene causes a subset of human T cell acute lymphoblastic leukemias (T-ALL), including four cases that arose as adverse events in gene therapy... 
Transcription factors | Thymocytes | Transgenic animals | Acute T cell leukemia | Genes | Leukemia | Reports | Mice | Progenitor cells | Hematopoietic stem cells | Oncogenes | CHROMOSOMAL TRANSLOCATIONS | ACTIVATION | HEMATOPOIESIS | SCID-X1 | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | TRANSCRIPTION | T-CELL LEUKEMIA | GENE-THERAPY | PROTEIN RBTN2 | RETROVIRAL INSERTION | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | T-Lymphocytes - physiology | Up-Regulation | Oligonucleotide Array Sequence Analysis | Humans | Preleukemia - pathology | Gene Expression Profiling | T-Lymphocytes - transplantation | DNA-Binding Proteins - metabolism | Metalloproteins - metabolism | Cell Transformation, Neoplastic - genetics | Preleukemia - genetics | Metalloproteins - genetics | Thymus Gland - pathology | Transcription, Genetic | Cell Differentiation | Proto-Oncogene Proteins | Thymus Gland - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | T-Lymphocyte Subsets | Precursor Cells, T-Lymphoid - physiology | LIM Domain Proteins | Down-Regulation | Mice, Transgenic | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Preleukemia - metabolism | Adaptor Proteins, Signal Transducing | Animals | Precursor Cells, T-Lymphoid - transplantation | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Development and progression | Thymoma | Properties | Cancer cells | Mutation | Cellular biology | Gene expression | Lymphocytes | Rodents | Index Medicus
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2005, Volume 175, Issue 3, pp. 1694 - 1705
During thymic T cell development, immature CD4+CD8+ double-positive (DP) thymocytes develop either into CD4+CD8- Th cells or CD4-CD8+ CTLs. Differentially... 
CD8-Positive T-Lymphocytes - cytology | Thymoma - genetics | CD4-Positive T-Lymphocytes - immunology | CD4-CD8 Ratio | CD8-Positive T-Lymphocytes - metabolism | Growth Inhibitors - biosynthesis | Growth Inhibitors - genetics | Thymus Gland - metabolism | CD4 Antigens - genetics | Amino Acid Sequence | DNA-Binding Proteins - physiology | Thymoma - immunology | CD4-Positive T-Lymphocytes - metabolism | CD8 Antigens - biosynthesis | Mice, Transgenic | Core Binding Factor Alpha 3 Subunit | Down-Regulation - genetics | Mice, Knockout | Cell Differentiation - immunology | Killer Cells, Natural - cytology | Cell Line, Tumor | Growth Inhibitors - physiology | Integrin alpha Chains - biosynthesis | Lymphopenia - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Antigens, CD - biosynthesis | Transcription Factors - deficiency | Molecular Sequence Data | DNA-Binding Proteins - deficiency | Cell Differentiation - genetics | Cell Lineage - genetics | Transcription Factors - physiology | Growth Inhibitors - deficiency | Mice, Inbred C57BL | Gene Silencing | Thymus Gland - cytology | Transforming Growth Factor beta - physiology | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, Inbred C3H | Animals | Down-Regulation - immunology | Thymus Gland - immunology | CD4 Antigens - biosynthesis | Histocompatibility Antigens Class II - genetics | Lymphopenia - genetics | DNA-Binding Proteins - biosynthesis | Cell Lineage - immunology | Crosses, Genetic | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Lung Cancer, ISSN 0169-5002, 2012, Volume 79, Issue 3, pp. 228 - 235
Abstract Background Thymic epithelial tumors include several entities with different biologic behavior. Chemotherapy is indicated in advanced disease, but... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | Immunohistochemistry | Gene expression | Thymidylate synthase | Thymic carcinoma | Topoisomerase 2alpha | ACTIVATION | DIHYDROPYRIMIDINE DEHYDROGENASE | PANCREATIC-CANCER | THYMOMA | TIME QUANTITATIVE PCR | CHEMOTHERAPY | GEMCITABINE | LUNG-CANCER | ONCOLOGY | RESPIRATORY SYSTEM | SQUAMOUS-CELL CARCINOMA | EPITHELIAL TUMORS | Endonucleases - genetics | Thymus Neoplasms - enzymology | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Thymus Neoplasms - genetics | Male | Thymoma - genetics | DNA Repair - genetics | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Young Adult | Poly-ADP-Ribose Binding Proteins | TOR Serine-Threonine Kinases - genetics | Thymus Neoplasms - pathology | Aged, 80 and over | Antigens, Neoplasm - metabolism | Adult | Female | Thymoma - drug therapy | Thymoma - pathology | Antigens, Neoplasm - genetics | DNA Topoisomerases, Type II - metabolism | RNA, Messenger - genetics | Thymoma - enzymology | Thymidylate Synthase - metabolism | Thymus Neoplasms - drug therapy | DNA-Binding Proteins - genetics | Thymidylate Synthase - genetics | ral Guanine Nucleotide Exchange Factor - genetics | Cell Transformation, Neoplastic | Adolescent | DNA Topoisomerases, Type II - genetics | Aged | ral Guanine Nucleotide Exchange Factor - metabolism | Chemotherapy | Messenger RNA | Genes | DNA | DNA repair | Cancer | Tumors | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 2090 - 2108
Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4(+) T effector cell subsets. Herein, we show that mTOR complex 1... 
MAMMALIAN TARGET | EFFECTOR | MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-CONTROL | ACTIVATION | TUBEROUS SCLEROSIS COMPLEX | MEMORY DEVELOPMENT | GENE-PRODUCTS | TUMOR-SUPPRESSOR TSC1 | TRANSCRIPTION FACTOR | CUTTING EDGE | Recombinant Fusion Proteins - immunology | Ovalbumin - immunology | CD8-Positive T-Lymphocytes - transplantation | Male | Multiprotein Complexes - genetics | Ras Homolog Enriched in Brain Protein | Glycolysis - drug effects | TOR Serine-Threonine Kinases - deficiency | CD4-CD8 Ratio | TOR Serine-Threonine Kinases - genetics | Lymphopoiesis - physiology | Peptide Fragments - immunology | CD8-Positive T-Lymphocytes - metabolism | TOR Serine-Threonine Kinases - physiology | Thymoma - therapy | Multiprotein Complexes - deficiency | Proto-Oncogene Proteins c-akt - metabolism | Transduction, Genetic | Lymphocyte Activation | Thymoma - immunology | Melanoma, Experimental - therapy | Monomeric GTP-Binding Proteins - deficiency | Multiprotein Complexes - physiology | Cell Line, Tumor | Mice | Mice, Congenic | Protein Processing, Post-Translational | CD8-Positive T-Lymphocytes - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Adoptive Transfer | Mechanistic Target of Rapamycin Complex 2 | Mechanistic Target of Rapamycin Complex 1 | Deoxyglucose - therapeutic use | Melanoma, Experimental - immunology | Deoxyglucose - pharmacology | Female | Neuropeptides - genetics | Genes, Reporter | Rapamycin-Insensitive Companion of mTOR Protein | Neuropeptides - deficiency | Sirolimus - therapeutic use | Mice, Inbred C57BL | Monomeric GTP-Binding Proteins - genetics | Sirolimus - pharmacology | Carrier Proteins - genetics | Animals | Immunologic Memory | Interferon-gamma - biosynthesis | Index Medicus | Abridged Index Medicus | Metabolism | Oncology | Immunology
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2016, Volume 6, Issue 1, pp. 37576 - 37576
Journal Article