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Bone, ISSN 8756-3282, 2010, Volume 47, Issue 2, pp. 309 - 319
Abstract Adenosine 5′-monophosphate-activated protein kinase (AMPK), a regulator of energy homeostasis, has a central role in mediating the appetite-modulating... 
Orthopedics | Knockout mice | Energy metabolism | Bone | Metformin | AMP kinase | Osteoblasts | OSTEOBLASTIC MC3T3-E1 CELLS | FOOD-INTAKE | PROLIFERATION | ANTIDIABETIC DRUGS | INSULIN SENSITIVITY | BMP-2 EXPRESSION | ENERGY HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | DIFFERENTIATION | ROSIGLITAZONE | Enzyme Activators - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | AMP-Activated Protein Kinases - metabolism | Osteogenesis - physiology | Alkaline Phosphatase - metabolism | RNA, Messenger - metabolism | AMP-Activated Protein Kinases - deficiency | Protein Subunits - metabolism | Aminoimidazole Carboxamide - pharmacology | Bone and Bones - drug effects | Ribonucleotides - pharmacology | Osteoblasts - cytology | Bone and Bones - cytology | Protein Subunits - genetics | Tibia - enzymology | Osteoblasts - enzymology | Metformin - pharmacology | Osteoblasts - drug effects | Osteogenesis - drug effects | RNA, Messenger - genetics | Rats | Bone and Bones - enzymology | Enzyme Activation - drug effects | Tibia - drug effects | Mice, Knockout | Neurosecretory Systems - enzymology | Organ Size - drug effects | Phenotype | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Cell Differentiation - drug effects | Protein Subunits - deficiency | Cell Proliferation - drug effects | Mice | AMP-Activated Protein Kinases - genetics
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 06/2012, Volume 227, Issue 6, pp. 2622 - 2631
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 03/2018, Volume 233, Issue 3, pp. 2398 - 2408
Currently, there are no medications available to treat aseptic loosening of orthopedic implants. Using osteoprotegerin fusion protein (OPG‐Fc), we previously... 
bone implant | mechanical instability | Wnt signaling | GSK‐3β | osteolysis | GSK-3β | CELLS | ACTIVATION | PHYSIOLOGY | RESORPTION | BONE MORPHOGENETIC PROTEIN-2 | WNT16 | RAT MODEL | CELL BIOLOGY | IN-VIVO | FRACTURES | FLUID PRESSURE | GSK-3 beta | EXPRESSION | RANK Ligand - metabolism | Tartrate-Resistant Acid Phosphatase - blood | Alkaline Phosphatase - metabolism | Male | RNA, Messenger - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Bone Plates | Tibia - pathology | Collagen Type I - genetics | Prosthesis Failure | Time Factors | Osteolysis - prevention & control | Osteolysis - pathology | Disease Models, Animal | Bone Morphogenetic Protein 2 - genetics | Tibia - enzymology | Osteoclasts - pathology | Alkaline Phosphatase - genetics | Prosthesis Implantation - instrumentation | Rats, Sprague-Dawley | beta Catenin - metabolism | Osteolysis - enzymology | Osteoprotegerin - metabolism | Bone Morphogenetic Protein 2 - metabolism | Osteoprotegerin - genetics | Collagen Type I - metabolism | Osteoblasts - enzymology | Osteolysis - genetics | Osteoblasts - drug effects | Osteogenesis - drug effects | RNA, Messenger - genetics | Gene Expression Regulation | Glycogen Synthase Kinase 3 beta - antagonists & inhibitors | Transcription Factors - genetics | Tibia - drug effects | Glycogen Synthase Kinase 3 beta - metabolism | Tibia - surgery | beta Catenin - genetics | RANK Ligand - genetics | Transcription Factors - metabolism | Osteoblasts - pathology | Animals | Wnt Signaling Pathway - drug effects | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Osteoclasts - enzymology | Protein Kinase Inhibitors - pharmacology | Core Binding Factor Alpha 1 Subunit - genetics | Osteoclasts - drug effects | Mechanical instability | Osteolysis | Bone implant | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | bone implant; GSK-3 beta; mechanical instability; osteolysis; Wnt signaling | Farmakologi och toxikologi | Pharmacology and Toxicology
Journal Article
Amino Acids, ISSN 0939-4451, 11/2012, Volume 43, Issue 5, pp. 1905 - 1918
d-Amino acid oxidase (DAAO), a FAD-dependent peroxisomal flavoenzyme that catalyzes oxidation of d-amino acids to hydrogen peroxide, is distributed in the... 
