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EXPERIMENTAL CELL RESEARCH, ISSN 0014-4827, 07/2007, Volume 313, Issue 11, pp. 2504 - 2520
Pyostaglandin E-2 (PGE(2)) and prostacyclin are lipid mediators produced by cyclooxygenase and implicated in the regulation of vascular function, wound repair,... 
cytoskeleton | PROTEIN-KINASE | permeability | small GTPases | PKA | EXCHANGE FACTOR TIAM1 | lung endothelium | GEFs | SPHINGOSINE 1-PHOSPHATE | CELL BIOLOGY | SIGNAL-TRANSDUCTION | CYCLIC-AMP | PROSTANOID RECEPTORS | CELL JUNCTIONS | ONCOLOGY | IN-VIVO | RHO GTPASES | CYTOSKELETAL REARRANGEMENT | Proto-Oncogene Proteins c-vav - antagonists & inhibitors | Proto-Oncogene Proteins c-vav - genetics | Humans | rac GTP-Binding Proteins - metabolism | Male | Lung - cytology | Respiratory Distress Syndrome, Adult - metabolism | Adherens Junctions - metabolism | rac GTP-Binding Proteins - antagonists & inhibitors | Blood-Air Barrier - drug effects | Cyclic AMP-Dependent Protein Kinases - genetics | Guanine Nucleotide Exchange Factors - metabolism | rac GTP-Binding Proteins - genetics | Epoprostenol - pharmacology | Lung - metabolism | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | Cyclic AMP-Dependent Protein Kinases - metabolism | Dinoprostone - pharmacology | Guanine Nucleotide Exchange Factors - genetics | Cytoskeleton - pathology | Respiratory Distress Syndrome, Adult - prevention & control | Endothelial Cells - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Blood-Air Barrier - cytology | Permeability | Adherens Junctions - pathology | Epoprostenol - analogs & derivatives | Animals | Blood-Air Barrier - metabolism | Guanine Nucleotide Exchange Factors - antagonists & inhibitors | Lung - drug effects | Adherens Junctions - drug effects | rac1 GTP-Binding Protein - antagonists & inhibitors | Cytoskeleton - metabolism | Mice | Cytoskeleton - drug effects | Proto-Oncogene Proteins c-vav - metabolism | rac1 GTP-Binding Protein - metabolism | Endothelial Cells - drug effects | rac1 GTP-Binding Protein - genetics
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2012, Volume 22, Issue 10, pp. 1479 - 1501
Journal Article
Breast Cancer Research, ISSN 1465-5411, 06/2017, Volume 19, Issue 1, pp. 74 - 15
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, p. e0187094
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e53123
Microtubule-associated protein 1B (MAP1B) is a neuronal protein involved in the stabilization of microtubules both in the axon and somatodendritic... 
ACTIN STRESS FIBERS | HEAVY-CHAIN | INVASION | POLARITY | MULTIDISCIPLINARY SCIENCES | GROWTH | PLECKSTRIN HOMOLOGY DOMAIN | AXON FORMATION | RHO-GTPASES | IDENTIFICATION | HIPPOCAMPAL-NEURONS | Guanine Nucleotide Exchange Factors - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Cells, Cultured | Cytoskeleton - genetics | Cercopithecus aethiops | Rats | Neurons - cytology | Hippocampus - cytology | Neoplasm Proteins - metabolism | Hippocampus - metabolism | Microtubules - metabolism | Animals | Guanine Nucleotide Exchange Factors - metabolism | Microtubules - genetics | Cytoskeleton - metabolism | Neurons - metabolism | Neoplasm Proteins - genetics | COS Cells | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Post-translational modification | Neurons | Actin | Polymerization | Amino acids | G proteins | Tubulins | Muscle proteins | Biotechnology | Laboratories | Homology | Activation | Biology | Kinases | Inactivation | Guanine | Proteins | Signal transduction | Tubulin | Compartments | Microtubule-associated proteins | Pleckstrin | Microtubule-associated protein 1 | Post-translation | Binding | Deactivation | Cloning | Tiam1 protein | Rac1 protein | Cytoskeleton | Regulation | Guanosinetriphosphatase
Journal Article
Biochemical journal, ISSN 0264-6021, 2006, Volume 397, Issue 1, pp. 39 - 45
The Rac-specific GEF (guanine-nucleotide exchange factor) Tiam1 (T-lymphoma invasion and metastasis 1) regulates migration, cell-matrix and cell-cell adhesion... 
Arp2/3 complex | p21-Arc | T-lymphoma invasion and metastasis 1 (Tiam1) | Wiskott-Aldrich syndrome protein (WASP) | Rac1 | Actin | CYTOSKELETON | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GUANINE-NUCLEOTIDE EXCHANGE | actin | EPITHELIAL-CELLS | RHO ACTIVITY | GTPASES | PLECKSTRIN HOMOLOGY DOMAIN | N-WASP | DEPOLYMERIZING PROTEIN | T-lymphoma invasion and metastasis I (Tiam1) | CELL-CELL ADHESION | Cytoskeletal Proteins | Protein Structure, Tertiary | Actin Cytoskeleton | Signal Transduction | Actins - metabolism | rac GTP-Binding Proteins - metabolism | Neuropeptides - metabolism | Nerve Tissue Proteins | Neoplasm Proteins - metabolism | Actin-Related Protein 2-3 Complex - chemistry | Two-Hybrid System Techniques | Actin-Related Protein 2-3 Complex - metabolism | Animals | Chromatography, Affinity | Guanine Nucleotide Exchange Factors - metabolism | Fluorescent Antibody Technique | Cytoskeleton - metabolism | Mice | rac1 GTP-Binding Protein | T-Lymphoma Invasion and Metastasis-inducing Protein 1 | Tiam1, T-lymphoma invasion and metastasis | Arp, actin-related protein | MDCK, Madin–Darby canine kidney cells | Arp2 | FL, full-length | WASP, Wiskott–Aldrich syndrome protein | CC, coiled-coil | 3AT, 3-aminotriazole | Wiskott–Aldrich syndrome protein (WASP) | WAVE, WASP-family verprolin homologous protein | IRSp53, insulin receptor substrate p53 | PIR121, p53-inducible mRNA with an Mr of 140000 | Rac interacting binding | GEF, guanine-nucleotide exchange factor | GST, glutathione S-transferase | JIP, c-Jun N-terminal kinase-interacting protein | Cdc42, cell division cycle 42 | PAK, p21-activated kinase | Arc, Arp complex | 3 complex | HA, haemagglutinin | PH, pleckstrin homology | PHn, N-terminal PH domain | CRIB, Cdc42 | Ex, extended | DH, Dbl homology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 49, pp. 20173 - 20183
Brain ischemia causes oxygen and glucose deprivation (OGD) in neurons, triggering a cascade of events leading to synaptic accumulation of glutamate. Excessive... 
cortex | Tiam1 | PTPRT | NMDA RECEPTOR | hippocampus | BIOCHEMISTRY & MOLECULAR BIOLOGY | OGD | ischemia | CELL-DEATH | BCR | DENDRITIC SPINES | GTPase-activating protein (GAP) | BRAIN ISCHEMIA | NMDA receptor (NMDAR) | FYN | ISCHEMIC-STROKE | guanine nucleotide exchange factor (GEF) | KINASES | Neurobiology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2019, Volume 116, Issue 11, pp. 4999 - 5008
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 11/2008, Volume 9, Issue 11, pp. 846 - 859
Journal Article