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Journal Article
Chemistry & Biodiversity, ISSN 1612-1872, 04/2019, Volume 16, Issue 4, p. n/a
A series of analogs containing tetrahydrothieno[3,2‐ c ]pyridine‐2‐carboxamide as a building block with numerous alicyclic and aromatic amines were... 
tetrahydrothieno[3,2 | prasugrel | biological activity | pyridine | Lipinski's rule | antiplatelet activity | synthesis design | ADENOSINE-DIPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2-c]pyridine | tetrahydrothieno | CHEMISTRY, MULTIDISCIPLINARY | CLOPIDOGREL | TICLOPIDINE | DRUGS | Aggregation | Alkaloids | Aromatic amines | Pyridine | Synthesis | Blood platelets | Analysis | Organic compounds
Journal Article
Journal Article
American Heart Journal, ISSN 0002-8703, 2014, Volume 169, Issue 4, pp. 472 - 478.e5
Journal Article
European Heart Journal, ISSN 0195-668X, 12/2011, Volume 32, Issue 23, pp. 2933 - 2944
Journal Article
Current Opinion in Hematology, ISSN 1065-6251, 09/2009, Volume 16, Issue 5, pp. 371 - 377
Journal Article
Circulation, ISSN 0009-7322, 12/2010, Volume 122, Issue 24, pp. 2619 - 2633
proton pump inhibitors | antiplatelet drugs | gastrointestinal hemorrhage | platelet aggregation inhibitors | aspirin | thienopyridine | AHA Scientific Statements | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIOVASCULAR EVENTS | TRANSIENT ISCHEMIC ATTACK | ACID SUPPRESSION | ACUTE CORONARY SYNDROMES | H-2-RECEPTOR ANTAGONISTS | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ACUTE MYOCARDIAL-INFARCTION | PERIPHERAL VASCULAR DISEASE | PLACEBO-CONTROLLED TRIAL | ST-SEGMENT ELEVATION | Piperazines - administration & dosage | Prasugrel Hydrochloride | Purinergic P2Y Receptor Antagonists - administration & dosage | Thiophenes - adverse effects | Cardiovascular Diseases - drug therapy | Humans | Thienopyridines - adverse effects | Thienopyridines - metabolism | Piperazines - metabolism | Thiophenes - metabolism | Thiophenes - administration & dosage | Aspirin - administration & dosage | Purinergic P2Y Receptor Antagonists - metabolism | Histamine H2 Antagonists - administration & dosage | Purinergic P2Y Receptor Antagonists - adverse effects | Drug Interactions | Proton Pump Inhibitors - administration & dosage | Aspirin - adverse effects | Aspirin - metabolism | Platelet Aggregation Inhibitors - administration & dosage | Ticlopidine - adverse effects | Ticlopidine - metabolism | Ticlopidine - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Platelet Aggregation Inhibitors - metabolism | Drug Therapy, Combination | Platelet Aggregation Inhibitors - adverse effects | Proton Pump Inhibitors - adverse effects | Thienopyridines - administration & dosage | Risk Factors | Histamine H2 Antagonists - adverse effects | Piperazines - adverse effects | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Gastrointestinal Hemorrhage - chemically induced | Gastrointestinal Hemorrhage - prevention & control | Histamine H2 Antagonists - metabolism | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cytochrome P-450 CYP2C19 | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Proton Pump Inhibitors - metabolism
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2013, Volume 61, Issue 20, pp. 2060 - 2066
Objectives This study sought to evaluate whether prasugrel may serve as an alternative to clopidogrel in patients with triple therapy. Background Approximately... 
