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Genes and Development, ISSN 0890-9369, 06/2006, Volume 20, Issue 12, pp. 1569 - 1574
The tumor suppressor PTEN is frequently inactivated in human cancers. A major downstream effector of PTEN is Akt, which is hyperactivated via PTEN... 
Intestinal polyps | PIN | Endometrium carcinoma | Thyroid and adrenal tumors | Cancer therapy | AKT/PKB | GENETICALLY-ENGINEERED MICE | PTEN | DEVELOPMENTAL BIOLOGY | PHOSPHOINOSITIDE 3-KINASE | CANCER | CELL BIOLOGY | cancer therapy | PATHWAY | thyroid and adrenal tumors | NEOPLASIA | RELEVANCE | intestinal polyps | MUTATION | GENETICS & HEREDITY | endometrium carcinoma | Prostatic Intraepithelial Neoplasia - pathology | Thyroid Neoplasms - enzymology | Proto-Oncogene Proteins c-akt - deficiency | Male | Intestinal Polyps - enzymology | Proto-Oncogene Proteins c-akt - genetics | Adrenal Gland Neoplasms - enzymology | Prostatic Neoplasms - genetics | Endometrial Neoplasms - genetics | Neoplasms - genetics | Female | Pseudolymphoma - genetics | Pseudolymphoma - enzymology | Adrenal Gland Neoplasms - pathology | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Endometrial Neoplasms - enzymology | Neoplasms - enzymology | PTEN Phosphohydrolase - metabolism | Pseudolymphoma - pathology | Thyroid Neoplasms - genetics | Animals | Prostatic Intraepithelial Neoplasia - enzymology | Intestinal Polyps - pathology | Prostatic Neoplasms - enzymology | Endometrial Neoplasms - pathology | Heterozygote | Mice | Prostatic Intraepithelial Neoplasia - genetics | Neoplasms - pathology | Adrenal Gland Neoplasms - genetics | Thyroid Neoplasms - pathology | Research Communication
Journal Article
Cancer Research, ISSN 0008-5472, 11/2010, Volume 70, Issue 21, pp. 8874 - 8885
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 10, pp. 839 - 847
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7387, pp. 100 - 104
Inhibition of the BRAF(V600E) oncoprotein by the small-molecule drug PLX4032 (vemurafenib) is highly effective in the treatment of melanoma(1). However, colon... 
PANITUMUMAB | TARGET | CETUXIMAB | MELANOMA | BRAF MUTATIONS | MULTIDISCIPLINARY SCIENCES | PAPILLARY THYROID-CARCINOMA | KRAS | METASTATIC COLORECTAL-CANCER | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - agonists | Apoptosis - drug effects | Colorectal Neoplasms - genetics | Humans | Antineoplastic Agents - therapeutic use | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | Colorectal Neoplasms - drug therapy | HEK293 Cells | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cetuximab | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Colorectal Neoplasms - enzymology | Antibodies, Monoclonal - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Quinazolines - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Feedback, Physiological - drug effects | Indoles - therapeutic use | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Colorectal Neoplasms - pathology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Proteins | Library collections | Studies | Phosphorylation | Kinases | Tumors
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2014, Volume 53, Issue 1, pp. 75 - 87
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2013, Volume 19, Issue 23, pp. 6556 - 6565
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2010, Volume 28, Issue 14, pp. 2323 - 2330
Purpose Mutations in the RET proto-oncogene and vascular endothelial growth factor receptor (VEGFR) activity are critical in the pathogenesis of medullary... 
INHIBITION | RECIST | SOLID TUMORS | ANGIOGENESIS | ONCOLOGY | PATHWAY | TARGETS | RET PROTOONCOGENE MUTATIONS | CARCINOMA | EXPRESSION | Niacinamide - analogs & derivatives | Thyroid Neoplasms - enzymology | United States | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Benzenesulfonates - therapeutic use | Phenylurea Compounds | Positron-Emission Tomography | Benzenesulfonates - administration & dosage | Protein Kinase Inhibitors - adverse effects | Benzenesulfonates - adverse effects | Carcinoma, Medullary - enzymology | Young Adult | Carcinoma, Medullary - drug therapy | Pyridines - adverse effects | Carcinoma, Medullary - secondary | Time Factors | Biomarkers, Tumor - metabolism | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Adult | Female | Proto-Oncogene Proteins c-ret - antagonists & inhibitors | Pyridines - therapeutic use | Pyridines - administration & dosage | Thyroid Neoplasms - mortality | Carcinoma, Medullary - mortality | Administration, Oral | Carcinoma, Medullary - genetics | Kaplan-Meier Estimate | Treatment Outcome | Disease-Free Survival | Magnetic Resonance Imaging | Protein Kinase Inhibitors - administration & dosage | Thyroid Neoplasms - genetics | Thyroid Neoplasms - drug therapy | Protein Kinase Inhibitors - therapeutic use | Aged | Mutation | Proto-Oncogene Proteins c-ret - genetics | Thyroid Neoplasms - pathology | Index Medicus | Original Reports | Endo5
Journal Article