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Molecules (Basel, Switzerland), ISSN 1420-3049, 2016, Volume 21, Issue 6, pp. 704 - 704
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2013, Volume 4, Issue 3, pp. 349 - 352
Clopidogrel (CPG) is an antithrombotic prodrug that needs hepatic cytochrome P450 (CYP) enzymes for its bioactivation. The clinical effects of CPG have been... 
bioactivation potentiation | clinical variability | targeted metabolic shift | piperidine deuteration | Clopidogrel resistance | prodrug attrition | CHEMISTRY, MEDICINAL | MECHANISM | INVOLVEMENT | PREVENTION | BIOACTIVATION | IDENTIFICATION | TICLOPIDINE | RESISTANCE | ADENOSINE DIPHOSPHATE | AGGREGATION | ACTIVE METABOLITE
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2010, Volume 38, Issue 1, pp. 92 - 99
The aim of the current study is to identify the human cytochrome P450 (P450) isoforms involved in the two oxidative steps in the bioactivation of clopidogrel... 
MECHANISM-BASED INHIBITION | ANTIAGGREGATING ACTIVITY | POLYMORPHISMS | PHARMACOKINETICS | TICLOPIDINE | PHARMACOLOGY & PHARMACY | PRASUGREL | PHARMACODYNAMICS | MONOCLONAL-ANTIBODIES | Microsomes - metabolism | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Cytochrome P-450 Enzyme System - metabolism | Sulfaphenazole - pharmacology | Microsomes - drug effects | Cytochrome P-450 CYP3A - genetics | Cytochrome P-450 CYP1A2 - genetics | Antibodies - immunology | Omeprazole - pharmacology | Microsomes, Liver - enzymology | Platelet Aggregation Inhibitors - pharmacokinetics | Ticlopidine - pharmacokinetics | Oxidoreductases, N-Demethylating - metabolism | Aryl Hydrocarbon Hydroxylases - immunology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Ticlopidine - analogs & derivatives | Oxidoreductases, N-Demethylating - immunology | Cytochrome P-450 CYP3A - metabolism | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Theophylline - pharmacology | Kinetics | Cytochrome P-450 CYP2C9 | Theophylline - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Glutathione - metabolism | Ketoconazole - pharmacology | Biotransformation - physiology | Cytochrome P-450 CYP1A2 Inhibitors | Microsomes, Liver - drug effects | Ticlopidine - metabolism | NADP - metabolism | Platelet Aggregation Inhibitors - metabolism | Cytochrome P-450 CYP3A - immunology | Cell Line | Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors | Cytochrome P-450 CYP1A2 - immunology | Biocatalysis | Mephenytoin - analogs & derivatives | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Mephenytoin - pharmacology | Antibodies - pharmacology | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP2C19 | Clopidogrel | Cytochrome P-450 CYP2B6
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2018, Volume 379, Issue 3, pp. 215 - 225
In this international, randomized trial, patients with minor stroke or TIA who received clopidogrel plus aspirin had a lower risk of major ischemic events but... 
TRIAL | MEDICINE, GENERAL & INTERNAL | EFFICACY | TICAGRELOR | SAFETY | MINOR STROKE | ATTACK | Stroke - prevention & control | Ischemic Attack, Transient - drug therapy | Double-Blind Method | Humans | Middle Aged | Male | Risk | Brain Ischemia - prevention & control | Secondary Prevention | Stroke - drug therapy | Ischemia - mortality | Ticlopidine - analogs & derivatives | Aspirin - administration & dosage | Drug Therapy, Combination - adverse effects | Aspirin - adverse effects | Platelet Aggregation Inhibitors - administration & dosage | Ticlopidine - adverse effects | Ticlopidine - administration & dosage | Clopidogrel | Female | Aged | Myocardial Infarction - prevention & control | Hemorrhage - chemically induced | Platelet Aggregation Inhibitors - adverse effects | Stroke (Disease) | Cerebral ischemia | Safety and security measures | Dosage and administration | Drug therapy | Stroke patients | Health aspects | Risk factors | Myocardial infarction | Cerebral infarction | Aspirin | Stroke | Nuclear magnetic resonance--NMR | Medical imaging | Transient ischemic attack | Hemorrhage | Neurological diseases | Ischemia | Blood platelets | Tomography | Blood pressure | Diabetes | Drug dosages | Neurological disorders | Brain Ischemia | Ischemic Attack | administration & dosage | Combination | Transient | Neurologi | chemically induced | Drug Therapy | prevention & control | Ticlopidine | Neurology | Myocardial Infarction | analogs & derivatives | Platelet Aggregation Inhibitors | adverse effects | mortality
Journal Article
European heart journal, ISSN 1522-9645, 2013, Volume 34, Issue 23, pp. 1708 - 1713
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2017, Volume 377, Issue 16, pp. 1513 - 1524
In this trial, dabigatran plus a P2Y 12 inhibitor was compared with warfarin plus a P2Y 12 inhibitor and aspirin after PCI in patients with atrial... 
MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | HEART-DISEASE | MYOCARDIAL-INFARCTION | ORAL ANTICOAGULATION | 2011 ACCF/AHA/SCAI GUIDELINE | AMERICAN-COLLEGE | ASSOCIATION TASK-FORCE | TRIPLE THERAPY | ANTIPLATELET THERAPY | CONSENSUS DOCUMENT | Dabigatran - adverse effects | Ticlopidine - therapeutic use | Humans | Middle Aged | Warfarin - adverse effects | Male | Risk | Dabigatran - therapeutic use | Incidence | Warfarin - therapeutic use | Purinergic P2Y Receptor Antagonists - adverse effects | Drug Therapy, Combination - adverse effects | Adenosine - adverse effects | Adenosine - therapeutic use | Female | Aspirin - therapeutic use | Platelet Aggregation Inhibitors - therapeutic use | Ticagrelor | Purinergic P2Y Receptor Antagonists - therapeutic use | Hemorrhage - epidemiology | Atrial Fibrillation - drug therapy | Atrial Fibrillation - therapy | Anticoagulants - therapeutic use | Anticoagulants - adverse effects | Ticlopidine - analogs & derivatives | Adenosine - analogs & derivatives | Clopidogrel | Aged | Hemorrhage - chemically induced | Percutaneous Coronary Intervention | Warfarin | Atrial fibrillation | Dosage and administration | Research | Thromboembolism | Hemorrhage | Health aspects | Myocardial infarction | Cerebral infarction | Cardiac arrhythmia | Anticoagulants | Aspirin | Stroke | Embolisms | Preventive medicine | Thrombosis | Bleeding | Embolism | Fibrillation | Cardiology | Drug therapy | Drug dosages | Geriatrics
Journal Article
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 12/2013, Volume 310, Issue 23, pp. 2510 - 2522
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2017, Volume 376, Issue 1, pp. 32 - 40
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2014, Volume 371, Issue 11, pp. 1016 - 1027
This study compared administration of the antiplatelet agent ticagrelor in the ambulance with administration in the cath lab in patients with ST-segment... 
MEDICINE, GENERAL & INTERNAL | PERCUTANEOUS CORONARY INTERVENTION | GLYCOPROTEIN IIB/IIIA INHIBITORS | CLOPIDOGREL | MANAGEMENT | INITIATION | PLATELET INHIBITION | DOUBLE-BLIND | IIB-IIIA INHIBITORS | PRASUGREL | PRIMARY ANGIOPLASTY | Myocardial Infarction - mortality | Purinergic P2Y Receptor Antagonists - administration & dosage | Humans | Middle Aged | Male | Purinergic P2Y Receptor Antagonists - adverse effects | Adenosine - adverse effects | Ticlopidine - adverse effects | Ticlopidine - administration & dosage | Female | Drug Therapy, Combination | Myocardial Infarction - diagnosis | Double-Blind Method | Time-to-Treatment | Anticoagulants - therapeutic use | Electrocardiography - drug effects | Adenosine - administration & dosage | Anticoagulants - adverse effects | Ticlopidine - analogs & derivatives | Coronary Angiography | Myocardial Infarction - drug therapy | Myocardial Reperfusion | Adenosine - analogs & derivatives | Aged | Hemorrhage - chemically induced | Emergency Medical Services | Administration | Care and treatment | Hospitals | Research | Management | Heart attack | Risk factors | Myocardial infarction | Heart attacks | Catheterization | Angiography | Clinical trials | Patients | Thrombosis | Thrombolysis | Bleeding | Clinical outcomes | Studies | Reperfusion | Blood platelets | Coronary vessels | Implants | Intubation | Acute coronary syndromes | Drug therapy | Infart de miocardi | Adenosine | Malalties coronàries | Anticoagulants (Medicine) | Anticoagulants (Medicina) | Adenosina | Coronary diseases
Journal Article