Life Sciences | Biochemistry, general | Morphine tolerance | Analytical Chemistry | 5-Chloro-benzo[ d ]isoxazol-3-ol (CBIO) | Life Sciences, general | Biochemical Engineering | Neurobiology | Proteomics | Gene silencer siRNA/DAAO | Bone cancer pain | d -Amino acid oxidase (DAAO) | 5-Chloro-benzo[d]isoxazol-3-ol (CBIO) | D-Amino acid oxidase (DAAO) | CENTRAL SENSITIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | NITRO-D-ARGININE | CHIRAL INVERSION | RAT MODEL | MURINE MODEL | INDUCED TONIC PAIN | MORPHINE-TOLERANCE | CENTRAL-NERVOUS-SYSTEM | HYDROGEN-PEROXIDE | Spinal Cord - drug effects | Gene Expression - drug effects | Rats, Wistar | Analgesia - methods | D-Amino-Acid Oxidase - antagonists & inhibitors | Astrocytes - pathology | Analgesics, Opioid - pharmacology | Astrocytes - enzymology | Pain - metabolism | Bone Neoplasms - pathology | Carcinoma 256, Walker - pathology | Pain - drug therapy | Spinal Cord - pathology | Bone Neoplasms - physiopathology | Carcinoma 256, Walker - physiopathology | Female | D-Amino-Acid Oxidase - metabolism | Tibia - physiopathology | Injections, Spinal | Astrocytes - drug effects | Tibia - enzymology | Bone Neoplasms - enzymology | Morphine - pharmacology | Receptors, Opioid, mu - metabolism | Enzyme Inhibitors - pharmacology | Spinal Cord - enzymology | D-Amino-Acid Oxidase - genetics | Hyperalgesia - prevention & control | Rats | Tibia - drug effects | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Isoxazoles - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Carcinoma 256, Walker - enzymology | Pain - physiopathology | Receptors, Opioid, mu - genetics
Journal Article
Bone, ISSN 8756-3282, 2004, Volume 35, Issue 5, pp. 1107 - 1119
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 09/2012, Volume 27, Issue 9, pp. 1936 - 1950
Like bone mass, bone quality is specified in development, actively maintained postnatally, and disrupted by disease. The roles of osteoblasts, osteoclasts, and... 
MATRIX METALLOPROTEINASE–13 | OSTEOCYTE | REMODELING | FRACTURE RESISTANCE | BONE QUALITY | OSTEOCYTE PERILACUNAR REMODELING | BONE MATRIX | MATRIX METALLOPROTEINASE-13 | CORTICAL BONE | BIOCHEMICAL MARKERS | CALCIUM DEFICIENCY | MECHANICAL-PROPERTIES | GROWTH-FACTOR-BETA | BIOMECHANICAL PROPERTIES | 1-YEAR TREATMENT | CANCELLOUS BONE | AGE-RELATED-CHANGES | NONENZYMATIC GLYCATION | ENDOCRINOLOGY & METABOLISM | Bone Matrix - metabolism | Lactation | Bone Matrix - diagnostic imaging | Osteocytes - enzymology | X-Ray Microtomography | Tibia - pathology | Matrix Metalloproteinase 13 - deficiency | Fractures, Bone - enzymology | Female | Fractures, Bone - diagnostic imaging | Tibia - physiopathology | Tibia - enzymology | Bone Resorption - physiopathology | Osteoclasts - pathology | Tibia - diagnostic imaging | Organ Size | Osteoclasts - metabolism | Bone Matrix - pathology | Matrix Metalloproteinase 13 - metabolism | Protein Transport | Bone Resorption - diagnostic imaging | Collagen - metabolism | Osteoblasts - pathology | Biomechanical Phenomena | Animals | Calcification, Physiologic | Bone Resorption - pathology | Fractures, Bone - physiopathology | Osteocytes - pathology | Fractures, Bone - pathology | Mice | Osteoblasts - metabolism | Bone Remodeling | Osteogenesis | Biological products | Fractures | Phosphatases | Collagen | Analysis | Stem cells | Bones | Health aspects | Density | Bone remodelling | Mechanical properties | Osteocytes | SOST protein | Matrix metalloproteinase | Collagenase 3 | Osteoblasts | Diaphysis | Bone histomorphometry | Bone mass | Molecular modelling | Cross-linking | Extracellular matrix | Osteoclasts | Acid phosphatase (tartrate-resistant) | Bone loss | Bone matrix | matrix metalloproteinase-13 | remodeling | fracture resistance | bone matrix | osteocyte | bone quality | osteocyte perilacunar remodeling
Journal Article
Cancer Investigation, ISSN 0735-7907, 2009, Volume 27, Issue 4, pp. 435 - 442
Journal Article
Journal Article