Cardiovascular | Internal Medicine | clopidogrel | aspirin | prasugrel | high platelet reactivity | vitamin K antagonist | drug-eluting stent(s) | CARDIAC & CARDIOVASCULAR SYSTEMS | BLEEDING RISK | DOSE CLOPIDOGREL | EUROPEAN-SOCIETY | ANTIPLATELET THERAPY | CONSENSUS DOCUMENT | ATRIAL-FIBRILLATION | ANTITHROMBOTIC MANAGEMENT | PERCUTANEOUS CORONARY INTERVENTION | TASK-FORCE | Piperazines - administration & dosage | Prasugrel Hydrochloride | Drug-Eluting Stents | Purinergic P2Y Receptor Antagonists - administration & dosage | Anticoagulants - administration & dosage | Humans | Middle Aged | Male | Thiophenes - administration & dosage | Ticlopidine - analogs & derivatives | Aspirin - administration & dosage | Patient Selection | Vitamin K - antagonists & inhibitors | Myocardial Ischemia - etiology | Platelet Aggregation Inhibitors - administration & dosage | Myocardial Ischemia - therapy | Aged, 80 and over | Ticlopidine - administration & dosage | Female | Aged | Myocardial Ischemia - mortality | Drug Therapy, Combination | Percutaneous Coronary Intervention | Cohort Studies | Aspirin | Anticoagulants (Medicine) | Stent (Surgery) | Adenosine triphosphatase | Studies | Confidence intervals | Heart attacks | Blood platelets | Mortality | Population | Drug therapy | Acute coronary syndromes | Thrombosis | Drug dosages
Journal Article
The American Journal of Gastroenterology, ISSN 0002-9270, 12/2010, Volume 105, Issue 12, pp. 2533 - 2549
This expert consensus document was developed by the American College of Cardiology Foundation (ACCF), the American College of Gastroenterology (ACG), and the... 
proton pump inhibitors | aspirin | ACCF Expert Consensus Document antiplatelet drugs | gastrointestinal hemorrhage | thienopyridine | platelet aggregation inhibitors | CARDIOVASCULAR EVENTS | TRANSIENT ISCHEMIC ATTACK | ACID SUPPRESSION | ACUTE CORONARY SYNDROMES | H-2-RECEPTOR ANTAGONISTS | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | ACUTE MYOCARDIAL-INFARCTION | PLACEBO-CONTROLLED TRIAL | ST-SEGMENT ELEVATION | GASTROENTEROLOGY & HEPATOLOGY | Piperazines - administration & dosage | Prasugrel Hydrochloride | Purinergic P2Y Receptor Antagonists - administration & dosage | Thiophenes - adverse effects | Cardiovascular Diseases - drug therapy | Humans | Thienopyridines - adverse effects | Thienopyridines - metabolism | Piperazines - metabolism | Thiophenes - metabolism | Thiophenes - administration & dosage | Aspirin - administration & dosage | Purinergic P2Y Receptor Antagonists - metabolism | Histamine H2 Antagonists - administration & dosage | Purinergic P2Y Receptor Antagonists - adverse effects | Drug Interactions | Proton Pump Inhibitors - administration & dosage | Aspirin - adverse effects | Aspirin - metabolism | Platelet Aggregation Inhibitors - administration & dosage | Ticlopidine - adverse effects | Ticlopidine - metabolism | Ticlopidine - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Platelet Aggregation Inhibitors - metabolism | Drug Therapy, Combination | Platelet Aggregation Inhibitors - adverse effects | Proton Pump Inhibitors - adverse effects | Thienopyridines - administration & dosage | Risk Factors | Histamine H2 Antagonists - adverse effects | Piperazines - adverse effects | Ticlopidine - analogs & derivatives | Aryl Hydrocarbon Hydroxylases - metabolism | Gastrointestinal Hemorrhage - chemically induced | Gastrointestinal Hemorrhage - prevention & control | Histamine H2 Antagonists - metabolism | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Cytochrome P-450 CYP2C19 | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Proton Pump Inhibitors - metabolism
Journal Article
DRUG DISCOVERY TODAY, ISSN 1359-6446, 01/2019, Volume 24, Issue 1, pp. 325 - 333
The P2Y(12) receptor is one of eight known P2Y receptor subtypes, and belongs to the G-protein-coupled receptor (GPCR) family. The P2Y(12) receptor is highly... 
CANGRELOR | POTENT | CLOPIDOGREL | METABOLISM | TICAGRELOR | TICLOPIDINE | PHARMACOLOGY | ANTHRAQUINONE DERIVATIVES | PHARMACOLOGY & PHARMACY | INHIBITORS | ANTIPLATELET
Journal Article
Lancet, The, ISSN 0140-6736, 2009, Volume 374, Issue 9706, pp. 1967 - 1974
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2014, Volume 64, Issue 10, pp. 1005 - 1014
Journal Article